Your session is about to expire
What is Zyflo
ZileutonThe Generic name of this drug
Treatment SummaryZileuton is a medication that helps reduce the symptoms of asthma. It works by blocking the formation of certain substances called leukotrienes, which cause inflammation, swelling, increased mucus production, and constriction of the airways in asthmatic patients. The drug is specifically designed to inhibit the enzyme 5-lipoxygenase, which is responsible for forming leukotrienes from arachidonic acid. Zileuton was previously available as an immediate release tablet in the US, but has since been withdrawn from the market.
Zyflois the brand name
Zyflo Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zyflo
Zileuton
1996
14
Approved as Treatment by the FDA
Zileuton, also known as Zyflo, is approved by the FDA for 2 uses such as Asthma and Asthma .Asthma
Asthma
Helps manage Chronic Asthma
Effectiveness
How Zyflo Affects PatientsZileuton is a drug used to treat asthma. It works by blocking the leukotriene synthesis pathway, which is thought to contribute to asthma symptoms. It has been shown to reduce asthma symptoms caused by cold air in humans.
How Zyflo works in the bodyZileuton helps relieve symptoms of asthma by blocking the production of substances called leukotrienes. Leukotrienes cause inflammation and narrowing of the airways in asthmatic patients. Zileuton specifically targets 5-lipoxygenase, an enzyme that makes leukotrienes. By blocking the formation of these substances, Zileuton helps reduce inflammation, bronchial spasms, and other asthma symptoms. Both the R(+) and S(-) enantiomers of the drug have been shown to be effective in laboratory studies.
When to interrupt dosage
The suggested dosage of Zyflo is contingent upon the diagnosed condition. The measure, as stated in the table below, is subject to the mode of administration (e.g. Tablet - Oral or Tablet, extended release).Condition
Dosage
Administration
Asthma
, 600.0 mg
, Tablet, extended release - Oral, Tablet, extended release, Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Asthma
, 600.0 mg
, Tablet, extended release - Oral, Tablet, extended release, Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Zyflo ContraindicationsCondition
Risk Level
Notes
acute liver disease
Do Not Combine
Pulse Frequency
Do Not Combine
Common Zyflo Drug Interactions
Drug Name
Risk Level
Description
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Zileuton.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Zileuton.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Zileuton.
Bendamustine
Major
The metabolism of Bendamustine can be decreased when combined with Zileuton.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Zileuton.
Zyflo Toxicity & Overdose RiskThe lowest amount of zileuton that has been found to be lethal in mice is 500-4000mg/kg and in rats it is 300-1000mg/kg. This is much higher than the maximum recommended human daily dose.
Zyflo Novel Uses: Which Conditions Have a Clinical Trial Featuring Zyflo?
A total of 147 active clinical trials are currently exploring the efficacy of Zyflo in providing relief from Asthma.Condition
Clinical Trials
Trial Phases
Asthma
158 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1, Phase 3
Asthma
1 Actively Recruiting
Not Applicable
Zyflo Reviews: What are patients saying about Zyflo?
5Patient Review
8/3/2020 At 73, I'm quite active for my age. I can attribute a lot of that to Zyflo and its ability to help me breathe more deeply. That being said, it is rather pricey and the generic brand works just as well.
5Patient Review
4/3/2009 This medication has made a world of difference for my COPD. I haven't found anything that works better.
5Patient Review
3/17/2008 I can breathe again. So much better than Singlair ever was.
5Patient Review
5/16/2008 Allergist changed my prescription to this and it helped a lot more. I can finally breathe properly and don't have headaches anymore.
5Patient Review
10/5/2013 Z has been a total game-changer for me and my asthma. I was using corticosteroids to manage it before, but this medication is much more effective.
5Patient Review
10/16/2007 This medication has improved my quality of life by allowing me to breathe more easily.
4.3Patient Review
1/13/2010 I was very surprised when my monthly pharmacy bill went up $22, especially since I am on Social Security Disability and don't have a lot of extra money. I wish there was a generic option.
4.3Patient Review
3/26/2008 This medication works well to control my asthma, but I have noticed some side effects like yellowing of the eyes, fatigue, and muscle aches.
4Patient Review
4/19/2010 I did experience some lightheadedness after taking the medication, but it was not severe and it went away quickly.
4Patient Review
10/3/2007 This medication is a big improvement from Singular, which was my previous prescription. The only downside is that I have to remember to take it four times per day.
3.7Patient Review
10/4/2007 Zyflo CR is much easier to use and I haven't had any side-effects.
3.3Patient Review
10/27/2007 I switched from Singulair to Zyflo about a year ago, and I believe the medication is more effective than Singulair. The main problem is that it is hard to take -- I have to take one pill every six hours. I often forget to take it, or simply sleep through a dose. The medication is also expensive.
2Patient Review
2/12/2013 These drugs really disturbed my stomach and now my eyes feel gritty all day. My asthma is better, but I don't know if it's worth feeling this lousy constantly.
Patient Q&A Section about zyflo
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What type of drug is Zyflo?
"This is a prescription medication for the treatment of asthma symptoms that comes in tablet form. It may be used alone or in conjunction with other drugs and is part of a class of drugs called 5-Lipoxygenase Inhibitors. Its safety and effectiveness in children under 12 years of age have not been established."
Answered by AI
What are the side effects of Zyflo?
"The side effects of this medication may include nausea, an upset stomach, diarrhea, trouble sleeping, or cold symptoms (a stuffy nose, sinus pain, sneezing, or a sore throat). Other potential side effects include a headache, weakness, or muscle pain."
Answered by AI
What is Zyflo used for?
"Zileuton is a medication used to help control and prevent asthma symptoms, such as wheezing and shortness of breath. Controlling these symptoms allows you to keep up with your usual activities and decreases the amount of time you miss from work or school. You need to use this medication consistently to get the best results."
Answered by AI
Is there a generic for Zyflo?
"At this time, there is no FDA-approved generic form of Zyflo available in the United States. Be aware that some online pharmacies may attempt to sell a counterfeit or fake version of this drug. These medications may be dangerous and potentially unsafe."
Answered by AI