Corticotropin

Stevens-Johnson Syndrome, Chorioretinitis, Iridocyclitis + 24 more
Treatment
2 FDA approvals
20 Active Studies for Corticotropin

What is Corticotropin

CorticotropinThe Generic name of this drug
Treatment SummaryCorticotropin (also known as ACTH or adrenocorticotropic hormone) is a hormone produced by the pituitary gland. It plays an important role in the communication between the hypothalamus, the pituitary gland, and the adrenal glands.
H.P. Actharis the brand name
image of different drug pills on a surface
Corticotropin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
H.P. Acthar
Corticotropin
2005
4

Approved as Treatment by the FDA

Corticotropin, otherwise known as H.P. Acthar, is approved by the FDA for 2 uses including Infantile Spasms (IS) and Spasms, Infantile .
Infantile Spasms (IS)
Helps manage Infantile Spasms (IS)
Spasms, Infantile
Helps manage Infantile Spasms (IS)

Effectiveness

How Corticotropin Affects PatientsCorticotropin encourages the adrenal glands to produce hormones called corticosteroids. These hormones, including glucocorticoids and androgens, help regulate the body’s daily rhythms. Corticotropin does this by activating certain receptors on the cells of the adrenal gland.
How Corticotropin works in the bodyCorticotropin helps diagnose adrenal function by stimulating certain cells to produce steroids. In people with healthy adrenal function, this steroid release increases the amount of cholesterol in the mitochondria. However, corticotropin does not work in patients with primary adrenal insufficiency. The way it works to treat infantile myoclonic seizures is unknown.

When to interrupt dosage

The suggested measure of Corticotropin is contingent upon the diagnosed disorder, including Erythema Multiforme, Sarcoidosis and Diuresis. The dosage also deviates according to the approach of administration (e.g. Injection or Intramuscular; Subcutaneous) as shown in the table underneath.
Condition
Dosage
Administration
Arthritis, Juvenile
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Stevens-Johnson Syndrome
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Chorioretinitis
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Iridocyclitis
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Nephrotic Syndrome
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Polymyositis
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Serum Sickness
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Arthritis, Gouty
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Sarcoidosis
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Dermatomyositis
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Erythema Multiforme
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
induction of Diuresis
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Diuresis
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Optic Neuritis
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Acute Coryza
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Psoriatic Arthritis
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Rheumatoid Arthritis
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Lupus
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Ankylosing Spondylitis
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous
Allergic Conjunctivitis (AC)
, 40.0 units, 80.0 [USP'U]/mL, 80.0 [iU]/mL, 40.0 units/mL
, Intramuscular; Subcutaneous, Gel, Gel - Intramuscular; Subcutaneous, Powder, for solution - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Powder, for solution, Injection, Injection - Intramuscular; Subcutaneous, Intravenous, Injection - Intravenous

Warnings

Corticotropin Contraindications
Condition
Risk Level
Notes
Postoperative
Do Not Combine
Keratitis, Herpetic
Do Not Combine
Pulse Frequency
Do Not Combine
A History of Gastric or Duodenal Ulcers
Do Not Combine
Adrenocortical Hyperfunction
Do Not Combine
Scleroderma
Do Not Combine
Hypertensive disease
Do Not Combine
Addison Disease
Do Not Combine
Mycoses
Do Not Combine
Osteoporosis
Do Not Combine
Congestive Heart Failure
Do Not Combine
Pulse Frequency
Do Not Combine
Peptic Ulcer
Do Not Combine
There are 20 known major drug interactions with Corticotropin.
Common Corticotropin Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Corticotropin is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Corticotropin is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abemaciclib
Major
The metabolism of Abemaciclib can be increased when combined with Corticotropin.
Abetimus
Major
The risk or severity of adverse effects can be increased when Corticotropin is combined with Abetimus.
Acalabrutinib
Major
The metabolism of Acalabrutinib can be increased when combined with Corticotropin.
image of a doctor in a lab doing drug, clinical research

Corticotropin Novel Uses: Which Conditions Have a Clinical Trial Featuring Corticotropin?

27 active exploratory trials are being conducted to evaluate the potential of Corticotropin in providing relief from Inflammation, Sarcoidosis and Polymyositis.
Condition
Clinical Trials
Trial Phases
Stevens-Johnson Syndrome
2 Actively Recruiting
Phase 3, Phase 1
Serum Sickness
0 Actively Recruiting
Multiple Sclerosis
0 Actively Recruiting
Optic Neuritis
2 Actively Recruiting
Phase 2
Allergic Conjunctivitis (AC)
2 Actively Recruiting
Phase 3
Chorioretinitis
0 Actively Recruiting
Nephrotic Syndrome
4 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Iritis
0 Actively Recruiting
Iridocyclitis
0 Actively Recruiting
Diuresis
0 Actively Recruiting
Sarcoidosis
0 Actively Recruiting
induction of Diuresis
0 Actively Recruiting
Proteinuria
0 Actively Recruiting
Erythema Multiforme
1 Actively Recruiting
Phase 2
Psoriasis
0 Actively Recruiting
Rheumatoid Arthritis
53 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Arthritis, Juvenile
1 Actively Recruiting
Not Applicable
Lupus
57 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 3, Phase 4
Arthritis, Gouty
0 Actively Recruiting
Psoriatic Arthritis
26 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 4, Phase 2

Corticotropin Reviews: What are patients saying about Corticotropin?

3.3Patient Review
12/16/2013
Corticotropin for Inflammation of the Lining of a Joint
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about corticotropin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does the corticotropin hormone do?

"Corticotropin-releasing hormone (CRH) is a peptide hormone that activates the synthesis and release of adrenocorticotropic hormone (ACTH) from the pituitary gland. CRH affects our response to stress, addiction and depression."

Answered by AI

Is corticotropin the same as cortisol?

"When cortisol levels are low, a hormone called corticotrophin-releasing hormone (CRH) is released from a group of cells in the hypothalamus. This hormone then stimulates the pituitary gland to secrete adrenocorticotropic hormone (ACTH) into the bloodstream."

Answered by AI

Is corticotropin a steroid?

"The effects of corticotropin are similar to those of the steroids (hydrocortisone, androgens) that it causes to be released from the adrenal cortex. If corticotropin is taken in large doses for a long time, it can cause the clinical picture known as Cushing's syndrome."

Answered by AI

Is corticotropin a drug?

"Corticotropin is a hormone that can be used to treat a variety of conditions, including multiple sclerosis, psoriatic or rheumatoid arthritis, ankylosing spondylitis, lupus, severe allergic reactions, breathing disorders, and inflammatory conditions of the eyes."

Answered by AI

Clinical Trials for Corticotropin

Have you considered Corticotropin clinical trials? We made a collection of clinical trials featuring Corticotropin, we think they might fit your search criteria.
Have you considered Corticotropin clinical trials? We made a collection of clinical trials featuring Corticotropin, we think they might fit your search criteria.
Have you considered Corticotropin clinical trials? We made a collection of clinical trials featuring Corticotropin, we think they might fit your search criteria.
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