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What is Gralise
GabapentinThe Generic name of this drug
Treatment SummaryGabapentin is a medication used to treat certain types of seizures and neuropathic pain. It was approved by the FDA in 1993 and is commonly prescribed today. Gabapentin has advantages over other anti-epileptic drugs including fewer side effects, a wider range of therapeutic doses, and no interaction with other medications. It is related to another medication called pregabalin.
Neurontinis the brand name
Gralise Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Neurontin
Gabapentin
1993
1133
Effectiveness
How Gralise Affects PatientsGabapentin is a medication used to treat seizures and neuropathic pain. It works by blocking the nerve signals that cause these issues. It is generally considered to be very safe, as even very large doses of it do not cause any serious harm in rats. However, it is not effective for absence seizures and can be dangerous for people with mixed seizure disorders that include absence seizures. Gabapentin can also cause a severe allergic reaction known as multi-organ hypersensitivity (DRESS), which can be fatal if not treated early. Signs of this reaction include fever, swollen lymph nodes, and rash.
How Gralise works in the bodyWe don't know exactly how gabapentin works in the body, but there are a few likely pathways. Gabapentin likely blocks the action of a subunit of voltage-gated calcium channels, which helps reduce the activity of nerves and could explain its effects on chronic pain and epilepsy. It also may work on adenosine receptors and potassium channels, though it's not clear how important these pathways are.
When to interrupt dosage
The measure of Gralise is contingent upon the diagnosed situation, including Epilepsies, Postherpetic Neuralgia and Seizures. The dosage likewise fluctuates in accordance with the technique of delivery (e.g. Tablet or Tablet - Oral) featured in the table beneath.Condition
Dosage
Administration
Postherpetic Neuralgia
100.0 mg, 300.0 mg, , 400.0 mg, 800.0 mg, 600.0 mg, 250.0 mg/mL, 0.6 mg, 3.0 mg/mg, 1.0 mg/mg, 8.0 mg/mg, 6.0 mg/mg, 4.0 mg/mg, 1.0 mg/mL, 1.05 mg/mg, 1.08 mg/mg, 5.7 mg/mg, 900.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Topical, Kit - Topical, Suspension, Suspension - Oral, Oral; Topical, Kit - Oral; Topical, Cream, Cream - Topical, Tablet, coated - Oral, Tablet, coated, Kit - Cutaneous; Oral, Cutaneous; Oral
Seizures
100.0 mg, 300.0 mg, , 400.0 mg, 800.0 mg, 600.0 mg, 250.0 mg/mL, 0.6 mg, 3.0 mg/mg, 1.0 mg/mg, 8.0 mg/mg, 6.0 mg/mg, 4.0 mg/mg, 1.0 mg/mL, 1.05 mg/mg, 1.08 mg/mg, 5.7 mg/mg, 900.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Topical, Kit - Topical, Suspension, Suspension - Oral, Oral; Topical, Kit - Oral; Topical, Cream, Cream - Topical, Tablet, coated - Oral, Tablet, coated, Kit - Cutaneous; Oral, Cutaneous; Oral
Neuralgia
100.0 mg, 300.0 mg, , 400.0 mg, 800.0 mg, 600.0 mg, 250.0 mg/mL, 0.6 mg, 3.0 mg/mg, 1.0 mg/mg, 8.0 mg/mg, 6.0 mg/mg, 4.0 mg/mg, 1.0 mg/mL, 1.05 mg/mg, 1.08 mg/mg, 5.7 mg/mg, 900.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Topical, Kit - Topical, Suspension, Suspension - Oral, Oral; Topical, Kit - Oral; Topical, Cream, Cream - Topical, Tablet, coated - Oral, Tablet, coated, Kit - Cutaneous; Oral, Cutaneous; Oral
Epilepsies
100.0 mg, 300.0 mg, , 400.0 mg, 800.0 mg, 600.0 mg, 250.0 mg/mL, 0.6 mg, 3.0 mg/mg, 1.0 mg/mg, 8.0 mg/mg, 6.0 mg/mg, 4.0 mg/mg, 1.0 mg/mL, 1.05 mg/mg, 1.08 mg/mg, 5.7 mg/mg, 900.0 mg
, Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Kit, Kit - Oral, Solution, Solution - Oral, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Topical, Kit - Topical, Suspension, Suspension - Oral, Oral; Topical, Kit - Oral; Topical, Cream, Cream - Topical, Tablet, coated - Oral, Tablet, coated, Kit - Cutaneous; Oral, Cutaneous; Oral
Warnings
Gralise has one contraindication and should be avoided under the circumstances outlined in the below table.Gralise ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Gabapentin may interact with Pulse Frequency
Common Gralise Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Gabapentin may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Gabapentin may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Gabapentin is combined with Oliceridine.
