Demadex

Oral administration complication, Swollen feet or ankles, induction of Diuresis + 4 more
Treatment
8 FDA approvals
20 Active Studies for Demadex

What is Demadex

TorasemideThe Generic name of this drug
Treatment SummaryTorasemide is a medication used to lower blood pressure. It belongs to a class of drugs called loop diuretics, which work by helping the body get rid of excess fluid. Torasemide was first approved by the FDA in 1993 and has been used to treat high blood pressure ever since.
Demadexis the brand name
Demadex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Demadex
Torasemide
2000
115

Approved as Treatment by the FDA

Torasemide, also known as Demadex, is approved by the FDA for 8 uses which include Heart failure and Hypertensive disease .
Heart failure
Helps manage Heart Failure
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Edema
Helps manage Edema
Liver Disease
Helps manage Liver Disease
Kidney Diseases
Helps manage Kidney Diseases
Swollen feet or ankles
Helps manage Edema
Chronic Kidney Disease (CKD)
Helps manage Kidney Diseases
Congestive Heart Failure
Helps manage Heart Failure

Effectiveness

How Demadex Affects PatientsTorasemide is used to help reduce fluid buildup, acid-base balance, and potassium levels in people with acute renal failure. It increases the amount of sodium and chloride in the urine, and also helps lower blood pressure and the amount of fluid in the body. Torasemide decreases aldosterone levels, which helps prevent potassium loss and may reduce heart failure-related collagen buildup. It may also reduce myocardial fibrosis by reducing collagen accumulation.
How Demadex works in the bodyTorasemide is part of a group of drugs called loop diuretics. It works by reducing the amount of oxygen that needs to be used in the kidneys. This is done by blocking a transport molecule from binding to chloride ions. Torasemide also affects the renin-angiotensin-aldosterone system, which helps regulate blood pressure. It does this by blocking the formation of aldosterone, a hormone that helps control the balance of salt and water in the body.

When to interrupt dosage

The proposed dosage of Demadex depends upon the determined situation, including Swelling, Diuresis and Oral administration inconvenience. The measurement of dosage is contingent upon the delivery system (e.g. Oral or Tablet) noted in the table beneath.
Condition
Dosage
Administration
Swollen feet or ankles
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Tablet, Oral, Tablet - Oral, Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid, Liquid - Intravenous, Tablet, film coated - Oral, Tablet, film coated
Hypertensive disease
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Tablet, Oral, Tablet - Oral, Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid, Liquid - Intravenous, Tablet, film coated - Oral, Tablet, film coated
induction of Diuresis
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Tablet, Oral, Tablet - Oral, Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid, Liquid - Intravenous, Tablet, film coated - Oral, Tablet, film coated
Oral administration complication
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Tablet, Oral, Tablet - Oral, Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid, Liquid - Intravenous, Tablet, film coated - Oral, Tablet, film coated
Diuresis
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Tablet, Oral, Tablet - Oral, Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid, Liquid - Intravenous, Tablet, film coated - Oral, Tablet, film coated
Chronic Kidney Disease (CKD)
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Tablet, Oral, Tablet - Oral, Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid, Liquid - Intravenous, Tablet, film coated - Oral, Tablet, film coated
Congestive Heart Failure
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Tablet, Oral, Tablet - Oral, Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid, Liquid - Intravenous, Tablet, film coated - Oral, Tablet, film coated

Warnings

Demadex has three cautions and should not be taken concurrently with the ailments listed in the following table.Demadex Contraindications
Condition
Risk Level
Notes
Anuria
Do Not Combine
Hepatic Encephalopathy
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Torasemide may interact with Pulse Frequency
There are 20 known major drug interactions with Demadex.
Common Demadex Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Torasemide.
Amifostine
Major
Torasemide may increase the hypotensive activities of Amifostine.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Torasemide.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Torasemide.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Torasemide.
Demadex Toxicity & Overdose RiskThe lowest dose of torasemide that is toxic to rats is 5 g/kg. Overdoses can lead to a loss of fluids and electrolytes which can cause drowsiness, confusion, low blood pressure, low sodium and potassium levels, dehydration, and circulatory collapse. Torasemide does not increase the risk of cancer and has not been shown to be mutagenic, fetotoxic, or teratogenic.

Demadex Novel Uses: Which Conditions Have a Clinical Trial Featuring Demadex?

