Invega Sustenna

Schizophrenia, Schizoaffective Disorder, Antidepressants + 3 more
Treatment
20 Active Studies for Invega Sustenna

What is Invega Sustenna

PaliperidoneThe Generic name of this drug
Treatment SummaryPaliperidone is a medication used to treat schizophrenia. It works similarly to risperidone, by blocking dopamine and serotonin receptors in the brain. Paliperidone can also block other receptors, such as alpha 1 and alpha 2 adrenergic receptors and H1 histaminergic receptors. It was approved by the FDA in 2006 and can be taken in either pill form, a monthly injection, a three-month injection, or a six-month injection.
Invegais the brand name
image of different drug pills on a surface
Invega Sustenna Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Invega
Paliperidone
2006
81

Effectiveness

How Invega Sustenna Affects PatientsPaliperidone is an antipsychotic drug developed by Janssen Pharmaceutica. It is chemically similar to the older antipsychotic drug risperidone. The exact way that paliperidone works is not known, but it is thought to work in a similar way to risperidone.
How Invega Sustenna works in the bodyPaliperidone is a medication used to treat schizophrenia. We don't know exactly how it works, but it likely has something to do with blocking dopamine and serotonin receptors in the brain.

When to interrupt dosage

The measure of Invega Sustenna is contingent upon the diagnosed affliction, including Therapeutic procedure, Schizophrenia and Mood stabilizing agents. The magnitude of dosage shifts as per the method of delivery featured in the table beneath.
Condition
Dosage
Administration
Schizophrenia
, 6.0 mg, 3.0 mg, 1.5 mg, 9.0 mg, 75.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 12.0 mg, 25.0 mg, 175.0 mg, 263.0 mg, 350.0 mg, 525.0 mg, 390.0 mg/mL, 780.0 mg/mL, 1170.0 mg/mL, 156.0 mg/mL, 234.0 mg/mL, 2730.0 mg/mL, 410.0 mg/mL, 546.0 mg/mL, 819.0 mg/mL, 750.0 mg/mL, 150.0 mg/mL, 1.5 mg/mg, 100.0 mg/mL, 500.0 mg/mL, 250.0 mg/mL, 263.0 mg/mL, 350.0 mg/mL, 525.0 mg/mL, 1750.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 1092.0 mg/mL, 1560.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Suspension, extended release - Intramuscular, Intramuscular, Suspension, extended release, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Injection, Injection - Intramuscular
Antidepressants
, 6.0 mg, 3.0 mg, 1.5 mg, 9.0 mg, 75.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 12.0 mg, 25.0 mg, 175.0 mg, 263.0 mg, 350.0 mg, 525.0 mg, 390.0 mg/mL, 780.0 mg/mL, 1170.0 mg/mL, 156.0 mg/mL, 234.0 mg/mL, 2730.0 mg/mL, 410.0 mg/mL, 546.0 mg/mL, 819.0 mg/mL, 750.0 mg/mL, 150.0 mg/mL, 1.5 mg/mg, 100.0 mg/mL, 500.0 mg/mL, 250.0 mg/mL, 263.0 mg/mL, 350.0 mg/mL, 525.0 mg/mL, 1750.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 1092.0 mg/mL, 1560.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Suspension, extended release - Intramuscular, Intramuscular, Suspension, extended release, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Injection, Injection - Intramuscular
Mood stabilizing agents
, 6.0 mg, 3.0 mg, 1.5 mg, 9.0 mg, 75.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 12.0 mg, 25.0 mg, 175.0 mg, 263.0 mg, 350.0 mg, 525.0 mg, 390.0 mg/mL, 780.0 mg/mL, 1170.0 mg/mL, 156.0 mg/mL, 234.0 mg/mL, 2730.0 mg/mL, 410.0 mg/mL, 546.0 mg/mL, 819.0 mg/mL, 750.0 mg/mL, 150.0 mg/mL, 1.5 mg/mg, 100.0 mg/mL, 500.0 mg/mL, 250.0 mg/mL, 263.0 mg/mL, 350.0 mg/mL, 525.0 mg/mL, 1750.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 1092.0 mg/mL, 1560.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Suspension, extended release - Intramuscular, Intramuscular, Suspension, extended release, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Injection, Injection - Intramuscular
