Synarel

Endometriosis, Puberty, Precocious

Treatment

4 FDA approvals

20 Active Studies for Synarel

Treatment for

Endometriosis

What is Synarel

NafarelinThe Generic name of this drug

Treatment SummaryNafarelin is a hormone medication used to treat central precocious puberty and endometriosis. It works by mimicking the natural gonadotropin-releasing hormone in the body and stimulating hormones responsible for sexual development and reproductive function.

Synarelis the brand name

image of different drug pills on a surface

Synarel Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Synarel

Nafarelin

1990

Approved as Treatment by the FDA

Nafarelin, also called Synarel, is approved by the FDA for 4 uses like Central Precocious Puberty (CPP) and Endometriosis .

Central Precocious Puberty (CPP)

Endometriosis

Puberty, Precocious

Effectiveness

How Synarel Affects PatientsNafarelin is a drug that works to stimulate the pituitary gland to release hormones, LH and FSH, which in turn lead to a rise in gonadal steroid production. Taking this drug twice a day lead to decreased gonadal steroid levels after about 4 weeks. When the treatment is stopped, normal pituitary and ovarian function is restored, and the levels of estradiol return to the pre-treatment levels. It should be noted that endometriosis may return after stopping any hormonal therapy or surgery that leaves the ovaries and/or uterus intact.

How Synarel works in the bodyNafarelin works by blocking the GnRH receptor and decreasing production of hormones like estrogen and testosterone. This leads to a decrease in secondary sexual characteristics in children, a dramatic decrease in the hormones that cause endometriosis, and the suppression of growth in children. When nafarelin is stopped, hormone levels usually return to what they were before treatment.

When to interrupt dosage

The measure of Synarel is subject to the identified affliction. The amount of dosage is contingent upon the method of administration detailed in the below table.

Condition

Dosage

Administration

Endometriosis

, 2.0 mg/mL, 0.2 mg/pump actuation

Nasal, , Aerosol, metered, Aerosol, metered - Nasal, Liquid, Liquid - Nasal, Spray, metered, Spray, metered - Nasal

Puberty, Precocious

, 2.0 mg/mL, 0.2 mg/pump actuation

Nasal, , Aerosol, metered, Aerosol, metered - Nasal, Liquid, Liquid - Nasal, Spray, metered, Spray, metered - Nasal

Warnings

Synarel has two contra-indications, thus it should not be used in cases of the conditions in the following table.Synarel Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Vaginal Hemorrhage

Do Not Combine

There are 20 known major drug interactions with Synarel.

Common Synarel Drug Interactions

Drug Name

Risk Level

Description

Capromab pendetide

Major

Nafarelin may decrease effectiveness of Capromab pendetide as a diagnostic agent.

Corifollitropin alfa

Major

The therapeutic efficacy of Corifollitropin alfa can be increased when used in combination with Nafarelin.

Choline C 11

Minor

Nafarelin may decrease effectiveness of Choline C 11 as a diagnostic agent.

Acipimox

Moderate

The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nafarelin is combined with Acipimox.

Aluminium clofibrate

Moderate

The risk or severity of myopathy, rhabdomyolysis, and myoglobinuria can be increased when Nafarelin is combined with Aluminium clofibrate.

Synarel Toxicity & Overdose RiskTests on animals have found no negative effects from administering up to 60 times the recommended human dose of GnRH analogs. So far, no negative effects have been reported from overdosing on this drug.

image of a doctor in a lab doing drug, clinical research

Synarel Novel Uses: Which Conditions Have a Clinical Trial Featuring Synarel?

30 active studies are presently investigating the potential of Synarel to address Central Precocious Puberty (CPP) symptoms.

Condition

Clinical Trials

Trial Phases

Puberty, Precocious

1 Actively Recruiting

Phase 3

Endometriosis

28 Actively Recruiting

Early Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4

Synarel Reviews: What are patients saying about Synarel?

4.3Patient Review

2/22/2017

Synarel for Endometriosis

This is the only treatment that has given me any relief from my endometriosis. I've been using it for three months now, and it's really helped. However, under the new insurance program, I won't be able to afford it.

3Patient Review

5/15/2014

Synarel for Endometriosis

This was my doctor's go-to recommendation for endometriosis after two surgeries. It took a little while to start working, but it completely changed my life for the better. I was pain-free for three years – something I hadn't experienced since I was a preteen. Unfortunately, when my original prescribing doctor retired, their replacement refused to let me continue taking it because they said I had been on it for too long (six years). Just a few short years later, I ended up getting a complete hysterectomy. If only I could have stayed on the Synarel!

2.3Patient Review

2/19/2014

Synarel for Endometriosis

This treatment caused me severe sinus pain, and I developed ringing in my ears after using it for just two weeks. The ringing/fuzzy sound is still happening even after stopping the spray five weeks into the course.I have stopped using it and, two weeks later, I am still having trouble hearing over the noise in my ears. It did start to ease some of my abdominal pains but, overall, this was a very unpleasant experience.

1Patient Review

5/8/2010

Synarel for Endometriosis

Do not use this medication under any circumstances. It caused me debilitating, long-term depression and I will never be the same.

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Patient Q&A Section about synarel

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Synarel a hormone blocker?

"Nafarelin spray interrupts the creation of regularly occurring female sexual orientations. Your PCP will reveal to you how often to utilize it. You might need to rehash the portion on the off chance that you sneeze promptly in the wake of utilizing the shower."

Answered by AI

What is Synarel used for in IVF?

"A specialist may prescribe Synarel to assist with in-vitro fertilisation (IVF) by decreasing the amount of estrogen produced by the ovaries. This provides more control for subsequent stimulation of the ovaries to produce eggs."

Answered by AI

What does Synarel spray do?

"This medication helps to decrease the amount of abnormal tissue, as well as the symptoms of endometriosis, such as pelvic pain, painful menstrual cramps, and pain during/after sex. This medication is also used by children to treat a certain type of early puberty, known as central precocious puberty, which is caused by an excess of gonadotropins."

Answered by AI

How quickly does Synarel work?

"For that reason, you need to take it as an intranasal spray two to three times a day, starting two to three months before you want your periods to stop.

Reduced oestrogen levels will usually be observed after one month of taking Synarel, in the form of either stopped or reduced periods. Synarel needs to be absorbed into the bloodstream in order to be effective, so it is administered as an intranasal spray two to three times a day, ideally starting two to three months before periods are desired to be stopped."

Answered by AI