Premarin

Atrophic Vaginitis, Low Testosterone, Osteoporosis + 19 more

Treatment

10 FDA approvals

20 Active Studies for Premarin

Treatment for

Atrophic Vaginitis

What is Premarin

Conjugated estrogensThe Generic name of this drug

Treatment SummaryConjugated estrogens are a combination of female hormones used to treat a variety of conditions, including osteoporosis. This medication is usually made from pregnant mare's urine, which is then combined with a sodium sulfate to make it more water-soluble. The mixture contains estrone sulfate, equilin sulfate, 17-alpha-dehydroequilenin sulfate, equilenin sulfate, 17-alpha and 17-beta-dihydroequilenin sulfate, 17-alpha-estradiolsulfate, and 17-beta-estradiol

Premarinis the brand name

image of different drug pills on a surface

Premarin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Premarin

Conjugated estrogens

1956

60

Approved as Treatment by the FDA

Conjugated estrogens, also known as Premarin, is approved by the FDA for 10 uses including Vasomotor System and hypoestrogenism .

Vasomotor System

Used to treat Moderate to Severe Vasomotor Symptoms in combination with Methyltestosterone

hypoestrogenism

Low Testosterone

Osteoporosis

Used to treat Osteoporosis in combination with Bazedoxifene

Advance Directives

Atrophy of vulva

Premature Menopause

Palliative Treatment

Hot flashes

Used to treat Menopause in combination with Methyltestosterone

female castration

Effectiveness

How Premarin Affects PatientsEstrogens attach to the estrogen receptor, which triggers a series of steps and leads to certain genes being turned on. This is known to be similar in strength to the hormone estrone, and has effects on the bones and cardiovascular system. After taking conjugated estrogens, people typically experience more stable blood pressure, better urinary function, and balanced development of female hormones. It also helps with bone loss by preventing the breakdown of bones and restoring the balance. Finally, it also reduces testosterone levels and luteinizing hormone.

How Premarin works in the bodyConjugated estrogens work by binding to estrogen receptors found in different tissues. This binding triggers the production of DNA, RNA, and proteins in those tissues. This then reduces the release of certain hormones from the brain. The exact way in which conjugated estrogens work varies depending on the specific component of the product.

When to interrupt dosage

The prescribed quantity of Premarin is contingent upon the determined condition, such as severe Dyspareunia, female castration and moderate Dyspareunia. The dose varies as per the method of delivery (e.g. Powder, for solution - Intramuscular; Intravenous or Oral) featured in the table below.

Condition

Dosage

Administration

Vasomotor System

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

Palliative Treatment

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

Premature Menopause

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

Advance Directives

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

Vulvitis

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

Atrophic Vaginitis

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

severe Dyspareunia

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

female castration

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

hormonal imbalance

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

Atrophy of vulva

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

Estrogen Replacement Therapy

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

Uterine hemorrhage

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

Kraurosis Vulvae

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

Vulvitis

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

Vulvitis

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

Hot flashes

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

hypoestrogenism

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

Metastatic Breast Cancer

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

moderate Dyspareunia

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

Low Testosterone

25.0 mg/mL, , 0.000625 mg/mg, 0.625 mg, 1.25 mg, 0.3 mg, 0.9 mg, 0.45 mg, 25.0 mg, 2.5 mg

, Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intramuscular; Intravenous, Vaginal, Cream, Cream - Vaginal, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Kit; Tablet, Kit; Tablet - Oral, Tablet, extended release, Tablet, extended release - Oral, Topical; Vaginal, Cream - Topical; Vaginal, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Kit, Kit - Oral

Warnings

Premarin has fourteen contraindications. It should not be administered alongside the conditions delineated in the following table.Premarin Contraindications

Condition

Risk Level

Notes

Pulmonary Embolism

Do Not Combine

estrogen-dependent neoplasia

Do Not Combine

antithrombin deficiency

Do Not Combine

undiagnosed abnormal genital bleeding

Do Not Combine

Breast Cancer

Do Not Combine

Thromboembolism

Do Not Combine

Deep Vein Thrombosis

Do Not Combine

Deep Vein Thrombosis

Do Not Combine

Protein C Deficiency

Do Not Combine

Thrombophilia

Do Not Combine

Breast

Do Not Combine

Liver Dysfunction

Do Not Combine

Protein Deficiency

Do Not Combine

Pulmonary Embolism

Do Not Combine

There are 20 known major drug interactions with Premarin.

