What is Dantrium
DantroleneThe Generic name of this drug
Treatment SummaryDantrolene is a drug that does not act like other similar drugs, such as phenytoin, to treat seizures. It is a chemical derivative of hydantoin.
Dantrolene Sodiumis the brand name
Dantrium Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Dantrolene Sodium
Dantrolene
2005
36
Effectiveness
How Dantrium Affects PatientsDantrolene is a muscle relaxant and is the only effective treatment for malignant hyperthermia. It works by blocking the contractility of the muscle beyond the myoneural junction and by stopping the release of calcium from the sarcoplasmic reticulum. In those with malignant hyperthermia, certain triggering agents (e.g anesthetic drugs) can cause an increase in myoplasmic calcium which leads to a malignant hyperthermia crisis. Dantrolene helps to restore the normal level of calcium in the myoplasm, thus reducing the risk of a crisis.
How Dantrium works in the bodyDantrolene works by reducing the amount of calcium available to cause muscle contractions. It does this by attaching to the muscle's ryanodine receptors, which are responsible for releasing calcium from the sarcoplasmic reticulum.
When to interrupt dosage
The measure of Dantrium is contingent upon the recognized affliction, including Stroke, Spasticity and Spinal Cord Injury. The amount of dosage alters, in line with the mode of delivery (e.g. Capsule - Oral or Injection, solution - Intravenous) featured in the table beneath.Condition
Dosage
Administration
Stroke
50.0 mg, , 250.0 mg/mL, 2.0 mg/mL, 100.0 mg, 25.0 mg, 20.0 mg
Capsule - Oral, Injection, solution - Intravenous, Injection, Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Intravenous, , Injection, powder, for solution, Injection - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Capsule, Injection, suspension, Injection, solution, Powder, for solution, Injection, suspension - Intravenous
Spasticity
50.0 mg, , 250.0 mg/mL, 2.0 mg/mL, 100.0 mg, 25.0 mg, 20.0 mg
Capsule - Oral, Injection, solution - Intravenous, Injection, Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Intravenous, , Injection, powder, for solution, Injection - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Capsule, Injection, suspension, Injection, solution, Powder, for solution, Injection, suspension - Intravenous
Spinal Cord Injury
50.0 mg, , 250.0 mg/mL, 2.0 mg/mL, 100.0 mg, 25.0 mg, 20.0 mg
Capsule - Oral, Injection, solution - Intravenous, Injection, Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Intravenous, , Injection, powder, for solution, Injection - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Capsule, Injection, suspension, Injection, solution, Powder, for solution, Injection, suspension - Intravenous
prophylaxis of Malignant hyperthermia
50.0 mg, , 250.0 mg/mL, 2.0 mg/mL, 100.0 mg, 25.0 mg, 20.0 mg
Capsule - Oral, Injection, solution - Intravenous, Injection, Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Intravenous, , Injection, powder, for solution, Injection - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Capsule, Injection, suspension, Injection, solution, Powder, for solution, Injection, suspension - Intravenous
Multiple Sclerosis
50.0 mg, , 250.0 mg/mL, 2.0 mg/mL, 100.0 mg, 25.0 mg, 20.0 mg
Capsule - Oral, Injection, solution - Intravenous, Injection, Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Intravenous, , Injection, powder, for solution, Injection - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Capsule, Injection, suspension, Injection, solution, Powder, for solution, Injection, suspension - Intravenous
Cerebral Palsy
50.0 mg, , 250.0 mg/mL, 2.0 mg/mL, 100.0 mg, 25.0 mg, 20.0 mg
Capsule - Oral, Injection, solution - Intravenous, Injection, Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Intravenous, , Injection, powder, for solution, Injection - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Capsule, Injection, suspension, Injection, solution, Powder, for solution, Injection, suspension - Intravenous
Malignant Hyperthermia
50.0 mg, , 250.0 mg/mL, 2.0 mg/mL, 100.0 mg, 25.0 mg, 20.0 mg
Capsule - Oral, Injection, solution - Intravenous, Injection, Oral, Powder, for solution - Intravenous, Injection, powder, lyophilized, for solution, Intravenous, , Injection, powder, for solution, Injection - Intravenous, Injection, powder, lyophilized, for solution - Intravenous, Injection, powder, for solution - Intravenous, Capsule, Injection, suspension, Injection, solution, Powder, for solution, Injection, suspension - Intravenous
Warnings
Dantrium ContraindicationsCondition
Risk Level
Notes
Muscle Spasticity
Do Not Combine
Hepatitis
Do Not Combine
Cirrhosis
Do Not Combine
active hepatic disease
Do Not Combine
Muscle Spasticity
Do Not Combine
Locomotion
Do Not Combine
Common Dantrium Drug Interactions
Drug Name
Risk Level
Description
Agmatine
Major
The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Agmatine.
Amiodarone
Major
The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Amiodarone.
Amlodipine
Major
The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Amlodipine.
Aranidipine
Major
The risk or severity of hyperkalemia can be increased when Dantrolene is combined with Aranidipine.
Azelastine
Major
Dantrolene may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Dantrium Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats has been found to be 7400mg/kg. Overdosing on the drug can lead to muscle weakness, altered consciousness (such as feeling drowsy or going into a coma), vomiting, diarrhea, and having crystals in the urine.
Dantrium Novel Uses: Which Conditions Have a Clinical Trial Featuring Dantrium?
258 active investigations are currently assessing the potential of Dantrium to improve Multiple Sclerosis, Spinal Cord Injury and Spasticity symptoms.Condition
Clinical Trials
Trial Phases
Multiple Sclerosis
198 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4, Early Phase 1
Spinal Cord Injury
47 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Early Phase 1, Phase 3
Spasticity
4 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Cerebral Palsy
1 Actively Recruiting
Not Applicable
Stroke
14 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
prophylaxis of Malignant hyperthermia
0 Actively Recruiting
Malignant Hyperthermia
0 Actively Recruiting
Dantrium Reviews: What are patients saying about Dantrium?
5Patient Review
3/20/2012 I've been taking Dantrium for over 40 years and it's really helped with my muscle spasticity. I also take Valium, but neither of them have ever given me any negative side effects.
Patient Q&A Section about dantrium
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of dantrolene?
"The following effects may occur as your body adjusts to the medication: drowsiness, dizziness, weakness, tiredness, nausea, and diarrhea. These effects usually lessen after several days. Headache, constipation, trouble speaking, and drooling may also occur. If you experience any of these effects for an extended period of time, or if they worsen, notify your doctor or pharmacist."
Answered by AI
What class of drug is Dantrium?
"Dantrium is a type of drug known as a Skeletal Muscle Relaxant."
Answered by AI
What is Dantrium IV?
"Dantrium Intravenous (dantrolene sodium) is mainly used as an emergency treatment for malignant hyperthermia, which is a rare reaction to medications (mainly anesthetics). Dantrium Intravenous is available in generic form."
Answered by AI
What is the medication Dantrium used for?
"The medication is used to treat muscle tightness and cramping caused by certain nerve disorders such as spinal cord injury, stroke, cerebral palsy, and multiple sclerosis. It relaxes the muscles."
Answered by AI