Natesto

Orchitis, Puberty, Delayed, Gonadotrophin releasing hormone deficiency + 9 more

Treatment

17 FDA approvals

3 Active Studies for Natesto

What is Natesto

Testosterone

The Generic name of this drug

Treatment Summary

Testosterone is a male sex hormone used to treat conditions caused by low or absent testosterone levels in the body. Testosterone works by activating certain genes in the body which are responsible for the development of male reproductive organs and secondary sex characteristics. Testosterone was first isolated and synthesized in 1935.

Androderm

is the brand name

image of different drug pills on a surface

Natesto Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Androderm

Testosterone

1995

90

Approved as Treatment by the FDA

Testosterone, commonly known as Androderm, is approved by the FDA for 17 uses including Spermatic Cord Torsion and Puberty, Delayed .

Spermatic Cord Torsion

Helps manage Torsion of testis

Puberty, Delayed

Used to treat Puberty, Delayed in combination with Testosterone enanthate

Hypogonadism

Helps manage Hypergonadotropic Hypogonadism

Breast

Used to treat inoperable, metastatic Breast cancer in combination with Testosterone enanthate

Torsion of testis

Helps manage Torsion of testis

Hypothalamo-pituitary disorder

Helps manage Hypothalamo-pituitary disorder

Delayed Puberty

Used to treat Puberty, Delayed in combination with Testosterone enanthate

Orchitis

Helps manage Orchitis

Orchitis

Helps manage Orchitis

Hypergonadotropic Hypogonadism

Helps manage Hypergonadotropic Hypogonadism

Hypogonadotropic hypogonadism

Gonadotrophin releasing hormone deficiency

Helps manage Gonadotrophin releasing hormone deficiency

1 to 5 years post-menopausal

Used to treat 1 to 5 years post-menopausal in combination with Testosterone enanthate

Anorchia

Helps manage vanishing testis syndrome

Orchidectomy

Helps manage Orchidectomy

inoperable, metastatic Breast cancer

Used to treat inoperable, metastatic Breast cancer in combination with Testosterone enanthate

Hypogonadism

Helps manage Idiopathic Hypogonadotropic Hypogonadism

Effectiveness

How Natesto Affects Patients

Testosterone helps to create the physical traits and organs associated with being male. How long it works can vary from person to person, but it typically lasts 10-100 minutes. This drug is considered safe, as normal testosterone levels in adult men range from 300-1000ng/dL. It's important to be aware that this drug can be transferred to children through skin contact, so patients should be warned of this risk.

How Natesto works in the body

The androgen receptor is a protein found in cells throughout the body. It binds to male hormones like testosterone, allowing them to enter the cell. The androgen receptor can then move into the nucleus, which activates the genes needed for male development. This includes the growth of organs like the prostate, penis, and scrotum, as well as secondary sexual characteristics like facial and body hair.

When to interrupt dosage

The recommended quantity of Natesto is contingent upon the diagnosed condition, such as Gonadotrophin releasing hormone deficiency, Orchidectomy and Orchitis. The amount of dosage shifts in line with the method of administration specified in the table below.

Condition

Dosage

Administration

Breast

, 0.01 mg/mg, 0.05 mg/mg, 75.0 mg, 100.0 mg/mL, 0.0162 mg/mg, 0.2 mg/hour, 0.4 mg/hour, 200.0 mg/mL, 30.0 mg/mL, 30.0 mg, 100.0 mg, 200.0 mg, 37.5 mg, 25.0 mg, 50.0 mg, 87.5 mg, 40.0 mg, 1.0 %, 4.5 %, 0.03 mg/hour, 5.5 mg, 0.1 mg/mg, 250.0 mg/mL, 0.0125 mg/mg, 12.5 mg, 12.2 mg, 24.3 mg, 0.025 mg/mg, 0.25 mg/hour, 0.5 mg/hour, 0.055 mg/mg, 0.00162 mg/mg, 0.02025 mg/mg, 0.0405 mg/mg, 30.0 mg/pump actuation, 12.5 mg/pump actuation, 60.0 mg

