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What is Renvela
SevelamerThe Generic name of this drug
Treatment SummarySevelamer, sold under the brand name Renagel, is a medication used to prevent excess phosphate from building up in the blood of people with chronic kidney failure.
Renagelis the brand name
Renvela Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Renagel
Sevelamer
2006
81
Approved as Treatment by the FDA
Sevelamer, otherwise called Renagel, is approved by the FDA for 2 uses including Hyperphosphataemia and Hemodialysis .Hyperphosphataemia
Helps manage Hyperphosphataemia
Hemodialysis
Helps manage Hemodialysis Treatment
Effectiveness
How Renvela Affects PatientsPeople with end-stage kidney disease often have too much phosphorus in their bodies, which can cause calcium to build up in the wrong places and lead to more serious conditions. This extra phosphorus can also cause high levels of parathyroid hormone, which can cause bone diseases like osteitis fibrosa. To help with this, doctors can prescribe Sevelamer, a medicine that helps reduce phosphorus levels in the body. It is usually taken with meals and has been shown to lower phosphorus levels in people on dialysis. It also helps lower bad cholesterol (LDL) and total cholesterol levels.
How Renvela works in the bodySevelamer stops too much phosphate from entering the body. It does this by binding to dietary phosphate in the gut, stopping it from being absorbed. This lowers the amount of phosphate in the bloodstream, which in turn lowers the levels of a hormone that controls phosphate levels.
When to interrupt dosage
The recommended measure of Renvela is contingent upon the diagnosed health issue. The dosage fluctuates as per the method of delivery (e.g. Parenteral or Capsule) highlighted in the below table.Condition
Dosage
Administration
Hemodialysis
800.0 mg, , 400.0 mg, 403.0 mg, 1600.0 mg, 2400.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Powder, for suspension, Powder, for suspension - Oral, Tablet, film coated - Parenteral, Parenteral
Hyperphosphataemia
800.0 mg, , 400.0 mg, 403.0 mg, 1600.0 mg, 2400.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Powder, for suspension, Powder, for suspension - Oral, Tablet, film coated - Parenteral, Parenteral
Warnings
There are 20 known major drug interactions with Renvela.Common Renvela Drug Interactions
Drug Name
Risk Level
Description
Mycophenolic acid
Major
The serum concentration of Mycophenolic acid can be decreased when it is combined with Sevelamer.
Raloxifene
Major
Sevelamer can cause a decrease in the absorption of Raloxifene resulting in a reduced serum concentration and potentially a decrease in efficacy.
Technetium Tc-99m oxidronate
Major
Sevelamer may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
(R)-warfarin
Minor
Sevelamer can cause a decrease in the absorption of (R)-warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.
(S)-Warfarin
Minor
Sevelamer can cause a decrease in the absorption of (S)-Warfarin resulting in a reduced serum concentration and potentially a decrease in efficacy.
Renvela Toxicity & Overdose RiskSevelamer has been administered to healthy volunteers at doses of up to 14 grams per day for 8 days, and to hemodialysis patients at doses up to 13 grams per day without any reported adverse effects. Since sevelamer is not absorbed into the body, the risk of systemic toxicity is low, and there have been no reported overdoses in patients.
Renvela Novel Uses: Which Conditions Have a Clinical Trial Featuring Renvela?
11 current trials are examining the potential of Renvela to mitigate Hyperphosphataemia.Condition
Clinical Trials
Trial Phases
Hyperphosphataemia
0 Actively Recruiting
Hemodialysis
11 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Phase 1
Renvela Reviews: What are patients saying about Renvela?
5Patient Review
6/28/2012 I've been on this medication for about a year now, and unfortunately the constipation has gotten progressively worse. I take four pills with food, but my last phosphorus reading was 10.2. I eat healthy and have a bowel movement only once or twice a week. My blood pressure has also been running low since starting this medication (80/40), so I stopped taking it today. They gave me Fosrenol as an alternative, but I'm afraid to try it because it's in the same class of medications with similar side effects. Does anyone have any recommendations?
5Patient Review
1/9/2013 I experienced some stomach upset, but the medication was effective. I didn't like how often I had to take it, and there were some unknown side effects. However, overall I was pleased with the results.
5Patient Review
6/6/2014 Since taking this medication, I've been suffering from dry mouth and constipation. It's become a real problem; I have to take two pills after every meal just to get by.
3.7Patient Review
1/18/2011 This medication caused me some bad diarrhea at first, but adding Hyomax has helped a lot. I'm still new to dialysis so time will tell how well this treatment works long term.
3.7Patient Review
2/19/2014 I've been taking this medication since March 2012 with no issues.
3.3Patient Review
3/17/20093.3Patient Review
6/16/2011 I experienced some major stomach pains and constipation while taking this medication. I decided to switch to another drug, but that caused even more problems.
2.7Patient Review
3/1/20092.7Patient Review
7/6/2014 I've been using Renvela for six months now with good results. My blood work has come back normal and I haven't had any negative side effects that I'm aware of. All in all, I'm pretty pleased with this medication.
2.3Patient Review
11/15/20081.3Patient Review
5/25/2011 From my limited experience, this seemed to work well.
1Patient Review
2/26/2018 We're really worried about my mother since she started taking this medication and her blood pressure has been spiking to dangerous levels.
1Patient Review
4/20/2015 Taking three pills three times daily made me feel lightheaded at times.
Patient Q&A Section about renvela
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What type of medication is Renvela?
"Renvela is a prescription medication used to relieve symptoms associated with an imbalance of phosphorus in the blood for CKD patients who are undergoing dialysis. It may be used in conjunction with other drugs, and is classified as a phosphorus scavenger."
Answered by AI
What is the medication Renvela used for?
"High phosphate levels may cause serious medical problems such as weak bones, joint pain, calcification of soft tissues, and heart disease. Sevelamer works by adsorbing phosphate from your gastrointestinal tract, so it is important to take sevelamer with meals or snacks.
Generic Name: sevelamer carbonate
Sevelamer is used to lower high blood phosphate levels in patients who are on dialysis due to severe kidney disease. Dialysis helps to remove some phosphate from the blood, but it is difficult to remove enough to keep phosphate levels balanced. High phosphate levels can cause serious medical problems such as weak bones, joint pain, calcification of soft tissues, and heart disease. Sevelamer works by adsorbing phosphate from the gastrointestinal tract. It is important to take sevelamer with meals or snacks."
Answered by AI
When should Renvela be taken?
"You should take Renvela three times a day with meals to help control phosphorus levels in your body. Renvela binds to phosphorus in the foods you eat and then carries it through your digestive tract and out of your body."
Answered by AI
Why do kidney patients take Renvela?
"Renvela may be used as a first-line treatment for controlling phosphorus levels in the blood of patients with chronic kidney disease who rely on dialysis. It is important to control phosphorus levels in the blood of patients receiving dialysis."
Answered by AI