There are 700 clinical trials in progress to assess the utility of Demadex in treating Congestive Heart Failure, inducing Diuresis and managing Hepatitis.
Condition
Clinical Trials
Trial Phases
Diuresis
0 Actively Recruiting
Swollen feet or ankles
5 Actively Recruiting
Phase 2, Not Applicable, Phase 4
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Chronic Kidney Disease (CKD)
28 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4
Oral administration complication
0 Actively Recruiting
Congestive Heart Failure
184 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
induction of Diuresis
0 Actively Recruiting

Demadex Reviews: What are patients saying about Demadex?

5Patient Review
6/25/2009
Demadex for Visible Water Retention
The medication was easy to take and it did help lower my blood pressure and fluid retention. However, I experienced extreme joint and muscle pain as a side effect that forced me to discontinue use. Unfortunately, the side effects lasted longer than the benefits of the medication.
5Patient Review
9/29/2011
Demadex for Visible Water Retention
I've been using Demadex since 2003 to combat sudden water retention (which my maternal grandmother also experienced at the same age). The generic torsemide didn't work for me, but Demadex has given me excellent results. Just be warned that you'll need to be near a restroom because it takes effect within half an hour! I haven't experienced any side effects, but I do eat a banana every day to replenish potassium and have regular blood tests. I would highly recommend this medication.
5Patient Review
4/10/2011
Demadex for Accumulation of Fluid Resulting from Chronic Heart Failure
I've been on Demidex for a few months and, while I did have some muscle cramping the first time I took it, I haven't experienced any negative side effects this time around.
5Patient Review
11/5/2007
Demadex for Fluid in the Lungs due to Chronic Heart Failure
4.7Patient Review
12/27/2010
Demadex for Accumulation of Fluid Resulting from Chronic Heart Failure
I was struggling with a lot of edema and within a week of taking this medication, I saw incredible results. Here's hoping the next week brings even more improvement!
4.7Patient Review
3/26/2010
Demadex for High Blood Pressure
I've used this medication for a number of years with great results. However, in December of 2009 I started becoming dehydrated and vomiting (dry heaves) and had diarrhea for several hours. I was admitted to the ER and then to the hospital. They didn't give me Demadex while I was there, and I haven't used it since coming home. It did reduce the edema in my legs though - less swelling.
3.7Patient Review
5/13/2010
Demadex for Visible Water Retention
I found this drug to be very effective in reducing fluid retention.
3.7Patient Review
6/26/2010
Demadex for Edema with Defective Kidney Function
Worked great the first day! I experienced some pretty severe side effects, though.
3.3Patient Review
1/10/2010
Demadex for Accumulation of Fluid Resulting from Chronic Heart Failure
No improvement after several days. In fact, potassium levels became so depleted that I had to take breaks from the treatment to urinate and recover some energy.
3Patient Review
5/18/2019
Demadex for High Blood Pressure
I started taking this medication while I was in the hospital. A few months later, I developed blisters on my tongue whenever I took the pill. It wasn't worth the pain to continue taking this medicine.
3Patient Review
5/19/2009
Demadex for High Blood Pressure
I was still experiencing fairly regular muscle and joint pain, even with potassium. Additionally, I generally felt run down and exhausted.
2.7Patient Review
9/11/2008
Demadex for High Blood Pressure
I'm really thirsty since starting this medication, and I've also developed some pain in both of my nipples. Are those side effects that I should be aware of?
2Patient Review
2/1/2012
Demadex for Visible Water Retention
After just three days of taking this medication, I started vomiting uncontrollably and had to be hospitalized. Once I was released, I thought maybe it wasn't the drug that caused the problem so I tried taking it again. Unfortunately, the same thing happened. While the medication is effective, my body can't tolerate it.
1Patient Review
7/5/2009
Demadex for Visible Water Retention
I started taking this for fluid retention and it's already helping! I can see my ankles again, which is a huge relief.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about demadex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Demadex stronger than Lasix?

"Furosemide (Lasix) is the most widely used diuretic in heart failure patients, however torsemide (Demadex) has a better pharmacokinetic and pharmacodynamic profile. Torsemide is more potent with a longer half-life and greater bioavailability."

Answered by AI

How quickly does Demadex work?

