Vandazole

Pouchitis, Liver Abscess, Amebic, Lung Abscess + 53 more

Treatment

41 FDA approvals

20 Active Studies for Vandazole

What is Vandazole

Metronidazole

The Generic name of this drug

Treatment Summary

Metronidazole is a type of antibiotic that can be used to treat a variety of infections, including bacterial and parasitic ones. It is available as a capsule, tablet, topical cream, gel, and suppository. Metronidazole has been used to treat gastrointestinal infections for many years. It is also effective for trichomoniasis, giardiasis, and amebiasis.

Flagyl

is the brand name

image of different drug pills on a surface

Vandazole Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Flagyl

Metronidazole

1963

449

Approved as Treatment by the FDA

Metronidazole, commonly known as Flagyl, is approved by the FDA for 41 uses including Abscess and Bone and Joint Infections .

Abscess

Bone and Joint Infections

Liver Abscess

Communicable Diseases

Osteomyelitis

Bacterial Endocarditis

Helicobacter Pylori Infection

Used to treat Helicobacter Pylori Infection in combination with Bismuth subsalicylate

Abdominal Abscess

Abdominal Infection

Skin and skin structure infections

Gynaecological infection

Lung Abscess

Endometritis

Central Nervous System Bacterial Infections

Bacterial Meningitis

Pneumonia

intra-abdominal bacterial infections

hepatic abscess

Tubo-ovarian abscess

Lung Abscess

Curling Ulcer

Used to treat Duodenal Ulcer in combination with Bismuth subsalicylate

Lower respiratory tract infection bacterial

Bacterial Septicemia

Bacteria, Anaerobic

Bacterial Infections

Duodenal Ulcer

Used to treat Duodenal Ulcer in combination with Bismuth subsalicylate

Meningitis

Abscess, Intra-Abdominal

Empyema

asymptomatic Trichomoniasis

Exposure via partner

Endomyometritis

Bacterial Peritonitis

Central Nervous System Bacterial Infections

Empyema

Trichomonas Infections

Endometritis

Endometritis

Bacteria

Endocarditis, Bacterial

Communicable Diseases

Effectiveness

How Vandazole Affects Patients

Metronidazole is used to treat certain types of bacterial and parasite infections. It works by damaging the DNA of the germs, making them unable to reproduce. It is mostly effective against anaerobic bacteria, but does not work against most other types of bacteria or parasites. It is important to be aware of the risk of convulsions and nerve damage that can occur when taking metronidazole, especially when taking large doses. If these side effects occur, the drug should be stopped immediately. Metronidazole has been linked to cancer in mice and rats, but it is not clear if this

How Vandazole works in the body

Metronidazole is used to treat infections caused by certain bacteria and parasites. It is believed to work by blocking the production of essential molecules in these organisms, like DNA and electron-transport proteins. The drug enters cells and is then reduced to nitro radicals, which are toxic to anaerobic and microaerophilic organisms. This prevents the organisms from replicating, which eventually kills them.

When to interrupt dosage

The amount of Vandazole relies on the determined condition, for example Exposure via partner, Skin and Curling Ulcer. The measure of dosage fluctuates as per the technique of delivery (e.g. Capsule or Vaginal) featured in the table below.

Condition

Dosage

Administration

Bacterial Vaginosis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Exposure via partner

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Tubo-ovarian abscess

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Bacterial Septicemia

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Vaginitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Bacterial Peritonitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Trichomonas Vaginitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

post-surgical vaginal cuff infection

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Inflammatory Papule

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Pouchitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Giardiasis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Vulvovaginitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Uterine Cervicitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Communicable Diseases

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Candida albicans

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Bacterial Meningitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Sinusitis

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Endocarditis, Bacterial

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Operative Surgical Procedures

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Lockjaw

5.0 mg/mL, , 0.0075 mg/mg, 500.0 mg, 0.01 mg/mg, 7.5 mg/mL, 250.0 mg, 375.0 mg, 0.065 mg/mg, 125.0 mg, 10.0 %, 0.75 %, 1.0 %, 750.0 mg, 0.001 mg/mg, 200.0 mg, 400.0 mg, 100.0 mg/mL, 0.013 mg/mg, 0.5 mg/mg

