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Proton Beam Therapy

Adjuvant Whole Pelvis (WP) Pencil Beam Scanning Proton Radiation (PBS PRT) for Uterine Cancer (GynWPProton Trial)

N/A

Recruiting

Led By Neil K Taunk, MD, MSCTS

Research Sponsored by Abramson Cancer Center of the University of Pennsylvania

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Histologically confirmed cervical or endometrial cancer

Indication for adjuvant whole pelvic radiation therapy, with or without systemic therapy

Timeline

Screening 3 weeks

Treatment Varies

Follow Up the survival data will be followed until up to 2 years.

Awards & highlights

GynWPProton Trial Summary

This trial is a study being conducted at multiple hospitals to test the use of a specific type of radiation therapy called Whole Pelvis Pencil Beam Scanning Proton Radiation in women who have had surgery for

Who is the study for?

This trial is for adults over 18 with confirmed cervical or endometrial cancer who need additional radiation therapy after surgery. Participants should be able to perform daily activities with minimal assistance (ECOG 0-2) and must provide written consent.Check my eligibility

What is being tested?

The study is testing a type of targeted radiation called Whole Pelvis Pencil Beam Scanning Proton Radiation in patients who have had surgery for gynecologic cancers, aiming to reduce gastrointestinal side effects.See study design

What are the potential side effects?

Potential side effects may include acute gastrointestinal issues such as nausea, vomiting, diarrhea, and abdominal pain due to the radiation targeting the pelvic area.

GynWPProton Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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My cancer is confirmed to be either cervical or endometrial.

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I am recommended to have radiation therapy for my pelvic area, with or without additional treatments.

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I am 18 years old or older.

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I am able to get out of my bed or chair and move around.

GynWPProton Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ the survival data will be followed until up to 2 years.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~the survival data will be followed until up to 2 years.

This trial's timeline: 3 weeks for screening, Varies for treatment, and the survival data will be followed until up to 2 years. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Acute clinician-reported gastrointestinal (GI) toxicity.

Secondary outcome measures

Acute clinician-reported genitourinary (GU) toxicity.

Acute patient-reported gastrointestinal (GI) and genitourinary (GU) toxicity and quality of life.

Loco-regional recurrence free survival, disease free survival, and overall survival.

GynWPProton Trial Design

1Treatment groups

Experimental Treatment

Group I: Adjuvant Whole Pelvis (WP) Pencil Beam Scanning Proton Radiation (PBS PRT)Experimental Treatment1 Intervention

The study intervention is Whole Pelvis (WP) Pencil Beam Scanning Proton Radiation (PBS PRT) as part of the definitive treatment of gynecologic cancers in the post-hysterectomy, adjuvant setting. Patients will be treated with doses of 45 or 50.4 Gy in 1.8 Gy daily fractions. The volume treated will include the whole pelvis according to Radiation Therapy Oncology Group post-hysterectomy pelvis guidelines.

0 / 4Eligibility criteria met

Find a Location

Who is running the clinical trial?

Abramson Cancer Center of the University of PennsylvaniaLead Sponsor

359 Previous Clinical Trials

105,019 Total Patients Enrolled

University of PennsylvaniaLead Sponsor

2,005 Previous Clinical Trials

42,882,262 Total Patients Enrolled

Abramson Cancer Center at Penn MedicineLead Sponsor

387 Previous Clinical Trials

145,619 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any available positions for patients in this ongoing clinical trial?

"According to the data available on clinicaltrials.gov, this study is currently actively searching for eligible participants. The initial posting of the trial was made on November 6th, 2023 and it was last updated on December 19th, 2023."

Answered by AI

What is the current number of individuals actively engaged in this clinical study?

"Indeed, the details on clinicaltrials.gov indicate that this particular study is actively seeking eligible participants. The initial posting date was recorded as November 6th, 2023 and the most recent update occurred on December 19th, 2023. To meet its objectives, the trial aims to enroll a total of 25 individuals from a single designated location."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Whole Pelvis Proton Radiation for Gynecologic Cancer

2023. "Whole Pelvis Proton Radiation for Gynecologic Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05758688.

All > Uterine Cancer