Methylphenidate + Exercise for Prostate Cancer
Trial Summary
Will I have to stop taking my current medications?
The trial requires that you stop taking certain medications, such as methylphenidate, monoamine oxidase inhibitors, tricyclic antidepressants, clonidine, and some others. If you are currently taking any of these, you may need to stop before participating.
What data supports the effectiveness of the treatment Exercise Program for Prostate Cancer?
Research shows that exercise can help reduce the side effects of prostate cancer treatments, improve muscle strength, and enhance quality of life for patients. Studies have found that supervised exercise programs can lead to better endurance, reduced depression, and improved overall health in men undergoing prostate cancer treatment.12345
Is the combination of exercise and methylphenidate safe for prostate cancer patients?
Exercise is generally safe for prostate cancer patients and can help manage treatment-related side effects like fatigue and muscle weakness. It is recommended to be done under supervision to maximize benefits and minimize risks. However, there is no specific safety data available for the combination of exercise and methylphenidate in this context.46789
How does the Methylphenidate + Exercise treatment for prostate cancer differ from other treatments?
This treatment is unique because it combines a medication, Methylphenidate, with an exercise program to potentially reduce the side effects of androgen-deprivation therapy (ADT) in prostate cancer patients. Exercise has been shown to improve quality of life and reduce fatigue, which are common issues with ADT, making this approach novel compared to standard treatments that do not typically include physical activity as a component.1681011
What is the purpose of this trial?
This phase II/III trial studies how well methylphenidate and exercise work in reducing cancer-related fatigue in patients with prostate cancer. Methylphenidate is a type of central nervous system stimulant that can improve cognitive ability, mainly in memory and cognitive function. Exercise can improve mood and the physical aspects of cancer-related fatigue. Giving methylphenidate in combination with exercise may work better in reducing cancer-related fatigue in patients with prostate cancer.
Research Team
Sriram Yennu, MD
Principal Investigator
M.D. Anderson Cancer Center
Eligibility Criteria
This trial is for adult prostate cancer patients experiencing fatigue, who are about to start radiotherapy with androgen deprivation therapy. Participants should not be heavily involved in exercise, have a stable cognitive status, adequate hemoglobin levels, and must be able to consent and follow the study protocol.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either methylphenidate or placebo and undergo an exercise or stretching program for 12 weeks
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Exercise Intervention
- Methylphenidate
Find a Clinic Near You
Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator