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Atezolizumab for Sarcoma
Study Summary
This trial studies atezolizumab in treating patients with chondrosarcoma or clear cell sarcoma.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2019 Phase 3 trial • 1225 Patients • NCT02008227Trial Design
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- My kidney function, measured by creatinine clearance, is adequate.You cannot have participated in any other experimental treatment within the last 4 weeks (or within five half lives of the investigational product, whichever is shorter) before starting this study.I have a specific type of cancer that is spreading and causing more symptoms.Your hemoglobin (a protein in your blood) levels are at least 8 grams per deciliter (a unit of measurement for blood).I do not have any unmanaged ongoing illnesses.I am willing to give samples for research and I am 18 or older.My brain cancer has not worsened for at least 1 month after treatment.I have active tuberculosis.I haven't had major surgery in the last 28 days and don't expect to need one during the study.My cancer is not removable by surgery and has specific genetic markers or is a certain type.I have a tumor that can be measured with imaging or physical exam.My heart function is classified as good or better.Your bilirubin levels are normal, but if you have a condition called Gilbert disease, your bilirubin levels can be up to three times the normal limit.I can take care of myself but might not be able to do heavy physical work.I have brain metastases but don't need immediate brain-specific treatment.I had cancer before, but it won't affect this treatment's test.I have been treated with drugs targeting PD-1 or PD-L1.I finished my last cancer treatment at least 4 weeks ago or 5 half-lives of the treatment, whichever is shorter, and have recovered from its side effects.I have a history of specific lung conditions or signs of lung inflammation on a CT scan.I have not received a live vaccine in the last 4 weeks and won't need one during the study.I have not had signs of infection in the last 2 weeks.You have a history or risk of an autoimmune disease.I am at least 2 years old if at the NCI Clinical Center, or 12 years old at other sites.You have enough platelets in your blood, with a count of at least 100,000/mcL.I am at least 2 years old if at NCI, or 12 years old at other sites.I haven't taken any immune-weakening drugs in the last 2 weeks.You are expected to live for at least 3 more months.I have a tumor that can be measured and is at least as big as specified.I have not taken antibiotics in the last 2 weeks.I have a significant liver condition.I have a specific type of advanced sarcoma that is growing and cannot be surgically removed.I haven't taken any immune-boosting drugs in the last 6 weeks.I am HIV-positive, on treatment, and my viral load is undetectable.I have not had severe infections in the last 4 weeks.My cancer has a specific genetic change or is a certain type of sarcoma.I am mostly self-sufficient and can carry out daily activities.You have a sufficient amount of a type of white blood cell called neutrophils, with a count of at least 1,000 per microliter of blood.You are currently pregnant or breastfeeding.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
To what extent is the population being treated in this inquiry?
"Unfortunately, this clinical trial has already closed its recruitment phase. Although it was initially posted on September 9th 2020 and last updated November 18th 2022, no more patients can be accepted into the study. If you are still looking for other studies to join, there are currently 456 trials recruiting participants with clear cell sarcoma of soft tissue and 351 trials utilizing Atezolizumab actively admitting volunteers."
Has the efficacy of Atezolizumab been tested in any other medical experiments?
"Atezolizumab was first explored in 2008 at SCRI Tennessee Oncology Chattanooga and has since been studied 80 times. Currently, there are 351 ongoing clinical trials across the globe with a concentration of sites located in Toronto, Ontario."
Is this research unprecedented in its methodology?
"The pharmaceutical company Hoffmann-La Roche conducted the inaugural clinical trial of Atezolizumab in 2008, with 720 participants. After a successful Phase 2 drug approval, there are now 351 active studies for this medication being held across 74 countries and 1645 cities."
Has Atezolizumab acquired governmental sanction for medicinal use?
"The safety of Atezolizumab was rated as a 2 due to the lack of clinical data demonstrating efficacy, despite some preliminary evidence suggesting it is safe."
Is there still availability for participants in this experiment?
"Per the clinicaltrials.gov registry, recruitment for this trial has been discontinued since November 18th 2022. Despite that, 807 other trials are still searching for potential candidates at present time."
To what extent is this trial being implemented across various venues?
"Individuals who are interested in participating may do so at University Health Network-Princess Margaret Hospital (Toronto, Ontario), USC / Norris Comprehensive Cancer Center (Los Angeles, California), Emory University Hospital Midtown (Atlanta, Georgia) and 13 additional locations."
For which conditions is Atezolizumab conventionally deployed?
"Atezolizumab is a staple treatment for small cell lung cancer and has seen success in battling malignant neoplasms, non-small cell lung carcinoma, and postoperative ailments."
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