Mosaic Website for Blood Cancer Patients

(Mosaic Trial)

Recruiting at 3 trial locations

Overseen By Sonia Zavala

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Northwestern University

Disqualifiers: Behavioral intervention, Tandem transplant, Cognitive impairment, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 5

356 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores whether a special website, called Mosaic, can help blood cancer patients feel better during their stem cell transplant journey. Patients will use either an intervention website designed to reduce stress and improve quality of life or a similar control website. The trial will determine if users of the intervention website report less distress and better coping skills compared to the control group. Individuals diagnosed with blood cancer who are preparing for a stem cell transplant and are comfortable using a website in English or Spanish may be a good fit for this study. As an unphased trial, this study offers a unique opportunity to contribute to innovative research aimed at enhancing patient well-being during challenging treatments.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It seems to focus on using a website to improve outcomes for blood cancer patients undergoing stem cell transplants.

What prior data suggests that the Mosaic website is safe for blood cancer patients?

Research has shown that the Mosaic website is designed to help blood cancer patients manage stress and improve their quality of life during stem cell transplants. No specific evidence indicates any safety concerns or side effects from using the Mosaic website.

This trial differs from traditional ones because it involves a website, not a drug or medical treatment, so typical side effects don't apply. The website serves as a support system, offering educational content and stress management resources to help patients feel more prepared and cope better during their treatment.

In summary, no data suggests safety issues with the Mosaic website. It is a digital tool meant to provide support, not a medical treatment with potential physical side effects. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the Mosaic website for blood cancer patients because it's not just another information source; it's a comprehensive tool combining educational content with stress management and coping strategies specifically designed for transplant patients. Unlike standard care options that may offer fragmented information, this website provides a seamless experience in both English and Spanish, ensuring accessibility and inclusivity. Additionally, it links to trusted, provider-reviewed resources, setting it apart by integrating valuable psychosocial support, which could significantly enhance a patient's transplant journey.

What evidence suggests that the Mosaic website is effective for improving patient-reported outcomes in blood cancer patients?

Research has shown that the Mosaic website, available to participants in this trial, can improve patients' emotional and physical well-being. This tool uses artificial intelligence to provide tailored support and information. Studies have found that personalized assistance like this can reduce stress and enhance the quality of life for patients undergoing challenging treatments such as stem cell transplants. The Mosaic website aims to boost feelings of readiness and confidence by offering coping tools and educational resources, potentially leading to better mental and physical health for blood cancer patients during treatment. ^{1 6 7 8 9}

Are You a Good Fit for This Trial?

Adult blood cancer patients scheduled for allogeneic or autologous stem cell transplant are eligible. The trial is suitable for those with conditions like myelodysplastic syndrome, multiple myeloma, leukemia, lymphoma, and other hematological malignancies.

Inclusion Criteria

Interested in using a website to learn about stem cell transplant

Ability to understand and willingness to sign an informed consent document and comply with all study procedures

My medical records show I have blood cancer.

Exclusion Criteria

Unable to provide meaningful consent (severe cognitive impairment or language difficulties)

I am currently in a program to help with stress, health quality, or symptoms.

I am preparing for my first stem cell transplant.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Pre-transplant Baseline Assessment

Participants complete a baseline assessment before the scheduled stem cell transplant

1 week

1 visit (in-person or virtual)

Post-transplant Follow-up

Participants complete follow-up assessments at 2, 4, 6, and 8 months post-transplant to evaluate psychological distress, symptoms, and quality of life

8 months

4 visits (virtual)

Long-term Follow-up

Participants are monitored for long-term outcomes beyond the initial 8-month follow-up period

6 months

What Are the Treatments Tested in This Trial?

Interventions

• Mosaic

Trial Overview

The Mosaic Trial compares the effects of an intervention website designed to support patients' psychological and physical well-being against a control educational website. Participants will be randomly assigned to one of these websites before their transplant.

How Is the Trial Designed?

Group I: Intervention Website Experimental Treatment 1 Intervention

The intervention website pairs experiential information about transplant with (1) coordinated coping and stress management training and resources to support skill practice and (2) an educational component that includes educational content and links to well-established, vetted websites that provide broader, provider-reviewed information about the transplant process and links to psychosocial resources. Participants can toggle between English and Spanish content, and they will be able to use this website throughout their participation in the study.

Group II: Enhanced Usual Care (Control) website Active Control 1 Intervention

The control website pairs (1) coordinated coping and stress management training and resources to support skill practice with (2) an educational component that includes educational content and links to well-established, vetted websites that provide broader, provider-reviewed information about the transplant process and links to psychosocial resources, using the same technology platform and look/feel as the intervention website. Participants can toggle between the English and Spanish versions of the website and they will be able to use this website throughout their participation in the study.

Who Is Running the Clinical Trial?

Northwestern University

Lead Sponsor

Trials

1,674

Recruited

989,000+

National Cancer Institute (NCI)

Collaborator

Trials

14,080

Recruited

41,180,000+

Georgetown University

Collaborator

Trials

355

Recruited

142,000+

Hackensack Meridian Health

Collaborator

Trials

141

Recruited

42,900+

Published Research Related to This Trial

In a study involving 79 cancer patients (30 Black and 49 White), electronic patient-reported outcomes (ePROs) were found to be valuable for symptom monitoring, with Black patients reporting greater benefits in facilitating discussions with clinicians compared to White patients.

While most participants preferred a web-based system, Black patients showed a higher preference for automated telephone options and paper-based formats, indicating the need for diverse ePRO options to accommodate varying e-health literacy levels among patients.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Racial differences in user experiences and perceived value of electronic symptom monitoring in a cohort of black and white bladder and prostate cancer patients. Samuel, CA., Smith, AB., Elkins, W., et al.[2022]

The QuestLeukemia mobile app was found to be an effective educational tool for pediatric patients preparing for hematopoietic cell transplantation (HCT), enhancing their disease knowledge and autonomy, as reported by both patients and parents.

Participants rated the app highly for usability and enjoyment, with average scores indicating it was easy to use (4.93), enjoyable (4.79), and comprehensive (4.71), suggesting it could positively impact the HCT experience for children.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Usability and Acceptability of the QuestLeukemia Mobile Application: A Pilot Study for An Educational and Psychological Intervention for Children with Chronic Illnesses. Meyer, R., Wang, K., Yearley, A., et al.[2022]

Citations

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Mosaic Trial for Stem Cell Transplant Recipients

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ascopubs.org/doi/10.1200/CCI.24.00008

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Mosaic Website for Blood Cancer Patients

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nature.com

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Both MBL and mCAs have been found to increase the risk of CLL and lymphoid malignancies, and the aim of our study was to investigate how mCAs ...

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Both MBL and mCAs have been found to increase the risk of CLL and lymphoid malignancies, and the aim of our study was to investigate how mCAs relate to MBL, ...

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9/11 Study Shows How Toxic Exposures May Lead to ...

Conditions. Chromosome Disorders; Disorders Affecting Muscles; Disorders Affecting the Kidneys & Reproductive Organs