VX-121 Combination Therapy for Cystic Fibrosis
What You Need to Know Before You Apply
What is the purpose of this trial?
The purpose of this study is to evaluate the long-term safety, tolerability, and efficacy of VX-121/tezacaftor/deutivacaftor (VX-121/TEZ/D-IVA) in participants with cystic fibrosis.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
Is VX-121 Combination Therapy for Cystic Fibrosis safe for humans?
What data supports the effectiveness of the drug VX-121/TEZ/D-IVA for cystic fibrosis?
Research shows that similar combination treatments like tezacaftor and ivacaftor improve the function of the CFTR protein, which is often defective in cystic fibrosis patients. This suggests that VX-121/TEZ/D-IVA, which includes similar components, may also be effective in treating cystic fibrosis.23678
Are You a Good Fit for This Trial?
This trial is for individuals with cystic fibrosis who previously participated in certain VX-121 studies and completed the treatment or visits, even if they had interruptions. It's not open to pregnant or breastfeeding women or those who couldn't tolerate the drug before.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment Part A
Participants receive VX-121/TEZ/D-IVA once daily
Treatment Part B
Participants continue to receive VX-121/TEZ/D-IVA once daily
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- VX-121/TEZ/D-IVA
Find a Clinic Near You
Who Is Running the Clinical Trial?
Vertex Pharmaceuticals Incorporated
Lead Sponsor
Dr. David Altshuler
Vertex Pharmaceuticals Incorporated
Chief Medical Officer since 2020
MD, PhD
Dr. Reshma Kewalramani
Vertex Pharmaceuticals Incorporated
Chief Executive Officer since 2020
MD, trained in internal medicine and nephrology