Chlorpheniramine Maleate
Catarrh, Angioedema, Hives + 4 more
Treatment
11 FDA approvals
5 Active Studies for Chlorpheniramine Maleate
Treatment for
Catarrh
What is Chlorpheniramine Maleate
Dexchlorpheniramine maleate
The Generic name of this drug
Treatment Summary
Dexchlorpheniramine is a stronger form of chlorpheniramine, a first-generation antihistamine. It is the single active variant of the original form and is more effective at treating allergies and hay fever symptoms.
Dexchlorpheniramine Maleate
is the brand name
Chlorpheniramine Maleate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dexchlorpheniramine Maleate
Dexchlorpheniramine maleate
1984
4
Approved as Treatment by the FDA
Dexchlorpheniramine maleate, also known as Dexchlorpheniramine Maleate, is approved by the FDA for 11 uses which include Vasomotor Rhinitis and Allergic Rhinitis (AR) .
Vasomotor Rhinitis
Helps manage Vasomotor Rhinitis
Allergic Rhinitis (AR)
Helps manage Allergic Rhinitis (AR)
Angioedema
Helps manage Angioedema
Urticaria
Helps manage Urticaria
Catarrh
Rhinitis, Vasomotor
Helps manage Vasomotor Rhinitis
Hypersensitivity
Hives
Helps manage Urticaria
Allergic Conjunctivitis (AC)
Helps manage Allergic Conjunctivitis (AC)
Angioedema
Helps manage Angioedema
Dermographism
Helps manage Dermographism
Effectiveness
How Chlorpheniramine Maleate Affects Patients
During allergic reactions, an allergen triggers the release of histamine from cells like mast cells and basophils, which can cause a variety of symptoms like itching, flushing, headaches, and breathing problems. Dexchlorpheniramine is a drug that blocks histamine from attaching to receptors in the body, providing temporary relief from hay fever and other allergy symptoms like sneezing, itchy eyes, and a runny nose.
How Chlorpheniramine Maleate works in the body
Dexchlorpheniramine works by blocking the effect of histamine in certain parts of the body, including the stomach, blood vessels and lungs. It does this by competing with histamine for certain receptor sites. Dexchlorpheniramine is more effective than other forms of chlorpheniramine because it is twice as strong.
When to interrupt dosage
The advocated dosage of Chlorpheniramine Maleate is contingent upon the diagnosed condition, such as Allergic Conjunctivitis (AC), Angioedema and Hay Fever. The quantity of dosage may vary, in accordance with the delivery technique featured in the table below.
Condition
Dosage
Administration
Catarrh
, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg
Tablet, coated - Oral, , Tablet, coated, Oral, Liquid - Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution - Oral, Solution, Tablet, multilayer, Tablet, multilayer - Oral, Syrup - Oral, Syrup, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Angioedema
, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg
Tablet, coated - Oral, , Tablet, coated, Oral, Liquid - Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution - Oral, Solution, Tablet, multilayer, Tablet, multilayer - Oral, Syrup - Oral, Syrup, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Hives
, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg
Tablet, coated - Oral, , Tablet, coated, Oral, Liquid - Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution - Oral, Solution, Tablet, multilayer, Tablet, multilayer - Oral, Syrup - Oral, Syrup, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Dermographism
, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg
Tablet, coated - Oral, , Tablet, coated, Oral, Liquid - Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution - Oral, Solution, Tablet, multilayer, Tablet, multilayer - Oral, Syrup - Oral, Syrup, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Rhinitis, Vasomotor
, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg
Tablet, coated - Oral, , Tablet, coated, Oral, Liquid - Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution - Oral, Solution, Tablet, multilayer, Tablet, multilayer - Oral, Syrup - Oral, Syrup, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Hypersensitivity
, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg
Tablet, coated - Oral, , Tablet, coated, Oral, Liquid - Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution - Oral, Solution, Tablet, multilayer, Tablet, multilayer - Oral, Syrup - Oral, Syrup, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Allergic Conjunctivitis (AC)
, 2.0 mg, 2.0 mg/mL, 0.5 mg/mL, 1.0 mg/mL, 6.0 mg, 1.0 mg, 3.0 mg
Tablet, coated - Oral, , Tablet, coated, Oral, Liquid - Oral, Solution / drops, Liquid, Solution / drops - Oral, Solution - Oral, Solution, Tablet, multilayer, Tablet, multilayer - Oral, Syrup - Oral, Syrup, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral
Warnings
There are 20 known major drug interactions with Chlorpheniramine Maleate.
Common Chlorpheniramine Maleate Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Dexchlorpheniramine maleate.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Dexchlorpheniramine maleate.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Dexchlorpheniramine maleate is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Dexchlorpheniramine maleate is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Dexchlorpheniramine maleate is combined with Artemether.
Chlorpheniramine Maleate Toxicity & Overdose Risk
Decreased activity in the brain and spinal cord.
Chlorpheniramine Maleate Novel Uses: Which Conditions Have a Clinical Trial Featuring Chlorpheniramine Maleate?
150 active clinical trials are being conducted to assess the utility of Chlorpheniramine Maleate in relieving Allergy, Dermographism and Catarrh Symptoms.
Condition
Clinical Trials
Trial Phases
Angioedema
2 Actively Recruiting
Phase 4, Phase 1, Phase 2
Hives
0 Actively Recruiting
Hypersensitivity
1 Actively Recruiting
Phase 4
Allergic Conjunctivitis (AC)
1 Actively Recruiting
Phase 2
Catarrh
0 Actively Recruiting
Rhinitis, Vasomotor
1 Actively Recruiting
Not Applicable
Dermographism
0 Actively Recruiting
Patient Q&A Section about chlorpheniramine maleate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Does chlorpheniramine maleate 2 mg make you sleepy?
"Chlorphenamine is known to have drowsy effects, while non-drowsy antihistamines such as cetirizine, fexofenadine, and loratadine are less likely to cause drowsiness."
Answered by AI
What is chlorpheniramine maleate used for?
"Chlorpheniramine is a medication that helps to relieve symptoms such as red, itchy, watery eyes; sneezing; an itchy nose or throat; and a runny nose. These symptoms are often caused by allergies, hay fever, or the common cold. Chlorpheniramine can help control the symptoms of a cold or allergies but will not treat the underlying cause of the symptoms or speed up the recovery process."
Answered by AI