Therapeutic procedure
, 6.0 mg, 3.0 mg, 1.5 mg, 9.0 mg, 75.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 12.0 mg, 25.0 mg, 175.0 mg, 263.0 mg, 350.0 mg, 525.0 mg, 390.0 mg/mL, 780.0 mg/mL, 1170.0 mg/mL, 156.0 mg/mL, 234.0 mg/mL, 2730.0 mg/mL, 410.0 mg/mL, 546.0 mg/mL, 819.0 mg/mL, 750.0 mg/mL, 150.0 mg/mL, 1.5 mg/mg, 100.0 mg/mL, 500.0 mg/mL, 250.0 mg/mL, 263.0 mg/mL, 350.0 mg/mL, 525.0 mg/mL, 1750.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 1092.0 mg/mL, 1560.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Suspension, extended release - Intramuscular, Intramuscular, Suspension, extended release, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Injection, Injection - Intramuscular
Therapeutic procedure
, 6.0 mg, 3.0 mg, 1.5 mg, 9.0 mg, 75.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 12.0 mg, 25.0 mg, 175.0 mg, 263.0 mg, 350.0 mg, 525.0 mg, 390.0 mg/mL, 780.0 mg/mL, 1170.0 mg/mL, 156.0 mg/mL, 234.0 mg/mL, 2730.0 mg/mL, 410.0 mg/mL, 546.0 mg/mL, 819.0 mg/mL, 750.0 mg/mL, 150.0 mg/mL, 1.5 mg/mg, 100.0 mg/mL, 500.0 mg/mL, 250.0 mg/mL, 263.0 mg/mL, 350.0 mg/mL, 525.0 mg/mL, 1750.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 1092.0 mg/mL, 1560.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Suspension, extended release - Intramuscular, Intramuscular, Suspension, extended release, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Injection, Injection - Intramuscular
Schizoaffective Disorder
, 6.0 mg, 3.0 mg, 1.5 mg, 9.0 mg, 75.0 mg, 100.0 mg, 50.0 mg, 150.0 mg, 12.0 mg, 25.0 mg, 175.0 mg, 263.0 mg, 350.0 mg, 525.0 mg, 390.0 mg/mL, 780.0 mg/mL, 1170.0 mg/mL, 156.0 mg/mL, 234.0 mg/mL, 2730.0 mg/mL, 410.0 mg/mL, 546.0 mg/mL, 819.0 mg/mL, 750.0 mg/mL, 150.0 mg/mL, 1.5 mg/mg, 100.0 mg/mL, 500.0 mg/mL, 250.0 mg/mL, 263.0 mg/mL, 350.0 mg/mL, 525.0 mg/mL, 1750.0 mg/mL, 700.0 mg/mL, 1000.0 mg/mL, 1092.0 mg/mL, 1560.0 mg/mL
, Oral, Tablet, extended release, Tablet, extended release - Oral, Suspension, extended release - Intramuscular, Intramuscular, Suspension, extended release, Injection, suspension, extended release, Injection, suspension, extended release - Intramuscular, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Injection, Injection - Intramuscular

Warnings

There are 20 known major drug interactions with Invega Sustenna.
Common Invega Sustenna Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be increased when it is combined with Paliperidone.
Acepromazine
Major
Paliperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Alfuzosin
Major
Paliperidone may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Paliperidone may increase the antipsychotic activities of Amisulpride.
Aripiprazole lauroxil
Major
Paliperidone may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole lauroxil.
Invega Sustenna Toxicity & Overdose RiskOverdosing on Sinemet can cause confusion, seizures, or abnormal movements of the head and neck, which may increase the risk of inhaling vomit when attempting to induce vomiting.
image of a doctor in a lab doing drug, clinical research

Invega Sustenna Novel Uses: Which Conditions Have a Clinical Trial Featuring Invega Sustenna?

