Yupelri

Chronic Obstructive Pulmonary Disease
Treatment
20 Active Studies for Yupelri

What is Yupelri

RevefenacinThe Generic name of this drug
Treatment SummaryRevefenacin is a type of long-acting muscarinic antagonist (LABA) medicine. It is prescribed for maintenance therapy of chronic obstructive pulmonary disease (COPD) and is the first once-daily nebulized LAMA treatment. Revefenacin was developed by Theravance Biopharma and approved by the FDA in 2018.
Yupelriis the brand name
image of different drug pills on a surface
Yupelri Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Yupelri
Revefenacin
2018
2

Effectiveness

How Yupelri Affects PatientsRevefenacin is a long-acting bronchodilator that has fewer anti-muscarinic side effects. Clinical trials found that it works for a long period of time, and that a single dose of 88 mcg can effectively open up the airways. In tests, patients using Revefenacin were less likely to need rescue inhalers and had increased peak expiratory flow rate that kept increasing until day 7. It was also found to be more selective of the lungs than other LAMAs, leading to fewer sialagogue effects.
How Yupelri works in the bodyRevefenacin is an inhaled medicine that blocks the cholinergic receptors in the airways. It prevents acetylcholine, a chemical messenger, from binding to the receptors, which reduces the muscle contractions of the airways. This helps reduce the severity and frequency of COPD exacerbations. Revefenacin is a long-acting blocker, meaning it only needs to be taken once a day.

When to interrupt dosage

The measure of Yupelri is contingent upon the diagnosed circumstances. The amount of dosage is contingent on the administration strategy (e.g. Solution or Respiratory (inhalation)) outlined in the table beneath.
Condition
Dosage
Administration
Chronic Obstructive Pulmonary Disease
0.175 mg/mL,
Respiratory (inhalation), Solution - Respiratory (inhalation), Solution,

Warnings

Yupelri Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Revefenacin may interact with Pulse Frequency
There are 20 known major drug interactions with Yupelri.
Common Yupelri Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Revefenacin is combined with Aclidinium.
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Revefenacin.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Revefenacin.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Revefenacin.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Revefenacin is combined with Cimetropium.
Yupelri Toxicity & Overdose RiskRevefenacin does not cause the typical side effects associated with anticholinergic medications. Studies have shown that it does not cause cancer, mutate DNA, or affect fertility. Signs and symptoms of overdose include nausea, vomiting, dizziness, feeling faint, blurred vision, increased pressure in the eyes, constipation, and difficulty urinating.
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Yupelri Novel Uses: Which Conditions Have a Clinical Trial Featuring Yupelri?

At present, 98 studies are actively investigating the potential of Yupelri to ameliorate Chronic Obstructive Pulmonary Disease (COPD).
Condition
Clinical Trials
Trial Phases
Chronic Obstructive Pulmonary Disease
104 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4

Yupelri Reviews: What are patients saying about Yupelri?

5Patient Review
11/23/2020
Yupelri for Chronic Obstructive Lung Disease
I've been using this medication for close to a year and it's helping. My breathing has gone from 80% two years ago to 90% today, as demonstrated by my most recent test.
5Patient Review
7/23/2019
Yupelri for Chronic Obstructive Lung Disease
This medication has helped me to breathe more easily and with less pressure on my chest. I am able to move more air now, and this drug has been a miracle for my quality of life.
2Patient Review
10/15/2022
Yupelri for Chronic Obstructive Lung Disease
For a while, this medication seemed to help. But after a couple weeks, it stopped having any effect whatsoever. And it's way too expensive for the results (or lack thereof).
2Patient Review
5/7/2019
Yupelri for Chronic Obstructive Lung Disease
Unfortunately, this breathing treatment made my condition worse rather than better. I had to wait for nearly two hours before I could breathe normally again. Needless to say, I won't be using it again and am still on the lookout for a Spiriva alternative.
1Patient Review
11/8/2019
Yupelri for Chronic Obstructive Lung Disease
Unfortunately, my shortness of breath returned less than six hours after taking this medication.
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Patient Q&A Section about yupelri

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can Yupelri and albuterol be taken together?

"There is no interaction between albuterol and Yupelri according to current research. However, this does not mean that there is no possibility of an interaction. You should always consult your healthcare provider."

Answered by AI

Is Yupelri a nebulizer?

"Yupelri is a long-term COPD treatment that comes in a vial. Inhale it through your nebulizer once a day to improve your symptoms and help you breathe better."

Answered by AI

What is the drug Yupelri used for?

"YUPELRI is a prescription medicine used to treat chronic obstructive pulmonary disease (COPD). COPD is a long-term (chronic) lung disease that includes chronic bronchitis, emphysema, or both."

Answered by AI

Is Yupelri a steroid?

"Yupelri (revefenacin) is not a steroid. It is a long-acting muscarinic antagonist (LAMA). While steroids lower inflammation (swelling) in the airways of your lungs, Yupelri (revefenacin) opens up your airway passages in your lungs so you can breathe easier."

Answered by AI

Clinical Trials for Yupelri

Have you considered Yupelri clinical trials? We made a collection of clinical trials featuring Yupelri, we think they might fit your search criteria.
Have you considered Yupelri clinical trials? We made a collection of clinical trials featuring Yupelri, we think they might fit your search criteria.
Have you considered Yupelri clinical trials? We made a collection of clinical trials featuring Yupelri, we think they might fit your search criteria.