Injection, solution, Injection, solution - Intravenous, Intravenous, , Gel - Topical, Topical, Gel, Oral, Tablet, Cream, Cream - Topical, Tablet - Oral, Lotion - Topical, Lotion, Solution, Solution - Intravenous, Capsule, Capsule - Oral, Vaginal, Suppository, Suppository - Vaginal, Cream - Vaginal, Tablet, film coated - Oral, Tablet, film coated, Gel - Vaginal, Tablet, film coated, extended release, Ointment - Topical, Insert - Vaginal, Insert, Kit, Tablet, extended release - Oral, Tablet, extended release, Tablet, film coated, extended release - Oral, Suppository - Rectal, Rectal, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Kit - Oral, Ointment

Warnings

Vandazole has three contraindications, thus it must not be taken when experiencing the circumstances listed in the following table.

Vandazole Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Metronidazole may interact with Pulse Frequency

Pregnancy Trimester, First

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Metronidazole may interact with Pulse Frequency

There are 20 known major drug interactions with Vandazole.

Common Vandazole Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be decreased when combined with Metronidazole.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be decreased when combined with Metronidazole.

Alectinib

Major

The metabolism of Alectinib can be decreased when combined with Metronidazole.

Alpelisib

Major

The metabolism of Alpelisib can be decreased when combined with Metronidazole.

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Metronidazole.

Vandazole Toxicity & Overdose Risk

The most toxic dose of metronidazole for rats is 5000mg/kg. Symptoms of an overdose may include nerve issues, confusion, seizures, a reaction to alcohol, dark urine, a bad taste in the mouth, nausea, stomach pain, and dizziness, as well as a reduced number of white blood cells. There is no specific antidote for metronidazole overdose, so treatments involve supportive care and taking activated charcoal to remove any unabsorbed drug from the stomach. People should also contact their local poison control center for more information on how to manage an overdose.

Vandazole Novel Uses: Which Conditions Have a Clinical Trial Featuring Vandazole?

179 active studies are currently being conducted to assess the potential of Vandazole for the treatment of Curling Ulcer, Periodontitis and Central Nervous System Bacterial Infections.

Condition

Clinical Trials

Trial Phases

Lockjaw

0 Actively Recruiting

Uterine Cervical Erosion

0 Actively Recruiting

Gum Disease

3 Actively Recruiting

Phase 3, Not Applicable

Abdominal Infection

0 Actively Recruiting

Rosacea

0 Actively Recruiting

Balantidiasis

0 Actively Recruiting

Empyema

1 Actively Recruiting

Phase 4

Abdominal Abscess

2 Actively Recruiting

Phase 4, Phase 1, Phase 2

Bacteria

0 Actively Recruiting

Trichomonas Infections

0 Actively Recruiting

Vulvovaginitis

0 Actively Recruiting

Lung Abscess

0 Actively Recruiting

Pouchitis

5 Actively Recruiting

Phase 2, Phase 3, Early Phase 1, Phase 4

Atopic Dermatitis

12 Actively Recruiting

Phase 2, Phase 3, Phase 4, Not Applicable

Acne Vulgaris

0 Actively Recruiting

Operative Surgical Procedures

0 Actively Recruiting

Liver Abscess, Amebic

0 Actively Recruiting

Trichomonas Vaginitis

2 Actively Recruiting

Phase 2, Phase 4

Amebic colitis

0 Actively Recruiting

Rosacea

2 Actively Recruiting

Early Phase 1, Phase 2

Vandazole Reviews: What are patients saying about Vandazole?

5

Patient Review

3/29/2010

Vandazole for Vaginosis caused by Bacteria

I saw a big difference after just one use, but I followed the instructions and used it for five days. I'm pretty confident that the infection is gone now.

5

Patient Review

1/27/2014

Vandazole for Vaginosis caused by Bacteria

Unfortunately, this medication made my BV worse. It was very messy and I had to wear a mini pad constantly, which was really inconvenient. After using it for the recommended five days, my BV seemed worse than before I started taking the medication. I didn't experience any side effects, but at $15 per treatment, I feel like it should have been more effective. My doctor has now prescribed the pill form of flagyl (500 mg, 2x per day for 7 days) and I'm hopeful that it will clear up my BV.

