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What is Ninlaro
IxazomibThe Generic name of this drug
Treatment SummaryIxazomib is an oral medication used to treat multiple myeloma. It is taken in combination with lenalidomide and dexamethasone, and is usually prescribed to patients who have received at least one prior therapy. It works by inhibiting proteasomes (proteins that help break down proteins) and is sold under the brand name Ninlaro. It was found to be as effective as bortezomib (the first proteasome inhibitor approved for multiple myeloma) in controlling myeloma growth and preventing bone loss. The drug was approved by the FDA in 2015.
Ninlarois the brand name
Ninlaro Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Ninlaro
Ixazomib
2015
6
Approved as Treatment by the FDA
Ixazomib, commonly known as Ninlaro, is approved by the FDA for 1 uses which include Multiple Myeloma .Multiple Myeloma
Used to treat Multiple Myeloma (MM) in combination with Dexamethasone
Effectiveness
How Ninlaro Affects PatientsTests done in laboratories have shown that ixazomib can kill multiple myeloma cells. In tests on mice, ixazomib was able to slow down tumor growth.
How Ninlaro works in the bodyIxazomib is a type of medication that stops the 20S proteasome from breaking down proteins. This causes proteins to build up and stop the cell from functioning properly, leading to cell death.
When to interrupt dosage
The amount of Ninlaro is contingent upon the diagnosed affliction. The dosage fluctuates in accordance with the technique of delivery noted in the table below.Condition
Dosage
Administration
Multiple Myeloma
, 2.3 mg, 3.0 mg, 4.0 mg
, Oral, Capsule, Capsule - Oral
Warnings
There are 20 known major drug interactions with Ninlaro.Common Ninlaro Drug Interactions
Drug Name
Risk Level
Description
Albutrepenonacog alfa
Minor
Ixazomib may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Almasilate
Minor
Ixazomib may decrease the excretion rate of Almasilate which could result in a higher serum level.
Antithrombin III human
Minor
Ixazomib may decrease the excretion rate of Antithrombin III human which could result in a higher serum level.
Baricitinib
Minor
Ixazomib may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Benserazide
Minor
Ixazomib may decrease the excretion rate of Benserazide which could result in a higher serum level.
Ninlaro Toxicity & Overdose RiskLess than 1% of patients taking Ixazomib have reported liver-related illnesses such as liver damage, fatty liver, hepatitis, or bile duct blockage. Taking Ixazomib while pregnant can cause harm to the baby, so it is important for women of reproductive age to avoid becoming pregnant while taking this drug.
Ninlaro Novel Uses: Which Conditions Have a Clinical Trial Featuring Ninlaro?
11 studies are presently assessing the utility of Ninlaro in the treatment of Multiple Myeloma.Condition
Clinical Trials
Trial Phases
Multiple Myeloma
12 Actively Recruiting
Phase 2, Phase 1
Ninlaro Reviews: What are patients saying about Ninlaro?
5Patient Review
10/25/2018 I just finished my seventh cycle of this treatment, and it was much more tolerable than Pomalyst, Kyprolis, or Velcade. That being said, all of those treatments worked for me in one way or another.
1Patient Review
10/16/2016 I will update this review in three weeks after taking the medication for an extended period of time.
Patient Q&A Section about ninlaro
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long does it take NINLARO to work?
"The median time it took for patients to see their first response was shorter when taking the NINLARO regimen compared to the placebo regimen. However, it should be noted that it took longer for some patients to see a response."
Answered by AI
Is NINLARO the same as Velcade?
"The drugs Ninlaro and Velcade are both targeted therapies for multiple myeloma that work in the same way by inhibiting proteasomes."
Answered by AI
Is NINLARO a chemotherapy drug?
"The anticancer drug Ninlaro is used to treat multiple myeloma. It is used in combination with the drugs lenalidomide and dexamethasone."
Answered by AI
What are the side effects of NINLARO?
"The following text describes some of the possible side effects of a medication. Diarrhea, nausea, vomiting, constipation, dry eyes, blurred vision, or eye redness/itching/discharge may occur. These side effects can be severe in some cases. To prevent or relieve these side effects, your doctor may prescribe medication."
Answered by AI