What is Dostinex
CabergolineThe Generic name of this drug
Treatment SummaryCabergoline is a long-acting medication that works by blocking the action of a hormone called prolactin and stimulating dopamine receptors. It is used to treat elevated levels of prolactin in the body, which can cause symptoms such as menstrual irregularities, infertility, and breast milk production. Cabergoline is also approved to treat Parkinson's syndrome.
Dostinexis the brand name
Dostinex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dostinex
Cabergoline
1996
16
Approved as Treatment by the FDA
Cabergoline, also known as Dostinex, is approved by the FDA for 5 uses which include Pituitary Adenoma and Inhibition of physiological lactation .Pituitary Adenoma
Inhibition of physiological lactation
Hyperprolactinemia
idiopathic hyperprolactinemic disorder
Inhibition of physiological lactation therapy
Effectiveness
How Dostinex Affects PatientsCabergoline affects special receptors in the brain, particularly ones related to movement disorders. It is thought that by triggering certain types of these receptors, it can help reduce symptoms of Parkinson's. It can also reduce the amount of prolactin released by the pituitary gland. However, when too much dopamine is active in certain areas of the brain, it can cause hallucinations and delusions, which are similar to those seen in people with schizophrenia.
How Dostinex works in the bodyCabergoline is a long-acting drug that binds to dopamine D2 receptors. It helps reduce the amount of calcium entering cells, preventing them from sending signals that control muscle movement. This makes it useful for people with movement disorders. Cabergoline also stops cells from activating proteins that promote tumor growth, and blocks other signaling pathways in the brain. It has very little effect on other types of receptors, like dopamine D1, alpha-1 and alpha-2 adrenergic, and 5-HT1 and 5-HT2 serotonin receptors.
When to interrupt dosage
The measure of Dostinex relies upon the indicated condition, including idiopathic hyperprolactinemic disorder, Hyperprolactinemia and Pituitary Adenoma. The amount varies as per the technique of delivery (e.g. Oral or Tablet) mentioned in the table hereunder.Condition
Dosage
Administration
Inhibition of physiological lactation
, 0.5 mg
Oral, Tablet, , Tablet - Oral
Pituitary Adenoma
, 0.5 mg
Oral, Tablet, , Tablet - Oral
Hyperprolactinemia
, 0.5 mg
Oral, Tablet, , Tablet - Oral
Inhibition of physiological lactation therapy
, 0.5 mg
Oral, Tablet, , Tablet - Oral
idiopathic hyperprolactinemic disorder
, 0.5 mg
Oral, Tablet, , Tablet - Oral
Warnings
Dostinex has five counter-indications, so it must not be consumed when encountering any of the conditions in the following table.Dostinex ContraindicationsCondition
Risk Level
Notes
history of cardiac valvular disorders
Do Not Combine
history of pericardial fibrosis
Do Not Combine
Pulmonary Fibrosis
Do Not Combine
Retroperitoneal fibrosis
Do Not Combine
Hypertensive disease
Do Not Combine
Common Dostinex Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
Cabergoline may increase the hypertensive and vasoconstricting activities of 4-Bromo-2,5-dimethoxyphenethylamine.
4-Methoxyamphetamine
Major
Cabergoline may increase the hypertensive and vasoconstricting activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
Cabergoline may increase the vasoconstricting activities of 5-methoxy-N,N-dimethyltryptamine.
Abediterol
Major
Cabergoline may increase the hypertensive and vasoconstricting activities of Abediterol.
Adrafinil
Major
Cabergoline may increase the hypertensive and vasoconstricting activities of Adrafinil.
Dostinex Toxicity & Overdose RiskOverdosing on this drug could cause a stuffy nose, fainting, or hallucinations.
Dostinex Novel Uses: Which Conditions Have a Clinical Trial Featuring Dostinex?
Currently, there are 5 active studies exploring the potential of Dostinex for treating idiopathic hyperprolactinemic disorder, Hyperprolactinemia and Inhibition of physiological lactation.Condition
Clinical Trials
Trial Phases
Hyperprolactinemia
1 Actively Recruiting
Phase 1
Pituitary Adenoma
2 Actively Recruiting
Phase 1, Not Applicable
Inhibition of physiological lactation therapy
1 Actively Recruiting
Phase 2
idiopathic hyperprolactinemic disorder
0 Actively Recruiting
Inhibition of physiological lactation
0 Actively Recruiting
Dostinex Reviews: What are patients saying about Dostinex?
