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What is Enzalutamide
EnzalutamideThe Generic name of this drug
Treatment SummaryEnzalutamide is a medication used to treat prostate cancer that does not respond to other treatments. It works by blocking androgen receptors, which stops hormones from stimulating tumor growth. Enzalutamide was approved by the FDA in 2012 under the brand name Xtandi.
Xtandiis the brand name
Enzalutamide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Xtandi
Enzalutamide
2012
5
Effectiveness
How Enzalutamide Affects PatientsEnzalutamide is a drug designed to stop prostate cancer from progressing. It does this by blocking the hormones and hormone receptors that cause prostate cells to grow. After a few years, prostate cancer will start to become resistant to hormone deprivation treatment, but studies show that Enzalutamide can help to slow the growth of prostate cancer cells. Clinical trials suggest that Enzalutamide can reduce the risk of death in patients by 37% compared to those taking a placebo. The drug also reduces serum PSA levels for at least 12 weeks, although this effect may be short-lived.
How Enzalutamide works in the bodyEnzalutamide is a drug that blocks the effects of testosterone and other male hormones on cancer cells. It prevents testosterone and other hormones from binding to the androgen receptor, a protein that tells the cancer cell to grow and spread. Enzalutamide is more effective at blocking hormones from binding to the receptor than some other drugs, and it has fewer side effects. It also works better than testosterone at preventing cancer cells from growing and spreading.
When to interrupt dosage
The recommended amount of Enzalutamide is contingent upon the diagnosed illness. The dose may also differ as per the administration approach (e.g. Capsule - Oral or Tablet - Oral) outlined in the table below.Condition
Dosage
Administration
Malignant Neoplasms
, 40.0 mg, 80.0 mg
, Oral, Capsule, Capsule - Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Malignant neoplasm of prostate
, 40.0 mg, 80.0 mg
, Oral, Capsule, Capsule - Oral, Tablet - Oral, Tablet, Tablet, film coated, Tablet, film coated - Oral
Warnings
There are 20 known major drug interactions with Enzalutamide.Common Enzalutamide Drug Interactions
Drug Name
Risk Level
Description
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be increased when combined with Enzalutamide.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be increased when combined with Enzalutamide.
5-androstenedione
Major
The metabolism of 5-androstenedione can be increased when combined with Enzalutamide.
6-O-benzylguanine
Major
The metabolism of 6-O-benzylguanine can be increased when combined with Enzalutamide.
7-ethyl-10-hydroxycamptothecin
Major
The metabolism of 7-ethyl-10-hydroxycamptothecin can be increased when combined with Enzalutamide.
Enzalutamide Toxicity & Overdose RiskIn studies with mice, taking enzalutamide orally during pregnancy caused embryo-fetal death, resorptions, and changes in the distance between genitalia, as well as cleft palate and missing palatine bone when taken at the highest dose. Rats who were given a single oral dose of 30 mg/kg on the 14th day of gestation had a fetal concentration of enzalutamide that was about 0.3 times that found in the mother's plasma. Enzalutamide may also reduce fertility in males. The most common side effects reported in adults include fatigue, back pain, diarrhea, joint pain, fl
Enzalutamide Novel Uses: Which Conditions Have a Clinical Trial Featuring Enzalutamide?
There are 30 ongoing trials assessing the potential of Enzalutamide for Castration Treatment.Condition
Clinical Trials
Trial Phases
Malignant neoplasm of prostate
11 Actively Recruiting
Phase 1, Early Phase 1, Phase 2, Not Applicable, Phase 4
Malignant Neoplasms
2 Actively Recruiting
Phase 2, Phase 3
Enzalutamide Reviews: What are patients saying about Enzalutamide?
5Patient Review
11/21/2014 Really effective with only a few small side effects. The fatigue is the worst part, but it's worth it considering how well this works. It's also quite expensive though.
2.3Patient Review
4/22/2013 I didn't find this treatment very effective. My disease progressed and I developed new bony metastasis within the 3 months of taking it. It's well tolerated though, with the main side effects being hot flashes and constant nausea.
Patient Q&A Section about enzalutamide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is enzalutamide better than chemotherapy?
"In a study of men with metastatic prostate cancer who had not received chemotherapy, those who were treated with enzalutamide had a longer time until cancer progression or death, improved overall survival, and delayed the need for chemotherapy by a median of 17 months."
Answered by AI
Is enzalutamide a form of chemotherapy?
"Xtandi is not a chemotherapy drug. Although it is used to treat cancer, Xtandi is a type of hormone therapy that works by preventing prostate cancer cells from growing and spreading by blocking the action of a group of hormones called androgens."
Answered by AI
How effective is enzalutamide for prostate cancer?
"On average, men who were given enzalutamide lived about 29% longer than men who were given placebo."
Answered by AI
How long do you take enzalutamide for?
"Xtandi is typically taken until prostate cancer starts to progress or spread (metastasize). It can cause side effects or adverse events, so the patient may need to stop taking it at some point."
Answered by AI
What are the side effects of taking enzalutamide?
"If you're experiencing any of the following, you may be suffering from a lack of vitamin d: weakness, tiredness, joint pain, muscle weakness or stiffness, weight loss, loss of appetite, headache, and dizziness."
Answered by AI