44 Participants Needed

Peanut Snacks for Weight Loss

(BERN Trial)

PI
RM
Overseen ByResearch Manager
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Rutgers, The State University of New Jersey
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it excludes those who regularly use medications affecting bone metabolism or the gastrointestinal tract. It's best to discuss your specific medications with the trial coordinators.

What data supports the effectiveness of the treatment Nut-free Snack, Peanut Snack Experimental for weight loss?

Research suggests that consuming peanuts as part of a weight loss diet can help manage body weight and improve diet quality by reducing the intake of less healthy snacks. Additionally, studies show that eating nuts does not lead to weight gain, which supports the idea that peanuts can be part of a weight management strategy.12345

Is it safe to consume peanuts as part of a diet for weight management?

Research indicates that consuming peanuts as part of a diet is generally safe for healthy adults. In a study, participants who added peanuts to their diet experienced increased energy intake and snacking frequency, but there were no significant adverse effects reported. Peanuts may help improve diet quality by reducing consumption of less healthy snacks.12346

How does the Peanut Snack treatment for weight loss differ from other treatments?

The Peanut Snack treatment for weight loss is unique because it involves consuming peanuts before meals, which may help with satiety (feeling full) and reduce the intake of other less healthy snacks. Unlike traditional low-fat diets, this approach leverages the potential benefits of peanuts in managing weight and improving blood sugar control.23478

What is the purpose of this trial?

The aging population is rapidly increasing, and it is important to identify dietary factors that can prevent disease and promote health in this group. Legumes, such as peanuts, are a plant-based food high in protein and unsaturated fat making this a healthy choice but are not consumed frequently enough in older adults. Studies have shown that regular nut consumption is associated with lower adiposity and reduced weight gain, and several dietary pattern studies indicate that nuts and legumes are associated with better bone health. In addition, our preliminary translational data indicates that a higher monounsaturated fatty acid (MUFA) intake is associated with improved bone mineral density (BMD) and quality. Given these findings, the proposed study aims to examine the impact of consuming peanut products on bone health, metabolic health (e.g., serum glucose, insulin, lipids and inflammation), markers of brain and sleep health, and physical function in overweight and obese older adults before and after a six-month weight loss intervention using a randomized controlled design. The results of this study have the potential to provide valuable insights into the role of peanuts as a sources of fatty acids in promoting health and preventing disease in at-risk adults.

Eligibility Criteria

This trial is for overweight and obese older adults interested in weight loss. Participants should be willing to consume peanut products or nut-free snacks as part of the study. The focus is on how these diets affect bone health, metabolism, brain function, sleep quality, and physical ability.

Inclusion Criteria

Body mass index (25-42 kg/m2) or evidence of pre-clinical obesity
Agree to be randomly assigned to consume a daily peanut snack or nut-free snack for 24 weeks
Must attend on-site visits (about 10) in New Brunswick, NJ, USA (transportation/reimbursement for travel not included)
See 1 more

Exclusion Criteria

Peanut allergies or intolerances
Participants with >5% weight loss in the past 6 months or extreme dietary/physical activity habits
Individuals with significant psychiatric or food disorders
See 11 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants consume peanut products or a nut-free snack during a six-month weight loss intervention

24 weeks

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • Nut-free Snack
  • Peanut Snack Experimental
Trial Overview The study tests the effects of a peanut snack versus a nut-free snack on various health aspects during a six-month weight loss program. It aims to see if peanuts improve bone density, metabolic markers like blood sugar and cholesterol levels, brain health, sleep patterns, and physical performance.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: PeanutExperimental Treatment1 Intervention
Peanut products
Group II: Nut-free snackActive Control1 Intervention
Grain snack (nut-free)

Find a Clinic Near You

Who Is Running the Clinical Trial?

Rutgers, The State University of New Jersey

Lead Sponsor

Trials
471
Recruited
81,700+

Findings from Research

Consuming 35 g of peanuts before two main meals as part of a weight loss diet led to weight loss similar to a traditional low-fat diet over 6 months, with no significant difference in body weight between the two groups.
Participants who consumed peanuts experienced a greater reduction in systolic blood pressure compared to the control group, suggesting that peanut intake may help lower cardiovascular disease risk.
The Effect of a Peanut-Enriched Weight Loss Diet Compared to a Low-Fat Weight Loss Diet on Body Weight, Blood Pressure, and Glycemic Control: A Randomized Controlled Trial.Petersen, KS., Murphy, J., Whitbread, J., et al.[2023]
In a study involving 54 overweight and obese adults, consuming mixed nuts as a snack led to lower levels of appetite hormones like leptin and ghrelin, indicating increased satiety without raising blood glucose or insulin levels.
In contrast, pretzel consumption resulted in higher subjective satiety and lower hunger but also caused significant increases in glucose and insulin, suggesting that mixed nuts may be a healthier snack option for weight management.
Mixed Nuts May Promote Satiety While Maintaining Stable Blood Glucose and Insulin in Healthy, Obese, and Overweight Adults in a Two-Arm Randomized Controlled Trial.Godwin, N., Roberts, T., Hooshmand, S., et al.[2019]

References

Effects of peanut oil load on energy expenditure, body composition, lipid profile, and appetite in lean and overweight adults. [2022]
The Effect of a Peanut-Enriched Weight Loss Diet Compared to a Low-Fat Weight Loss Diet on Body Weight, Blood Pressure, and Glycemic Control: A Randomized Controlled Trial. [2023]
Snacking, Satiety, and Weight: A Randomized, Controlled Trial. [2018]
The addition of peanuts to habitual diets is associated with lower consumption of savory non-core snacks by men and sweet non-core snacks by women. [2018]
Intake of Nuts or Nut Products Does Not Lead to Weight Gain, Independent of Dietary Substitution Instructions: A Systematic Review and Meta-Analysis of Randomized Trials. [2023]
Study protocol for a 9-month randomised controlled trial assessing the effects of almonds versus carbohydrate-rich snack foods on weight loss and weight maintenance. [2021]
Mixed Tree Nut Snacks Compared to Refined Carbohydrate Snacks Resulted in Weight Loss and Increased Satiety during Both Weight Loss and Weight Maintenance: A 24-Week Randomized Controlled Trial. [2021]
Mixed Nuts May Promote Satiety While Maintaining Stable Blood Glucose and Insulin in Healthy, Obese, and Overweight Adults in a Two-Arm Randomized Controlled Trial. [2019]
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