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Procedure

Negative Pressure Ventilation for Acute Hypercapnic Respiratory Failure

N/A

Recruiting

Led By Dennis Chairman, MD

Research Sponsored by University of Missouri-Columbia

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Admission diagnosis of hypercapnic respiratory failure

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1-3 days

Awards & highlights

Study Summary

This trial will compare two treatments to help people with breathing problems due to too much carbon dioxide in the body.

Who is the study for?

This trial is for adults over 21 hospitalized with acute hypercapnic respiratory failure, which means they have too much carbon dioxide in their blood. They must not be pregnant, prisoners, or have a BMI over 50. Also excluded are those with chest injuries/surgeries, chest wall defects, or muscle/nerve issues affecting breathing.Check my eligibility

What is being tested?

The study is testing the effectiveness of Biphasic Cuirass Ventilation (BCV) compared to Non-invasive Positive Pressure Ventilation (NPPV) in managing patients with acute hypercapnic respiratory failure to see if BCV can help them breathe easier and manage carbon dioxide levels.See study design

What are the potential side effects?

While the side effects aren't detailed here, generally non-invasive ventilation can cause discomfort on the skin where it contacts the body, dry mouth or nosebleeds from airflow pressure changes.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I was admitted for high carbon dioxide levels in my blood.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1-3 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1-3 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1-3 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Resolution of Hypercapnic Respiratory Failure

Trial Design

2Treatment groups

Active Control

Group I: Intervention ArmActive Control1 Intervention

Patient in this arm will be placed on Biphasic Cuirass Ventilation

Group II: Conventional ArmActive Control1 Intervention

Patients will be placed on Non invasive positive pressure ventilation per current standard of care.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of Missouri-ColumbiaLead Sponsor

362 Previous Clinical Trials

628,064 Total Patients Enrolled

Hayek MedicalUNKNOWN

1 Previous Clinical Trials

20 Total Patients Enrolled

Dennis Chairman, MDPrincipal InvestigatorUniversity of Missouri-Columbia

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research project accept individuals over the age of fifty?

"This clinical trial is designed for patients ranging from 21 to 90 years old. In addition, there are 22 trials available for individuals younger than 18 and 159 studies accessible to persons over 65."

Answered by AI

Who could potentially apply for participation in this investigation?

"The requirements to be accepted in this clinical trial are having acute respiratory failure and being between 21-90 years old. Approximately 50 people will be permitted into the study."

Answered by AI

Are participants still being accepted for this research project?

"As indicated on clinicaltrials.gov, this experiment is not presently accepting applicants; it was initially posted in October of 2023 and last modified at the end of that month. Despite its current status, there are 181 other studies actively recruiting patients right now."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Impact of Negative Pressure Ventilation in Patients Hospitalized With Acute Hypercapnic Respiratory Failure

Dennis Chairman 2024. "Impact of Negative Pressure Ventilation in Patients Hospitalized With Acute Hypercapnic Respiratory Failure". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06108284.

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