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What is Jalyn
DutasterideThe Generic name of this drug
Treatment SummaryDutasteride, sold under the brand name Avodart, is a medication used to treat benign prostatic hyperplasia (BPH) in men. It works by blocking two types of enzymes (type 1 and type 2 5α-reductase) that convert testosterone into dihydrotestosterone (DHT), which contributes to the enlargement of the prostate gland. Dutasteride was approved by the FDA in 2001 and is as effective as another medication (finasteride) for treating BPH. Dutasteride has also been studied for treating hair loss, but it is not currently approved for this use
Avodartis the brand name
Jalyn Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Avodart
Dutasteride
2002
57
Approved as Treatment by the FDA
Dutasteride, also called Avodart, is approved by the FDA for 3 uses including Benign Prostatic Hyperplasia and Enlarged Prostate .Benign Prostatic Hyperplasia
Used to treat symptomatic benign prostatic hyperplasia (BPH) in combination with Tamsulosin
Enlarged Prostate
Helps manage Benign Prostatic Hyperplasia (BPH)
Enlarged Prostate
Used to treat Enlarged Prostate in combination with Tamsulosin
Effectiveness
How Jalyn Affects PatientsDutasteride is a drug that works to lower the levels of a hormone called dihydrotestosterone (DHT) that is found in the body. It can help reduce the size of the prostate gland, improve urinary flow, and ease symptoms of benign prostatic hyperplasia. After taking dutasteride for 1-2 weeks, the amount of DHT in the body is decreased by 85-90%. After taking it for one year, most people have a decrease in DHT of over 90%. Additionally, dutasteride may also reduce the levels of prostate-specific antigen (PSA) in people with
How Jalyn works in the bodyDutasteride reduces the levels of DHT, a hormone linked to prostate growth. It does this by forming a complex with an enzyme in the prostate that converts testosterone into DHT. By binding to this enzyme, it prevents it from doing its job, so the levels of DHT are reduced. Dutasteride is more effective at reducing DHT levels than other drugs, reducing levels by more than 90%. It does not bind to the androgen receptor, but it is a competitive and specific inhibitor of both Type I and Type II 5α-reductase isoenzymes. This means that it prevents the enzyme from
When to interrupt dosage
The suggested dosage of Jalyn is affected by the recognized condition, including Benign Prostatic Hyperplasia, Enlarged Prostate and Enlarged Prostate. The amount of dosage can be found in the table below, contingent upon the technique of delivery (e.g. Capsule or Capsule, extended release - Oral).Condition
Dosage
Administration
Benign Prostatic Hyperplasia
0.5 mg,
, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral
Enlarged Prostate
0.5 mg,
, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral
Enlarged Prostate
0.5 mg,
, Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral
Warnings
Jalyn has three contraindications, and it should not be used in conjunction with the conditions outlined in the following table.Jalyn ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
intended pregnancy
Do Not Combine
Pulse Frequency
Do Not Combine
Common Jalyn Drug Interactions
Drug Name
Risk Level
Description
Alfuzosin
Major
Dutasteride may increase the hypotensive activities of Alfuzosin.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Dutasteride.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Dutasteride.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Dutasteride.
Carbamazepine
Major
The metabolism of Carbamazepine can be decreased when combined with Dutasteride.
Jalyn Toxicity & Overdose RiskThe toxic dose of dutasteride in rabbits is greater than 2,000 mg/kg. In studies involving people taking a single dose of dutasteride up to 80 times the normal dose, only minor side effects such as reduced libido, impotence, gynecomastia, and ejaculation problems were reported. There is no known antidote for overdose. In animal studies, high doses of dutasteride caused decreased fertility in male rats and signs of non-specific, reversible toxicity in rats and dogs. Pregnant women should not take dutasteride as it may cause harm to male fetuses.
Jalyn Novel Uses: Which Conditions Have a Clinical Trial Featuring Jalyn?
21 active clinical trials are being conducted to assess the potential of Jalyn to treat Enlarged Prostate, Benign Prostatic Hyperplasia and other related conditions.Condition
Clinical Trials
Trial Phases
Enlarged Prostate
0 Actively Recruiting
Enlarged Prostate
21 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3
Benign Prostatic Hyperplasia
0 Actively Recruiting
Jalyn Reviews: What are patients saying about Jalyn?
5Patient Review
2/2/2013 Though it is quite pricey, this medication appears to be doing its job. I wish there was a less expensive generic option available, but as it stands, I have to pay over one hundred dollars every three months.
4.7Patient Review
8/22/2013 This treatment has been a game-changer for me. I no longer have to self-catheterize, and I can't tell you how much of an improvement that has been in my quality of life.
4.7Patient Review
12/26/2012 Jalyn is a slow-acting medication, and it's quite expensive compared to its alternatives. However, it is more convenient because you only have to take one pill instead of two.
4.3Patient Review
2/26/2014 Upon taking one pill for two days in a row, I found that my urinary and bowel functions greatly improved.
4.3Patient Review
5/29/2013 Jayln gives me heartburn, so I make sure to eat something when I take it.
4Patient Review
1/9/2014 This treatment can cause some sexual side effects, but they are usually temporary and shouldn't be a big problem.
4Patient Review
6/10/2013 I started developing some soreness and tenderness in my breasts. I'm worried because I don't know if this drug can cause cancer.
4Patient Review
12/22/20123.7Patient Review
5/15/2013 My libido has decreased since taking this medication. However, my wife is much happier now. I also experience anal itch and a general sense of unease about being on medication for the rest of my life. The increased cancer risk is concerning.
3.7Patient Review
10/2/2013 I've been having trouble sleeping through the night since I started taking this medication. My doctor said to take it at bedtime, but I've read that it's supposed to be taken after a meal. I'm not sure when the best time to take it is, but I do know that it sometimes gets stuck in my throat.
3.7Patient Review
11/27/2013 I take this drug once a day, but I don't feel like it's doing much.
3.7Patient Review
3/28/2013 I was unaware of the increased risk of prostate cancer associated with this treatment.
3.3Patient Review
12/11/20123Patient Review
3/13/2013 Though this medication did away with my erections, it also caused me a lot of anal itching. The co-pay is really expensive, too. Overall, I didn't see any difference between the generic and name brand version.
2.3Patient Review
2/14/2013 I've been taking this medication for approximately three weeks. I have found that, while it has improved my bathroom habits, there has been a significant reduction in my semen output. My libido is still just as strong as before beginning the treatment, though.
2.3Patient Review
6/9/2013 My primary care doctor told me to discontinue using this product. I was prescribed it by a urologist, and during the year I used it, I lost muscle mass in my legs and butt, and my skin became pale. My energy levels were so low that I couldn't even do a day's work without taking multiple rests. The urologist said that the drug was blocking my testosterone, which caused the problems noted. In the last two weeks, I've just been using Flomax, and I'm feeling a little better. Hopefully I'll get my legs and ass back!
2.3Patient Review
12/19/20122Patient Review
1/6/2014 I have experienced many of the same side effects as others who have taken this drug, and I am concerned that it may increase my risk of prostate cancer. If this is true, the drug should be removed from the approved list of prescriptions. I will be visiting my primary doctor this week for further observation and opinion.
Patient Q&A Section about jalyn
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the drug Jalyn used for?
"This product is used by men to treat the symptoms of an enlarged prostate. Dutasteride works by reducing the size of the enlarged prostate. Tamsulosin is an alpha-blocker that works by relaxing muscles in the bladder and prostate."
Answered by AI
How much does jalyn cost?
"Jalyn is a medication that is used to treat an enlarged prostate. It works by reducing the amount of a hormone that leads to prostate growth. It also relaxes the muscles in the prostate and bladder, which makes it easier to urinate. The lowest GoodRx price for the most common version of generic Jalyn is around $90.41, 81% off the average retail price of $485.22."
Answered by AI
What is the generic name for jalyn?
"The drug Jalyn, which is a combination of dutasteride and tamsulosin, is now available as a generic medication. This may be a much cheaper option than the brand version of the drug."
Answered by AI
What are the side effects of dutasteride tamsulosin?
"The following side effects may occur: feeling dizzy, lightheaded, or sleepy; having a stuffy or runny nose; having sexual problems; having pain or swelling in the testicles; or having bigger or more tender breasts."
Answered by AI