Gralise

Neuralgia, Postherpetic, Seizures, Neuralgia + 1 more

Treatment

5 Active Studies for Gralise

Treatment for

Neuralgia, Postherpetic

What is Gralise

Gabapentin

The Generic name of this drug

Treatment Summary

Gabapentin is a medication used to treat certain types of seizures and neuropathic pain. It was approved by the FDA in 1993 and is commonly prescribed today. Gabapentin has advantages over other anti-epileptic drugs including fewer side effects, a wider range of therapeutic doses, and no interaction with other medications. It is related to another medication called pregabalin.

Neurontin

is the brand name

image of different drug pills on a surface

Gralise Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Neurontin

Gabapentin

1993

1133

Effectiveness

How Gralise Affects Patients

Gabapentin is a medication used to treat seizures and neuropathic pain. It works by blocking the nerve signals that cause these issues. It is generally considered to be very safe, as even very large doses of it do not cause any serious harm in rats. However, it is not effective for absence seizures and can be dangerous for people with mixed seizure disorders that include absence seizures. Gabapentin can also cause a severe allergic reaction known as multi-organ hypersensitivity (DRESS), which can be fatal if not treated early. Signs of this reaction include fever, swollen lymph nodes, and rash.

How Gralise works in the body

We don't know exactly how gabapentin works in the body, but there are a few likely pathways. Gabapentin likely blocks the action of a subunit of voltage-gated calcium channels, which helps reduce the activity of nerves and could explain its effects on chronic pain and epilepsy. It also may work on adenosine receptors and potassium channels, though it's not clear how important these pathways are.

When to interrupt dosage

The measure of Gralise is contingent upon the diagnosed situation, including Epilepsies, Postherpetic Neuralgia and Seizures. The dosage likewise fluctuates in accordance with the technique of delivery (e.g. Tablet or Tablet - Oral) featured in the table beneath.

Condition

Dosage

Administration

Neuralgia

100.0 mg, 300.0 mg, , 400.0 mg, 800.0 mg, 600.0 mg, 250.0 mg/mL, 0.6 mg, 3.0 mg/mg, 1.0 mg/mg, 8.0 mg/mg, 6.0 mg/mg, 4.0 mg/mg, 1.0 mg/mL, 1.05 mg/mg, 1.08 mg/mg, 5.7 mg/mg, 900.0 mg

Oral, Capsule, Capsule - Oral, , Tablet, film coated, Tablet, film coated - Oral, Tablet - Oral, Tablet, Kit, Kit - Oral, Solution - Oral, Solution, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Kit - Topical, Topical, Suspension - Oral, Suspension, Kit - Oral; Topical, Oral; Topical, Cream, Cream - Topical, Tablet, coated, Tablet, coated - Oral, Cutaneous; Oral, Kit - Cutaneous; Oral

Epilepsy

100.0 mg, 300.0 mg, , 400.0 mg, 800.0 mg, 600.0 mg, 250.0 mg/mL, 0.6 mg, 3.0 mg/mg, 1.0 mg/mg, 8.0 mg/mg, 6.0 mg/mg, 4.0 mg/mg, 1.0 mg/mL, 1.05 mg/mg, 1.08 mg/mg, 5.7 mg/mg, 900.0 mg

Neuralgia, Postherpetic

100.0 mg, 300.0 mg, , 400.0 mg, 800.0 mg, 600.0 mg, 250.0 mg/mL, 0.6 mg, 3.0 mg/mg, 1.0 mg/mg, 8.0 mg/mg, 6.0 mg/mg, 4.0 mg/mg, 1.0 mg/mL, 1.05 mg/mg, 1.08 mg/mg, 5.7 mg/mg, 900.0 mg

Seizures

100.0 mg, 300.0 mg, , 400.0 mg, 800.0 mg, 600.0 mg, 250.0 mg/mL, 0.6 mg, 3.0 mg/mg, 1.0 mg/mg, 8.0 mg/mg, 6.0 mg/mg, 4.0 mg/mg, 1.0 mg/mL, 1.05 mg/mg, 1.08 mg/mg, 5.7 mg/mg, 900.0 mg

Warnings

Gralise has one contraindication and should be avoided under the circumstances outlined in the below table.

Gralise Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Gabapentin may interact with Pulse Frequency

There are 20 known major drug interactions with Gralise.

Common Gralise Drug Interactions

Drug Name

Risk Level

Description

Azelastine

Major

Gabapentin may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Ethanol

Major

Gabapentin may increase the central nervous system depressant (CNS depressant) activities of Ethanol.

Oliceridine

Major

The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Gabapentin is combined with Oliceridine.

Thalidomide

Major

Gabapentin may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.

