Nuprin

Insomnia, Catarrh, Chronic Pain + 33 more

Treatment

13 FDA approvals

20 Active Studies for Nuprin

What is Nuprin

Ibuprofen

The Generic name of this drug

Treatment Summary

Ibuprofen is a commonly used medication to reduce inflammation and pain. It was created in 1960 as an alternative to aspirin and was finally patented in 1961. Ibuprofen was first available for medical purposes in the UK in 1969 and the US in 1974. It can be purchased over-the-counter without a prescription. Ibuprofen is made of two components, the R-enantiomer and the S-enantiomer. The S-enantiomer is believed to have a stronger effect on reducing inflammation and pain.

Motrin

is the brand name

image of different drug pills on a surface

Nuprin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Motrin

Ibuprofen

1974

2460

Approved as Treatment by the FDA

Ibuprofen, also called Motrin, is approved by the FDA for 13 uses including Acute Pain and Dysmenorrhea .

Acute Pain

Used to treat Pain, Acute in combination with Oxycodone

Dysmenorrhea

Mild pain

Gastric Ulcer

Used to treat Gastric Ulcer in combination with Famotidine

Rheumatoid Arthritis

Used to treat Rheumatoid Arthritis in combination with Famotidine

Stomach Ulcer

Used to treat Gastric Ulcer in combination with Famotidine

Pain, Acute

Used to treat Pain, Acute in combination with Oxycodone

Osteoarthritis (OA)

Used to treat Osteoarthritis (OA) in combination with Famotidine

Migraine

Osteoarthritis

Used to treat Osteoarthritis (OA) in combination with Famotidine

Fever

Headache

Menstrual Distress (Dysmenorrhea)

Effectiveness

How Nuprin Affects Patients

Ibuprofen works to reduce pain, fever, and inflammation by blocking the enzymes (COX-1 and COX-2) that produce certain hormones (prostanoids). It can also reduce the pain transmission that occurs in the spinal cord and brain. Ibuprofen helps with dental procedures by decreasing inflammation and swelling in the affected area. It can also reduce joint pain for those with rheumatic diseases. Ibuprofen is widely used in over-the-counter products to reduce menstrual pain, fever, and migraines. Low doses of ibuprofen over a long period of time may reduce neurodeg

How Nuprin works in the body

Ibuprofen is a type of medicine called a non-steroidal anti-inflammatory drug (NSAID). It works by blocking two enzymes called cyclooxygenase-1 and cyclooxygenase-2. By blocking these enzymes, ibuprofen reduces pain, fever and inflammation, while also causing some side effects like stomach ulcers.

When to interrupt dosage

The measure of Nuprin relies upon the determined illness, for example, smooth muscle relaxation before radiological techniques, Catarrh and Pain alleviation. The quantity of dosage is contingent upon the mode of delivery (e.g. Kit - Oral; Topical or Tablet) featured in the following table.

Condition

Dosage

Administration

Acute Pain

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Chronic Pain

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Migraine

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Analgesics

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Migraine Disorders

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Muscle Spasticity

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Cystic Fibrosis

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Premature Birth

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Spasm

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Dysmenorrhea

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Muscle Relaxation

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Mild pain

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Primary Dysmenorrhoea

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Pain

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Arthritis, Gouty

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Pain

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Opioids

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Stomach Ulcer

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Nasal Congestion

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Juvenile arthritis

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Capsule, coated, Capsule, coated - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Solution, Injection, solution, Injection, solution - Intravenous, Tablet, extended release, Tablet, extended release - Oral, Kit - Oral, Solution - Oral, Injection - Intravenous, Injection, Topical, Cream - Topical, Cream, Kit - Oral; Topical, Oral; Topical, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Solution / drops, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical

Warnings

Nuprin has two contraindications and should not be utilized when suffering from the issues listed in the following table.

Nuprin Contraindications

Condition

Risk Level

Notes

Coronary Artery Bypass Grafting

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Nuprin.

Common Nuprin Drug Interactions

Drug Name

Risk Level

Description

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Ibuprofen.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Ibuprofen.

Enasidenib

Major

The metabolism of Enasidenib can be decreased when combined with Ibuprofen.

Erlotinib

Major

The metabolism of Erlotinib can be decreased when combined with Ibuprofen.

Fluorouracil

Major

The metabolism of Fluorouracil can be decreased when combined with Ibuprofen.

