Mirabegron

Overactive Bladder Syndrome, Neurogenic Detrusor Overactivity, Obesity

Treatment

2 FDA approvals

20 Active Studies for Mirabegron

Treatment for

Overactive Bladder Syndrome

What is Mirabegron

MirabegronThe Generic name of this drug

Treatment SummaryMirabegron is a medication that relaxes the bladder muscles to help with urinary frequency and incontinence. It is different from other treatments because it doesn’t have the same range of side effects as other medications. It was approved by the FDA in 2012 and can be used to treat adults with overactive bladder. In 2021, an extended-release granule formulation was approved for pediatric patients with neurogenic detrusor overactivity. Mirabegron is also used in other countries like Canada, the European Union, and Japan.

Myrbetriqis the brand name

image of different drug pills on a surface

Mirabegron Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Myrbetriq

Mirabegron

2012

Approved as Treatment by the FDA

Mirabegron, also known as Myrbetriq, is approved by the FDA for 2 uses which include Overactive Bladder Syndrome (OABS) and Overactive Bladder Syndrome .

Overactive Bladder Syndrome (OABS)

Used to treat Overactive Bladder Syndrome (OABS) in combination with Solifenacin

Overactive Bladder Syndrome

Used to treat Overactive Bladder Syndrome (OABS) in combination with Solifenacin

Effectiveness

How Mirabegron Affects PatientsMirabegron relaxes the bladder muscles, allowing the bladder to hold more urine and decreasing urgency. It has been reported to cause urinary retention in people with bladder outlet obstruction, so should be used with caution in these patients. Mirabegron also increases both blood pressure and heart rate, which can be dangerous for those with uncontrolled hypertension, so should also be used with caution in these cases.

How Mirabegron works in the bodyMirabegron is a drug that relaxes the muscles of the bladder, allowing it to hold more urine. This can help relieve feelings of urgency and the need to go to the bathroom frequently.

When to interrupt dosage

The proposed measurement of Mirabegron is contingent upon the diagnosed state, for example Neurogenic Detrusor Overactivity, Overactive Bladder Syndrome and weight no less than 35 kg. The amount likewise fluctuates relying upon the approach of delivery (e.g. Granule, for suspension, extended release - Oral or Tablet, extended release - Oral) indicated in the table beneath.

Condition

Dosage

Administration

Overactive Bladder Syndrome

, 25.0 mg, 50.0 mg, 8.0 mg/mL

Oral, , Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Granule, for suspension, extended release - Oral, Granule, for suspension, extended release

Neurogenic Detrusor Overactivity

, 25.0 mg, 50.0 mg, 8.0 mg/mL

Obesity

, 25.0 mg, 50.0 mg, 8.0 mg/mL

Warnings

Mirabegron Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Mirabegron may interact with Pulse Frequency

There are 20 known major drug interactions with Mirabegron.

Common Mirabegron Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The serum concentration of Abemaciclib can be increased when it is combined with Mirabegron.

Axitinib

Major

The serum concentration of Axitinib can be increased when it is combined with Mirabegron.

Bendamustine

Major

The serum concentration of Bendamustine can be increased when it is combined with Mirabegron.

Binimetinib

Major

The serum concentration of Binimetinib can be increased when it is combined with Mirabegron.

Cabazitaxel

Major

The serum concentration of Cabazitaxel can be increased when it is combined with Mirabegron.

Mirabegron Toxicity & Overdose RiskTaking too much of this drug can cause racing heartbeats and an increased heart rate. Long-term overdoses may also cause a rise in blood pressure. If someone overdoses on this drug, they should be monitored by an ECG and receive supportive treatments to help reduce any symptoms.

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Mirabegron Novel Uses: Which Conditions Have a Clinical Trial Featuring Mirabegron?

33 active clinical trials are currently being conducted to explore the possible benefits of Mirabegron in treating Neurogenic Detrusor Overactivity, weight at least 35 kg and Overactive Bladder Syndrome.

Condition

Clinical Trials

Trial Phases

Obesity

0 Actively Recruiting

Overactive Bladder Syndrome

36 Actively Recruiting

Not Applicable, Phase 3, Phase 4, Phase 1, Phase 2

Neurogenic Detrusor Overactivity

3 Actively Recruiting

Phase 2, Phase 3, Phase 1

Mirabegron Reviews: What are patients saying about Mirabegron?

5Patient Review

1/25/2013

Mirabegron for Overactive Bladder

5Patient Review

5/25/2013

Mirabegron for Overactive Bladder

This medication is much cheaper than having a surgical implant, and it works just as well for me. The only downside is that it's still pretty pricey.

5Patient Review

7/10/2015

Mirabegron for Urine Leakage When there is a Strong Desire to Void

Worked great with no real side effects to speak of. The only problem is that it's quite expensive--$116 a month.

4.7Patient Review

6/26/2014

Mirabegron for Overactive Bladder

I had leakage and urgent incontinence/flooding. Detrol was effective but dry mouth was horrible. Mirabegron has worked almost as well and with no side effects.

4.3Patient Review

7/27/2016

Mirabegron for Overactive Bladder

I was pleasantly surprised at how quickly this medication worked. However, I developed an upset stomach as a result of taking it. This seems to be a common side effect, but it's still worth mentioning.

View All Reviews

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Patient Q&A Section about mirabegron

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the best time to take mirabegron?

"You can take mirabegron at any time of day, but try to take your doses at the same time of day each day to avoid missing doses. Swallow the tablet with a drink of water."

Answered by AI

What type of drug is mirabegron?

"Paraphrase:

Mirabegron belongs to a class of medications called beta-3 adrenergic agonists. These drugs work by relaxing the muscles in the bladder, which prevents frequent or uncontrolled urination."

Answered by AI

What is the drug mirabegron used for?

"a strong need to pee often (urinary frequency)

leaking urine (urinary incontinence)

waking up at night to urinate (nocturia)

Mirabegron eases the symptoms of overactive bladder but does not cure the condition. Symptoms it alleviates include:

sudden and urgent need to urinate

frequent need to urinate

urinary incontinence

waking up at night to urinate"

Answered by AI

What are the side effects of taking mirabegron?

"The following are symptoms of a bladder infection: bladder pain, bloody or cloudy urine, difficult, burning, or painful urination, frequent urge to urinate, pounding in the ears, slow, fast, or irregular heartbeat."

Answered by AI

Clinical Trials for Mirabegron

Have you considered Mirabegron clinical trials? We made a collection of clinical trials featuring Mirabegron, we think they might fit your search criteria.

Have you considered Mirabegron clinical trials? We made a collection of clinical trials featuring Mirabegron, we think they might fit your search criteria.