Travoprost

Glaucoma, Open Angle Glaucoma, Ocular Hypertension

Treatment

6 FDA approvals

18 Active Studies for Travoprost

What is Travoprost

Travoprost

The Generic name of this drug

Treatment Summary

Travoprost ophthalmic solution is a medication used to treat open-angle glaucoma and ocular hypertension. It works by lowering the pressure inside the eye and is a synthetic form of prostaglandin F2alpha. It is the only prostaglandin analog approved by the FDA for first-line treatment of glaucoma that does not contain the preservative benzalkonium chloride. Travoprost is also approved in the EU for use in children as young as 2 months who have ocular hypertension or glaucoma.

Travatan

is the brand name

image of different drug pills on a surface

Travoprost Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Travatan

Travoprost

2001

15

Approved as Treatment by the FDA

Travoprost, also known as Travatan, is approved by the FDA for 6 uses such as Open Angle Glaucoma (OAG) and Increased Intra Ocular Pressure (IOP) .

Open Angle Glaucoma (OAG)

Helps manage Open Angle Glaucoma (OAG)

Increased Intra Ocular Pressure (IOP)

Helps manage Increased Intra Ocular Pressure (IOP)

Ocular Hypertension

Helps manage Ocular Hypertension

Ocular Hypertension

Helps manage Ocular Hypertension

Open Angle Glaucoma

Helps manage Open Angle Glaucoma (OAG)

Glaucoma

Helps manage Increased Intra Ocular Pressure (IOP)

Effectiveness

How Travoprost Affects Patients

Travoprost is a medication that is made from a synthetic form of a hormone that helps regulate blood pressure. It is quickly broken down into an active form in the cornea, and binds to a receptor in the body that helps regulate blood pressure.

How Travoprost works in the body

Travoprost is a medication that helps reduce the pressure inside the eye. It's a full agonist, meaning it binds to the prostaglandin FP receptor and stimulates it. This increases the flow of fluid out of the eye, lowering the pressure. The effects of Travoprost can be seen in a couple of hours, and the effects last for over 24 hours with just a single dose.

When to interrupt dosage

The advised measure of Travoprost is contingent upon the diagnosed condition, for example, Open Angle Glaucoma, Ocular Hypertension and Enhanced Intra Ocular Pressure (IOP). The dose is contingent upon the technique of delivery (e.g. Solution or Ophthalmic) expressed in the accompanying table.

Condition

Dosage

Administration

Glaucoma

, 0.04 mg/mL, 0.004 %, 0.03 mg/mL, 0.003 %

Ophthalmic, , Solution / drops - Ophthalmic, Solution / drops, Solution - Ophthalmic, Solution

Open Angle Glaucoma

, 0.04 mg/mL, 0.004 %, 0.03 mg/mL, 0.003 %

Ophthalmic, , Solution / drops - Ophthalmic, Solution / drops, Solution - Ophthalmic, Solution

Ocular Hypertension

, 0.04 mg/mL, 0.004 %, 0.03 mg/mL, 0.003 %

Ophthalmic, , Solution / drops - Ophthalmic, Solution / drops, Solution - Ophthalmic, Solution

Warnings

Travoprost Contraindications

Condition

Risk Level

Notes

Attemping to get pregnant

Do Not Combine

There are 20 known major drug interactions with Travoprost.

Common Travoprost Drug Interactions

Drug Name

Risk Level

Description

Acebutolol

Minor

Travoprost may increase the hypotensive activities of Acebutolol.

Aliskiren

Minor

Travoprost may increase the hypotensive activities of Aliskiren.

Alprenolol

Minor

Travoprost may increase the hypotensive activities of Alprenolol.

Ambrisentan

Minor

Travoprost may increase the hypotensive activities of Ambrisentan.

Amlodipine

Minor

Travoprost may increase the hypotensive activities of Amlodipine.

Travoprost Toxicity & Overdose Risk

No cases of overdose have been reported for travoprost. If a topical overdose does occur, it should be flushed out with lukewarm water. Treatment for an oral overdose should be symptomatic and supportive. Travoprost is not recommended for pregnant women or those who are breastfeeding, as the medication could be passed to the fetus or baby. Animal studies have found excretion of travoprost and its metabolites in breast milk. There is no data on the effects of travoprost on human fertility, but animal studies did not find any negative effects on fertility at doses 250 times higher than the recommended human

image of a doctor in a lab doing drug, clinical research

Travoprost Novel Uses: Which Conditions Have a Clinical Trial Featuring Travoprost?

