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Molecular Profiling for Brain Tumor (PNOC008 Trial)
PNOC008 Trial Summary
This trial will test a new treatment approach for children with High-grade gliomas HGG that is based on each patient's tumor gene expression, whole-exome sequencing (WES), targeted panel profile (UCSF 500 gene panel), and RNA-Seq.
PNOC008 Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowPNOC008 Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.PNOC008 Trial Design
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Who is running the clinical trial?
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- I am 21 years old or younger.My seizures are under control.I started radiation therapy within 6 weeks after my cancer was first diagnosed.I am not on any cancer treatment now, except possibly steroids or temozolomide at a specific dose.I have a high-grade glioma (HGG) that is newly diagnosed, and I've had a tissue sample taken.I can attend follow-up visits or do them via telemedicine.I can perform daily activities with some assistance or am wheelchair-bound but active.I do not have any severe illnesses that could interfere with the study.I am not pregnant or breastfeeding and have a negative pregnancy test.My cancer has enough tissue available for detailed genetic testing.I started radiation therapy less than 3 weeks ago.
- Group 1: Diffuse midline HGG (Stratum B)
- Group 2: Newly diagnosed HGG (Stratum A)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
How many facilities are carrying out this investigation?
"The research initiative is recruiting patients at Ann & Robert H. Lurie Children's Hospital of Chicago in the city of Chicago, Illinois; University of Utah located in Salt Lake City, Utah; and University of California, San Diego Rady Children's Hospital based in San Diego, California as well as 12 other medical sites."
How many participants are included in this trial's enrollment?
"The recruitment goal of this medical trial is 44 individuals that meet the eligibility requirements. Sites where patients can sign up for participation include Ann & Robert H. Lurie Children's Hospital of Chicago and University of Utah, both based in the United States of America."
Are there any available slots to participate in this experiment?
"As per clinicaltrials.gov, recruitment for this trial is still ongoing and the original posting was made on November 28th 2018 with a most recent update from August 9th 2022."
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