Magic Ink for Breast Cancer

Overseen By Michael Dominello, DO

Age: 18+

Sex: Female

Trial Phase: Academic

Sponsor: Barbara Ann Karmanos Cancer Institute

Disqualifiers: Prior radiation, Tattoo allergy, Psoriasis, Pregnant, BMI > 44.5

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

30 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores the safety and effectiveness of Magic Ink, a special tattoo ink, for women with breast cancer undergoing radiation therapy. The researchers aim to determine if Magic Ink is as safe as regular tattoo ink and remains visible for radiation therapists during treatment. Women diagnosed with certain stages of breast cancer and planning to start radiation after surgery might be suitable candidates. Participants will receive Magic Ink tattoos and undergo skin assessments and surveys to track their experiences. As an unphased trial, this study provides a unique opportunity for patients to contribute to innovative research that could enhance radiation therapy experiences.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that Magic Ink is safe for use in radiation therapy for breast cancer patients?

Research has shown that Magic Ink tattoos have undergone thorough testing and are considered safe and effective. This ink is unique because it appears only under ultraviolet light, distinguishing it from regular tattoo inks. So far, studies have not identified any major safety issues with Magic Ink. Although general concerns exist about tattoos being linked to a higher risk of certain cancers, this has not been specifically associated with Magic Ink.

The trial compares Magic Ink to regular tattoo ink to ensure it is equally safe. Previous studies have generally found regular tattoo inks to be well-tolerated, though individual reactions can vary. Participants in the trial will have their skin checked for irritation or other issues. Current evidence suggests Magic Ink is safe, but this trial will help confirm that. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the Magic Ink treatment because it offers a novel way to improve precision in breast cancer radiation therapy. Unlike traditional methods that rely on visible ink or skin markers, Magic Ink uses a tattoo ink that is only visible under ultraviolet light. This means it can provide guidance for radiation without permanent visible marks, potentially reducing discomfort and improving the patient experience. By enhancing accuracy in targeting cancer cells while minimizing impact on healthy tissue, Magic Ink could lead to more effective and less invasive treatment options.

What evidence suggests that Magic Ink is effective for breast cancer radiation treatment?

Research has shown that Magic Ink, visible only under ultraviolet light, can enhance the quality of life for cancer patients undergoing radiation therapy. Studies have found that patients with these UV ink tattoos were very satisfied with their appearance and felt free to wear any clothing they desired, unlike some who used regular tattoo ink. Additionally, Magic Ink may simplify the setup process for radiation therapists. Overall, early evidence suggests that Magic Ink may be as safe and effective as regular tattoo ink for marking treatment areas. ^{1 6 7 8 9}

Who Is on the Research Team?

Michael Dominello, DO

Principal Investigator

Wayne State University

Are You a Good Fit for This Trial?

This trial is for women over 18 with stage 0, I, II or III breast cancer who are planning radiation therapy post-surgery. They must understand and sign consent, have a good performance status (able to carry out normal activities), and not be at risk of pregnancy either through surgery, menopause, same-sex relationships or agree to use contraception.

Inclusion Criteria

I agree to use two effective birth control methods if I can have children.

I am in a same-sex relationship and cannot become pregnant.

I agree to abstain from all sexual activity.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Radiation

Participants receive Magic Ink tattoos and undergo radiation treatment

6-8 weeks

Weekly visits for radiation therapy

Follow-up

Participants are monitored for safety and effectiveness after treatment

3 months

Skin assessment at 1 week and 3 months post-treatment

What Are the Treatments Tested in This Trial?

Interventions

• Magic Ink

Trial Overview The study tests if Magic Ink tattoos used for marking radiation treatment areas on the skin are as safe as standard tattoo ink in breast cancer patients. It checks visibility during treatment and impact on body image via surveys before and after radiation therapy.

How Is the Trial Designed?

Group I: Magic Ink tattoo Experimental Treatment 1 Intervention

Magic Ink tattoo ink which is only visible when exposed to ultraviolet light will be used to mark radiation guidance

Who Is Running the Clinical Trial?

Barbara Ann Karmanos Cancer Institute

Lead Sponsor

Trials

166

Recruited

9,300+

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC10999588/

Prospective evaluation of patient-reported outcomes ... showed that all patients with UV ink tattoos were satisfied with tattoo appearance and did not feel cautious about clothing choices versus 82.4% ...

2. withpower.com withpower.com/trial/phase-breast-neoplasms-7-2025-1ff8c

Magic Ink for Breast Cancer Trial Overview The study tests if Magic Ink tattoos used for marking radiation treatment areas on the skin are as safe as standard tattoo ink in breast cancer ...

3. sciencedirect.com sciencedirect.com/science/article/pii/S2405632425000393

Evaluation of tattoo reliability in breast cancer re-irradiation Prospective evaluation of patient-reported outcomes of invisible ink tattoos for the delivery of external beam radiation therapy: the PREFER ...

4. advancesradonc.org advancesradonc.org/article/S2452-1094(23)00012-X/fulltext

Accuracy and Efficiency of Patient Setup Using Surface ... Here, we sought to compare the setup performance of tattoos versus AlignRT for patients with breast cancer receiving APBI. Using image guidance ...

5. healio.com healio.com/news/hematology-oncology/20240516/invisible-ink-for-radiation-may-improve-patient-quality-of-life

Invisible ink for radiation may improve patient quality of life A novel invisible ink tattoo technique may improve long-term quality of life and emotional well-being for people with cancer who undergo radiation therapy.

6. hyprskn.com hyprskn.com/testing

Clinical Testing While extensive testing has already been conducted to demonstrate the safety and effectiveness of our Magic Ink tattoos, we believe in continually pushing the ...

7. ecancer.org ecancer.org/en/news/26094-tattoos-may-be-linked-to-an-increased-risk-of-cancer

Tattoos may be linked to an increased risk of cancer Using data from Danish twin pairs, they found that tattooed individuals are more frequently diagnosed with skin and lymphoma cancers compared to ...

8. cbs42.com cbs42.com/business/press-releases/cision/20251110NY19453/from-treatment-to-triumph-tattoo-artists-are-coming-together-to-turn-cancer-survivors-radiation-marks-into-symbols-of-strength

From Treatment to Triumph: Tattoo Artists Are Coming ... A study in The Breast Journal found that approximately 70% of women who received breast cancer radiotherapy tattoos reported negative feelings ...

9. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC5604906/

A randomized control trial evaluating fluorescent ink versus ... Pre-treatment radiographers were trained in the safe and effective administration of UV ink tattoos. All patients were positioned on a breast board (Medtec ...