Nuprin

Insomnia, Catarrh, Chronic Pain + 33 more

Treatment

13 FDA approvals

20 Active Studies for Nuprin

What is Nuprin

Ibuprofen

The Generic name of this drug

Treatment Summary

Ibuprofen is a commonly used medication to reduce inflammation and pain. It was created in 1960 as an alternative to aspirin and was finally patented in 1961. Ibuprofen was first available for medical purposes in the UK in 1969 and the US in 1974. It can be purchased over-the-counter without a prescription. Ibuprofen is made of two components, the R-enantiomer and the S-enantiomer. The S-enantiomer is believed to have a stronger effect on reducing inflammation and pain.

Motrin

is the brand name

image of different drug pills on a surface

Nuprin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Motrin

Ibuprofen

1974

2460

Approved as Treatment by the FDA

Ibuprofen, also called Motrin, is approved by the FDA for 13 uses including Acute Pain and Dysmenorrhea .

Acute Pain

Used to treat Pain, Acute in combination with Oxycodone

Dysmenorrhea

Mild pain

Gastric Ulcer

Used to treat Gastric Ulcer in combination with Famotidine

Rheumatoid Arthritis

Used to treat Rheumatoid Arthritis in combination with Famotidine

Stomach Ulcer

Used to treat Gastric Ulcer in combination with Famotidine

Pain, Acute

Used to treat Pain, Acute in combination with Oxycodone

Osteoarthritis (OA)

Used to treat Osteoarthritis (OA) in combination with Famotidine

Migraine

Osteoarthritis

Used to treat Osteoarthritis (OA) in combination with Famotidine

Fever

Headache

Menstrual Distress (Dysmenorrhea)

Effectiveness

How Nuprin Affects Patients

Ibuprofen works to reduce pain, fever, and inflammation by blocking the enzymes (COX-1 and COX-2) that produce certain hormones (prostanoids). It can also reduce the pain transmission that occurs in the spinal cord and brain. Ibuprofen helps with dental procedures by decreasing inflammation and swelling in the affected area. It can also reduce joint pain for those with rheumatic diseases. Ibuprofen is widely used in over-the-counter products to reduce menstrual pain, fever, and migraines. Low doses of ibuprofen over a long period of time may reduce neurodeg

How Nuprin works in the body

Ibuprofen is a type of medicine called a non-steroidal anti-inflammatory drug (NSAID). It works by blocking two enzymes called cyclooxygenase-1 and cyclooxygenase-2. By blocking these enzymes, ibuprofen reduces pain, fever and inflammation, while also causing some side effects like stomach ulcers.

When to interrupt dosage

The measure of Nuprin relies upon the determined illness, for example, smooth muscle relaxation before radiological techniques, Catarrh and Pain alleviation. The quantity of dosage is contingent upon the mode of delivery (e.g. Kit - Oral; Topical or Tablet) featured in the following table.

Condition

Dosage

Administration

Analgesics

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Premature Birth

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Pain

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Arthritis, Gouty

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Spasm

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Chronic Pain

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Migraine

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Migraine Disorders

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Muscle Spasticity

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Opioids

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Stomach Ulcer

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Nasal Congestion

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Cystic Fibrosis

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Dysmenorrhea

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Juvenile arthritis

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Muscle Relaxation

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Pain

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Acute Pain

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Mild pain

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Primary Dysmenorrhoea

200.0 mg, , 50.0 mg/mL, 100.0 mg/mL, 100.0 mg, 800.0 mg, 600.0 mg, 400.0 mg, 4.0 mg/mg, 4.0 mg, 20.0 mg/mL, 220.0 mg, 6.0 mg/mg, 8.0 mg/mg, 300.0 mg, 50.0 mg, 10.0 mg/mL, 256.0 mg, 5.0 mg/mL, 800.0 mg/mL, 1.0 mg/mL, 400.0 mg/mL, 0.02 mg/mg, 97.5 mg, 0.2 mg, 8.0 mg/mL, 0.2 mg/mg, 125.0 mg, 40.0 mg/mL