Nuprin Toxicity & Overdose Risk

Taking more than 99 mg/kg of ibuprofen can cause abdominal pain, nausea, vomiting, fatigue, dizziness, vertigo, insomnia, headaches, fainting, ringing in the ears, depression of the central nervous system, seizures, and difficulty breathing. Very young pediatric patients may experience metabolic acidosis, abnormal liver function, high potassium levels, kidney failure, coma, and apnea. The toxic dose of ibuprofen for rats is 636 mg/kg, for mice is 740 mg/kg, and for guinea pigs is 495 mg/kg.

Nuprin Novel Uses: Which Conditions Have a Clinical Trial Featuring Nuprin?

531 active studies are assessing the potential of Nuprin to reduce symptoms of Rheumatoid Arthritis, Chronic Pain and Migraines.

Condition

Clinical Trials

Trial Phases

Premature Birth

23 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1

Rheumatoid Arthritis

54 Actively Recruiting

Not Applicable, Phase 3, Phase 1, Phase 2, Phase 4

Influenza

0 Actively Recruiting

Pain

0 Actively Recruiting

Aquaporin 2

3 Actively Recruiting

Phase 3, Not Applicable, Phase 2

Chronic Pain

106 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Phase 3, Early Phase 1, Phase 1

Migraine

43 Actively Recruiting

Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1

Muscle Relaxation

0 Actively Recruiting

Juvenile arthritis

6 Actively Recruiting

Phase 2, Not Applicable, Phase 3

Migraine

13 Actively Recruiting

Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4

Acute Pain

2 Actively Recruiting

Not Applicable, Phase 1

Primary Dysmenorrhoea

2 Actively Recruiting

Not Applicable

Nasal Congestion

0 Actively Recruiting

Catarrh

0 Actively Recruiting

Pericarditis

2 Actively Recruiting

Phase 2, Phase 3

Arthritis, Gouty

0 Actively Recruiting

Insomnia

0 Actively Recruiting

Pain

0 Actively Recruiting

Cystic Fibrosis

0 Actively Recruiting

Pain

0 Actively Recruiting

Nuprin Reviews: What are patients saying about Nuprin?

5

Patient Review

3/16/2009

Nuprin for Pain

3.7

Patient Review

2/6/2020

Nuprin for Migraine Headache

IT TOOK THE HEADACHE AWAY BUT IT MADE MY WHOOOLE BODY ITCH

Patient Q&A Section about nuprin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What drug is Nuprin?

"Nuprin Ibuprofen is an NSAID that is used to treat mild to moderate pain, and helps to relieve symptoms of arthritis such as inflammation, swelling, stiffness, and joint pain."

Answered by AI

Why was Nuprin taken off the market?

"New jersey's pharmacists believe that ibuprofen, while safe and effective as a prescription drug, may be dangerous for those with heart or kidney trouble, hypertension, or other medical conditions when used without a prescription in Advil and Nuprin. This is especially true for pregnant women."

Answered by AI

What are Nuprin tablets used for?

"Nuprin is taken to reduce the risk of blood clots forming and thereby prevent further: • heart attacks • strokes • cardiovascular problems in patients who suffer from stable angina (a type of chest pain)."

Answered by AI

Is there aspirin in Nuprin?

"Aspirin that is taken once a day at a low dose is a medication that prevents blood clotting. It is also called acetylsalicylic acid. You need a prescription to be able to get it, and it is also sold under the brand names Caprin, Nuprin, and Nu-seals."

Answered by AI

Clinical Trials for Nuprin

Image of Alberta Children's Hospital in Calgary, Canada.

