Zyflo

Asthma, Asthma

Treatment

4 FDA approvals

20 Active Studies for Zyflo

Treatment for

Asthma

What is Zyflo

ZileutonThe Generic name of this drug

Treatment SummaryZileuton is a medication that helps reduce the symptoms of asthma. It works by blocking the formation of certain substances called leukotrienes, which cause inflammation, swelling, increased mucus production, and constriction of the airways in asthmatic patients. The drug is specifically designed to inhibit the enzyme 5-lipoxygenase, which is responsible for forming leukotrienes from arachidonic acid. Zileuton was previously available as an immediate release tablet in the US, but has since been withdrawn from the market.

Zyflois the brand name

image of different drug pills on a surface

Zyflo Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Zyflo

Zileuton

1996

Approved as Treatment by the FDA

Zileuton, also known as Zyflo, is approved by the FDA for 4 uses such as Asthma and Chronic Asthma .

Asthma

Chronic Asthma

Helps manage Chronic Asthma

Asthma

Helps manage Chronic Asthma

Asthma

Effectiveness

How Zyflo Affects PatientsZileuton is a drug used to treat asthma. It works by blocking the leukotriene synthesis pathway, which is thought to contribute to asthma symptoms. It has been shown to reduce asthma symptoms caused by cold air in humans.

How Zyflo works in the bodyZileuton helps relieve symptoms of asthma by blocking the production of substances called leukotrienes. Leukotrienes cause inflammation and narrowing of the airways in asthmatic patients. Zileuton specifically targets 5-lipoxygenase, an enzyme that makes leukotrienes. By blocking the formation of these substances, Zileuton helps reduce inflammation, bronchial spasms, and other asthma symptoms. Both the R(+) and S(-) enantiomers of the drug have been shown to be effective in laboratory studies.

When to interrupt dosage

The suggested dosage of Zyflo is contingent upon the diagnosed condition. The measure, as stated in the table below, is subject to the mode of administration (e.g. Tablet - Oral or Tablet, extended release).

Condition

Dosage

Administration

Asthma

, 600.0 mg

, Tablet, extended release - Oral, Tablet, extended release, Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral

Asthma

, 600.0 mg

Warnings

Zyflo Contraindications

Condition

Risk Level

Notes

Liver Failure, Acute

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Zyflo.

Common Zyflo Drug Interactions

Drug Name

Risk Level

Description

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Zileuton.

Anagrelide

Major

The metabolism of Anagrelide can be decreased when combined with Zileuton.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Zileuton.

Bendamustine

Major

The metabolism of Bendamustine can be decreased when combined with Zileuton.

Clomipramine

Major

The metabolism of Clomipramine can be decreased when combined with Zileuton.

Zyflo Toxicity & Overdose RiskThe lowest amount of zileuton that has been found to be lethal in mice is 500-4000mg/kg and in rats it is 300-1000mg/kg. This is much higher than the maximum recommended human daily dose.

image of a doctor in a lab doing drug, clinical research

Zyflo Novel Uses: Which Conditions Have a Clinical Trial Featuring Zyflo?

A total of 147 active clinical trials are currently exploring the efficacy of Zyflo in providing relief from Asthma.

Condition

Clinical Trials

Trial Phases

Asthma

87 Actively Recruiting

Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 1, Phase 3

Asthma

2 Actively Recruiting

Not Applicable, Phase 2

Zyflo Reviews: What are patients saying about Zyflo?

5Patient Review

8/3/2020

Zyflo for Late Onset Asthma

At 73, I'm quite active for my age. I can attribute a lot of that to Zyflo and its ability to help me breathe more deeply. That being said, it is rather pricey and the generic brand works just as well.

5Patient Review

4/3/2009

Zyflo for Late Onset Asthma

This medication has made a world of difference for my COPD. I haven't found anything that works better.

5Patient Review

3/17/2008

Zyflo for Asthma Prevention

I can breathe again. So much better than Singlair ever was.

5Patient Review

5/16/2008

Zyflo for Allergic Asthma

Allergist changed my prescription to this and it helped a lot more. I can finally breathe properly and don't have headaches anymore.

5Patient Review

10/5/2013

Zyflo for Allergic Asthma

Z has been a total game-changer for me and my asthma. I was using corticosteroids to manage it before, but this medication is much more effective.

View All Reviews

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Patient Q&A Section about zyflo

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of drug is Zyflo?

"This is a prescription medication for the treatment of asthma symptoms that comes in tablet form. It may be used alone or in conjunction with other drugs and is part of a class of drugs called 5-Lipoxygenase Inhibitors. Its safety and effectiveness in children under 12 years of age have not been established."

Answered by AI

What are the side effects of Zyflo?

"The side effects of this medication may include nausea, an upset stomach, diarrhea, trouble sleeping, or cold symptoms (a stuffy nose, sinus pain, sneezing, or a sore throat). Other potential side effects include a headache, weakness, or muscle pain."

Answered by AI

What is Zyflo used for?

"Zileuton is a medication used to help control and prevent asthma symptoms, such as wheezing and shortness of breath. Controlling these symptoms allows you to keep up with your usual activities and decreases the amount of time you miss from work or school. You need to use this medication consistently to get the best results."

Answered by AI

Is there a generic for Zyflo?

"At this time, there is no FDA-approved generic form of Zyflo available in the United States. Be aware that some online pharmacies may attempt to sell a counterfeit or fake version of this drug. These medications may be dangerous and potentially unsafe."

Answered by AI