Daridorexant

Minor

The risk or severity of CNS depression can be increased when Gabapentin is combined with Daridorexant.

Gralise Toxicity & Overdose Risk

The highest safe dose of gabapentin in humans is 2.86mg/kg and in rats it was found to be greater than 8000mg/kg. Overdosing on gabapentin can cause symptoms such as dizziness, drowsiness, slurred speech, tiredness, loss of consciousness, and diarrhea. Treatment for overdose should focus on controlling symptoms and dialysis may be beneficial for those with poor kidney function. If gabapentin is taken with other drugs that depress the central nervous system, such as opioids, it can lead to coma or death.

image of a doctor in a lab doing drug, clinical research

Gralise Novel Uses: Which Conditions Have a Clinical Trial Featuring Gralise?

Two active investigations are assessing the efficacy of Gralise in alleviating Postherpetic Neuralgia, Epilepsies and Seizures.

Condition

Clinical Trials

Trial Phases

Epilepsy

0 Actively Recruiting

Seizures

5 Actively Recruiting

Phase 3, Phase 2, Phase 1

Neuralgia, Postherpetic

0 Actively Recruiting

Neuralgia

0 Actively Recruiting

Gralise Reviews: What are patients saying about Gralise?

Patient Review

9/16/2015

Gralise for Neuropathic Pain

Gralise has been a godsend for my arthritis.

Patient Review

8/16/2016

Gralise for Neuropathic Pain

Gralise has been much more effective than Gabapentin for managing my neuropathic pain, with none of the grogginess or low energy. I highly recommend it.

Patient Review

5/30/2014

Gralise for Acute Pain Following an Operation

I had some side effects while my dosage was being increased which made me a bit hesitant to go up to the full 1800 mg. That said, the pain relief has been really good and worth it for me.

3.7

Patient Review

1/2/2016

Gralise for Neuropathic Pain

I experienced weight gain and fatigue while taking gralise. Once I started, it was difficult to stop. Additionally, it's quite costly; especially given that it didn't completely alleviate my pain (I still had to rely on other forms of medication). My doctor wanted me to take more of the drug, but I refused.

Patient Review

9/29/2019

Gralise for Neuropathic Pain

There's a significant chance you'll gain weight if you start taking this drug, which is something they don't mention when prescribing it. Also, it's nearly impossible to stop once you've started, so be very careful before making the decision to begin treatment with Gralise.

Patient Review

8/20/2016

Gralise for Neuropathic Pain

Gralise worked great for me at first, but now the pain is coming back more and more. I'm not happy with the pain or the cost of this medication.

Patient Review

11/5/2015

Gralise for Neuropathic Pain

The effects of this treatment only last for around twelve hours, and then you have to take more.

Patient Review

5/18/2016

Gralise for Neuropathic Pain

In the beginning, this medication made me feel really out of it. I'm on the trial pack right now and, 13 days in, I'm finally feeling more alert again. I skipped a day at one point and realized how quickly I had become addicted to it when I felt extremely depressed the next day. This drug is not easy to wean off of, so I'm not sure if I will continue taking it.

1.7

Patient Review

8/25/2014

Gralise for Neuropathic Pain

I started taking this medication a week ago and have already experienced extreme dizziness, nerve tics, shaking, and anxiety. I've had similar issues with other drugs in the past; gabapentin didn't work well and also caused awful side effects. Based on all of this, I want to discontinue use of this drug but am waiting to hear back from my doctor first.

1.7

Patient Review

7/3/2014

Gralise for Neuropathic Pain

I find it difficult to remember to take Gralise at the same time each day, so I often forget. This causes me problems and I want to stop taking the medication, but my doctor won't tell me how.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about gralise

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the side effects of taking gralise?

"The person experiences dizziness, a spinning sensation (vertigo), sleepiness, drowsiness, weakness, a tired feeling, headache, and swelling of the extremities."

Answered by AI

Does gralise cause weight gain?

"Gabapentin is a medication used to help manage certain epileptic seizures, relieve pain for some conditions, such as shingles, and control side effects like dizziness, drowsiness, weight gain, and uncoordinated movement."

Answered by AI

Is gralise the same as gabapentin?

"Taking the wrong medication can have serious consequences.

Both medications, Gralise and Neurontin, contain the active ingredient gabapentin. However, they are not the same medication, and cannot be used interchangeably. Taking 300mg of Gralise is not the same as taking 300mg of Neurontin. Taking the wrong medication can have serious consequences."

Answered by AI

What is gralise used to treat?

"GRALISE® is a prescription medicine that is used to treat pain from damaged nerves in adults who are 18 years of age or older. This medicine is used to treat neuropathic pain that follows healing of shingles, which is a painful rash that comes after a herpes zoster infection."

Answered by AI