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What is Wellbutrin Sr
BupropionThe Generic name of this drug
Treatment SummaryBupropion (known as Wellbutrin®) is a drug that helps to balance the levels of norepinephrine and dopamine in the brain. It is usually prescribed to treat depression, seasonal affective disorder, and to help people quit smoking. Bupropion is different from other antidepressants because it does not affect serotonin, which can lead to fewer side effects. It also has similar effectiveness to other drugs for treating depression, but it is less likely to cause sexual side effects, sleepiness, or weight gain. Bupropion is sometimes used with naltrexone in the brand name drug Contrave® to help
Wellbutrinis the brand name
Wellbutrin Sr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Wellbutrin
Bupropion
1986
741
Approved as Treatment by the FDA
Bupropion, also known as Wellbutrin, is approved by the FDA for 3 uses which include Smoke and Smoking Cessation .Smoke
Smoking Cessation
Depression
Effectiveness
How Wellbutrin Sr Affects PatientsBupropion is a drug used to treat depression and is not related to other antidepressant drugs. It works by blocking serotonin type 3A receptors, and increasing the effects of dopamine and norepinephrine in the brain. It can also act as a stimulant and has some potential for abuse. People with seizure disorders should not take bupropion as it can lower the seizure threshold. It can also increase blood pressure, but clinical trials have not shown it increases the risk of stroke or heart attack.
How Wellbutrin Sr works in the bodyBupropion is a medication used to treat depression and aid in smoking cessation. It does this by blocking the uptake of neurotransmitters in the brain, such as norepinephrine and dopamine. Unlike other medications for depression, it has fewer side effects such as weight gain, sedation, and sexual dysfunction. When used to help stop smoking, bupropion works by blocking nicotine's effects on the body and creating effects similar to nicotine. When combined with naltrexone in the drug Contrave, it can help with weight management by reducing appetite and increasing energy expenditure.
When to interrupt dosage
The measure of Wellbutrin Sr is contingent upon the identified affliction, including Depressive Bipolar Disorder, Depression and Disease. The dosage can differ, depending on the delivery technique (e.g. Tablet, extended release or Tablet, film coated, extended release) featured in the accompanying table.Condition
Dosage
Administration
Obesity
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Smoke
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Seasonal Affective Disorder
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Attention Deficit Hyperactivity Disorder
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Reducing diet
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Depression
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Smoking Cessation
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Mood Disorders
, 174.0 mg, 348.0 mg, 522.0 mg, 150.0 mg, 100.0 mg, 75.0 mg, 200.0 mg, 300.0 mg, 450.0 mg, 90.0 mg, 8.0 mg
, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Occlusive dressing technique, Tablet, film coated, extended release - Occlusive dressing technique, Tablet - Occlusive dressing technique, Tablet, film coated - Occlusive dressing technique, Kit
Warnings
Wellbutrin Sr ContraindicationsCondition
Risk Level
Notes
Bulimia Nervosa
Do Not Combine
ethanol
Do Not Combine
Hypertensive disease
Do Not Combine
Anorexia Nervosa
Do Not Combine
abrupt cessation of barbiturates
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Epilepsy
Do Not Combine
abrupt cessation of antiepileptic drugs
Do Not Combine
Benzodiazepines
Do Not Combine
Pulse Frequency
Do Not Combine
Anorexia Nervosa
Do Not Combine
Anorexia Nervosa
Do Not Combine
Common Wellbutrin Sr Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
The metabolism of 4-Methoxyamphetamine can be decreased when combined with Bupropion.
5-methoxy-N,N-dimethyltryptamine
Major
The metabolism of 5-methoxy-N,N-dimethyltryptamine can be decreased when combined with Bupropion.
Acebutolol
Major
The metabolism of Acebutolol can be decreased when combined with Bupropion.
Acetaminophen
Major
The metabolism of Acetaminophen can be decreased when combined with Bupropion.
Almotriptan
Major
The metabolism of Almotriptan can be decreased when combined with Bupropion.
Wellbutrin Sr Toxicity & Overdose RiskOverdosing on a medication can lead to seizures, hallucinations, passing out, an abnormally fast heart rate, and cardiac arrest.
Wellbutrin Sr Novel Uses: Which Conditions Have a Clinical Trial Featuring Wellbutrin Sr?
490 active studies are investigating the potential of Wellbutrin Sr to manage Attention Deficit Hyperactivity Disorder, Depression and Smoking Cessation.Condition
Clinical Trials
Trial Phases
Smoke
0 Actively Recruiting
Attention Deficit Hyperactivity Disorder
71 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1
Mood Disorders
22 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Early Phase 1, Phase 4, Phase 1
Smoking Cessation
97 Actively Recruiting
Early Phase 1, Phase 2, Phase 4, Not Applicable, Phase 1, Phase 3
Obesity
135 Actively Recruiting
Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1, Early Phase 1
Depression
199 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Seasonal Affective Disorder
0 Actively Recruiting
Reducing diet
0 Actively Recruiting
Wellbutrin Sr Reviews: What are patients saying about Wellbutrin Sr?
5Patient Review
8/11/2016 I was first prescribed the generic version of this drug for four months, but it didn't work. My doctor then switched me to the brand name Wellbutrin SR 150 mg 2x day and I saw major differences within two weeks. I'm much more energized and happier now. This medication is a wonder drug for happiness. Thank you GlaxoSmithKline for such a wonderful medication.
5Patient Review
11/21/2017 This medication really helped me to quit smoking. I didn't experience any withdrawal symptoms or headaches, and after just two doses I couldn't stand the taste of cigarettes anymore. It's an easy way to quit and, even after finishing the full course, the nicotine was totally out of my system because I had no desire to go back at all! The only side effect that my boyfriend noticed was that he said I was a little more aggressive and short with him.
