Pioglitazone Hydrochloride

Type 2 Diabetes, Diabetic Neuropathy, Physical Activity + 2 more
Treatment
20 Active Studies for Pioglitazone Hydrochloride

What is Pioglitazone Hydrochloride

PioglitazoneThe Generic name of this drug
Treatment SummaryPioglitazone is a medication used to help manage type 2 diabetes mellitus in combination with diet, exercise, and other antidiabetic drugs. It works by increasing insulin sensitivity and helping the body take up glucose from the blood. It belongs to a class of drugs called thiazolidinediones, which also includes rosiglitazone and troglitazone. However, due to the presence of adverse effects and warnings, as well as safer and more effective alternatives, pioglitazone has become less popular in recent years.
Actosis the brand name
image of different drug pills on a surface
Pioglitazone Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Actos
Pioglitazone
1999
257

Effectiveness

How Pioglitazone Hydrochloride Affects PatientsPioglitazone helps the body make better use of insulin, which can lower blood sugar levels and reduce the amount of insulin in the body. However, taking pioglitazone can lead to fluid buildup in the body, which can worsen congestive heart failure. Additionally, there is some evidence that pioglitazone may increase the risk of bladder cancer, so it should be used with caution in patients with a history of bladder cancer or active bladder cancer.
How Pioglitazone Hydrochloride works in the bodyPioglitazone works by increasing the body's sensitivity to insulin. It does this by activating a receptor in muscles, fat, and liver cells that controls how much glucose and fat the body produces. This helps to reduce insulin resistance which is a common symptom of type 2 diabetes. It also helps to reduce the amount of glucose the body produces, which helps to improve overall insulin sensitivity.

When to interrupt dosage

The measure of Pioglitazone Hydrochloride is contingent upon the established ailment, including Diet, Physical Activity and Type 2 Diabetes. The amount likewise varies as per the technique of delivery (e.g. Tablet, film coated or Tablet, film coated - Oral) specified in the table beneath.
Condition
Dosage
Administration
Type 2 Diabetes
, 45.0 mg, 30.0 mg, 15.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Diabetic Neuropathy
, 45.0 mg, 30.0 mg, 15.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Type 2 Diabetes
, 45.0 mg, 30.0 mg, 15.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Physical Activity
, 45.0 mg, 30.0 mg, 15.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique
Diet
, 45.0 mg, 30.0 mg, 15.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Occlusive dressing technique, Tablet - Occlusive dressing technique

Warnings

Pioglitazone Hydrochloride Contraindications
Condition
Risk Level
Notes
Hypesthesia
Do Not Combine
Hypesthesia
Do Not Combine
uninvestigated macroscopic hematuria
Do Not Combine
Urinary Bladder
Do Not Combine
Urinary Bladder
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Pioglitazone may interact with Pulse Frequency
There are 20 known major drug interactions with Pioglitazone Hydrochloride.
Common Pioglitazone Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Pioglitazone.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Pioglitazone.
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Pioglitazone.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Pioglitazone.
Fosphenytoin
Major
The metabolism of Fosphenytoin can be decreased when combined with Pioglitazone.
Pioglitazone Hydrochloride Toxicity & Overdose RiskThe lowest toxic dose of pioglitazone in mice is 24mg/kg over 4 days and in rats is 3mg/kg over 6 days. One person overdosed on pioglitazone by taking 120mg daily for 4 days, then 180mg daily for 7 days without any negative effects. If someone takes too much pioglitazone, they should be monitored and given supportive care based on their symptoms.
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Pioglitazone Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Pioglitazone Hydrochloride?

300 active studies are in progress to assess the potential of Pioglitazone Hydrochloride in managing Type 2 Diabetes, Type 2 Diabetes Complications and Physical Activity.
Condition
Clinical Trials
Trial Phases
Physical Activity
35 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1
Type 2 Diabetes
175 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Diabetic Neuropathy
6 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Type 2 Diabetes
90 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Diet
5 Actively Recruiting
Not Applicable, Phase 1

Pioglitazone Hydrochloride Reviews: What are patients saying about Pioglitazone Hydrochloride?

5Patient Review
11/21/2016
Pioglitazone Hydrochloride for Type 2 Diabetes Mellitus
I've heard that this medication can have some pretty severe side effects. Has anyone else experienced this?
5Patient Review
12/9/2016
Pioglitazone Hydrochloride for Type 2 Diabetes Mellitus
This worked really well for me and I'm very pleased with the results.
5Patient Review
8/6/2014
Pioglitazone Hydrochloride for Type 2 Diabetes Mellitus
This didn't work for me, unfortunately.
5Patient Review
10/20/2013
Pioglitazone Hydrochloride for Type 2 Diabetes Mellitus
4.7Patient Review
5/13/2020
Pioglitazone Hydrochloride for Type 2 Diabetes Mellitus
This worked well for me with no side effects. Just be patient- it can take up to three months to see the full benefits.
View All Reviews
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Patient Q&A Section about pioglitazone hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is metformin and pioglitazone the same?

"This medicine helps patients with type 2 diabetes by helping the body use insulin better and reducing the absorption and release of sugar. It does not help patients with insulin-dependent or type 1 diabetes."

Answered by AI

What is pioglitazone Hydrochloride used for?

"Pioglitazone is a medication used to treat high blood sugar levels caused by type 2 diabetes. It may be used alone or with other medicines, such as insulin, metformin, or sulfonylurea agents. Pioglitazone works by helping your body use insulin better."

Answered by AI

When is the best time to take pioglitazone?

"To take pioglitazone, swallow the tablet whole with a drink of water at any time, for example in the morning or evening. Try to take pioglitazone at the same time every day."

Answered by AI

What are side effects of pioglitazone?

"Some potential side effects of taking metformin include Blurred vision or other changes in vision, flushed, dry skin, fruit-like breath odor, headache, increased thirst, increased urination, muscle pain or soreness, and problems with your teeth."

Answered by AI

Clinical Trials for Pioglitazone Hydrochloride

Have you considered Pioglitazone Hydrochloride clinical trials? We made a collection of clinical trials featuring Pioglitazone Hydrochloride, we think they might fit your search criteria.
Have you considered Pioglitazone Hydrochloride clinical trials? We made a collection of clinical trials featuring Pioglitazone Hydrochloride, we think they might fit your search criteria.
Have you considered Pioglitazone Hydrochloride clinical trials? We made a collection of clinical trials featuring Pioglitazone Hydrochloride, we think they might fit your search criteria.