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What is Nitrolingual
NitroglycerinThe Generic name of this drug
Treatment SummaryNitroglycerin is a medication used to treat chest pain and high blood pressure. It was approved by the FDA in 2000 and comes in a variety of forms, including a spray, tablets, intravenous injections, and a transdermal patch. Nitroglycerin can also be used in an ointment to ease the pain associated with anal fissures and was approved for this purpose in 1955.
Nitroglycerinis the brand name
Nitrolingual Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Nitroglycerin
Nitroglycerin
1981
182
Effectiveness
How Nitrolingual Affects PatientsNitroglycerin relaxes the walls of your blood vessels, allowing for increased blood flow to the heart and a decrease in the pressure of your heart's walls. This can help reduce angina symptoms. However, taking nitroglycerin for a long time can cause your body to become used to it, resulting in it becoming less effective. It may also cause problems like increased sensitivity to other substances that make your blood vessels constrict.
How Nitrolingual works in the bodyNitroglycerin works to widen your blood vessels, allowing for easier blood flow. It does this by converting to nitric oxide in smooth muscle cells. Nitric oxide activates an enzyme called guanylate cyclase, which in turn produces a compound called cyclic guanosine 3',5'-monophosphate (cGMP) in the walls of your veins, arteries, and cardiac tissue. This compound causes protein kinase-dependent phosphorylation and leads to your blood vessels relaxing, allowing for increased blood flow.
When to interrupt dosage
Condition
Dosage
Administration
induction of Intraoperative Hypotension
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
prophylaxis of Angina pectoris
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Congestive Heart Failure
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Chest Pain
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Coronary Artery Disease (CAD)
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Hypotension
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Anal Fissure
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Hypertensive disease
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Myocardial Infarction
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
insufficient response to beta-blockers
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
nitroglycerin
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Pain
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Angina Attacks
, 160.0 mg, 20.0 mg, 40.0 mg, 60.0 mg, 80.0 mg, 120.0 mg, 0.02 mg/mg, 0.1 mg/hour, 0.2 mg/hour, 0.4 mg/hour, 0.6 mg/hour, 2.5 mg, 9.0 mg, 6.5 mg, 0.4 mg, 0.25 mg/hour, 0.5 mg/hour, 1.0 mg/hour, 1.5 mg/hour, 0.004 mg/mg, 0.3 mg, 5.0 mg/mL, 37.4 mg, 20.8 mg, 50.0 mg, 1.0 mg, 2.0 %, 0.6 mg, 75.0 mg, 54.0 mg, 36.0 mg, 18.0 mg, 25.0 mg, 2.6 mg, 100.0 mg, 0.1 mg/mL, 0.2 mg/mL, 0.4 mg/mL, 0.0004 mg/mg, 18.0 mg/[USP'U], 12.5 mg, 1.0 mg/mL, 0.8 mg/hour, 7.2 mg/cm2, 0.4 mg/pump actuation, 6.0 mg/cm2
, Transdermal, Patch, Patch - Transdermal, Topical, Ointment, Ointment - Topical, Oral, Capsule, Capsule - Oral, Sublingual, Tablet - Sublingual, Tablet, Spray, Spray - Oral, Tablet - Oral, Aerosol, metered, Aerosol, metered - Sublingual, Spray, metered, Spray, metered - Oral, Ointment - Rectal, Rectal, Spray, metered - Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Intravenous, Injection, solution, Injection, solution - Intravenous, Film, extended release, Film, extended release - Transdermal, Patch, extended release, Patch, extended release - Transdermal, Liquid, Liquid - Intravenous, Solution, Solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Buccal, Tablet, extended release - Buccal, Injection, Injection - Intravenous, Powder, Powder - Sublingual, Transmucosal, Aerosol, spray, Aerosol, spray - Transmucosal, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous
Warnings
Nitrolingual ContraindicationsCondition
Risk Level
Notes
pericardial tamponade
Do Not Combine
Pulse Frequency
Do Not Combine
Hypovolemic Shock
Do Not Combine
Anemia
Do Not Combine
Pick Disease of Heart
Do Not Combine
Pulse Frequency
Do Not Combine
Acute Circulatory Failure
Do Not Combine
Intracranial Hypertension
Do Not Combine
Cardiomyopathy, Restrictive
Do Not Combine
Myocardial Infarction
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Nitroglycerin may interact with Pulse Frequency
Common Nitrolingual Drug Interactions
Drug Name
Risk Level
Description
Amediplase
Major
The therapeutic efficacy of Amediplase can be decreased when used in combination with Nitroglycerin.