Oral, Tablet, film coated - Oral, , Tablet, film coated, Tablet, coated, Suspension - Oral, Tablet, coated - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Suspension, Tablet, chewable, Tablet - Oral, Tablet, Suspension / drops, Suspension / drops - Oral, Liquid, Liquid - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Capsule, coated, Capsule, coated - Oral, Tablet, chewable - Oral, Capsule, Capsule - Oral, Kit; Tablet - Oral, Kit; Tablet, Capsule; Kit, Capsule; Kit - Oral, Intravenous, Solution - Intravenous, Injection, solution - Intravenous, Injection, solution, Injection - Intravenous, Injection, Oral; Topical, Topical, Cream - Topical, Cream, Kit - Topical, Solution - Topical, Gel - Topical, Gel, Solution / drops - Oral, Kit - Ophthalmic; Oral; Respiratory (inhalation); Topical, Ophthalmic; Oral; Respiratory (inhalation); Topical, Kit - Oral; Topical, Solution / drops, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated, Cream; Kit; Liquid; Ointment; Tablet; Tablet, chewable; Tablet, film coated - Oral; Topical, Tablet, extended release, Tablet, extended release - Oral

Warnings

Nuprin has two contraindications and should not be utilized when suffering from the issues listed in the following table.

Nuprin Contraindications

Condition

Risk Level

Notes

Coronary Artery Bypass Grafting

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Nuprin.

Common Nuprin Drug Interactions

Drug Name

Risk Level

Description

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Ibuprofen.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Ibuprofen.

Enasidenib

Major

The metabolism of Enasidenib can be decreased when combined with Ibuprofen.

Erlotinib

Major

The metabolism of Erlotinib can be decreased when combined with Ibuprofen.

Fluorouracil

Major

The metabolism of Fluorouracil can be decreased when combined with Ibuprofen.

Nuprin Toxicity & Overdose Risk

Taking more than 99 mg/kg of ibuprofen can cause abdominal pain, nausea, vomiting, fatigue, dizziness, vertigo, insomnia, headaches, fainting, ringing in the ears, depression of the central nervous system, seizures, and difficulty breathing. Very young pediatric patients may experience metabolic acidosis, abnormal liver function, high potassium levels, kidney failure, coma, and apnea. The toxic dose of ibuprofen for rats is 636 mg/kg, for mice is 740 mg/kg, and for guinea pigs is 495 mg/kg.

Nuprin Novel Uses: Which Conditions Have a Clinical Trial Featuring Nuprin?

531 active studies are assessing the potential of Nuprin to reduce symptoms of Rheumatoid Arthritis, Chronic Pain and Migraines.

Condition

Clinical Trials

Trial Phases

Premature Birth

25 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Phase 4, Phase 1

Rheumatoid Arthritis

54 Actively Recruiting

Not Applicable, Phase 3, Phase 1, Phase 2, Phase 4

Influenza

0 Actively Recruiting

Pain

0 Actively Recruiting

Aquaporin 2

3 Actively Recruiting

Phase 3, Not Applicable, Phase 2

Chronic Pain

122 Actively Recruiting

Not Applicable, Phase 2, Phase 4, Phase 3, Early Phase 1, Phase 1

Migraine

48 Actively Recruiting

Phase 4, Not Applicable, Phase 1, Phase 3, Phase 2, Early Phase 1

Muscle Relaxation

0 Actively Recruiting

Juvenile arthritis

6 Actively Recruiting

Phase 2, Not Applicable, Phase 3

Migraine

15 Actively Recruiting

Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4

Acute Pain

2 Actively Recruiting

Not Applicable, Phase 1

Primary Dysmenorrhoea

2 Actively Recruiting

Not Applicable

Nasal Congestion

0 Actively Recruiting

Catarrh

0 Actively Recruiting

Pericarditis

2 Actively Recruiting

Phase 2, Phase 3

Arthritis, Gouty

0 Actively Recruiting

Insomnia

0 Actively Recruiting

Pain

0 Actively Recruiting

Cystic Fibrosis

0 Actively Recruiting

Pain

0 Actively Recruiting

Nuprin Reviews: What are patients saying about Nuprin?

