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Intensive Cardiovascular Medication for Coronary Artery Disease (WARRIOR Trial)
WARRIOR Trial Summary
This trial is testing whether intensive treatment with statins, ACE inhibitors, and aspirin can reduce major adverse events in women with coronary artery disease who don't have blockages.
WARRIOR Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.WARRIOR Trial Design
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Who is running the clinical trial?
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- You had a heart attack in the last 30 days.You have a history of a certain heart condition called dilated or hypertrophic cardiomyopathy that is not caused by reduced blood flow to the heart.You have a serious problem with one of your heart valves or may need heart valve surgery in the next 3 years.You have a serious health condition that is expected to significantly shorten your life.You have had a bad reaction to both an ACE inhibitor and an ARB.You cannot take statin medication unless your doctor prescribes a replacement called PCSK9.If you are a pre-menopausal female, you need a negative pregnancy test before starting the study. If you have not gone through menopause or had certain surgeries to prevent pregnancy, you cannot participate if you are pregnant.Your heart is not pumping well, and you have been hospitalized for heart failure in the past 6 months.You have very poor kidney function or are on dialysis.You had a stroke or bleeding in the brain in the past 180 days.You have experienced symptoms that suggest a potential heart problem and have been referred for heart tests within the last 5 years.You do not have significant blockages in your heart arteries.
- Group 1: Intensive Medical Treatment (IMT)
- Group 2: Usual Care (UC)
- Approved for 30 Other Conditions - This treatment demonstrated efficacy for 30 other conditions.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Drug Has Already Been Approved - The FDA has already approved this drug, and is just seeking more data.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Do I meet the qualifications for participation in this experiment?
"This clinical trial is seeking 4,422 patients with coronary artery disease aged between 18 and 100. In order to apply for consideration, participants must demonstrate symptoms of suspected ischemia prompting referral for further evaluation by cardiac catheterization or coronary angiogram/CT angiogram within 5 years from their consent date; additionally they need to agree to provide written informed permission and have non-obstructive CAD (0-49% diameter reduction in a major epicardial vessel) or FFR > 0.80 ."
Could you elaborate on any precedent set by prior experiments using ACE-I (lisinopril) or ARB (losartan)?
"In 2005, Vermont Cancer Center first began researching the application of ACE-I (lisinopril) or ARB (losartan). Since then, a total of 1505 clinical trials have been concluded. Currently 290 medical studies are still running, with many conducted in New york City."
Is the FDA's stamp of approval applicable to lisinopril or losartan?
"The therapeutic potential of ACE-I (lisinopril) and ARB (losartan) has been confirmed in Phase 4 trials, representing a score of 3 on the safety scale."
Are individuals aged 55 years and older eligible for this research?
"This trial has specified that eligible participants must be between 18 and 100 years old. 73 studies are available for those younger than 18, while 1123 are open to individuals above the age of 65."
Are there any opportunities currently available to participate in this research?
"Affirmative. According to the information found on clinicaltrials.gov, this medical study is currently enrolling participants. It was first published on February 9th 2018 and last updated on September 14th 2021; a total of 4422 individuals are needed from 86 sites for completion of the trial."
At how many distinct facilities is this clinical trial administered?
"As evidenced by the list of 87 clinical trial sites, NYU Langone in New york City, Baptist Health in Jacksonville, Georgia and Advent Sebring in Sebring Mississippi are included among those offering this medication."
What conditions commonly necessitate the prescription of ACE-I (lisinopril) or ARB (losartan)?
"Lisinopril and losartan are commonly used to medicate coronary heart disease. These drugs may also help treat synovitis, anxiety, and other conditions related to the re-narrowing of a coronary artery."
Who else is applying?
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How old are they?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
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