Metaglip

Type 2 Diabetes

Treatment

2 FDA approvals

20 Active Studies for Metaglip

Treatment for

Type 2 Diabetes

What is Metaglip

GlipizideThe Generic name of this drug

Treatment SummaryGlipizide is a medication used to control blood sugar levels in people with type 2 diabetes. It was introduced in 1984 and is used in many countries such as Canada and the United States. Glipizide is in a group of drugs called sulfonylureas and is usually prescribed after the drug metformin. It works by stimulating the pancreas to make more insulin, which helps lower blood sugar levels. Glipizide is absorbed quickly and starts to work quickly, reducing the risk of long-term low blood sugar levels. Glipizide was approved by the FDA in 1994 and is available under the brand

Glipizideis the brand name

Metaglip Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Glipizide

1984

471

Approved as Treatment by the FDA

Glipizide, also called Glipizide, is approved by the FDA for 2 uses such as Type 2 Diabetes Mellitus and Type 2 Diabetes .

Type 2 Diabetes Mellitus

Helps manage Type 2 Diabetes Mellitus

Type 2 Diabetes

Helps manage Type 2 Diabetes Mellitus

Effectiveness

How Metaglip Affects PatientsGlipizide is a drug used to lower blood sugar levels. It typically takes around half an hour to start working, and its effects can last for up to 24 hours. Over time, glipizide does not cause fasting insulin levels to rise, but it does help with the insulin response to meals. Its main action is to stimulate the pancreas to produce insulin, but it also has other effects in the body, such as increasing glucose uptake in muscles and the liver, and reducing lipolysis in the liver and fat cells. However, long-term use of glipizide can lead to a reduced effect on

How Metaglip works in the bodyType 2 diabetes is a condition where your body cannot regulate its blood sugar levels. Glipizide is a medication that helps people with this condition. It works by stimulating the pancreas to make more insulin, which helps the body absorb glucose from the bloodstream. Glipizide also increases the number and sensitivity of insulin receptors in the body, which helps the body use glucose better. This medication helps control blood sugar levels and reduce the risk of long-term health complications.

When to interrupt dosage

The prescribed dosage of Metaglip is contingent upon the diagnosed disorder. The dose fluctuates predicated on the mode of delivery (e.g. Tablet - Oral or Tablet, film coated - Oral) specified in the table below.

Condition

Dosage

Administration

Type 2 Diabetes

2.5 mg, , 5.0 mg, 10.0 mg

, Oral, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Metaglip has seven contraindications and should not be taken in union with any of the conditions described in the table below.Metaglip Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

Acute Coryza

Do Not Combine

Metabolic acidosis

Do Not Combine

Comatose

Do Not Combine

Comatose

Do Not Combine

Diabetic Ketoacidosis

Do Not Combine

Comatose

Do Not Combine

There are 20 known major drug interactions with Metaglip.

Common Metaglip Drug Interactions

Drug Name

Risk Level

Description

(R)-warfarin

Minor

Glipizide may increase the anticoagulant activities of (R)-warfarin.

(S)-Warfarin

Minor

Glipizide may increase the anticoagulant activities of (S)-Warfarin.

Abrocitinib

Minor

The metabolism of Abrocitinib can be decreased when combined with Glipizide.

Aclidinium

Minor

Glipizide may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Acrivastine

Minor

Glipizide may decrease the excretion rate of Acrivastine which could result in a higher serum level.

Metaglip Toxicity & Overdose RiskThe toxic dose of glipizide in rats has been found to be greater than 4000 mg/kg when taken orally and 1200 mg/kg when taken intraperitoneally. The lowest toxic dose for children is 379 μg/kg. Symptoms of an overdose may include loss of consciousness, seizures, or other neurological impairments due to severe hypoglycemia. Treatment for an overdose should include glucagon or intravenous glucose and monitoring for at least 24-48 hours as hypoglycemia may recur. Mild hypoglycemic symptoms without loss of consciousness or neurological findings should be treated with oral glucose.

image of a doctor in a lab doing drug, clinical research

Metaglip Novel Uses: Which Conditions Have a Clinical Trial Featuring Metaglip?

162 active clinical trials are examining the potential of Metaglip to manage Type 2 Diabetes.

Condition

Clinical Trials

Trial Phases

Type 2 Diabetes

177 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1

Metaglip Reviews: What are patients saying about Metaglip?

5Patient Review

11/26/2011

Metaglip for Type 2 Diabetes Mellitus

I've been taking this medication for over six years to manage my blood sugar levels and it has been very effective.

4.7Patient Review

5/13/2008

Metaglip for Type 2 Diabetes Mellitus

4Patient Review

7/5/2010

Metaglip for Type 2 Diabetes Mellitus

I haven't experienced any particularly worrisome side effects with this medication, which is why I decided to switch from Avandia.

1.7Patient Review

10/23/2008

Metaglip for Type 2 Diabetes Mellitus

I've had some issues with diarrhea since starting this medication, but nothing that I can't manage.

Patient Q&A Section about metaglip

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does metaglip have metformin?

"The medication Metaglip is a combination of the drugs glipizide and metformin, and is used to treat diabetes."

Answered by AI

What are the side effects of metaglip?

"The symptoms of the disease include nausea and vomiting, diarrhea, stomach pain or upset, joint or muscle aches pain, headache, dizziness, cold symptoms such as a stuffy nose, sneezing, or sore throat."

Answered by AI

What is metaglip used for?

"This medication for diabetes is a combination of 2 drugs (glipizide and metformin). It is used with a diet and exercise program to control high blood sugar in patients with type 2 diabetes."

Answered by AI

What is the generic name for metaglip?

"Metformin hydrochloride is an oral antihyperglycemic drug used in the management of type 2 diabetes.

The METAGLIP™ Tablets contain two oral antihyperglycemic drugs, glipizide and metformin hydrochloride, which are used to manage type 2 diabetes. Glipizide is an oral antihyperglycemic drug from the sulfonylurea class. Metformin hydrochloride is another oral antihyperglycemic drug used to manage type 2 diabetes."

Answered by AI

Clinical Trials for Metaglip

Have you considered Metaglip clinical trials? We made a collection of clinical trials featuring Metaglip, we think they might fit your search criteria.

Have you considered Metaglip clinical trials? We made a collection of clinical trials featuring Metaglip, we think they might fit your search criteria.