Dostinex

Hyperprolactinemia, Inhibition of physiological lactation, Hyperprolactinemia + 2 more
Treatment
7 FDA approvals
3 Active Studies for Dostinex

What is Dostinex

CabergolineThe Generic name of this drug
Treatment SummaryCabergoline is a long-acting medication that works by blocking the action of a hormone called prolactin and stimulating dopamine receptors. It is used to treat elevated levels of prolactin in the body, which can cause symptoms such as menstrual irregularities, infertility, and breast milk production. Cabergoline is also approved to treat Parkinson's syndrome.
Dostinexis the brand name
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Dostinex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dostinex
Cabergoline
1996
16

Approved as Treatment by the FDA

Cabergoline, also known as Dostinex, is approved by the FDA for 7 uses which include Hyperprolactinemia and Pituitary Adenomas .
Hyperprolactinemia
Pituitary Adenomas
Inhibition of physiological lactation therapy
Hyperprolactinemia
Pituitary Adenoma
Inhibition of physiological lactation
Hyperprolactinemia

Effectiveness

How Dostinex Affects PatientsCabergoline affects special receptors in the brain, particularly ones related to movement disorders. It is thought that by triggering certain types of these receptors, it can help reduce symptoms of Parkinson's. It can also reduce the amount of prolactin released by the pituitary gland. However, when too much dopamine is active in certain areas of the brain, it can cause hallucinations and delusions, which are similar to those seen in people with schizophrenia.
How Dostinex works in the bodyCabergoline is a long-acting drug that binds to dopamine D2 receptors. It helps reduce the amount of calcium entering cells, preventing them from sending signals that control muscle movement. This makes it useful for people with movement disorders. Cabergoline also stops cells from activating proteins that promote tumor growth, and blocks other signaling pathways in the brain. It has very little effect on other types of receptors, like dopamine D1, alpha-1 and alpha-2 adrenergic, and 5-HT1 and 5-HT2 serotonin receptors.

When to interrupt dosage

The measure of Dostinex relies upon the indicated condition, including idiopathic hyperprolactinemic disorder, Hyperprolactinemia and Pituitary Adenoma. The amount varies as per the technique of delivery (e.g. Oral or Tablet) mentioned in the table hereunder.
Condition
Dosage
Administration
Inhibition of physiological lactation
0.5 mg,
, Oral, Tablet, Tablet - Oral
Pituitary Adenoma
0.5 mg,
, Oral, Tablet, Tablet - Oral
Inhibition of physiological lactation therapy
0.5 mg,
, Oral, Tablet, Tablet - Oral
Hyperprolactinemia
0.5 mg,
, Oral, Tablet, Tablet - Oral
Hyperprolactinemia
0.5 mg,
, Oral, Tablet, Tablet - Oral

Warnings

Dostinex has five counter-indications, so it must not be consumed when encountering any of the conditions in the following table.Dostinex Contraindications
Condition
Risk Level
Notes
history of pericardial fibrosis
Do Not Combine
Retroperitoneal fibrosis
Do Not Combine
Heart Valve Diseases
Do Not Combine
Pulmonary Fibrosis
Do Not Combine
Hypertensive disease
Do Not Combine
There are 20 known major drug interactions with Dostinex.
Common Dostinex Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
Cabergoline may increase the hypertensive and vasoconstricting activities of 4-Bromo-2,5-dimethoxyphenethylamine.
4-Methoxyamphetamine
Major
Cabergoline may increase the hypertensive and vasoconstricting activities of 4-Methoxyamphetamine.
5-methoxy-N,N-dimethyltryptamine
Major
Cabergoline may increase the vasoconstricting activities of 5-methoxy-N,N-dimethyltryptamine.
Abediterol
Major
Cabergoline may increase the hypertensive and vasoconstricting activities of Abediterol.
Adrafinil
Major
Cabergoline may increase the hypertensive and vasoconstricting activities of Adrafinil.
Dostinex Toxicity & Overdose RiskOverdosing on this drug could cause a stuffy nose, fainting, or hallucinations.
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Dostinex Novel Uses: Which Conditions Have a Clinical Trial Featuring Dostinex?

Currently, there are 5 active studies exploring the potential of Dostinex for treating idiopathic hyperprolactinemic disorder, Hyperprolactinemia and Inhibition of physiological lactation.
Condition
Clinical Trials
Trial Phases
Inhibition of physiological lactation therapy
1 Actively Recruiting
Phase 2
Pituitary Adenoma
2 Actively Recruiting
Phase 1, Not Applicable
Hyperprolactinemia
0 Actively Recruiting
Inhibition of physiological lactation
0 Actively Recruiting
Hyperprolactinemia
0 Actively Recruiting

Dostinex Reviews: What are patients saying about Dostinex?

5Patient Review
4/16/2009
Dostinex for Increased Levels of Prolactin in the Blood
I've been dealing with prolactinoma for about 25 years now, and this treatment has by far been the most effective in keeping my prolactin levels down. I highly recommend it to others who are struggling with a similar condition.
5Patient Review
1/15/2010
Dostinex for Increased Levels of Prolactin in the Blood
My prolactin levels were so high that it killed my sex drive and started to affect other aspects of my life. My doctor prescribed Dostinex, which completely changed things for the better. I highly recommend you speak with your own doctor about this treatment option.
5Patient Review
12/20/2021
Dostinex for Increased Levels of Prolactin in the Blood
I'm one of the few males who have tried Dostinex, and I'm happy to report that it worked great for me. My libido and erectile function both returned immediately after starting this medication, better than when I was 18!
5Patient Review
8/19/2014
Dostinex for Increased Levels of Prolactin in the Blood
I've found my erections to be both fuller and better since taking this product. Additionally, my sex drive has returned to its previous levels. I highly recommend it to others seeking similar results without any negative side effects, as I experienced none myself.
5Patient Review
3/12/2011
Dostinex for Increased Levels of Prolactin in the Blood
I felt lightheaded when I first started taking Dostinex, but now I'm okay. I take half a tablet twice a week.
View All Reviews
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Patient Q&A Section about dostinex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How quickly does Dostinex work?

"The Prolactin-lowering effect begins within 3 hours after administration and can last up to 7-28 days in healthy volunteers and patients with hyperprolactinaemia, and up to 14-21 days in postpartum women. The effect is related to the dose, both in terms of the degree of effect and how long it lasts."

Answered by AI

What are the side effects of Dostinex?

"feeling of movement,, headache,, fear,, anxiety,, restlessness

Nausea, vomiting, stomach pain, indigestion, constipation, gas, dizziness, spinning sensation, feeling of movement, headache, fear, anxiety, and restlessness are all possible side effects of this medication."

Answered by AI

What is the best time to take Dostinex?

"You should take cabergoline with a meal and a glass of water to reduce the risk of feeling nauseous. It's best to take it at the same time(s) each day, and if you're taking it weekly, make sure to take it on the same day each week."

Answered by AI

What is Dostinex used for?

"This medication can help to lower high levels of prolactin in your body, which can relieve symptoms such as unwanted breast milk and missed periods. It can also help if you're having difficulty getting pregnant."

Answered by AI

Clinical Trials for Dostinex

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