~133 spots leftby Jul 2027

Prolonged Exposure Therapy for PTSD and Substance Use Disorder

(PREVAIL Trial)

Recruiting at 3 trial locations
SK
Overseen byShannon Kehle-Forbes, PhD
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: Veterans Medical Research Foundation
No Placebo Group
Approved in 3 Jurisdictions

Trial Summary

What is the purpose of this trial?

The goal of this clinical trial is to learn if receiving Prolonged Exposure Therapy for PTSD in massed format (multiple sessions weekly) is as effective as receiving it with sessions once per week among veterans with PTSD and substance use disorder in intensive outpatient substance use treatment. The main questions it aims to answer are: * Will the massed format help participants complete and benefit from Prolonged Exposure in terms of PTSD symptoms? * Will it help participants reduce substance use? Participants who are in intensive substance use treatment will be asked to complete Prolonged Exposure with either weekly sessions or multiple sessions per week.

Research Team

SK

Shannon Kehle-Forbes, PhD

Principal Investigator

University of Minnesota

Eligibility Criteria

This trial is for veterans with PTSD and substance use disorder who are currently in intensive outpatient treatment. Participants will be asked to complete Prolonged Exposure Therapy, which requires attending either weekly sessions or multiple sessions per week.

Inclusion Criteria

Report substance use at least 20 of the last 90 days
Meet DSM-5 criteria for PTSD
Are able to give informed consent
See 2 more

Exclusion Criteria

I have significant memory or thinking problems.
I do not have thoughts of harming myself or others that need immediate attention.
Current unstable psychotic or manic symptoms not attributable to SUD

Treatment Details

Interventions

  • Prolonged Exposure Therapy (Behavioral Intervention)
Trial OverviewThe study is testing the effectiveness of Prolonged Exposure Therapy for PTSD when conducted in a massed format (multiple sessions weekly) compared to the standard once-a-week session schedule among veterans undergoing substance use treatment.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Massed PEExperimental Treatment1 Intervention
Prolonged Exposure delivered in a massed format - sessions multiple times per week
Group II: Weekly PEActive Control1 Intervention
Prolonged Exposure delivered with weekly sessions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Veterans Medical Research Foundation

Lead Sponsor

Trials
46
Recruited
5,100+

University of Minnesota

Collaborator

Trials
1,459
Recruited
1,623,000+

Center for Veterans Research and Education

Collaborator

Trials
13
Recruited
1,700+