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What is Carbamazepine
CarbamazepineThe Generic name of this drug
Treatment SummaryCarbamazepine, commonly known as Tegretol, is a medication used to prevent seizures and treat pain from a condition called trigeminal neuralgia. It was approved by the FDA in 1965 and is also used to treat symptoms of bipolar disorder. It was the first anticonvulsant drug specifically used to treat bipolar disorder.
Tegretolis the brand name
Carbamazepine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tegretol
Carbamazepine
1968
259
Approved as Treatment by the FDA
Carbamazepine, commonly known as Tegretol, is approved by the FDA for 7 uses like Partial Seizures With Secondary Generalization and Trigeminal Neuralgia .Partial Seizures With Secondary Generalization
Trigeminal Neuralgia
Helps manage Trigeminal Neuralgia (TN)
Seizures
Acute Mania
Bipolar Disorder
Bipolar Disorder
Chronic Pain
Helps manage Pain
Effectiveness
How Carbamazepine Affects PatientsCarbamazepine is a drug used to treat seizures and facial nerve pain. It also helps reduce symptoms of bipolar disorder. However, it has a narrow range in which it can be effective. People of Han Chinese ancestry may experience a severe reaction called Steven Johnson Syndrome or toxic epidermal necrolysis if they take carbamazepine.
How Carbamazepine works in the bodyCarbamazepine is a drug used to treat seizures and bipolar disorder. It is thought to work by preventing nerve signals from firing and blocking pain signals in the brain. It is also believed to increase dopamine turnover and increase GABA transmission, which helps treat manic and depressive symptoms. Unfortunately, some people have developed a resistance to the drug, and scientists are researching this issue to try to find a solution. Recently, they have identified a gene promoter that might be responsible for this resistance, which could be treated with methylation.
When to interrupt dosage
The prescribed measure of Carbamazepine is contingent upon the diagnosed state, including Partial Seizures With Secondary Generalization, Bipolar Disorder and Trigeminal Neuralgia. The amount of dosage is contingent upon the technique of administration as depicted in the table hereinafter.Condition
Dosage
Administration
Syndrome
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Bipolar Disorder
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Partial Seizures With Secondary Generalization
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Bipolar Disorder
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Restless Legs Syndrome (RLS)
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Chronic Pain
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Trigeminal Neuralgia
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Acute Mania
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Seizures
, 100.0 mg, 200.0 mg, 400.0 mg, 300.0 mg, 100.0 mg/mL, 20.0 mg/mL, 10.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Tablet, chewable, Tablet, chewable - Oral, Capsule, extended release, Capsule, extended release - Oral, Suspension, Suspension - Oral, Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, Solution, Solution - Oral
Warnings
Carbamazepine has six contraindications and should not be co-administered with any of the conditions found in the following table.Carbamazepine ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Bone Marrow
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Carbamazepine may interact with Pulse Frequency
Common Carbamazepine Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be increased when combined with Carbamazepine.
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Carbamazepine is combined with 2-Methoxyethanol.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Carbamazepine.
5-androstenedione
Major
The metabolism of 5-androstenedione can be increased when combined with Carbamazepine.
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of adverse effects can be increased when Carbamazepine is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Carbamazepine Toxicity & Overdose RiskThe lowest toxic dose of carbamazepine has been found to be 1920 mg/kg for females and 54 mg/kg for males. An overdose of this drug can cause symptoms to appear within 1-3 hours, including heart problems like rapid heartbeat, high or low blood pressure, muscle twitches, tremors, dilated pupils, nausea, vomiting, confusion, and difficulty breathing. In case of overdose, seek medical attention immediately and be sure to mention if multiple drugs were taken. Treatment may involve monitoring vital signs and providing supportive care.
Carbamazepine Novel Uses: Which Conditions Have a Clinical Trial Featuring Carbamazepine?
At present, 179 clinical trials are being conducted to assess the utility of Carbamazepine in providing relief from Partial Seizures With Secondary Generalization, Trigeminal Neuralgia and Restless Legs Syndrome (RLS).Condition
Clinical Trials
Trial Phases
Bipolar Disorder
0 Actively Recruiting
Syndrome
3 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Partial Seizures With Secondary Generalization
1 Actively Recruiting
Not Applicable
Bipolar Disorder
1 Actively Recruiting
Phase 4
Trigeminal Neuralgia
0 Actively Recruiting
Chronic Pain
174 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Acute Mania
0 Actively Recruiting
Restless Legs Syndrome (RLS)
1 Actively Recruiting
Not Applicable
Seizures
2 Actively Recruiting
Phase 3
Carbamazepine Reviews: What are patients saying about Carbamazepine?
5Patient Review
1/20/2016 I took this medication for 12 years. It was a life saver; the pain was intense. Three years ago, I had Gamma surgery and they clipped the nerve but I still have some pain but only take Neutotin 2 per day and 1 Carbamazephine. Could not have made it without it.
5Patient Review
8/31/2021 Carbamazepine was an absolute lifesaver for me. It worked immediately and stopped my seizures. I've been taking it for 10 years now and don't plan on stopping anytime soon.
4.7Patient Review
1/6/2016 I have to take 1400 mg of this medication every day to keep the pain at bay for my Trigeminal Neuralgia. While it does come with some side effects, they are nothing in comparison to the intense pain I feel without it. I've been having problems with my eyesight, balance, and energy levels; however, I am more concerned about the long-term damage this high dosage could do to my liver. Does anyone know of any statistics regarding this?
4.7Patient Review
10/19/2019 This medication helps me feel more even-keeled. Every so often, my doctor has to adjust the dosage based on blood tests. I don't want to be a zombie, so that's important to me.
4.7Patient Review
11/25/2015 This medication is effective for me
4.3Patient Review
1/13/2016 I had been suffering from trigeminal neuralgia for a few months when I decided to try carbamazepine. Within 24 hours, the pain was completely gone. I experienced relief for about a month before the pain slowly started to come back. It is now manageable at 400mg per day, and I've been taking it for 2-3 months with no significant side effects other than some mild word-finding difficulty and lowered energy levels.
4Patient Review
10/6/2017 I've been struggling with Trigeminal Neuralgia for the past few months and this medication has been a godsend. The pain is practically gone and I only have to take it twice a day. So far, the side effects have minimal compared to the episodes of neuralgia, so fingers crossed that I can control this without surgery.
2.7Patient Review
6/6/2021 The medication distributed by Costco has sugar that contains Fructose in it. I found out by googling that if you're fructose intolerant, then you shouldn't use this treatment. The main point is to be aware of the ingredients and not make the same mistake I did.
Patient Q&A Section about carbamazepine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What class of drug is carbamazepine?
"The medication Carbamazepine is an anticonvulsant which means it works to reduce abnormal electrical activity in the brain."
Answered by AI
Does carbamazepine help anxiety?
"Other conditions that carbamazepine may be used to treat include: depression (low mood) some anxiety and panic disorders."
Answered by AI
What are the serious side effects of carbamazepine?
"If you experience any of the following symptoms, you may be having an allergic reaction and should seek medical help: a skin rash that includes itchy, red, swollen, blistered, or peeling skin; wheezing; tightness in the chest or throat; difficulty breathing or talking; or swelling of the mouth, face, lips, tongue, or throat."
Answered by AI