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What is Aromasin
ExemestaneThe Generic name of this drug
Treatment SummaryExemestane is a pill that helps treat hormone-receptor-positive breast cancer in postmenopausal women. It works by blocking the aromatase enzyme from converting other hormones into estrogen. This prevents the cancer cells from using estrogen and stops the growth of the tumor.
Aromasinis the brand name
Aromasin Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Aromasin
Exemestane
1999
18
Approved as Treatment by the FDA
Exemestane, also known as Aromasin, is approved by the FDA for 4 uses which include Advance Directives and Postmenopause .Advance Directives
Postmenopause
Breast
2-3 years of tamoxifen therapy
Effectiveness
How Aromasin Affects PatientsAromatase inhibitors (AIs) are drugs that limit the amount of the hormone estrogen in the body by blocking the action of the enzyme aromatase. Selective AIs (SAIs) target just estrogen and leave other hormones produced by the adrenal glands alone. Examples of SAIs include anastrozole, letrozole, and exemestane.
How Aromasin works in the bodyExemestane is used to treat postmenopausal breast cancer. It works by blocking an enzyme called aromatase, which converts androgens to estrogens. Estrogen encourages the growth of some breast cancer cells, so blocking it can reduce the growth of cancer cells. Exemestane binds to the active site of the aromatase enzyme, which prevents it from working and reduces estrogen levels. Exemestane does not affect other enzymes in the body, and does not interfere with the production of corticosteroids or aldosterone. Reducing the amount of estrogen in the body can slow down tumor growth and help stop
When to interrupt dosage
The measure of Aromasin depends on the diagnosed condition, such as 2-3 years of tamoxifen therapy, Advance Directives and Breast. The amount of dosage is contingent upon the technique of delivery (e.g. Tablet - Oral or Tablet, film coated) noted in the table underneath.Condition
Dosage
Administration
Postmenopause
, 25.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral
2-3 years of tamoxifen therapy
, 25.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral
Advance Directives
, 25.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral
Breast
, 25.0 mg
, Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral
Warnings
There are 3 known major drug interactions with Aromasin.Common Aromasin Drug Interactions
Drug Name
Risk Level
Description
Haloperidol
Moderate
The serum concentration of Haloperidol can be increased when it is combined with Exemestane.
Methadone
Moderate
The serum concentration of Methadone can be increased when it is combined with Exemestane.
Tucatinib
Moderate
The metabolism of Tucatinib can be decreased when combined with Exemestane.
Aromasin Toxicity & Overdose RiskSeizures
Aromasin Novel Uses: Which Conditions Have a Clinical Trial Featuring Aromasin?
Currently, there are 20 active studies investigating the potential of Aromasin to provide Advance Directives, 2-3 years of tamoxifen therapy and Postmenopausal relief.Condition
Clinical Trials
Trial Phases
2-3 years of tamoxifen therapy
0 Actively Recruiting
Advance Directives
0 Actively Recruiting
Postmenopause
5 Actively Recruiting
Phase 2, Not Applicable
Breast
12 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3
Aromasin Reviews: What are patients saying about Aromasin?
5Patient Review
3/19/2022 Aromasin is by far the best treatment for high estrogen that I have tried in my years of heavy steroid use. It's helped me stay pain-free, without any joint issues or lethargy, and has allowed me to make gains in the gym.
4Patient Review
6/8/2014 Along with Aromasin for post-breast cancer care, I started taking kelp to help with the joint pain side effects. It's been a big help! If you're experiencing similar issues, this could be worth looking into.
2.7Patient Review
4/26/2016 I'm six weeks in on this medication, and I've found that it's really difficult for me to fall-and stay- asleep. Additionally, I sometimes have chest discomfort and have to take a few deep breaths to feel normal. Hot flashes like crazy during the first few hours after taking are another issue I've had to deal with. My appetite is off and I am not hungry at normal times of day; as a result, my glucose readings are all over the place. Not sure how long I will stay on this med before trying a different one.
2.3Patient Review
7/13/2017 I had significant problems with bone pain that led to many sleepless nights. After a year of this and no improvement, I've switched to Tamoxifen in the hopes that it will be more effective.
2.3Patient Review
10/31/2018 After being on arimadex for 3 and 1/2 years, I experienced some serious side effects like joint pain, weight gain, and high blood pressure. I switched to aromasin last week but it's been giving me terrible stomach issues. My oncologist says that checking my hormone levels wouldn't be accurate, but I don't see how that makes sense. Plus, the medication is expensive. I'm done taking it for now and will just consider going back on it every once in a while. Quality of life is important to me.
1.3Patient Review
2/4/2016 The muscle/joint pain is excruciating. It is to the point of intolerance. Also, my alk. phos has been elevated which has prompted me to stop this drug and seek further options.
1Patient Review
5/12/2015 The pain is unbearable and I feel like cancer would be easier to deal with. I'm only 35 but I can't get out of bed because my knees lock. This is horrible; I also have a headache and can't sleep.
1Patient Review
1/25/2016 I was diagnosed with stage 1 node negative breast cancer in October 2013. I had a lumpectomy, chemo, and radiation. I was then put on tamoxifen for about 4 months with no side effects. My oncologist then changed it to an aromatase inhibitor (AI), which caused me so much pain that he took me off of it. I tried another AI called Aromasin for four days, but had to be rushed to the ER because of a lump on my collarbone. Has anyone experienced this? Please post if you have any information. Thanks
1Patient Review
3/13/2016 This medication is really tough to deal with. The pain and depression it causes is really bad. I've spoken to my doctor about it, but she doesn't seem to believe me. I don't know how much longer I can take it.
Patient Q&A Section about aromasin
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Aromasin a chemotherapy drug?
"Aromasin is used to treat breast cancer in postmenopausal women. It is often given to women whose cancer has progressed even after taking tamoxifen for 2 to 3 years."
Answered by AI
How does Aromasin make you feel?
"Exemestane may make you feel nauseous or cause vomiting, but these symptoms generally improve over time."
Answered by AI
What does Aromasin do to the body?
"Aromasin prevents the enzyme aromatase from converting androgen into estrogen, thus reducing the amount of estrogen available to stimulate the growth of hormone receptor-positive breast cancer cells."
Answered by AI
Is Aromasin an estrogen blocker?
"Aromasin is a type of endocrine therapy that inhibits the aromatase enzyme. This lowers the level of the hormone estrogen in the body, which can starved cancer cells of their growth fuel. Aromasin is a pill that is taken orally."
Answered by AI