High vs Low Salt Diet for High Blood Pressure
Trial Summary
What is the purpose of this trial?
This trial will have participants follow different salt diets to see how their blood pressure changes. It focuses on middle-aged people from a previous study. Researchers believe that salt intake affects blood pressure through inflammation and want to understand this better.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but it includes people who are not on blood pressure medications or those with controlled blood pressure using up to 3 medications. If you are taking 4 or more blood pressure medications, you would not be eligible.
What data supports the effectiveness of the treatment High Salt Diet, Low Salt Diet for high blood pressure?
Is a low or high salt diet generally safe for humans?
Reducing salt intake is generally safe for most people and can help lower blood pressure, especially in older adults, African Americans, and those who are overweight. High salt intake can increase the risk of high blood pressure and related health issues, but reducing salt intake usually has minimal adverse effects unless done excessively.678910
How does the High vs Low Salt Diet treatment for high blood pressure differ from other treatments?
This treatment is unique because it directly compares the effects of high and low salt diets on blood pressure, whereas most existing treatments focus on reducing salt intake without exploring the potential effects of a high salt diet. Additionally, the research highlights that an excessively low salt diet might harm the heart, which is not commonly addressed in standard dietary recommendations for high blood pressure.3451112
Eligibility Criteria
This trial is for adults who have normal blood pressure or high blood pressure that's either untreated or controlled with up to three medications. Participants must not be on certain drugs like steroids, avoid anti-inflammatory meds, and can't have conditions like heart failure or severe allergies to food.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Low Salt Diet
Participants follow a low-salt diet for 7 days with meals prepared in the Metabolic Kitchen
High Salt Diet
Participants follow a high-salt diet for 7 days with supplementation of Na+ bullion packets
Follow-up
Participants are monitored for immune response and blood pressure changes after dietary interventions
Treatment Details
Interventions
- High Salt Diet
- Low Salt Diet
Find a Clinic Near You
Who Is Running the Clinical Trial?
Vanderbilt University Medical Center
Lead Sponsor
Northwestern University
Collaborator
University of Alabama at Birmingham
Collaborator