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FAZA PET/MRI Scan for Gastroesophageal Cancer

N/A

Recruiting

Led By Patrick Veit-Haibach, MD

Research Sponsored by University Health Network, Toronto

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 months after chemotheray

Awards & highlights

Study Summary

This trial will test if using PET/MRI with the radiotracer 18F-Fluoroazomycin Arabinoside (FAZA) can help predict how well a patient with metastatic Gastro-Oesophageal Cancer will respond to platinum-based chemotherapy.

Who is the study for?

This trial is for adults over 18 with advanced gastroesophageal cancer who can lie down for at least 30 minutes and have a kidney function test (GFR) above 45 ml/min. It's not suitable for those allergic to contrast agents, pregnant or breastfeeding women, anyone unable to consent, or those with allergies to ethanol.Check my eligibility

What is being tested?

The study tests if a PET/MRI scan using a special dye called FAZA can predict how well patients respond to standard platinum-based chemotherapy. Patients will get scanned before and after treatment to see if the level of oxygen in their tumors correlates with their response.See study design

What are the potential side effects?

There are generally minimal side effects associated with PET/MRI scans. However, there might be slight discomfort from lying still during the scan or rare allergic reactions to the contrast agent used.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 months after the chemotherapy

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 months after the chemotherapy

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 months after the chemotherapy for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Validation of FAZA PET/MRI as a biomarker of hypoxia

Secondary outcome measures

Evaluate tumour marker ctDNA in blood samples

Trial Design

1Treatment groups

Experimental Treatment

Group I: FAZA PET/MRI scanExperimental Treatment1 Intervention

FAZA PET/MRI scan before and after the standard of care chemotherapy

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

FAZA PET/MRI scan

2018

N/A

~40

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

University Health Network, TorontoLead Sponsor

1,476 Previous Clinical Trials

485,140 Total Patients Enrolled

Patrick Veit-Haibach, MDPrincipal InvestigatorUniversity Health Network, Toronto

7 Previous Clinical Trials

366 Total Patients Enrolled

Media Library

FAZA PET/MRI scan Clinical Trial Eligibility Overview. Trial Name: NCT04560036 — N/A

Gastroesophageal Cancer Research Study Groups: FAZA PET/MRI scan

Gastroesophageal Cancer Clinical Trial 2023: FAZA PET/MRI scan Highlights & Side Effects. Trial Name: NCT04560036 — N/A

FAZA PET/MRI scan 2023 Treatment Timeline for Medical Study. Trial Name: NCT04560036 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the upper limit of participants in this trial?

"Affirmative. Per the information posted on clinicaltrials.gov, this investigational trail is actively seeking out 40 individuals from 1 location. The initial posting was made on September 15th 2020 and it was last updatedon May 20th 2021."

Answered by AI

Are there still vacancies available to join this experiment?

"Affirmative. According to the information on clinicaltrials.gov, this research study is presently admitting applicants which was initially announced on September 15th 2020 and updated lastly on May 20th 2022. 40 individuals are required at 1 medical centre for participation in the trial."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

FAZA PETMRI Gastro-Oesophageal Study

2020. "FAZA PETMRI Gastro-Oesophageal Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04560036.