5Patient Review
10/17/2022 Wellbutrin has helped me lose weight and has also reduced my appetite. I've been taking it for about 8 months now and it's working pretty well.
5Patient Review
8/3/2016 This treatment has been great for me. I feel more organized and focused, and I'm interested in things that I had previously lost interest in.
5Patient Review
8/11/2016 I was first on the generic for four months, but it didn't work. My doctor put me on the brand name Wellbutrin SR 150 mg 2x day, and I saw a major difference after just two weeks. I feel much more energized and happier. This medication is a wonder drug for happiness!
5Patient Review
8/3/2016 I really love this treatment. I feel more organized and focused, and I'm interested in things that I had previously lost interest in.
5Patient Review
11/21/2017 This medication was incredibly effective in helping me quit smoking. I had no withdrawal symptoms or headaches, and after just two doses I couldn't stand the taste of cigarettes anymore. This is by far the easiest way to quit that I've ever tried, and even after completing the full course I still have no desire to go back. The only side effect my boyfriend noticed was that I became a little more aggressive and short-tempered with him.
5Patient Review
10/17/2022 I was a little worried when I started taking Wellbutrin, but it's really helped me cut down on my appetite and lose weight. So far, so good!
5Patient Review
8/14/2017 I felt the benefits of this treatment after just three days. Not only did it help me feel better, but I also stopped smoking cigarettes entirely!
5Patient Review
9/26/2016 I had more energy, less pain, and my mood improved while taking this medication!
5Patient Review
8/14/2017 I woke up on the third day feeling great. Not only did this treatment help with my original problem, but it also helped me quit smoking! I don't even have any cravings anymore.
5Patient Review
9/26/2016 I had more energy, felt less pain, and my mood improved while taking this medication!
4.3Patient Review
4/21/2016 I've taken Wellbutrin before for my depression and it really helped. I'm taking it again now and, though I'm suffering from dry mouth, it's manageable and my depression has significantly subsided.
4.3Patient Review
4/21/2016 I've taken Wellbutrin before. I'm taking it for severe depression this time. I've only taken it a few days now but I'm suffering from severe dry mouth and I'm drinking lots and lots of water. At least, my depression isn't so bad now, and that is the main idea.
3.7Patient Review
3/6/20163.7Patient Review
3/6/20163.3Patient Review
11/9/2016 This medication was helpful in curbing my smoking habit. I followed my doctor's advice and took it for six weeks before trying to quit. Two weeks before my chosen quitting date, I started tapering off. On the day I picked to stop, I had no issues putting down cigarettes for good.
3.3Patient Review
11/9/2016 I had attempted to quit smoking multiple times in the past, but always failed. However, this drug made it very easy for me to finally kick the habit. I followed my doctor's instructions and took the medication for six weeks before even trying to stop smoking. Then, two weeks before I actually wanted to quit, I picked a day and stuck to it.
2.3Patient Review
5/31/2017 I haven't experienced any benefits after three weeks of taking this medication. In fact, I've only noticed side effects like loss of appetite and nausea in the first week, and increased dreaming since then. If anything, I feel worse than before. Not sure if this is the right drug for me.
2.3Patient Review
5/31/2017 After three weeks of taking this drug, I saw no change whatsoever. If anything, the side effects (loss of appetite, nausea, increased dreaming) made me feel worse. Not sure if it's because this isn't the right medication for my specific needs or what, but I'll be discontinuing use nonetheless.
1.7Patient Review
4/4/2022 I had an awful experience taking Wellbutrin for my depression. The side effects were really bad (nausea, increased depression, dissociation/depersonalization) and I stopped taking it very quickly. My family was even afraid to leave me alone because of how moody and unhappy it made me.
1.7Patient Review
4/4/2022 Wellbutrin made me so miserable that I stopped taking it very quickly. The side effects were really bad (nausea, increased depression, dissociation/depersonalization). My family was even afraid to leave me alone because of how much my mood swings changed.
1Patient Review
10/18/2017 I just started taking Bupropion SR 150. Today was my first day. Changing from 75 mg effexor xr. I have been taking it for about 20 years because it suppressed my desires 100% which is the reason I took it. However, I now have major depression and my doctor changed my med to Bupropion.
1Patient Review
10/18/2017 I started taking Bupropion SR 150 today, as a change from my previous medication, effexor xr. I had been taking the latter for about 20 years because it effectively suppressed my desires; however, I now have major depression and my doctor changed my med to Bupropion.
Patient Q&A Section about wellbutrin sr
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long does it take for Wellbutrin SR to kick in?
"Within the first 1-2 weeks of taking the medication, you may see some improvement in your sleep, energy, or appetite. This improvement in physical symptoms can be a good sign that the medication is working. It may take 6-8 weeks for your mood and interest in activities to improve."
Answered by AI
What is the difference between Wellbutrin and Wellbutrin SR?
"The wellbutrin XL is an extended release tablet that is released more slowly than the Wellbutrin SR tablet. The SR tablet is only used for major depressive disorder (MDD), whereas the XL can be used for both MDD and seasonal affective disorder (SAD)."
Answered by AI
What does SR mean in Wellbutrin?
"Wellbutrin SR is the sustained-release version of the medication, whereas Wellbutrin XL is the extended-release version."
Answered by AI
How does Wellbutrin SR make you feel?
"Some of the most commonly reported side effects associated with taking WELLBUTRIN SR 400mg per day include abdominal pain, agitation, anxiety, dizziness, dry mouth, insomnia, myalgia, nausea, palpitation, pharyngitis, sweating, tinnitus, and urinary frequency."
Answered by AI