5Patient Review
4/16/2009 I've been dealing with prolactinoma for about 25 years now, and this treatment has by far been the most effective in keeping my prolactin levels down. I highly recommend it to others who are struggling with a similar condition.
5Patient Review
1/15/2010 My prolactin levels were so high that it killed my sex drive and started to affect other aspects of my life. My doctor prescribed Dostinex, which completely changed things for the better. I highly recommend you speak with your own doctor about this treatment option.
5Patient Review
12/20/2021 I'm one of the few males who have tried Dostinex, and I'm happy to report that it worked great for me. My libido and erectile function both returned immediately after starting this medication, better than when I was 18!
5Patient Review
8/19/2014 I've found my erections to be both fuller and better since taking this product. Additionally, my sex drive has returned to its previous levels. I highly recommend it to others seeking similar results without any negative side effects, as I experienced none myself.
5Patient Review
3/12/2011 I felt lightheaded when I first started taking Dostinex, but now I'm okay. I take half a tablet twice a week.
5Patient Review
4/7/20095Patient Review
7/28/2009 I had a brain operation to remove a prolactinoma in 2007. I've been taking dostinex 4 times per week since then, but the prolactin levels are still very high. It's frustrating how slowly it seems to be working, but this is the best treatment available right now so I'll continue to take it.
4.7Patient Review
1/5/2010 I was very pleased with how well this drug worked for me, but I'm confused as to why it was discontinued in the United States. According to reports, there may be heart damage associated with this medication; however, I have yet to experience any negative side effects. If anyone has any information on this, please let me know.
4.3Patient Review
6/13/2009 I had a pituitary tumor that caused my body to produce milk, even though I'm male. After trying this medication, the tumor has now vanished without needing surgery. Although I felt sick when I first started taking it, the results have been well worth it.
4.3Patient Review
10/12/2009 I had a great experience with this drug and didn't experience any negative side effects like nausea.
3.7Patient Review
11/13/2009 I was experiencing some severe dizziness, fatigue, and high blood pressure. Additionally, I had ringing in my ears which made it tough to sleep.
2.3Patient Review
6/22/2010 I'm only taking this medication because I have no other choice. It makes me feel exhausted constantly, and some days I just can't muster up the energy to do anything. Additionally, I get headaches several times a week, my breasts are often tender, and I've gained weight since starting this low dose.
1.7Patient Review
5/6/2018 While this treatment did lower my prolactin levels from 30 to 20, I experienced severe depression as a result. It was awful; I felt fear, anger, and sadness constantly. Panic attacks were also a regular occurrence. Thank goodness when I stopped taking the pill, these feelings started to dissipate until they eventually went away entirely. However, now my doctor wants me to try it again and I'm absolutely petrified.
Patient Q&A Section about dostinex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How quickly does Dostinex work?
"The Prolactin-lowering effect begins within 3 hours after administration and can last up to 7-28 days in healthy volunteers and patients with hyperprolactinaemia, and up to 14-21 days in postpartum women. The effect is related to the dose, both in terms of the degree of effect and how long it lasts."
Answered by AI
What are the side effects of Dostinex?
"feeling of movement,, headache,, fear,, anxiety,, restlessness
Nausea, vomiting, stomach pain, indigestion, constipation, gas, dizziness, spinning sensation, feeling of movement, headache, fear, anxiety, and restlessness are all possible side effects of this medication."
Answered by AI
What is the best time to take Dostinex?
"You should take cabergoline with a meal and a glass of water to reduce the risk of feeling nauseous. It's best to take it at the same time(s) each day, and if you're taking it weekly, make sure to take it on the same day each week."
Answered by AI
What is Dostinex used for?
"This medication can help to lower high levels of prolactin in your body, which can relieve symptoms such as unwanted breast milk and missed periods. It can also help if you're having difficulty getting pregnant."
Answered by AI