Enzalutamide

Malignant neoplasm of prostate, Malignant Neoplasms

Treatment

10 Active Studies for Enzalutamide

Treatment for

Malignant neoplasm of prostate

What is Enzalutamide

EnzalutamideThe Generic name of this drug

Treatment SummaryEnzalutamide is a medication used to treat prostate cancer that does not respond to other treatments. It works by blocking androgen receptors, which stops hormones from stimulating tumor growth. Enzalutamide was approved by the FDA in 2012 under the brand name Xtandi.

Xtandiis the brand name

image of different drug pills on a surface

Enzalutamide Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Xtandi

Enzalutamide

2012

Effectiveness

How Enzalutamide Affects PatientsEnzalutamide is a drug designed to stop prostate cancer from progressing. It does this by blocking the hormones and hormone receptors that cause prostate cells to grow. After a few years, prostate cancer will start to become resistant to hormone deprivation treatment, but studies show that Enzalutamide can help to slow the growth of prostate cancer cells. Clinical trials suggest that Enzalutamide can reduce the risk of death in patients by 37% compared to those taking a placebo. The drug also reduces serum PSA levels for at least 12 weeks, although this effect may be short-lived.

How Enzalutamide works in the bodyEnzalutamide is a drug that blocks the effects of testosterone and other male hormones on cancer cells. It prevents testosterone and other hormones from binding to the androgen receptor, a protein that tells the cancer cell to grow and spread. Enzalutamide is more effective at blocking hormones from binding to the receptor than some other drugs, and it has fewer side effects. It also works better than testosterone at preventing cancer cells from growing and spreading.

When to interrupt dosage

The recommended amount of Enzalutamide is contingent upon the diagnosed illness. The dose may also differ as per the administration approach (e.g. Capsule - Oral or Tablet - Oral) outlined in the table below.

Condition

Dosage

Administration

Malignant neoplasm of prostate

, 40.0 mg, 80.0 mg

, Oral, Capsule, Capsule - Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Malignant Neoplasms

, 40.0 mg, 80.0 mg

, Oral, Capsule, Capsule - Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral

Warnings

There are 20 known major drug interactions with Enzalutamide.

Common Enzalutamide Drug Interactions

Drug Name

Risk Level

Description

1,2-Benzodiazepine

Major

The metabolism of 1,2-Benzodiazepine can be increased when combined with Enzalutamide.

3,5-diiodothyropropionic acid

Major

The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Enzalutamide.

5-androstenedione

Major

The metabolism of 5-androstenedione can be increased when combined with Enzalutamide.

6-O-benzylguanine

Major

The metabolism of 6-O-benzylguanine can be increased when combined with Enzalutamide.

7-ethyl-10-hydroxycamptothecin

Major

The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Enzalutamide.

Enzalutamide Toxicity & Overdose RiskIn studies with mice, taking enzalutamide orally during pregnancy caused embryo-fetal death, resorptions, and changes in the distance between genitalia, as well as cleft palate and missing palatine bone when taken at the highest dose. Rats who were given a single oral dose of 30 mg/kg on the 14th day of gestation had a fetal concentration of enzalutamide that was about 0.3 times that found in the mother's plasma. Enzalutamide may also reduce fertility in males. The most common side effects reported in adults include fatigue, back pain, diarrhea, joint pain, fl

image of a doctor in a lab doing drug, clinical research

Enzalutamide Novel Uses: Which Conditions Have a Clinical Trial Featuring Enzalutamide?

There are 30 ongoing trials assessing the potential of Enzalutamide for Castration Treatment.

Condition

Clinical Trials

Trial Phases

Malignant neoplasm of prostate

8 Actively Recruiting

Early Phase 1, Phase 2, Not Applicable, Phase 1

Malignant Neoplasms

2 Actively Recruiting

Phase 3, Phase 1

Enzalutamide Reviews: What are patients saying about Enzalutamide?

5Patient Review

11/21/2014

Enzalutamide for Metastatic Castration-Resistant Prostate Cancer

Really effective with only a few small side effects. The fatigue is the worst part, but it's worth it considering how well this works. It's also quite expensive though.

2.3Patient Review

4/22/2013

Enzalutamide for Metastatic Castration-Resistant Prostate Cancer

I didn't find this treatment very effective. My disease progressed and I developed new bony metastasis within the 3 months of taking it. It's well tolerated though, with the main side effects being hot flashes and constant nausea.

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Patient Q&A Section about enzalutamide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enzalutamide better than chemotherapy?

"In a study of men with metastatic prostate cancer who had not received chemotherapy, those who were treated with enzalutamide had a longer time until cancer progression or death, improved overall survival, and delayed the need for chemotherapy by a median of 17 months."

Answered by AI

Is enzalutamide a form of chemotherapy?

"Xtandi is not a chemotherapy drug. Although it is used to treat cancer, Xtandi is a type of hormone therapy that works by preventing prostate cancer cells from growing and spreading by blocking the action of a group of hormones called androgens."

Answered by AI

How effective is enzalutamide for prostate cancer?

"On average, men who were given enzalutamide lived about 29% longer than men who were given placebo."

Answered by AI

How long do you take enzalutamide for?

"Xtandi is typically taken until prostate cancer starts to progress or spread (metastasize). It can cause side effects or adverse events, so the patient may need to stop taking it at some point."

Answered by AI

What are the side effects of taking enzalutamide?

"If you're experiencing any of the following, you may be suffering from a lack of vitamin d: weakness, tiredness, joint pain, muscle weakness or stiffness, weight loss, loss of appetite, headache, and dizziness."

Answered by AI

Clinical Trials for Enzalutamide

Have you considered Enzalutamide clinical trials? We made a collection of clinical trials featuring Enzalutamide, we think they might fit your search criteria.

Have you considered Enzalutamide clinical trials? We made a collection of clinical trials featuring Enzalutamide, we think they might fit your search criteria.