Therapeutic Cuddling for Pain in Critically Ill Children

< 65
All Sexes
Calgary, Canada

2.1 CONTEXT Pain and agitation are common comorbidities of pediatric critical illness due to both underlying disease processes and ICU related therapies. These are associated with both short and long term negative sequelae including increased mortality, length of stay, rates of ICU delirium, worse sleep, increased anxiety, depression, and chronic pain. The current standard of care to manage PICU associated pain and agitation is the use of analgosedation (e.g. opioids and benzodiazepines) these too are associated with increased time on the ventilator, length of stay, ICU delirium, and long term mental health and negative neuro-cognitive outcomes. Despite recommendations for increased use of non-pharmacologic therapies in the prevention and management of PICU associated pain, agitation, delirium, and analgosedation exposure, there are currently know therapies with clear evidence of efficacy. Therapeutic cuddling (e.g. kangaroo care, clothed cuddling, comfort holding, etc.) has been shown to decrease pain and anxiety in critically ill neonates, and healthy children and adults. Positive affective touch and hugging has known physiologic benefits and has been associated with decreased pain, improved immunity, and decreased mortality. Despite the potential for this intervention to aid in the prevention and management of PICU associated pain, agitation, delirium and analgosedation exposure, little data exists on efficacy of therapeutic cuddling in critically ill children. 2.2 OBJECTIVES 2.2.1 Primary Determine the feasibility of screening, consent, randomization, and retention of participants in a pragmatic RCT of therapeutic cuddling versus standard of care in the Alberta Children's Hospital Pediatric Intensive Care Unit. 2.2.2 Secondary 1. Determine treatment fidelity of participants randomized to the intervention arm. 2. Determine the prevalence of the therapeutic cuddling intervention in those randomized to the standard of care arm. 3. Determine the feasibility of measurement of key outcomes and co-variates (i.e., pain, agitation, sedation, delirium, analgosedation exposure, parental presence). 4. Describe the experience of patients, caregivers, and healthcare professionals in delivering/receiving the therapeutic cuddling intervention. 2.3 STUDY DESIGN Pilot feasibility randomized controlled trial of a structured co-designed therapeutic cuddling intervention as compared to the standard of care in a single tertiary care PICU. 2.4 DURATION 6 months to 1 year 2.5 LOCATION, DEPARTMENTS, AND FACILITY WHERE RESEARCH WILL BE UNDERTAKEN The pediatric intensive care unit at the Alberta Children's Hospital 2.6 SAMPLE SIZE A total sample size of 112 participants (56 per arm)

Recruiting
Has No Placebo

Alberta Children's Hospital

Image of University of Oklahoma Health Campus in Oklahoma City, United States.

Disulfiram for Rheumatoid Arthritis

18 - 75
All Sexes
Oklahoma City, OK

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent joint inflammation and systemic immune activation. Obesity is common among individuals with RA and is associated with increased disease activity, reduced treatment response, and worse functional outcomes. Inflammation in adipose tissue, driven in part by activation of the NLRP3 inflammasome and downstream gasdermin D (GSDMD)-mediated pathways, may contribute to systemic inflammation and RA disease severity. Disulfiram (DSF), an FDA-approved medication for alcohol use disorder, has recently been identified as an inhibitor of GSDMD-mediated inflammatory signaling and pyroptosis. Preclinical studies suggest that DSF reduces inflammasome activation, inflammatory cytokine release, and metabolic dysfunction. This study is a 12-week, randomized, double-blind, placebo-controlled pilot trial designed to evaluate the safety, tolerability, and preliminary efficacy of DSF in overweight and obese adults with active RA despite stable disease-modifying antirheumatic drug (DMARD) therapy. Participants will be randomized to receive either DSF (250 mg daily) or placebo. The primary objective is to assess safety and tolerability. Secondary and exploratory objectives include evaluating the effects of DSF on systemic inflammation, RA disease activity, metabolic parameters, and adipose tissue inflammasome activation. Findings from this study will inform the feasibility and design of larger clinical trials targeting GSDMD-mediated inflammation in RA.

Phase 2
Waitlist Available

University of Oklahoma Health Campus

Beatriz Y Hanaoka, MD, MSc

Image of Hopital general de Montreal in Montreal, Canada.

Nurse-led Telehealth for Rheumatoid Arthritis

18+
All Sexes
Montreal, Canada

Canada urgently needs new ways to provide rheumatology care that improve treatment and make it easier for people to get high-quality care. E-health technology is a new and promising way to do this, but it hasn't been studied much yet in rheumatology. The investigators will test a new way to help people with rheumatoid arthritis at four clinics in Quebec. This study will check if the new approach is easy to use, fits well into the clinics' daily routine, and if both patients and healthcare workers find it helpful and acceptable. This new approach involves nurses helping patients check their own health from home using an online platform. 104 adults who have rheumatoid arthritis and who have had a flare-up or a change in their medication in the last three months, will participate. Some will start using the online self-monitoring tool right away for 16 months, while others will continue with their usual care for 8 months before trying the tool. During the time they use the tool, they will fill out monthly online questionnaires to check their health. A rheumatology nurse will review their answers, suggest any needed care, provide personalized health information, and be available to answer questions through messages. This new way of care, where nurses help patients monitor their rheumatoid arthritis from home, helps make better use of limited specialist time. It's more convenient for patients, especially those who live far away, and helps meet their needs between regular doctor visits while keeping the quality of care high.