, Transdermal, Gel - Transdermal, Gel, Injection, solution - Intramuscular, Intramuscular, Gel - Topical, Topical, Subcutaneous, Pellet - Subcutaneous, Pellet, Solution, Solution - Topical, Tablet, Buccal, Pellet - Oral, Oral, Capsule, Capsule - Oral, Gel - Nasal, Patch - Transdermal, Nasal, Gel, metered - Topical, Gel, metered, Patch, Solution - Transdermal, Gel, metered - Nasal, Gel, metered - Transdermal, Pellet, implantable - Subcutaneous, Pellet, implantable, Pellet, implantable - Parenteral, Parenteral, Injection - Intramuscular, Tablet - Buccal, Suspension, Suspension - Intramuscular

Orchitis

, 0.01 mg/mg, 0.05 mg/mg, 75.0 mg, 100.0 mg/mL, 0.0162 mg/mg, 0.2 mg/hour, 0.4 mg/hour, 200.0 mg/mL, 30.0 mg/mL, 30.0 mg, 100.0 mg, 200.0 mg, 37.5 mg, 25.0 mg, 50.0 mg, 87.5 mg, 40.0 mg, 1.0 %, 4.5 %, 0.03 mg/hour, 5.5 mg, 0.1 mg/mg, 250.0 mg/mL, 0.0125 mg/mg, 12.5 mg, 12.2 mg, 24.3 mg, 0.025 mg/mg, 0.25 mg/hour, 0.5 mg/hour, 0.055 mg/mg, 0.00162 mg/mg, 0.02025 mg/mg, 0.0405 mg/mg, 30.0 mg/pump actuation, 12.5 mg/pump actuation, 60.0 mg

, Transdermal, Gel - Transdermal, Gel, Injection, solution - Intramuscular, Intramuscular, Gel - Topical, Topical, Subcutaneous, Pellet - Subcutaneous, Pellet, Solution, Solution - Topical, Tablet, Buccal, Pellet - Oral, Oral, Capsule, Capsule - Oral, Gel - Nasal, Patch - Transdermal, Nasal, Gel, metered - Topical, Gel, metered, Patch, Solution - Transdermal, Gel, metered - Nasal, Gel, metered - Transdermal, Pellet, implantable - Subcutaneous, Pellet, implantable, Pellet, implantable - Parenteral, Parenteral, Injection - Intramuscular, Tablet - Buccal, Suspension, Suspension - Intramuscular

Puberty, Delayed

, 0.01 mg/mg, 0.05 mg/mg, 75.0 mg, 100.0 mg/mL, 0.0162 mg/mg, 0.2 mg/hour, 0.4 mg/hour, 200.0 mg/mL, 30.0 mg/mL, 30.0 mg, 100.0 mg, 200.0 mg, 37.5 mg, 25.0 mg, 50.0 mg, 87.5 mg, 40.0 mg, 1.0 %, 4.5 %, 0.03 mg/hour, 5.5 mg, 0.1 mg/mg, 250.0 mg/mL, 0.0125 mg/mg, 12.5 mg, 12.2 mg, 24.3 mg, 0.025 mg/mg, 0.25 mg/hour, 0.5 mg/hour, 0.055 mg/mg, 0.00162 mg/mg, 0.02025 mg/mg, 0.0405 mg/mg, 30.0 mg/pump actuation, 12.5 mg/pump actuation, 60.0 mg

, Transdermal, Gel - Transdermal, Gel, Injection, solution - Intramuscular, Intramuscular, Gel - Topical, Topical, Subcutaneous, Pellet - Subcutaneous, Pellet, Solution, Solution - Topical, Tablet, Buccal, Pellet - Oral, Oral, Capsule, Capsule - Oral, Gel - Nasal, Patch - Transdermal, Nasal, Gel, metered - Topical, Gel, metered, Patch, Solution - Transdermal, Gel, metered - Nasal, Gel, metered - Transdermal, Pellet, implantable - Subcutaneous, Pellet, implantable, Pellet, implantable - Parenteral, Parenteral, Injection - Intramuscular, Tablet - Buccal, Suspension, Suspension - Intramuscular