"In patients with essential hypertension, DEMADEX has been shown in controlled studies to lower blood pressure when administered once a day at doses of 5 mg to 10 mg. The antihypertensive effect is most pronounced after 4 to 6 weeks of treatment, but it may continue to increase for up to 12 weeks."

Answered by AI

What are the side effects of Demadex?

"or menstrual irregularities

Some side effects of the medication include increased urination, dizziness, nausea, headache, diarrhea, constipation, and joint pain. In some cases, women may also experience irregularities in their menstrual cycle."

Answered by AI

What is the medication Demadex used for?

"Torsemide is used to reduce extra fluid in the body. This can lessen symptoms such as shortness of breath and swelling in your arms, legs, and abdomen."

Answered by AI

Clinical Trials for Demadex

Image of Lakeland Regional Hospital in Lakeland, United States.

Furosemide for Heart Failure

18+
All Sexes
Lakeland, FL
The goal of this clinical trial is to learn if increasing the dose of diuretics to achieve a higher urine sodium target produces better clinical results when treating patients hospitalized with acute heart failure when compared to lower urine sodium target and standard of care. The main questions it aims to answer are: 1. Does targeting a higher urine sodium goal achieve greater natriuresis and diuresis? 2. Does targeting a higher urine sodium goal reduce frequency of hospital readmissions? 3. Does targeting a higher urine sodium goal reduce hospital length of stay? Researchers will compare natriuresis-guided arms with standard of care to see if targeting higher natriuresis goals improves significantly over current practice. Participants will submit urine samples at routine intervals after being given diuretics to evaluate urine sodium concentration. If urine sodium is low then diuretic dose will be increased.
Phase 4
Waitlist Available
Lakeland Regional HospitalAnas Bizanti, MD
Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Have you considered Demadex clinical trials? We made a collection of clinical trials featuring Demadex, we think they might fit your search criteria.Go to Trials
Image of Los Angeles General Medical Center in Los Angeles, United States.

Supportive Management for Heart Failure and Methamphetamine Addiction

18+
All Sexes
Los Angeles, CA
Heart failure (HF) affects over 6 million people in the US and is a major cause of both hospital admissions and death. HF has many causes and contributing factors. One of the most aggressive forms of HF is associated with methamphetamine abuse, which has become its own epidemic in the US over the past twenty years. People who use methamphetamine tend to develop HF at a much younger age, with more severe disease and more serious consequences. A recent analysis using nationwide data, methamphetamine use doubled the risk of death or hospitalizations compared to non-users in patients with HF. Thus, methamphetamine users with HF represent a very high-risk group of patients from a healthcare perspective. HF may be reversible in some patients who use methamphetamine if patients can achieve 1) abstain from further methamphetamine use and 2) consistently take all the medications that can improve HF. These two goals are very difficult to achieve in practice, as the care of both methamphetamine addiction and HF requires specialized medical expertise and intensive regular follow up of patients. In general, achievement of one goal is not possible without the other. Patients who use methamphetamine have poor adherence to medical follow-up and therapies, and abstinence from methamphetamine is difficult to maintain. This is further complicated because the current model of HF care does not incorporate treatment for methamphetamine use. The current study proposes to launch a multidisciplinary clinic that treats both HF and methamphetamine use disorder at the same time. The HF care will be led by a cardiologist while the methamphetamine use treatment will be led by a psychiatric clinical pharmacist trained in addiction medicine. State-of-the-art HF care will include optimization of four pillar HF medications. Methamphetamine use treatment will include counseling and incentivized abstinence known as contingency management (CM). The investigators will manage the patients in the clinic for 6 months total. The investigators are interested in demonstrating that this integrated clinic model will result in improved delivery of care for these patients by reporting the rates of successful abstinence from methamphetamine, improved optimization of the four HF medications, and enhanced patient reported quality of life over the 6 months of follow up. The investigators will also collect data on the costs associated with providing this level of care and estimate a range of potential cost-savings.
Waitlist Available
Has No Placebo
Los Angeles General Medical Center (+1 Sites)Tien Ng, PharmD
Have you considered Demadex clinical trials? We made a collection of clinical trials featuring Demadex, we think they might fit your search criteria.Go to Trials
Have you considered Demadex clinical trials? We made a collection of clinical trials featuring Demadex, we think they might fit your search criteria.Go to Trials
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Terms of Service·Privacy Policy·Cookies·Security