Noroxin

Urinary Tract Infection (UTI), Urethritis gonococcal, Pyelonephritis + 6 more
Treatment
6 FDA approvals
3 Active Studies for Noroxin

What is Noroxin

NorfloxacinThe Generic name of this drug
Treatment SummaryNorfloxacin is a type of synthetic antibiotic used to fight a broad range of bacterial infections, such as those caused by gram-positive and gram-negative bacteria. It works by inhibiting bacterial DNA gyrase, a type of enzyme that helps the bacteria reproduce.
Noroxinis the brand name
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Noroxin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Noroxin
Norfloxacin
1986
2

Approved as Treatment by the FDA

Norfloxacin, commonly known as Noroxin, is approved by the FDA for 6 uses like Pyelonephritis and Pyelitis .
Pyelonephritis
Pyelitis
Urethritis gonococcal
Urinary Tract Infection (UTI)
Pyelonephritis
Gonococcal cervicitis

Effectiveness

How Noroxin Affects PatientsNorfloxacin is an antibiotic that stops bacteria from reproducing. It works by attaching itself to an enzyme called DNA gyrase, which is needed for bacteria to make copies of their DNA. Norfloxacin has 100 times more of an effect on bacterial DNA gyrase than it does on human DNA gyrase.
How Noroxin works in the bodyNorfloxacin works by blocking two enzymes that are important for bacteria to reproduce. These enzymes, called topoisomerase II and topoisomerase IV, are found in both Gram-positive and Gram-negative bacteria. The addition of a fluorine atom at the 6th position makes Norfloxacin more effective against Gram-negative bacteria, and a piperazine moiety at the 7th position helps it fight pseudomonal bacteria.

When to interrupt dosage

The proposed dose of Noroxin is dependent upon the determined condition, including Gonococcal cervicitis, Diarrhea and Spontaneous Bacterial Peritonitis (SBP). The measure of dosage fluctuates, in line with the mode of administration (e.g. Tablet or Solution - Ophthalmic) featured in the table beneath.
Condition
Dosage
Administration
Urinary Tract Infection (UTI)
, 400.0 mg, 3.0 mg/mL
, Oral, Tablet, Tablet - Oral, Solution, Ophthalmic, Solution - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral
Urethritis gonococcal
, 400.0 mg, 3.0 mg/mL
, Oral, Tablet, Tablet - Oral, Solution, Ophthalmic, Solution - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral
Pyelonephritis
, 400.0 mg, 3.0 mg/mL
, Oral, Tablet, Tablet - Oral, Solution, Ophthalmic, Solution - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral
Infectious diarrhea
, 400.0 mg, 3.0 mg/mL
, Oral, Tablet, Tablet - Oral, Solution, Ophthalmic, Solution - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral
Pyelitis
, 400.0 mg, 3.0 mg/mL
, Oral, Tablet, Tablet - Oral, Solution, Ophthalmic, Solution - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral
Diarrhea
, 400.0 mg, 3.0 mg/mL
, Oral, Tablet, Tablet - Oral, Solution, Ophthalmic, Solution - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral
Spontaneous Bacterial Peritonitis (SBP)
, 400.0 mg, 3.0 mg/mL
, Oral, Tablet, Tablet - Oral, Solution, Ophthalmic, Solution - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral
prophylaxis of Spontaneous Bacterial Peritonitis
, 400.0 mg, 3.0 mg/mL
, Oral, Tablet, Tablet - Oral, Solution, Ophthalmic, Solution - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral
Gonococcal cervicitis
, 400.0 mg, 3.0 mg/mL
, Oral, Tablet, Tablet - Oral, Solution, Ophthalmic, Solution - Ophthalmic, Tablet, film coated, Tablet, film coated - Oral

Warnings

Noroxin Contraindications
Condition
Risk Level
Notes
Tendinitis
Do Not Combine
Tendon structure
Do Not Combine
There are 20 known major drug interactions with Noroxin.
Common Noroxin Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
Norfloxacin may increase the QTc-prolonging activities of Amitriptyline.
Anagrelide
Major
The metabolism of Anagrelide can be decreased when combined with Norfloxacin.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Norfloxacin.
Bendamustine
Major
The metabolism of Bendamustine can be decreased when combined with Norfloxacin.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Norfloxacin.
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Noroxin Novel Uses: Which Conditions Have a Clinical Trial Featuring Noroxin?

25 clinical trials are currently being conducted to investigate the potential of Noroxin as a prophylactic against Spontaneous Bacterial Peritonitis, Pyelitis and Diarrhea.
Condition
Clinical Trials
Trial Phases
Diarrhea
0 Actively Recruiting
Urinary Tract Infection (UTI)
0 Actively Recruiting
Pyelonephritis
1 Actively Recruiting
Not Applicable
prophylaxis of Spontaneous Bacterial Peritonitis
0 Actively Recruiting
Infectious diarrhea
2 Actively Recruiting
Phase 3, Phase 1
Spontaneous Bacterial Peritonitis (SBP)
0 Actively Recruiting
Pyelitis
0 Actively Recruiting
Urethritis gonococcal
0 Actively Recruiting
Gonococcal cervicitis
0 Actively Recruiting

Noroxin Reviews: What are patients saying about Noroxin?

5Patient Review
12/21/2008
Noroxin for Urinary Tract Infection
5Patient Review
11/3/2009
Noroxin for Urinary Tract Infection
This worked well as a suppressant for me.
5Patient Review
6/13/2012
Noroxin for Urinary Tract Infection
This is my go-to medication when nothing else seems to work. It's really effective!
5Patient Review
11/30/2010
Noroxin for Inflamed Stomach/Intestines caused by Bacterial Infection
This treatment worked very quickly for me. I felt like a new person after taking the first dose!
3.3Patient Review
6/6/2012
Noroxin for Inflamed Stomach/Intestines caused by Bacterial Infection
The side effects of this drug are, unfortunately, quite severe. I experienced shrinking tendons, worsening arthritis pain, depression, and extreme fatigue. My face also swollen up pretty badly. Thankfully, though, I stopped taking the medication and felt much better almost immediately afterwards.
View All Reviews
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Patient Q&A Section about noroxin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is NOROXIN used for?

"It will not work for viral infections (such as common cold, flu).

Norfloxacin is used to treat a variety of bacterial infections. This medication belongs to a class of drugs known as quinolone antibiotics. It works by stopping the growth of bacteria. This antibiotic is only effective against bacterial infections and will not work for viral infections such as the common cold or flu."

Answered by AI

When should I take NOROXIN?

"Norfloxacin should be taken on an empty stomach, 1 hour before meals or 2 hours after meals. It is best to take the medicine at the same time each day, 10-12 hours apart. For example, between 7 and 8 am, and between 7 and 8 pm. The tablets should be swallowed whole with a glass of water."

Answered by AI

What are the side effects of NOROXIN?

"flu-like symptoms

Nausea, diarrhea, dizziness, stomach cramps, heartburn, rectal pain, lightheadedness, muscle and joint aches, and flu-like symptoms are all possible side effects of this medication."

Answered by AI

Clinical Trials for Noroxin

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