Gonadotrophin releasing hormone deficiency

, 0.01 mg/mg, 0.05 mg/mg, 75.0 mg, 100.0 mg/mL, 0.0162 mg/mg, 0.2 mg/hour, 0.4 mg/hour, 200.0 mg/mL, 30.0 mg/mL, 30.0 mg, 100.0 mg, 200.0 mg, 37.5 mg, 25.0 mg, 50.0 mg, 87.5 mg, 40.0 mg, 1.0 %, 4.5 %, 0.03 mg/hour, 5.5 mg, 0.1 mg/mg, 250.0 mg/mL, 0.0125 mg/mg, 12.5 mg, 12.2 mg, 24.3 mg, 0.025 mg/mg, 0.25 mg/hour, 0.5 mg/hour, 0.055 mg/mg, 0.00162 mg/mg, 0.02025 mg/mg, 0.0405 mg/mg, 30.0 mg/pump actuation, 12.5 mg/pump actuation, 60.0 mg

, Transdermal, Gel - Transdermal, Gel, Injection, solution - Intramuscular, Intramuscular, Gel - Topical, Topical, Subcutaneous, Pellet - Subcutaneous, Pellet, Solution, Solution - Topical, Tablet, Buccal, Pellet - Oral, Oral, Capsule, Capsule - Oral, Gel - Nasal, Patch - Transdermal, Nasal, Gel, metered - Topical, Gel, metered, Patch, Solution - Transdermal, Gel, metered - Nasal, Gel, metered - Transdermal, Pellet, implantable - Subcutaneous, Pellet, implantable, Pellet, implantable - Parenteral, Parenteral, Injection - Intramuscular, Tablet - Buccal, Suspension, Suspension - Intramuscular

1 to 5 years post-menopausal

, 0.01 mg/mg, 0.05 mg/mg, 75.0 mg, 100.0 mg/mL, 0.0162 mg/mg, 0.2 mg/hour, 0.4 mg/hour, 200.0 mg/mL, 30.0 mg/mL, 30.0 mg, 100.0 mg, 200.0 mg, 37.5 mg, 25.0 mg, 50.0 mg, 87.5 mg, 40.0 mg, 1.0 %, 4.5 %, 0.03 mg/hour, 5.5 mg, 0.1 mg/mg, 250.0 mg/mL, 0.0125 mg/mg, 12.5 mg, 12.2 mg, 24.3 mg, 0.025 mg/mg, 0.25 mg/hour, 0.5 mg/hour, 0.055 mg/mg, 0.00162 mg/mg, 0.02025 mg/mg, 0.0405 mg/mg, 30.0 mg/pump actuation, 12.5 mg/pump actuation, 60.0 mg

, Transdermal, Gel - Transdermal, Gel, Injection, solution - Intramuscular, Intramuscular, Gel - Topical, Topical, Subcutaneous, Pellet - Subcutaneous, Pellet, Solution, Solution - Topical, Tablet, Buccal, Pellet - Oral, Oral, Capsule, Capsule - Oral, Gel - Nasal, Patch - Transdermal, Nasal, Gel, metered - Topical, Gel, metered, Patch, Solution - Transdermal, Gel, metered - Nasal, Gel, metered - Transdermal, Pellet, implantable - Subcutaneous, Pellet, implantable, Pellet, implantable - Parenteral, Parenteral, Injection - Intramuscular, Tablet - Buccal, Suspension, Suspension - Intramuscular

Hypothalamo-pituitary disorder

, 0.01 mg/mg, 0.05 mg/mg, 75.0 mg, 100.0 mg/mL, 0.0162 mg/mg, 0.2 mg/hour, 0.4 mg/hour, 200.0 mg/mL, 30.0 mg/mL, 30.0 mg, 100.0 mg, 200.0 mg, 37.5 mg, 25.0 mg, 50.0 mg, 87.5 mg, 40.0 mg, 1.0 %, 4.5 %, 0.03 mg/hour, 5.5 mg, 0.1 mg/mg, 250.0 mg/mL, 0.0125 mg/mg, 12.5 mg, 12.2 mg, 24.3 mg, 0.025 mg/mg, 0.25 mg/hour, 0.5 mg/hour, 0.055 mg/mg, 0.00162 mg/mg, 0.02025 mg/mg, 0.0405 mg/mg, 30.0 mg/pump actuation, 12.5 mg/pump actuation, 60.0 mg

