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What is Hydroxychloroquine Sulfate
HydroxychloroquineThe Generic name of this drug
Treatment SummaryHydroxychloroquine is a medication used to treat malaria, rheumatoid arthritis, lupus, and other conditions. It was developed during World War II as a less toxic alternative to chloroquine and was approved by the FDA in 1955. The FDA previously authorized emergency use of hydroxychloroquine for the treatment of COVID-19, but revoked this authorization on June 15, 2020 due to safety concerns. A recent study found that hydroxychloroquine may be associated with increased risk of fatality when used to treat COVID-19.
Plaquenilis the brand name
Hydroxychloroquine Sulfate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Plaquenil
Hydroxychloroquine
1955
107
Approved as Treatment by the FDA
Hydroxychloroquine, also known as Plaquenil, is approved by the FDA for 8 uses which include Lupus Erythematosus, Discoid and Lupus .Lupus Erythematosus, Discoid
Lupus
Malaria
Malaria
Malaria
Rheumatoid Arthritis
Helps manage Rheumatoid Arthritis
Malaria
Malaria
Effectiveness
How Hydroxychloroquine Sulfate Affects PatientsHydroxychloroquine affects the way cells in the body work, and can help to reduce autoimmune diseases. It also stops plasmodia, a type of parasite, from getting energy from hemoglobin. Hydroxychloroquine is usually taken on a weekly basis, but it can cause low blood sugar levels in those with diabetes, so they should monitor their blood sugar levels closely. It is not effective in areas where malaria resistance to chloroquine has been reported.
How Hydroxychloroquine Sulfate works in the bodyHydroxychloroquine works by raising the pH of lysosomes inside the malaria parasite, preventing it from digesting hemoglobin. It can also stop a parasitic enzyme from working, trapping a toxic product in the cell. In human cells, hydroxychloroquine raises the pH of organelles, which reduces the inflammatory response and prevents the presentation of antigens to autoimmune T cells. It can also prevent viruses like SARS-CoV and SARS-CoV-2 from entering cells by inhibiting glycosylation of ACE2, the receptor they use to enter.
When to interrupt dosage
The measure of Hydroxychloroquine Sulfate is contingent upon the determined disorder, including Lupus Erythematosus, Discoid, Sjögren's Syndrome and Malaria. The quantity of dosage is contingent upon the technique of delivery (e.g. Oral or Tablet) featured in the table beneath.Condition
Dosage
Administration
Lupus Erythematosus, Discoid
, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Enteral, Tablet, film coated - Enteral
Porphyria Cutanea Tarda
, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Enteral, Tablet, film coated - Enteral
Rheumatoid Arthritis
, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Enteral, Tablet, film coated - Enteral
Q Fever
, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Enteral, Tablet, film coated - Enteral
Malaria
, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Enteral, Tablet, film coated - Enteral
Malaria
, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Enteral, Tablet, film coated - Enteral
Malaria
, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Enteral, Tablet, film coated - Enteral
Lupus
, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Enteral, Tablet, film coated - Enteral
Malaria
, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Enteral, Tablet, film coated - Enteral
Malaria
, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, Tablet - Oral, Enteral, Tablet, film coated - Enteral
Warnings
Hydroxychloroquine Sulfate ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Hydroxychloroquine may interact with Pulse Frequency
Common Hydroxychloroquine Sulfate Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Hydroxychloroquine is combined with 2-Methoxyethanol.
7-Nitroindazole
Major
The therapeutic efficacy of 7-Nitroindazole can be decreased when used in combination with Hydroxychloroquine.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Hydroxychloroquine is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Hydroxychloroquine is combined with Abetimus.
Acebutolol
Major
The risk or severity of QTc prolongation can be decreased when Hydroxychloroquine is combined with Acebutolol.
Hydroxychloroquine Sulfate Toxicity & Overdose RiskHydroxychloroquine overdose can cause headaches, drowsiness, blurry vision, and a decrease in potassium levels. In severe cases, it can lead to an abnormal heart rhythm, seizures, and even death. Treatment for overdose includes emptying the stomach with gastric lavage, administering activated charcoal, and giving fluids and medications such as diazepam and epinephrine. Monitoring of the patient should continue for at least 6 hours.
Hydroxychloroquine Sulfate Novel Uses: Which Conditions Have a Clinical Trial Featuring Hydroxychloroquine Sulfate?