5

Patient Review

3/16/2009

Nuprin for Pain

3.7

Patient Review

2/6/2020

Nuprin for Migraine Headache

IT TOOK THE HEADACHE AWAY BUT IT MADE MY WHOOOLE BODY ITCH

Patient Q&A Section about nuprin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What drug is Nuprin?

"Nuprin Ibuprofen is an NSAID that is used to treat mild to moderate pain, and helps to relieve symptoms of arthritis such as inflammation, swelling, stiffness, and joint pain."

Answered by AI

Why was Nuprin taken off the market?

"New jersey's pharmacists believe that ibuprofen, while safe and effective as a prescription drug, may be dangerous for those with heart or kidney trouble, hypertension, or other medical conditions when used without a prescription in Advil and Nuprin. This is especially true for pregnant women."

Answered by AI

What are Nuprin tablets used for?

"Nuprin is taken to reduce the risk of blood clots forming and thereby prevent further: • heart attacks • strokes • cardiovascular problems in patients who suffer from stable angina (a type of chest pain)."

Answered by AI

Is there aspirin in Nuprin?

"Aspirin that is taken once a day at a low dose is a medication that prevents blood clotting. It is also called acetylsalicylic acid. You need a prescription to be able to get it, and it is also sold under the brand names Caprin, Nuprin, and Nu-seals."

Answered by AI

Clinical Trials for Nuprin

Image of University of Texas Medical Branch in Galveston, United States.

Middle Meningeal Artery Stimulation for Migraine

18 - 100
All Sexes
Galveston, TX

This study is testing a new way to help with migraine headaches. Researchers want to see if it's safe and doable to stimulate a blood vessel in the head (called the middle meningeal artery) with microcatheters and microwires. This has never been done before for migraines and is an investigational treatment that is not part of standard migraine treatment. This stimulation would happen just before giving the standard lidocaine treatment, which is already routinely used for migraines. The goal is to see whether this new step could help improve headache outcomes. Two FDA-cleared medical devices will be used, the Cadwell Cascade 32 PRO and the Cadwell Guardian IONM System, to perform the stimulation and monitoring. In this study, the Cascade 32 PRO will be used in a way that is not part of its usual approved purpose (this is called "off-label" use) to gently deliver electrical pulses through a microcatheter. The Cadwell Guardian IONM System will be used in its normal, FDAapproved way for continuous monitoring during stimulation.

Recruiting
Has No Placebo

University of Texas Medical Branch

Peter Kan, MD,MPH

Image of Cincinnati Urogynecology Associates in Cincinnati, United States.

Nitrous Oxide for Pain During Bladder Botox Injections

18+
Female
Cincinnati, OH

The goal of this clinical trial is to assess if a mix of nitrous oxide and oxygen can improve pain control during bladder Botox injections. The primary question it aims to answer is: Does using nitrous oxide lower the overall level of pain during the procedure? Researchers will compare a 50:50 nitrous oxide/oxygen mixture (administered with the Pro-Nox system) plus standard care (with lidocaine in the bladder) to sham mask plus standard care to see if nitrous oxide works better for lowering pain. Participants will: * Receive their bladder Botox injection in the office setting * Either use nitrous oxide/oxygen plus standard care during the procedure, or sham mask plus standard care * Answer brief questions about pain, anxiety, satisfaction, and willingness to repeat the procedure

Phase 4
Waitlist Available

Cincinnati Urogynecology Associates (+1 Sites)

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Image of University of North Carolina at Chapel Hill in Chapel Hill, United States.