, Transdermal, Gel - Transdermal, Gel, Injection, solution - Intramuscular, Intramuscular, Gel - Topical, Topical, Subcutaneous, Pellet - Subcutaneous, Pellet, Solution, Solution - Topical, Tablet, Buccal, Pellet - Oral, Oral, Capsule, Capsule - Oral, Gel - Nasal, Patch - Transdermal, Nasal, Gel, metered - Topical, Gel, metered, Patch, Solution - Transdermal, Gel, metered - Nasal, Gel, metered - Transdermal, Pellet, implantable - Subcutaneous, Pellet, implantable, Pellet, implantable - Parenteral, Parenteral, Injection - Intramuscular, Tablet - Buccal, Suspension, Suspension - Intramuscular

Orchidectomy

, 0.01 mg/mg, 0.05 mg/mg, 75.0 mg, 100.0 mg/mL, 0.0162 mg/mg, 0.2 mg/hour, 0.4 mg/hour, 200.0 mg/mL, 30.0 mg/mL, 30.0 mg, 100.0 mg, 200.0 mg, 37.5 mg, 25.0 mg, 50.0 mg, 87.5 mg, 40.0 mg, 1.0 %, 4.5 %, 0.03 mg/hour, 5.5 mg, 0.1 mg/mg, 250.0 mg/mL, 0.0125 mg/mg, 12.5 mg, 12.2 mg, 24.3 mg, 0.025 mg/mg, 0.25 mg/hour, 0.5 mg/hour, 0.055 mg/mg, 0.00162 mg/mg, 0.02025 mg/mg, 0.0405 mg/mg, 30.0 mg/pump actuation, 12.5 mg/pump actuation, 60.0 mg

, Transdermal, Gel - Transdermal, Gel, Injection, solution - Intramuscular, Intramuscular, Gel - Topical, Topical, Subcutaneous, Pellet - Subcutaneous, Pellet, Solution, Solution - Topical, Tablet, Buccal, Pellet - Oral, Oral, Capsule, Capsule - Oral, Gel - Nasal, Patch - Transdermal, Nasal, Gel, metered - Topical, Gel, metered, Patch, Solution - Transdermal, Gel, metered - Nasal, Gel, metered - Transdermal, Pellet, implantable - Subcutaneous, Pellet, implantable, Pellet, implantable - Parenteral, Parenteral, Injection - Intramuscular, Tablet - Buccal, Suspension, Suspension - Intramuscular

Spermatic Cord Torsion

, 0.01 mg/mg, 0.05 mg/mg, 75.0 mg, 100.0 mg/mL, 0.0162 mg/mg, 0.2 mg/hour, 0.4 mg/hour, 200.0 mg/mL, 30.0 mg/mL, 30.0 mg, 100.0 mg, 200.0 mg, 37.5 mg, 25.0 mg, 50.0 mg, 87.5 mg, 40.0 mg, 1.0 %, 4.5 %, 0.03 mg/hour, 5.5 mg, 0.1 mg/mg, 250.0 mg/mL, 0.0125 mg/mg, 12.5 mg, 12.2 mg, 24.3 mg, 0.025 mg/mg, 0.25 mg/hour, 0.5 mg/hour, 0.055 mg/mg, 0.00162 mg/mg, 0.02025 mg/mg, 0.0405 mg/mg, 30.0 mg/pump actuation, 12.5 mg/pump actuation, 60.0 mg

, Transdermal, Gel - Transdermal, Gel, Injection, solution - Intramuscular, Intramuscular, Gel - Topical, Topical, Subcutaneous, Pellet - Subcutaneous, Pellet, Solution, Solution - Topical, Tablet, Buccal, Pellet - Oral, Oral, Capsule, Capsule - Oral, Gel - Nasal, Patch - Transdermal, Nasal, Gel, metered - Topical, Gel, metered, Patch, Solution - Transdermal, Gel, metered - Nasal, Gel, metered - Transdermal, Pellet, implantable - Subcutaneous, Pellet, implantable, Pellet, implantable - Parenteral, Parenteral, Injection - Intramuscular, Tablet - Buccal, Suspension, Suspension - Intramuscular