Common Premarin Drug Interactions

Drug Name

Risk Level

Description

Acenocoumarol

Major

The metabolism of Acenocoumarol can be decreased when combined with Conjugated estrogens.

Aminophylline

Major

The metabolism of Aminophylline can be decreased when combined with Conjugated estrogens.

Anagrelide

Major

The metabolism of Anagrelide can be decreased when combined with Conjugated estrogens.

Anastrozole

Major

The therapeutic efficacy of Anastrozole can be decreased when used in combination with Conjugated estrogens.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Conjugated estrogens.

Premarin Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats is more than 5000mg/kg. Symptoms of overdosing have not been reported, but some people have experienced nausea, vomiting, and abnormal bleeding (mostly in women). Taking this drug for an extended period of time may increase one's risk of developing certain types of cancer, such as breast, uterine, cervical, vaginal, testicular, and liver cancer.

image of a doctor in a lab doing drug, clinical research

Premarin Novel Uses: Which Conditions Have a Clinical Trial Featuring Premarin?

42 active clinical trials are currently being conducted to assess the potential of Premarin to combat Kraurosis Vulvae, Vasomotor System disorders and severe Dyspareunia.

Condition

Clinical Trials

Trial Phases

Atrophic Vaginitis

2 Actively Recruiting

Not Applicable

female castration

0 Actively Recruiting

Advance Directives

0 Actively Recruiting

Vulvitis

0 Actively Recruiting

hormonal imbalance

0 Actively Recruiting

Vulvitis

0 Actively Recruiting

hypoestrogenism

2 Actively Recruiting

Phase 4

Atrophy of vulva

1 Actively Recruiting

Not Applicable

severe Dyspareunia

0 Actively Recruiting

Vasomotor System

0 Actively Recruiting

Premature Menopause

1 Actively Recruiting

Phase 2

Vulvitis

0 Actively Recruiting

moderate Dyspareunia

0 Actively Recruiting

Kraurosis Vulvae

0 Actively Recruiting

Uterine hemorrhage

3 Actively Recruiting

Phase 3, Phase 2, Not Applicable

Organic Disease

0 Actively Recruiting

Low Testosterone

15 Actively Recruiting

Phase 1, Phase 4, Phase 2, Not Applicable

Hot flashes

22 Actively Recruiting

Phase 2, Not Applicable, Phase 1, Phase 4, Early Phase 1

Osteoporosis

40 Actively Recruiting

Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4, Phase 3

Palliative Treatment

0 Actively Recruiting

Premarin Reviews: What are patients saying about Premarin?

5Patient Review

10/18/2016

Premarin for Painful Sexual Intercourse due to Menopause

This cream has completely changed my life for the better. I was in so much pain that I had given up on sex, but now thanks to premarin I'm enjoying a healthy and active sex life again.

4Patient Review

9/10/2017

Premarin for Painful Sexual Intercourse due to Menopause

I've been struggling with vaginal dryness and painful intercourse for years. I tried different treatments on and off, but none of them really worked well enough to make a significant difference. Recently, I decided to experiment on my own, and I'm glad I did! After just two weeks of using this treatment every day, my libido is great and there's no more pain during sex.

4Patient Review

10/31/2017

Premarin for Postmenopausal Urethral Atrophy

Though this medication has helped me, I've had several instances of extreme throat swelling. Has anyone else experienced this side effect?

3.7Patient Review

7/1/2022

Premarin for Painful Sexual Intercourse due to Menopause

The product is extremely over price and you get very little of the product in the tube due to amount needed to achieve satisfaction. Over $400 per tube and insurance will pay only small amunt and restricts doses covered. I pay mostly out of pocket.

3.7Patient Review

7/12/2017

Premarin for Painful Sexual Intercourse due to Menopause

You can save a lot of money by getting this cream compounded at your local pharmacy.

3Patient Review

5/27/2018

Premarin for Painful Sexual Intercourse due to Menopause

I saw an increase in water retention after only one week of taking this medication. As a result, I've reduced my dosage in order to find the best balance between less water retention and improved vaginal dryness.