Pain Medicines for Period Pain in Crohn's Disease

18 - 44
Female
Chapel Hill, NC

The purpose of this pilot study is to prepare for a larger study that will compare the effectiveness and safety of two common pain medications, ibuprofen and acetaminophen, to help treat period cramps in women with Crohn's disease. The goal of this study is to identify any challenges in running a larger study. The investigators will track how many people sign up for the study, how well participants follow the study plan, how many people stay in the study, and whether they are able to complete all the study activities, such as taking the medication, submitting samples, and filling out surveys. During the study, participants will undergo a screening visit that includes a blood draw, physical exam, pregnancy test, stool testing, and complete surveys about Crohn's disease and menstrual cycles. Once this visit is complete, the rest of the study will occur at home. Participants will be assigned to take either ibuprofen or acetaminophen to help treat period cramps for four menstrual cycles in a row. Participants will take ibuprofen for two cycles and acetaminophen for two cycles. Participants will know which medication is being taken at any given time, but the order in which they take the medications will be randomly assigned. Before each menstrual cycle, participants will submit a stool sample and fill out a short (\<1 minute) electronic survey. When participants develop period cramps, they will take the assigned medication for three days and fill out short (\<1 minute) electronic surveys about their cramps. After participants finish taking the medication for three days, they will submit another stool sample and fill out two more short (\<1 minute) electronic surveys. After have completing this process for four menstrual cycles, a remote interview with a researcher to give feedback on the study will be conducted.

Waitlist Available
Has No Placebo

University of North Carolina at Chapel Hill

Erica J Brenner, MD, MSCR

Image of AltaSciences, Inc in Cypress, United States.

SBS-147 Safety Study

18 - 55
All Sexes
Cypress, CA

This study is part of the HEAL Initiative supported by the NIH. The purpose of this study is to learn how safe the study drug, SBS-147, is and how people's bodies respond to and process it. Researchers will also look for any side effects that may occur when taking SBS-147. Some participants will receive SBS-147, and others will receive a placebo, which looks the same but does not contain any medicine. This helps researchers fairly compare results. The study includes two parts: Single-Dose Group, where Participants receive SBS-147 or placebo one time. Multiple-Dose Group, where Participants receive SBS-147 or placebo once or twice daily for 7 days.

Phase 1
Waitlist Available

AltaSciences, Inc

Jeff Reich, MD

Sparian Biosciences, Inc

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Image of Royal Alexandra Hospital in Edmonton, Canada.

Oxygen Concentration for Premature Birth

No minimum age - 10
All Sexes
Edmonton, Canada

This study is aims to examine the best amount of oxygen to give preterm babies (born between 32 and 35 weeks) right after birth. In the past, doctors used high levels of oxygen, but research has shown that using lower levels might help reduce the risk of death in full-term babies without harming brain development. However, investigators don't know the best oxygen level for babies born a little early (32 to 35 weeks). Some early data suggests that giving lower oxygen levels (FiO2 0.3) may not help babies reach healthy oxygen levels by 5 minutes after birth. This study will compare two oxygen levels-FiO2 0.6 and FiO2 0.3 to see which helps babies breathe better and need less ongoing breathing support. Researchers will study over 1,500 babies in hospitals across Alberta, Canada, to find the safest approach for these babies.

Waitlist Available
Has No Placebo

Royal Alexandra Hospital

Georg Schmolzer

Image of Arizona State University in Phoenix, United States.

App-based Breathing Program for Migraine

18+
All Sexes
Phoenix, AZ

Migraine is one of the most common neurological disorders, characterized by recurrent headaches, sensitivity to light and movement, nausea, and autonomic dysregulation. Although mind-body interventions like biofeedback have shown their efficacy, they remain underutilized due to barriers such as transportation, time constraints, lack of awareness, stigma, and cost. A targeted approach to enhancing HRV is HRV biofeedback (HRVB), a technique using visual or auditory feedback to help people regulate HRV through slow-paced breathing and positive emotional regulation to promote ANS balance and emotional resilience. Investigators will conduct a remotely delivered pilot RCT of an 8-week, 10 min/day, novel app-based HRVB intervention compared to a sham control intervention (matching intervention time and attention with no biofeedback component) in adult with chronic migraine. Investigators hypothesize data collected from the study will: a) support the feasibility and acceptability of the remotely delivered app-based HRVB intervention among adults with chronic migraine, and b) provide insights into refining the intervention by examining patterns of change in migraine and psychological outcomes from pre- to post-intervention.

Waitlist Available
Online Trial

Arizona State University

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We made a collection of clinical trials featuring Nuprin, we think they might fit your search criteria.
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