34 active clinical trials are currently evaluating the potential of Travoprost in attenuating Ocular Hypertension, Increased Intra Ocular Pressure (IOP) and Open Angle Glaucoma.

Condition

Clinical Trials

Trial Phases

Open Angle Glaucoma

10 Actively Recruiting

Phase 3, Not Applicable, Phase 4

Glaucoma

0 Actively Recruiting

Ocular Hypertension

10 Actively Recruiting

Phase 3, Phase 1, Phase 2, Not Applicable, Phase 4

Travoprost Reviews: What are patients saying about Travoprost?

5

Patient Review

11/9/2021

Travoprost for Increased Pressure in the Eye

I've had great results with this medication, but the new packaging is harder to use. I have arthritis in my hands, so it's difficult for me to hold the bottle and keep my eye open at the same time. As a result, I end up wasting a drop or two every night.

4.7

Patient Review

3/30/2012

Travoprost for Increased Pressure in the Eye

TravatanZ was much gentler on my eyes than the previous prescription I had been using.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about travoprost

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is travoprost discontinued?

"The company that makes IZBA has notified the FDA that the drug will no longer be produced."

Answered by AI

What are the side effects of travoprost eye drops?

"The following side effects may occur: blurred vision, eye redness/discomfort/itching, feeling as if something is in your eye, dry eyes, tearing, eyelid crusting, increase in eyelash number/length/thickness, darkening of the eyelashes and eyelids, eyelid changes, or increased sensitivity to light."

Answered by AI

What is travoprost eye drops for?

"Travoprost is a medication used to manage ocular hypertension and open-angle glaucoma, by regulating the pressure in the eye. Excessive pressure in the eye can cause pain or vision changes. Travoprost is a prostaglandin, a type of medication that works by decreasing fluid production in the eye."

Answered by AI

Is travoprost and latanoprost the same?

"The study's concluded that travoprost is a more effective treatment than latanoprost and timolol for lowering intraocular pressure in patients with open-angle glaucoma or ocular hypertension."

Answered by AI

Clinical Trials for Travoprost

Have you considered Travoprost clinical trials?

We made a collection of clinical trials featuring Travoprost, we think they might fit your search criteria.
Go to Trials

Have you considered Travoprost clinical trials?

We made a collection of clinical trials featuring Travoprost, we think they might fit your search criteria.
Go to Trials
Image of Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham in Birmingham, United States.

AI-Based Screening for Glaucoma

18+
All Sexes
Birmingham, AL

The goal of this clinical trial is to learn if implementation of an eye screening program at Federally Qualified Health Center (FQHC) clinics provides results that participants may have glaucoma, and/or other eye conditions (diabetic retinopathy, cataract, visual acuity impairment). The glaucoma screening will incorporate use of an artificial intelligence (AI)-assisted screening tool. This project is called AI-RONA. The main questions it aims to answer are: * How does this eye screening program compare to the rate of glaucoma and other eye conditions detected at other FQHC clinics where the screening program has not been implemented? * Do particpants who screen positive for these conditions adhere to the physician's recommendation for a follow-up examination by an optometrist or ophthalmologist? * Are referral rates for a follow-up comprehensive eye exam by an optometrist or ophthalmologist similar to those implemented by an ophthalmologist using telemedicine (that is, using the results of the screening to make a diagnosis remotely)? * What is the cost-effectiveness of the AI-assisted screening program in diagnosing glaucoma as compared to a physician-guided program? * Are participants completing the screening satisfied with it? * Are physicians at the FQHC clinics administering the screening satisfied with it? Participants will: * Undergo an ocular screening whose goal is to detect glaucoma, diabetic retinopathy, cataract, and/or impairment in visual acuity. If the screening indicates that participants may have these conditions, participants will be referred for a comprehensive eye examination by an optometrist or ophthalmologist. * Following the screening, participants and physicians will complete a survey on their satisfaction with the program.

Recruiting
Has No Placebo

Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham

Cynthia Owsley, PhD

Have you considered Travoprost clinical trials?

We made a collection of clinical trials featuring Travoprost, we think they might fit your search criteria.
Go to Trials