Hypogonadism

, 0.01 mg/mg, 0.05 mg/mg, 75.0 mg, 100.0 mg/mL, 0.0162 mg/mg, 0.2 mg/hour, 0.4 mg/hour, 200.0 mg/mL, 30.0 mg/mL, 30.0 mg, 100.0 mg, 200.0 mg, 37.5 mg, 25.0 mg, 50.0 mg, 87.5 mg, 40.0 mg, 1.0 %, 4.5 %, 0.03 mg/hour, 5.5 mg, 0.1 mg/mg, 250.0 mg/mL, 0.0125 mg/mg, 12.5 mg, 12.2 mg, 24.3 mg, 0.025 mg/mg, 0.25 mg/hour, 0.5 mg/hour, 0.055 mg/mg, 0.00162 mg/mg, 0.02025 mg/mg, 0.0405 mg/mg, 30.0 mg/pump actuation, 12.5 mg/pump actuation, 60.0 mg

, Transdermal, Gel - Transdermal, Gel, Injection, solution - Intramuscular, Intramuscular, Gel - Topical, Topical, Subcutaneous, Pellet - Subcutaneous, Pellet, Solution, Solution - Topical, Tablet, Buccal, Pellet - Oral, Oral, Capsule, Capsule - Oral, Gel - Nasal, Patch - Transdermal, Nasal, Gel, metered - Topical, Gel, metered, Patch, Solution - Transdermal, Gel, metered - Nasal, Gel, metered - Transdermal, Pellet, implantable - Subcutaneous, Pellet, implantable, Pellet, implantable - Parenteral, Parenteral, Injection - Intramuscular, Tablet - Buccal, Suspension, Suspension - Intramuscular

Hypogonadotropic hypogonadism

, 0.01 mg/mg, 0.05 mg/mg, 75.0 mg, 100.0 mg/mL, 0.0162 mg/mg, 0.2 mg/hour, 0.4 mg/hour, 200.0 mg/mL, 30.0 mg/mL, 30.0 mg, 100.0 mg, 200.0 mg, 37.5 mg, 25.0 mg, 50.0 mg, 87.5 mg, 40.0 mg, 1.0 %, 4.5 %, 0.03 mg/hour, 5.5 mg, 0.1 mg/mg, 250.0 mg/mL, 0.0125 mg/mg, 12.5 mg, 12.2 mg, 24.3 mg, 0.025 mg/mg, 0.25 mg/hour, 0.5 mg/hour, 0.055 mg/mg, 0.00162 mg/mg, 0.02025 mg/mg, 0.0405 mg/mg, 30.0 mg/pump actuation, 12.5 mg/pump actuation, 60.0 mg

, Transdermal, Gel - Transdermal, Gel, Injection, solution - Intramuscular, Intramuscular, Gel - Topical, Topical, Subcutaneous, Pellet - Subcutaneous, Pellet, Solution, Solution - Topical, Tablet, Buccal, Pellet - Oral, Oral, Capsule, Capsule - Oral, Gel - Nasal, Patch - Transdermal, Nasal, Gel, metered - Topical, Gel, metered, Patch, Solution - Transdermal, Gel, metered - Nasal, Gel, metered - Transdermal, Pellet, implantable - Subcutaneous, Pellet, implantable, Pellet, implantable - Parenteral, Parenteral, Injection - Intramuscular, Tablet - Buccal, Suspension, Suspension - Intramuscular

Anorchia

, 0.01 mg/mg, 0.05 mg/mg, 75.0 mg, 100.0 mg/mL, 0.0162 mg/mg, 0.2 mg/hour, 0.4 mg/hour, 200.0 mg/mL, 30.0 mg/mL, 30.0 mg, 100.0 mg, 200.0 mg, 37.5 mg, 25.0 mg, 50.0 mg, 87.5 mg, 40.0 mg, 1.0 %, 4.5 %, 0.03 mg/hour, 5.5 mg, 0.1 mg/mg, 250.0 mg/mL, 0.0125 mg/mg, 12.5 mg, 12.2 mg, 24.3 mg, 0.025 mg/mg, 0.25 mg/hour, 0.5 mg/hour, 0.055 mg/mg, 0.00162 mg/mg, 0.02025 mg/mg, 0.0405 mg/mg, 30.0 mg/pump actuation, 12.5 mg/pump actuation, 60.0 mg