Waitlist Available
Has No Placebo

Hopital general de Montreal (+3 Sites)

Laetitia Michou, MD PhD

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We made a collection of clinical trials featuring Nuprin, we think they might fit your search criteria.
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Image of Marquette University in Milwaukee, United States.

Exercise for Pain

35 - 65
All Sexes
Milwaukee, WI

The goal of this clinical trial is to determine how male and female former athletes experience pain and respond to moderate-intensity exercise (strength versus aerobic) compared with both current master's athletes and nonathletes. The main questions this study aims to address are: 1. How do former athletes, master's athletes, and nonathletes experience pain? 2. How do different types of moderate-intensity exercise (strength versus aerobic exercise) influence pain in former athletes, master's athletes, and nonathletes? Participants will complete 3 different testing sessions: 1. Baseline testing including assessments of strength, cardiorespiratory fitness, and pain; 2. Strength exercise: pain assessments will occur before and after moderate-intensity strength training exercise; 3. Aerobic exercise: pain assessments will occur before and after moderate-intensity aerobic exercise. There will be a washout period of approximately one week or greater between each of the three different testing sessions. The order of conditions (strength versus aerobic exercise) will be randomized (crossover randomized trial design).

Recruiting
Has No Placebo

Marquette University

Jacob J Capin, DPT, PhD

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We made a collection of clinical trials featuring Nuprin, we think they might fit your search criteria.
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Image of Kingston Health Science Center in Kingston, Canada.

Caffeine for Premature Birth

No minimum age - 28
All Sexes
Kingston, Canada

The goal of this pilot clinical trial is to test if it is possible to conduct a larger study on the use of caffeine in preterm infants who need help with their breathing. It will also look at whether caffeine helps these infants get healthy enough to leave the hospital sooner. The main questions the researchers aim to answer are: Can the investigators successfully recruit and keep enough participants in the study? Do the medical teams follow the study drug instructions correctly? Does caffeine reduce the total time infants spend in the Neonatal Intensive Care Unit (NICU)? Researchers will compare caffeine to a placebo (a look-alike substance with no active medicine) to see if caffeine is a helpful treatment for babies born between 28 and 34 weeks of gestation who are using a breathing machine or oxygen. Participants will: Be randomly assigned to receive either caffeine or a placebo through an IV or a feeding tube. Receive the study treatment once a day as long as they require respiratory support (and for 24 hours after they stop). Be monitored by the research team for clinical outcomes like feeding progress, breathing stability, and growth until they are discharged from the hospital.

Phase 2
Waitlist Available

Kingston Health Science Center

Image of Children's Mercy in Kansas City, United States.

Virtual Reality Neurofeedback for Migraine

10 - 16
All Sexes
Kansas City, MO

The goal of this clinical trial is to learn whether a home-based virtual reality (VR) neurofeedback program is feasible and acceptable for adolescents with migraine. The study will also explore whether the program may improve headache-related outcomes. The main questions it aims to answer are: Is it feasible to enroll, randomize, and retain adolescents with migraine in this study? Do participants complete the VR sessions and study procedures as intended? Are there preliminary signals that the VR neurofeedback program may improve headache-related disability and symptoms? Researchers will compare Immersive Neurofeedback Self-Regulation Training (INSeRT), which uses brain activity recorded from a wearable electroencephalogram (EEG) headband to guide the VR experience, to a comparison VR program that presents immersive imagery without neurofeedback or guided relaxation training. Participants will: Complete a 4-week baseline period that includes headache logs, questionnaires, and a laboratory EEG assessment Be randomly assigned to one of two VR programs Complete VR sessions at home three times per week for 4 weeks Complete questionnaires at the end of treatment and again approximately 3 months later Repeat the laboratory EEG assessment at the end of treatment

Recruiting
Has No Placebo

Children's Mercy

Mark A Connelly, PhD

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We made a collection of clinical trials featuring Nuprin, we think they might fit your search criteria.
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