Sucralfate for Esophagitis
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial is testing sucralfate, a medication that protects the esophagus, to see if it can prevent or reduce symptoms of radiation esophagitis. The study focuses on patients undergoing radiation therapy who are at risk of developing this painful condition. Sucralfate works by coating the esophagus to shield it from damage. Sucralfate has been evaluated for its protective adherence to denuded surfaces and bile salt-binding properties, showing efficacy in treating reflux esophagitis.
Do I need to stop my current medications for the trial?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are actively taking opioid pain medications before starting radiation therapy.
Is sucralfate safe for human use?
How does the drug sucralfate differ from other treatments for esophagitis?
Sucralfate is unique because it acts locally in the esophagus by forming a protective barrier over damaged areas, which helps in healing and provides relief from symptoms. Unlike some other treatments, it does not work by reducing stomach acid but rather by enhancing the natural healing process of the esophageal lining.26789
What evidence supports the effectiveness of the drug sucralfate for treating esophagitis?
Who Is on the Research Team?
Jacob Shin, MD
Principal Investigator
Memorial Sloan Kettering Cancer Center
Are You a Good Fit for This Trial?
This trial is for adults over 18 who are undergoing thoracic irradiation and have a high risk of developing esophagitis due to their treatment. It's not for those with feeding tubes, current opioid use, known issues taking Sucralfate, or a history of opioid addiction.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive thoracic irradiation and are randomized to receive either sucralfate or usual care
Follow-up
Participants are monitored for safety and effectiveness after treatment, including opioid use and weight loss
What Are the Treatments Tested in This Trial?
Interventions
- Sucralfate
- Usual Care
Find a Clinic Near You
Who Is Running the Clinical Trial?
Memorial Sloan Kettering Cancer Center
Lead Sponsor