5

Patient Review

9/8/2012

Vandazole for Vaginosis caused by Bacteria

I got very dizzy and had pelvic cramping and nausea, and I didn't even drink any alcohol. I would rather be itchy!

5

Patient Review

2/10/2009

Vandazole for Vaginosis caused by Bacteria

5

Patient Review

4/22/2009

Vandazole for Vaginosis caused by Bacteria

4.7

Patient Review

8/6/2016

Vandazole for Vaginosis caused by Bacteria

I had been dealing with post-menopausal BV for three months before I got a diagnosis, and this gel was prescribed to me. I was worried about the possible side effects (I've used oral flagyl in the past and it really messed up my stomach), but thankfully this just contains parabens and propylene glycol. The five days passed quickly enough, and my condition is much improved now.

4

Patient Review

4/26/2010

Vandazole for Vaginosis caused by Bacteria

Unfortunately, this medication did not help me. I'm still in pain and now have to deal with a constant discharge and unpleasant odor. If anyone knows of an alternative treatment, please let me know!

3.7

Patient Review

4/2/2010

Vandazole for Vaginosis caused by Bacteria

Unfortunately, I had to discontinue this medication early due to the large amount of clotting discharge, swelling and rash. It was very painful to use.

3

Patient Review

5/20/2012

Vandazole for Vaginosis caused by Bacteria

I didn't have any success with this treatment, unfortunately. I'm looking into other options now. It's also important to note that I had a severe reaction to alcohol use while taking this drug. Do not drink alcohol, use mouthwash, or anything containing alcohol on your skin if you're taking this medication.

2.7

Patient Review

1/14/2012

Vandazole for Vaginosis caused by Bacteria

I felt better after the fifth dose of this medicine. I had to take two doses per day due to a severe infection. After the fifth dose, I started feeling tired, but the itching was gone. I washed myself two to three times a day to avoid too much moisture and hopefully prevent another yeast infection. I am on my sixth dose now and believe that this medicine has cured my infection.

2.7

Patient Review

6/11/2009

Vandazole for Vaginosis caused by Bacteria

2.3

Patient Review

10/17/2011

Vandazole for Vaginosis caused by Bacteria

This treatment immediately stopped the itching and sweating.

2.3

Patient Review

9/21/2010

Vandazole for Vaginosis caused by Bacteria

I've had better results treating BV with this method than taking pills.

2.3

Patient Review

8/9/2009

Vandazole for Vaginosis caused by Bacteria

I find this drug to be effective and easy to use.

2

Patient Review

9/23/2009

Vandazole for Vaginosis caused by Bacteria

I saw good results quickly, and it's been continuing to work well. The only downside is that I got sick after drinking alcohol--I hadn't realized that was a no-no while using this treatment!

2

Patient Review

8/15/2013

Vandazole for Vaginosis caused by Bacteria

This medication made my symptoms worse and caused a lot of terrible side effects. I wouldn't recommend it to anyone.

2

Patient Review

1/25/2014

Vandazole for Vaginosis caused by Bacteria

I was prescribed this, alongside an antibiotic, for irritation of my cervix and uterus. After taking the third dose of this medication, I experienced mild cramping. However, after the fourth dose, the cramping was unbearable. In my opinion, this medicine is not worth it.

1.7

Patient Review

5/5/2010

Vandazole for Vaginosis caused by Bacteria

I unfortunately had some negative reactions to this drug, including dry mouth and an increase in blood pressure. I only took half the recommended dose and still had these problems.

Patient Q&A Section about vandazole

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Vandazole gel used for?

"The purpose of this medication is to treat bacterial infections in the vagina. Metronidazole, the active ingredient, is an antibiotic that works by stopping the growth of bacteria."

Answered by AI

Does Vandazole treat BV?

"Vandazole is a prescription medicine used that belongs to a class of drugs called Antibiotics, Other; Vaginal Preparations, Other. It is used to treat the symptoms of bacterial Vaginosis and may be used alone or with other medications."