, Transdermal, Gel - Transdermal, Gel, Injection, solution - Intramuscular, Intramuscular, Gel - Topical, Topical, Subcutaneous, Pellet - Subcutaneous, Pellet, Solution, Solution - Topical, Tablet, Buccal, Pellet - Oral, Oral, Capsule, Capsule - Oral, Gel - Nasal, Patch - Transdermal, Nasal, Gel, metered - Topical, Gel, metered, Patch, Solution - Transdermal, Gel, metered - Nasal, Gel, metered - Transdermal, Pellet, implantable - Subcutaneous, Pellet, implantable, Pellet, implantable - Parenteral, Parenteral, Injection - Intramuscular, Tablet - Buccal, Suspension, Suspension - Intramuscular

Hypogonadism

, 0.01 mg/mg, 0.05 mg/mg, 75.0 mg, 100.0 mg/mL, 0.0162 mg/mg, 0.2 mg/hour, 0.4 mg/hour, 200.0 mg/mL, 30.0 mg/mL, 30.0 mg, 100.0 mg, 200.0 mg, 37.5 mg, 25.0 mg, 50.0 mg, 87.5 mg, 40.0 mg, 1.0 %, 4.5 %, 0.03 mg/hour, 5.5 mg, 0.1 mg/mg, 250.0 mg/mL, 0.0125 mg/mg, 12.5 mg, 12.2 mg, 24.3 mg, 0.025 mg/mg, 0.25 mg/hour, 0.5 mg/hour, 0.055 mg/mg, 0.00162 mg/mg, 0.02025 mg/mg, 0.0405 mg/mg, 30.0 mg/pump actuation, 12.5 mg/pump actuation, 60.0 mg

, Transdermal, Gel - Transdermal, Gel, Injection, solution - Intramuscular, Intramuscular, Gel - Topical, Topical, Subcutaneous, Pellet - Subcutaneous, Pellet, Solution, Solution - Topical, Tablet, Buccal, Pellet - Oral, Oral, Capsule, Capsule - Oral, Gel - Nasal, Patch - Transdermal, Nasal, Gel, metered - Topical, Gel, metered, Patch, Solution - Transdermal, Gel, metered - Nasal, Gel, metered - Transdermal, Pellet, implantable - Subcutaneous, Pellet, implantable, Pellet, implantable - Parenteral, Parenteral, Injection - Intramuscular, Tablet - Buccal, Suspension, Suspension - Intramuscular

Warnings

Natesto Contraindications

Condition

Risk Level

Notes

suspected pregnancy

Do Not Combine

Breast Cancer

Do Not Combine

There are 20 known major drug interactions with Natesto.

Common Natesto Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Testosterone.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Testosterone.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Testosterone.

Aminophylline

Major

The metabolism of Aminophylline can be increased when combined with Testosterone.

Astemizole

Major

The metabolism of Astemizole can be increased when combined with Testosterone.

Natesto Toxicity & Overdose Risk

There is not much information on overdosing on topical testosterone products. However, if someone takes an injectable form of this drug, they may suffer a stroke. To treat an overdose, stop taking the testosterone, wash off any topical product with soap and water, and get medical help for any symptoms.

image of a doctor in a lab doing drug, clinical research

Natesto Novel Uses: Which Conditions Have a Clinical Trial Featuring Natesto?

Presently, 10 active clinical trials are analyzing the potential of Natesto to reduce the symptoms of Orchitis, Testicular Torsion and Hypothalamo-pituitary Dysfunction.

Condition

Clinical Trials

Trial Phases

Hypothalamo-pituitary disorder

0 Actively Recruiting

1 to 5 years post-menopausal

0 Actively Recruiting

Hypogonadism

0 Actively Recruiting

Orchitis

0 Actively Recruiting

Spermatic Cord Torsion

0 Actively Recruiting

Orchidectomy

0 Actively Recruiting

Breast

0 Actively Recruiting

Hypogonadotropic hypogonadism

0 Actively Recruiting

Puberty, Delayed

0 Actively Recruiting

Gonadotrophin releasing hormone deficiency

0 Actively Recruiting

Anorchia

0 Actively Recruiting

Hypogonadism

3 Actively Recruiting

Phase 2

Natesto Reviews: What are patients saying about Natesto?

5

Patient Review

5/1/2018

Natesto for Deficiency of Luteinizing Hormone-Releasing Hormone

I really disliked this medication. It was a huge hassle to have to use it three times a day, and I always forgot the dose during work hours. Additionally, the gel felt really weird in my nose and made it feel constantly stuffed up.