221 active studies are being conducted to examine the capacity of Invega Sustenna to provide relief for Schizoaffective Disorder, Schizophrenia and Mood Stabilizing Agents.
Condition
Clinical Trials
Trial Phases
Mood stabilizing agents
0 Actively Recruiting
Antidepressants
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Schizophrenia
174 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1
Therapeutic procedure
0 Actively Recruiting
Schizoaffective Disorder
53 Actively Recruiting
Not Applicable, Phase 4, Phase 2, Phase 1, Early Phase 1, Phase 3

Invega Sustenna Reviews: What are patients saying about Invega Sustenna?

4.3Patient Review
5/26/2022
Invega Sustenna for Schizophrenia
No negative effects that I experienced. To be honest, it didn't completely stop the delusions, but I am satisfied overall.
4Patient Review
2/19/2021
Invega Sustenna for Schizophrenia
I was diagnosed with schizophrenia a few years ago and have been taking Invega for several months. It's helped me a lot, though I have put on quite a bit of weight since starting the medication.
3.7Patient Review
7/12/2020
Invega Sustenna for Schizophrenia
I was on this medication for over a year and felt amazing. But then, suddenly, it stopped working. I've tried other medications since, but nothing has given me the same results that this drug did. Has anyone else experienced something similar?
2.7Patient Review
1/27/2021
Invega Sustenna for Schizophrenia With Mood Changes
This medication caused me to gain weight and messed with my prolactin levels, which then led to even more health problems down the road. I don't recommend it to anyone.
2Patient Review
10/13/2022
Invega Sustenna for Schizophrenia
The side effects of this medication were really terrible. I was given Invega Sustenna 150mg, and it caused me to have head tremors and almost spasms. My speech was slurred, and I had difficulty carrying on a conversation. My memory has also been impacted negatively, and I haven't seen any improvement even after being off the medication for two months.
1.7Patient Review
3/17/2022
Invega Sustenna for Schizophrenia
The monthly 100mg dose really messed with my head. I felt disconnected from myself and the world around me. I also gained a lot of weight, had trouble sleeping, and lost all interest in sex. Worst experience ever.
1Patient Review
2/27/2021
Invega Sustenna for Schizophrenia
I've been miserable since beginning this treatment. I often experience mental blanks where I can't think of anything, or else my thoughts are very impoverished. I have no emotions and am always restless. In addition, I've gained weight and lost my sex drive. Finally, my memory, focus, concentration, and learning have all suffered.
1Patient Review
9/3/2022
Invega Sustenna for Schizophrenia
There are no benefits to this treatment, and the side effects are numerous. I stopped using it over a year ago and I'm still experiencing problems.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about invega sustenna

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does INVEGA SUSTENNA do?

"This drug is used to treat mental/mood disorders such as schizophrenia and schizoaffective disorder. Paliperidone is an antipsychotic drug of the atypical type. Its mechanism of action is based on restoring the balance of certain neurotransmitters in the brain."

Answered by AI

What are some common side effects with INVEGA SUSTENNA?

"The most common side effects of INVEGA SUSTENNA® are: reactions at the injection site; sleepiness or drowsiness; dizziness; feeling of inner restlessness or needing to be constantly moving; abnormal muscle movements, including tremor (shaking), shuffling, uncontrolled involuntary movements, and abnormal movements of your..."

Answered by AI

How long does an invega shot last?

"Invega Sustenna is a long-acting injectable formulation of paliperidone that provides coverage for 4 weeks."

Answered by AI

How often is INVEGA SUSTENNA given?

"The recommended amount of INVEGA SUSTENNA to start with is 234 mg on the first day of treatment, then 156 mg one week later. After the second initial dose, monthly maintenance doses can be given in the deltoid muscle or the gluteal muscle."

Answered by AI

Clinical Trials for Invega Sustenna

Have you considered Invega Sustenna clinical trials? We made a collection of clinical trials featuring Invega Sustenna, we think they might fit your search criteria.
Have you considered Invega Sustenna clinical trials? We made a collection of clinical trials featuring Invega Sustenna, we think they might fit your search criteria.
Have you considered Invega Sustenna clinical trials? We made a collection of clinical trials featuring Invega Sustenna, we think they might fit your search criteria.