Amifostine
Major
Nitroglycerin may increase the hypotensive activities of Amifostine.
Desmoteplase
Major
The therapeutic efficacy of Desmoteplase can be decreased when used in combination with Nitroglycerin.
Reteplase
Major
The therapeutic efficacy of Reteplase can be decreased when used in combination with Nitroglycerin.
Riociguat
Major
Nitroglycerin may increase the hypotensive activities of Riociguat.
Nitrolingual Toxicity & Overdose RiskThe toxic dose of nitroglycerin for rats is 105 mg/kg when taken orally and 23.2 mg/kg when taken intravenously. Overdosing on nitroglycerin can cause severe low blood pressure, headache, dizziness, rapid heartbeat, skin flushing, nausea, vomiting, shortness of breath, confusion, and paralysis. In rare cases, a condition called methemoglobinemia may occur, which can be treated with methylene blue unless a person has a known deficiency in an enzyme called G6PD. There is no known antidote for nitroglycerin overdose, so treatment involves managing the symptoms
Nitrolingual Novel Uses: Which Conditions Have a Clinical Trial Featuring Nitrolingual?
38 active trials are currently being conducted to investigate the potential of Nitrolingual to reduce the risk of Gastroesophageal variceal hemorrhage, Hypotension and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Congestive Heart Failure
23 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Myocardial Infarction
0 Actively Recruiting
Anal Fissure
0 Actively Recruiting
Chest Pain
6 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4
insufficient response to beta-blockers
0 Actively Recruiting
Hypotension
1 Actively Recruiting
Early Phase 1
Coronary Artery Disease (CAD)
1 Actively Recruiting
Not Applicable
induction of Intraoperative Hypotension
0 Actively Recruiting
prophylaxis of Angina pectoris
0 Actively Recruiting
nitroglycerin
0 Actively Recruiting
Hypertensive disease
0 Actively Recruiting
Angina Attacks
0 Actively Recruiting
Pain
0 Actively Recruiting
Nitrolingual Reviews: What are patients saying about Nitrolingual?
5Patient Review
2/11/2010 I've used this product a bunch of times and it really does work well. I actually prefer it to other similar products because it doesn't take forever to dissolve and it doesn't burn my gums.
5Patient Review
3/19/20094Patient Review
6/18/2009Patient Q&A Section about nitrolingual
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is nitrolingual the same as nitroglycerin?
"Nitrolingual Pumpspray is a nitrate that dilates blood vessels, making it easier for blood to flow through them. It is used to treat or prevent attacks of chest pain."
Answered by AI
How many times a day can you use nitro spray?
"Adults should take 2.5 to 6.5 mg of medication 3 to 4 times a day. If needed, a doctor may increase the dose."
Answered by AI
How long does nitrolingual spray take to work?
"It typically takes 1-3 minutes for the tablets to take effect, and the spray 1-3 minutes as well. To use the spray, administering 1-2 sprays under the tongue before beginning the desired activity."
Answered by AI
What is nitrolingual spray used for?
"This medication is used to relieve chest pain in people that have a certain heart condition. It may also be used before physical activities to help prevent chest pain. Nitroglycerin belongs to a class of drugs known as nitrates."
Answered by AI