Thalidomide
Major
Gabapentin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Daridorexant
Minor
The risk or severity of CNS depression can be increased when Gabapentin is combined with Daridorexant.
Gralise Toxicity & Overdose RiskThe highest safe dose of gabapentin in humans is 2.86mg/kg and in rats it was found to be greater than 8000mg/kg. Overdosing on gabapentin can cause symptoms such as dizziness, drowsiness, slurred speech, tiredness, loss of consciousness, and diarrhea. Treatment for overdose should focus on controlling symptoms and dialysis may be beneficial for those with poor kidney function. If gabapentin is taken with other drugs that depress the central nervous system, such as opioids, it can lead to coma or death.
Gralise Novel Uses: Which Conditions Have a Clinical Trial Featuring Gralise?
Two active investigations are assessing the efficacy of Gralise in alleviating Postherpetic Neuralgia, Epilepsies and Seizures.Condition
Clinical Trials
Trial Phases
Postherpetic Neuralgia
0 Actively Recruiting
Epilepsies
0 Actively Recruiting
Seizures
2 Actively Recruiting
Phase 3
Neuralgia
0 Actively Recruiting
Gralise Reviews: What are patients saying about Gralise?
5Patient Review
9/16/2015 Gralise has been a godsend for my arthritis.
4Patient Review
8/16/2016 Gralise has been much more effective than Gabapentin for managing my neuropathic pain, with none of the grogginess or low energy. I highly recommend it.
4Patient Review
5/30/2014 I had some side effects while my dosage was being increased which made me a bit hesitant to go up to the full 1800 mg. That said, the pain relief has been really good and worth it for me.
3.7Patient Review
1/2/2016 I experienced weight gain and fatigue while taking gralise. Once I started, it was difficult to stop. Additionally, it's quite costly; especially given that it didn't completely alleviate my pain (I still had to rely on other forms of medication). My doctor wanted me to take more of the drug, but I refused.
3Patient Review
9/29/2019 There's a significant chance you'll gain weight if you start taking this drug, which is something they don't mention when prescribing it. Also, it's nearly impossible to stop once you've started, so be very careful before making the decision to begin treatment with Gralise.
3Patient Review
8/20/2016 Gralise worked great for me at first, but now the pain is coming back more and more. I'm not happy with the pain or the cost of this medication.
3Patient Review
11/5/2015 The effects of this treatment only last for around twelve hours, and then you have to take more.
2Patient Review
5/18/2016 In the beginning, this medication made me feel really out of it. I'm on the trial pack right now and, 13 days in, I'm finally feeling more alert again. I skipped a day at one point and realized how quickly I had become addicted to it when I felt extremely depressed the next day. This drug is not easy to wean off of, so I'm not sure if I will continue taking it.
1.7Patient Review
8/25/2014 I started taking this medication a week ago and have already experienced extreme dizziness, nerve tics, shaking, and anxiety. I've had similar issues with other drugs in the past; gabapentin didn't work well and also caused awful side effects. Based on all of this, I want to discontinue use of this drug but am waiting to hear back from my doctor first.
1.7Patient Review
7/3/2014 I find it difficult to remember to take Gralise at the same time each day, so I often forget. This causes me problems and I want to stop taking the medication, but my doctor won't tell me how.
Patient Q&A Section about gralise
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of taking gralise?
"The person experiences dizziness, a spinning sensation (vertigo), sleepiness, drowsiness, weakness, a tired feeling, headache, and swelling of the extremities."
Answered by AI
Does gralise cause weight gain?
"Gabapentin is a medication used to help manage certain epileptic seizures, relieve pain for some conditions, such as shingles, and control side effects like dizziness, drowsiness, weight gain, and uncoordinated movement."
Answered by AI
Is gralise the same as gabapentin?
"Taking the wrong medication can have serious consequences.
Both medications, Gralise and Neurontin, contain the active ingredient gabapentin. However, they are not the same medication, and cannot be used interchangeably. Taking 300mg of Gralise is not the same as taking 300mg of Neurontin. Taking the wrong medication can have serious consequences."
Answered by AI
What is gralise used to treat?
"GRALISE® is a prescription medicine that is used to treat pain from damaged nerves in adults who are 18 years of age or older. This medicine is used to treat neuropathic pain that follows healing of shingles, which is a painful rash that comes after a herpes zoster infection."
Answered by AI