3Patient Review

4/10/2017

Premarin for Postmenopausal Urethral Atrophy

The applicator is very difficult to use. It doesn't attach to the tube well and you have to hold it while trying to squeeze the cream out, which is hard because the plunger is too small. Most of the cream stays in the tube.

3Patient Review

6/25/2020

Premarin for Painful Sexual Intercourse due to Menopause

The effects of this treatment don't last long after application.

2.7Patient Review

5/1/2019

Premarin for Painful Sexual Intercourse due to Menopause

I've only been using this for a short while due to pain during sex, but I haven't had the opportunity to test it out yet as my husband is away half the week. So far, no difference that I can tell. The pharmacist did help me find a coupon so it's not too expensive, though.

2.7Patient Review

11/12/2017

Premarin for Vaginal Inflammation due to Loss of Hormone Stimulation

My doctor only prescribed this estrogen hormonal therapy, which is quite expensive. A lot of the cream is wasted since it's flushed down the toilet.

2.3Patient Review

8/28/2019

Premarin for Postmenopausal Urethral Atrophy

I had two abnormal mammograms within two years of using this product. I'm still waiting on the results of the second one. My advice would be to stop using this if you have one bad mammogram.

2Patient Review

9/4/2019

Premarin for Painful Sexual Intercourse due to Menopause

I used Premarin for 3 months, but when I learned about the horrible conditions that the mares on Premarin farms are subjected to, I stopped immediately. To my surprise, I realized that I didn't really need it and could live very well without it. There were no bad side effects either...and I feel so good not being a part of the Premarin industry.

1.7Patient Review

11/10/2019

Premarin for Painful Sexual Intercourse due to Menopause

This treatment is driving me insane. One day I'm fine, the next day I'm okay, and by the third day I want to cry. I'm not sure if this is going to help me sexually. I haven't had sex in such a long time. It's not pleasant because you deal with pain. Another thing, I just read about the mares and the suffering these poor things go through.I'm going to ask my doctor to give me something different. I don't need a mare to suffer like I'm suffering, so I'll try something else.

1.7Patient Review

11/16/2019

Premarin for Wasting of Tissues of the Vulva

I'm thankful that I live in a country with socialized healthcare. This medication only cost me $35.79, and the government covered 75% of that because I'm over 65.

1Patient Review

2/17/2022

Premarin for Painful Sexual Intercourse due to Menopause

The prescribed amount is too small to insert and stay put. Additionally, it caused itching when some did stay in place.

1Patient Review

1/21/2020

Premarin for Painful Sexual Intercourse due to Menopause

I found out about how this company mistreats pregnant horses and kills their babies for profit, and it made me so angry that I will never use their products again.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about premarin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Premarin used for?

"This medication contains a female hormone that helps reduce symptoms of menopause, such as hot flashes and vaginal dryness. These symptoms are caused by the body making less estrogen."

Answered by AI

Is Premarin made from horse urINe?

"Premarin is a highly prescribed estrogen that can be taken orally or as a topical cream. This estrogen product is made from the urine of pregnant horses. It has been used as a hormone replacement therapy for postmenopausal women in the USA since 1942."

Answered by AI

Why was Premarin taken off the market?

"A government study of Wyeth's hormone replacement drugs, Prempro and Premarin, was discontinued in 2002 when new evidence suggested that taking Prempro heightened the risk of breast cancer, coronary heart disease, stroke, and pulmonary embolism, and that Premarin increased risk of stroke."

Answered by AI

What does Premarin do to your body?

"Hormone replacement therapy (HRT) containing the hormone estrogen in the form known as conjugated estrogens is a type of PREMARIN treatment that helps relieve the discomfort many women feel during and after menopause, including symptoms such as "hot flushes", sweating and vaginal dryness."

Answered by AI

Clinical Trials for Premarin

Image of Mayo Clinic in Rochester, United States.

Alisertib for Breast Cancer

This trial is testing a drug called alisertib in combination with endocrine therapy for patients with a specific type of breast cancer that has spread. The study aims to find the best dose of al

Waitlist Available

Mayo ClinicChief Scientific OfficerPuma Biotechnology, Inc.

Image of University of Colorado Anschutz Medical Campus in Aurora, United States.