141 active studies are currently being conducted to assess the potential of Hydroxychloroquine Sulfate to ameliorate Rheumatoid Arthritis, Q Fever and Porphyria Cutanea Tarda.Condition
Clinical Trials
Trial Phases
Q Fever
0 Actively Recruiting
Porphyria Cutanea Tarda
0 Actively Recruiting
Malaria
0 Actively Recruiting
Lupus Erythematosus, Discoid
2 Actively Recruiting
Phase 2
Malaria
0 Actively Recruiting
Malaria
0 Actively Recruiting
Malaria
0 Actively Recruiting
Rheumatoid Arthritis
61 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Malaria
0 Actively Recruiting
Lupus
63 Actively Recruiting
Phase 2, Not Applicable, Phase 1, Phase 3, Phase 4, Early Phase 1
Hydroxychloroquine Sulfate Reviews: What are patients saying about Hydroxychloroquine Sulfate?
4.7Patient Review
2/12/2020 I've been seeing significant improvements in my joint pain and swelling since starting this treatment a couple months ago. It's made daily life much more manageable.
4Patient Review
3/21/2020 I've been taking this medication for nearly two decades now and it's really helped me. It took a few months to start working, but the benefits have been great: reduced inflammation, no more joint pain, eliminated rashes, fever reduction, and an improved quality of life. So far there's also been no impact on my vision (which is tested yearly).
4Patient Review
9/22/2019 I've been on this medication for seven months now, and it's done wonders for my rheumatoid arthritis. The swelling in my hands has gone down, the stiffness is gone, and the pain is barely there. I almost forget that I have RA!
4Patient Review
10/30/2018 The only side effect I have experienced is nausea when taking the medicine and during the day. Luckily, it goes away after about 30-45 minutes.
3Patient Review
3/19/2022 I was taking sulfasalazine but had an allergic reaction to it six months into the treatment after being diagnosed. Now my doctors want me to try hydroxychloroquine.
2.7Patient Review
4/22/2020 Unfortunately, this caused a severe allergic reaction in me called Stevens Johnson Syndrome. It was incredibly painful and my skin blistered and peeled off. I also lost hair and nails were damaged.
2.3Patient Review
12/18/2018 I unfortunately constantly felt nauseous, was vomiting frequently, and had blurred vision while on this medication. Additionally, it seemed to negatively impact my congestive heart failure. All in all, a very unpleasant experience.
1.7Patient Review
2/16/2022 I took this for extremely dry eye and mouth and whole body pain. Only two weeks in and it feels like someone’s beating me with a hammer! This pain is excruciating and the headaches are all day every day! I’m trying to hang I. There for a while but I’m not sure how much more I can stand!
1.3Patient Review
2/11/2018 I took Hydroy for four months. I started getting worried about the potential side effects and got my eyes checked. Even though everything was fine, I stopped taking it anyway. A few days after stopping, I got hives and itching on my back, then bursitis in my left elbow and left knee. I started taking it again at my regular 200mg dose twice a day to see if the symptoms would go away.
1Patient Review
12/7/2017 I got Stevens/Johnson Syndrome, which is a potentially fatal condition characterized by a rash with blisters all over my body. I was hospitalized and had to use ice packs to cool down. After the blisters went away, my skin started peeling off in sheets. I also lost some of my hair and toenails. It was the most horrible thing that ever happened to me.
1Patient Review
4/4/2018 I'm starting today and really hoping for the best. I read some of the other reviews and was scared by some of the potential side effects, especially hair loss.
Patient Q&A Section about hydroxychloroquine sulfate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects to hydroxychloroquine?
"You may experience a headache, dizziness, loss of appetite, nausea, diarrhea, stomach pain, vomiting, or rash."
Answered by AI
What are the benefits of taking hydroxychloroquine?
"If you're suffering from lupus, hydroxychloroquine may be able to improve your symptoms over the long term, including reducing pain, swelling, and joint stiffness, as well as improving the rash. However, it may take up to 12 weeks for these benefits to become apparent. Hydroxychloroquine is most often taken in combination with other drugs, such as methotrexate."
Answered by AI
What is hydroxychloroquine sulphate used for?
"Hydroxychloroquine sulfate is an antimalarial medicine that is approved in the United States for either prevention or treatment of certain types of malaria, lupus erythematosus, and rheumatoid arthritis. It has not been approved for the treatment of COVID-19."
Answered by AI
Is hydroxychloroquine sulphate a steroid?
"Federal government websites often end in . gov or . mil. Before sharing sensitive information, make sure you're on a federal government site
Hydroxychloroquine may help to reduce the need for steroids in people with immune thrombocytopenia, according to a review of the medical literature. The review looked at data from several studies involving hydroxychloroquine as a treatment for immune thrombocytopenia, a condition in which the body's immune system attacks and destroys platelets. Hydroxychloroquine is typically used in combination with other immunosuppressive drugs, and the review found that it may help to reduce the dosage or duration of steroid therapy in some cases. The review also found that hydroxychloroquine was generally well-tolerated, with few serious side effects."
Answered by AI