Answered by AI

Can Vandazole treat yeast infection?

"This medicine will not treat a vaginal yeast infection. You could even develop a new vaginal yeast infection, which may need to be treated with antifungal medication. If you have symptoms such as itching or discharge during or after treatment with this medicine, tell your doctor."

Answered by AI

What are the side effects of Vandazole gel?

"Vaginal itching, discharge, or menstrual pain may be symptoms of an STD. Heavy bleeding, breast pain, headache, rash, or itching could also be signs of an STD. Stomach pain, nausea, diarrhea, cold symptoms like a stuffy nose, sneezing, or sore throat might also indicate an STD."

Answered by AI

Clinical Trials for Vandazole

Image of ALS Global in Irving, United States.

GX-03 for Eczema

18 - 70
All Sexes
Irving, TX

This is a randomized, double-blind, vehicle-controlled clinical study designed to evaluate the efficacy and safety of GX-03, a topically applied emollient, in adult subjects with moderate to severe eczema. Approximately 120 adult participants will be enrolled and randomized in a 1:1 ratio to receive either GX-03 or a petrolatum-based vehicle control for 8 consecutive weeks. Efficacy will be assessed using validated clinical outcome measures, including the Eczema Area and Severity Index (EASI), the Validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD™), and the Peak Pruritus Numeric Rating Scale (PP-NRS). Safety will be evaluated through monitoring of treatment-emergent adverse events throughout the study period.

Phase 2
Recruiting

ALS Global

Turn Therapeutics

Image of Seeding Labs INC in Austin, United States.

Tailored Recommendations for Infant Gut Microbiome

No minimum age - 3
All Sexes
Austin, TX

The goal of this clinical trial is to learn whether microbiome analysis, education, and personalized recommendations can improve gut health and reduce early markers of immune-related conditions in infants aged 0-3 months delivered via Cesarean section. The study aims to determine whether these interventions can increase beneficial bacteria, decrease C-section-associated microbiome signatures, reduce opportunistic pathogens, and improve functional potential for HMO digestion and SCFA production. The study also seeks to assess whether improvements in microbiome composition are associated with a reduced prevalence of early atopic symptoms. Researchers will compare three groups: a full intervention arm that receives microbiome reports, coaching, personalized recommendations, and educational materials; a limited intervention arm that receives simplified reports and basic recommendations; and a control arm that receives no results until study completion. This design allows evaluation of both a comprehensive intervention and a more scalable, minimal-results model. Participants will: 1. Provide six microbiome stool samples over a 24-month period. 2. Provide additional small stool samples at two timepoints for exploratory metabolomic analysis. 3. Receive microbiome reports and guidance according to their assigned study arm. 4. Complete surveys on infant health history, symptoms, diet, and environmental exposures. 5. Participate in standardized eczema assessment(s) administered by a Nurse Practitioner and evaluated by a Pediatric Allergy Specialist if any symptoms are reported. This study seeks to demonstrate that targeted microbiome support can positively shift gut microbial development in C-section infants and may reduce risks linked to the early stages of the atopic march. Findings may inform scalable strategies for delivering microbiome-based support in early life and improve long-term health outcomes for this high-risk population.

Waitlist Available
Has No Placebo

Seeding Labs INC

Qian Yuan, MD

Seeding, Inc DBA Tiny Health

Image of Children's of Alabama in Birmingham, United States.