Transdermal Estradiol Patch +2 More for Menopause

"This trial aims to study how the decrease in estrogen during menopause affects artery health and body fat distribution in women. The researchers will investigate whether low estrogen levels lead to decreased artery function and increased fat in

Waitlist Available

University of Colorado Anschutz Medical CampusKerrie Moreau, PhD

Image of University of Kentucky in Lexington, United States.

Alendronate for Osteoporosis

This trial aims to address the issue of age-related bone loss, which is often overlooked in current osteoporosis treatments. The study compares the effectiveness of two drugs, Alendronate and Terip

Waitlist Available

University of KentuckyHartmut H Malluche, MD

Image of UCLA Jonsson Comprehensive Cancer Center in Los Angeles, United States.

Sacituzumab govitecan for Breast Cancer

Los Angeles, CA

This trial aims to determine if the medication sacituzumab govitecan (SG) is effective in people with metastatic, hormone receptor positive (HR+)/human epidermal growth factor

Waitlist Available

UCLA Jonsson Comprehensive Cancer Center (+2 Sites)Reshma L Mahtani, D.O.Gilead Sciences

Have you considered Premarin clinical trials? We made a collection of clinical trials featuring Premarin, we think they might fit your search criteria.

Explore trials for Premarin

Image of Marone Cancer Center Cleveland Clinic Florida in Weston, United States.

Taletrectinib for Breast Cancer

This trial is testing a drug called talectrectinib to see if it is safe and well-tolerated in treating a specific type of breast cancer called Stage IV ILC with CDH1

Waitlist Available

Marone Cancer Center Cleveland Clinic Florida (+1 Sites)Megan KruseAnHeart Therapeutics Inc.

Image of Indiana University Hospital in Indianapolis, United States.

Suction Cervical Stabilizer +1 More for Abnormal Uterine Bleeding

Indianapolis, IN

This trial will compare a new device called a suction cervical stabilizer to the standard device called a single-tooth tenaculum. The new device has been approved by the FDA and has been shown to

Indiana University HospitalAlissa Conklin, MD

Image of Hybl Sports Medicine and Performance Center in Colorado Springs, United States.

Hot Water Therapy for Menopause

Colorado Springs, CO

This trial is studying the effects of hot water therapy on menopausal women. The researchers want to see if taking hot baths for multiple days in a row can reduce hot flash symptoms and improve mood.

Hybl Sports Medicine and Performance CenterNathan Morris, PhD

Image of Brigham and Women's Hospital in Boston, United States.

Time-restricted Eating for Menopause

This trial aims to see how restricting eating to only an 8-hour window each day affects the levels of fats in the blood and the composition of the body in women who are going through or have recently

Brigham and Women's HospitalLeilah K Grant, PhD

Have you considered Premarin clinical trials? We made a collection of clinical trials featuring Premarin, we think they might fit your search criteria.

Explore trials for Premarin

Image of Virginia Commonwealth University in Richmond, United States.

CALM +1 More for Brain Tumor

This trial is testing a therapy called CALM for people with brain cancer. It will compare CALM to the usual treatment that is currently used.

Virginia Commonwealth UniversityAshlee Loughan, Ph.D

Image of Stony Brook University Hospital in Stony Brook, United States.

SBRT for Lung Cancer

Stony Brook, NY

This trial is testing a radiation therapy to treat cancer in the spine without the need for major surgery.

Stony Brook University HospitalKartik Mani, MD PhD

Image of Citruslabs in Santa Monica, United States.

Probiotic Supplement for Menopause Symptoms

Santa Monica, CA

This trial tests if a probiotic supplement can reduce menopause symptoms like hot flashes, night sweats, mood swings, etc. Participants take a test product or placebo daily and provide data on weight, waist, sleep, and symptoms.

Waitlist Available

Dietary Supplement

CitruslabsManeuver Marketing

Image of Memorial Sloan Kettering Cancer Center in New York, United States.

18F-FDHT PET/MRI for Breast Cancer

This trial tests if PET/MRI scans can detect AR-positive breast cancer with accuracy.

Memorial Sloan Kettering Cancer CenterMaxine Jochelson, MD

Have you considered Premarin clinical trials? We made a collection of clinical trials featuring Premarin, we think they might fit your search criteria.

Explore trials for Premarin

Unbiased ResultsWe believe in providing patients with all the options.

Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.

Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.

Back to top

Terms of Service Privacy Policy Security