5

Patient Review

3/20/2018

Natesto for Primary Testicular Failure due to Inflammation of Testis

I felt more energetic pretty much as soon as I started taking this medication. Another big plus was that I started waking up on my own in the mornings, something I hadn't been able to do for years.

5

Patient Review

10/21/2022

Natesto for Deficiency of a Substance that Promotes Masculinization

I'm on day three of using this product, and I've already noticed more energy and a higher sex drive. At the gym, I feel like I have the extra boost of youth.

5

Patient Review

10/18/2015

Natesto for Deficient Activity of the Testis

5

Patient Review

11/10/2017

Natesto for Pituitary Hormone Deficiency

I was using Axiron, but found it really inconvenient because I had to shower before each application. When I heard about Natesto, which is applied nasally, I was hesitant; however, it has been very easy to use and I'm much more pleased with it. It's not any cheaper, but the convenience factor once you get used to it makes it worth the price tag.

4.7

Patient Review

5/30/2019

Natesto for Deficient Activity of the Testis

One downside to this treatment is that it can clog your nasal passages if you're not careful. Make sure to massage the area around your nose while using it for best results.

4.3

Patient Review

8/6/2020

Natesto for Deficient Activity of the Testis

I've been using Natesto for almost three months now and I'm really happy with the results. My sex drive has increased, as well as my testicle size (which was decreased by other TRT treatments).

4.3

Patient Review

3/14/2019

Natesto for Deficiency of a Substance that Promotes Masculinization

Out of all the options I've tried, this one is really the best.

4.3

Patient Review

12/21/2015

Natesto for Deficient Activity of the Testis

4

Patient Review

12/13/2018

Natesto for Deficient Activity of the Testis

I found this treatment to be much more effective than other options I've tried, like shots and axiron. There are also fewer ups and downs, which is great.

3.7

Patient Review

6/10/2020

Natesto for Deficient Activity of the Testis

I have tried injections, androgel, axiron, pellets for my low testosterone levels with some success.

2.3

Patient Review

2/1/2022

Natesto for Deficient Activity of Testes or Ovaries due to Chemotherapy

I had a tooth implant very close to the sinus wall, I suspect this product eroded the sinus wall exposing the implant and bone causing calcification and infection both in the sinus and gums.

Patient Q&A Section about natesto

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Natesto used for?

"Natesto is a prescription medication that contains testosterone and is designed to treat adult males who have low or no testosterone due to certain medical conditions. Your healthcare provider will test your testosterone levels in your blood before you start and while you are using Natesto."

Answered by AI

Is Natesto FDA approved?

"The US Food and Drug Administration approved Natesto Nasal Gel in May for adult males who have a deficiency or absence of the hormone testosterone due to conditions like primary hypogonadism or hypogonadotropic hypogonadism."

Answered by AI

How long does it take for Natesto to work?

"Testosterone levels reach their appropriate level within 40 minutes of using Natesto. You may start seeing your symptoms improve soon after taking the medication. Use Natesto at the same time every day to keep your testosterone levels normal."

Answered by AI

Is Natesto discontinued?

"Natesto has not been permanently discontinued in the United States."

Answered by AI

Clinical Trials for Natesto

Image of ReproNovo Investigational Site in Garden City, United States.

Leflutrozole for Hypogonadotropic Hypogonadism

18 - 49
Male
Garden City, NY

The goal of this clinical trial is to evaluate three doses of the drug leflutrozole on improvement of semen quality in men with hypogonadotropic hypogonadism, a condition that affects hormone levels and fertility. It will also study the safety of leflutrozole. The main questions it aims to answer are: * Does leflutrozole improve semen quality? * What medical problems do participants experience when taking leflutrozole? Researchers will compare leflutrozole to a placebo (a look-alike substance that contains no drug). Participants will: * Take leflutrozole or a placebo orally once a week for 16 weeks. * Visit the clinic every 4 weeks for checkups and tests. * Provide semen samples to measure changes in semen quality. * Have their blood tested to measure hormone levels and ensure safety. * Be monitored for any side effects.

Phase 2
Recruiting

ReproNovo Investigational Site (+2 Sites)

Medical Director

ReproNovo Aps