Antibiotic Duration for Infections in Children

60 - 17
All Sexes
Birmingham, AL

Infections like pneumonia, skin and soft tissue infection (also called SSTI or cellulitis), and urinary tract infections (UTI) are some of the most common reasons children get admitted to the hospital. All three of these conditions require antibiotics for treatment. Although antibiotics are needed to treat the infection and help children feel better, taking them longer than needed can negatively impact children and their families. Negative impacts include things like the burdens of taking more medications and medication side effects. There are guidelines (instructions) from expert medical organizations that suggest the number of days children need antibiotics, but they give a wide range (between 5 and 14 days). Unfortunately, these guidelines are not based on high-quality studies. National data suggests that doctors often choose on the higher end of this range when writing prescriptions for children in the hospital. Our three caregiver co-investigators, other parents of hospitalized children, doctors, other care providers, and researchers, all believe that additional study is needed to determine the best length of antibiotic treatment that weighs both the benefits and harms of antibiotics. The goal of our study is to understand if 5 total days of antibiotic treatment compared to 10 total days of antibiotic treatment is better for children who have been in the hospital for pneumonia, SSTI, or UTI. We will study this question through a randomized control trial. In other words, half of the children will receive 5-days of antibiotics and the other half will receive 10-days of antibiotics. Children in this study (and their caregivers) will not know how many days of antibiotics they will receive to cure their infection because some children will take a placebo (or a pill without antibiotics in it). Only the pharmacy will know if a child is getting antibiotic or placebo (for days 6-10 of treatment). During the first phase of the trial (feasibility phase), 4 hospitals will enroll children in the study. We plan on enrolling 50 patients during this phase. We are starting with just 4 hospitals, so our study team can create and update our study plans if needed. We will closely review information about how many patients and families agree to participate, and if they have any trouble completing any part of the study. We will also interview families to understand the choice to participate in the study, the choice not to participate in the study, and what it is like to be in the study. During the second study phase, we will enroll 1150 more patients across all 11 hospitals. Families will complete short, daily surveys until the 15th day after they started antibiotics, then a larger survey at day 15, at day 20, and at day 30. These surveys will ask about the child's symptoms and recovery from their illness, how the antibiotics are making them feel, and if they had to go back to their doctor, emergency room, or hospital. The answers to these questions will be combined to measure how well the child did, balancing feeling better and having bad effects from the antibiotics. We will use mathematical tests to determine which antibiotic duration is better for treating these illnesses. We will complete other mathematical tests to see if all children should receive the same length of antibiotics or if certain children should be prescribed shorter courses and others longer courses.

Phase 4
Waitlist Available

Children's of Alabama (+9 Sites)

Sunitha V Kaiser, MD, MSc

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Image of UNC Chapel Hill in Chapel Hill, United States.

Intrapleural Enzyme Therapy for Pleural Infection

18+
All Sexes
Chapel Hill, NC

The goal of this clinical trial is to find out if giving certain medications once a day works just as well as giving them twice a day to treat infections around the lungs (called pleural infections). These medications-tissue plasminogen activator (tPA) and deoxyribonuclease (DNase)-are placed through a chest tube into the space between the lung and the chest wall to help clear out the infection. The investigators are trying to learn: * Does using the medicine once a day work just as well as using it twice a day? * Are there any differences in outcomes between patients who get the medicine once a day versus twice a day? * Does more or less fluid remain in the chest (seen on a chest x-ray) depending on how often the medicine is given? Participants will: * Have an infection around their lung and will already be getting normal hospital care, including a chest tube to drain the infected fluid around their lung. * Be asked to give permission to join the study. * Be randomly chosen (like flipping a coin) to get the medications either once a day or twice a day through the chest tube.

Phase 4
Waitlist Available

UNC Chapel Hill

Jason Akulian, MD, MPH

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Image of Office of Dental Health, Department of Health and Senior Services in Jefferson City, United States.

Dental Care for Pneumonia Prevention

60 - 100
All Sexes
Jefferson City, MO

The goal of this study is to learn if dental infection control treatment delivered to older adult nursing home residents at their place of residence will result in : * improved dental health * reduced risk of pneumonia * better glucose control for diabetic patients compared to the pre-project dental and general health evaluations of residents and the pre-project facility incidence of pneumonia. Dental infection control treatment includes treating gum infections, stopping or slowing decay with fluoride, and assisting residents with effective tooth brushing and denture cleaning daily. Previous studies indicate dental infections can be inhaled and cause pneumonia or make diabetes worse. A shortage of dentists has limited care for nursing home residents. This project will allow dental hygienists and specially trained dental assistants to treat nursing home residents using telehealth methods (computers, cameras, internet, and telephone) to talk and work with dentists in different locations.

Recruiting
Has No Placebo

Office of Dental Health, Department of Health and Senior Services

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