Your session is about to expire
What is Demadex
TorasemideThe Generic name of this drug
Treatment SummaryTorasemide is a medication used to lower blood pressure. It belongs to a class of drugs called loop diuretics, which work by helping the body get rid of excess fluid. Torasemide was first approved by the FDA in 1993 and has been used to treat high blood pressure ever since.
Demadexis the brand name
Demadex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Demadex
Torasemide
2000
115
Approved as Treatment by the FDA
Torasemide, also known as Demadex, is approved by the FDA for 4 uses which include Congestive Heart Failure and Chronic Kidney Disease (CKD) .Congestive Heart Failure
Helps manage Heart Failure
Chronic Kidney Disease (CKD)
Helps manage Kidney Diseases
Swollen feet or ankles
Helps manage Edema
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Effectiveness
How Demadex Affects PatientsTorasemide is used to help reduce fluid buildup, acid-base balance, and potassium levels in people with acute renal failure. It increases the amount of sodium and chloride in the urine, and also helps lower blood pressure and the amount of fluid in the body. Torasemide decreases aldosterone levels, which helps prevent potassium loss and may reduce heart failure-related collagen buildup. It may also reduce myocardial fibrosis by reducing collagen accumulation.
How Demadex works in the bodyTorasemide is part of a group of drugs called loop diuretics. It works by reducing the amount of oxygen that needs to be used in the kidneys. This is done by blocking a transport molecule from binding to chloride ions. Torasemide also affects the renin-angiotensin-aldosterone system, which helps regulate blood pressure. It does this by blocking the formation of aldosterone, a hormone that helps control the balance of salt and water in the body.
When to interrupt dosage
The proposed dosage of Demadex depends upon the determined situation, including Swelling, Diuresis and Oral administration inconvenience. The measurement of dosage is contingent upon the delivery system (e.g. Oral or Tablet) noted in the table beneath.Condition
Dosage
Administration
Swollen feet or ankles
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Oral administration complication
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Hypertensive disease
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Congestive Heart Failure
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
induction of Diuresis
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Chronic Kidney Disease (CKD)
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Diuresis
, 5.0 mg, 100.0 mg, 10.0 mg, 20.0 mg, 10.0 mg/mL, 40.0 mg, 60.0 mg
, Oral, Tablet, Tablet - Oral, Intravenous, Injection, solution, Injection, solution - Intravenous, Liquid, Liquid - Intravenous, Tablet, film coated, Tablet, film coated - Oral
Warnings
Demadex has three cautions and should not be taken concurrently with the ailments listed in the following table.Demadex ContraindicationsCondition
Risk Level
Notes
Anuria
Do Not Combine
Hepatic coma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Torasemide may interact with Pulse Frequency
Common Demadex Drug Interactions
Drug Name
Risk Level
Description
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Torasemide.
Amifostine
Major
Torasemide may increase the hypotensive activities of Amifostine.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Torasemide.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Torasemide.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Torasemide.
Demadex Toxicity & Overdose RiskThe lowest dose of torasemide that is toxic to rats is 5 g/kg. Overdoses can lead to a loss of fluids and electrolytes which can cause drowsiness, confusion, low blood pressure, low sodium and potassium levels, dehydration, and circulatory collapse. Torasemide does not increase the risk of cancer and has not been shown to be mutagenic, fetotoxic, or teratogenic.
Demadex Novel Uses: Which Conditions Have a Clinical Trial Featuring Demadex?
There are 700 clinical trials in progress to assess the utility of Demadex in treating Congestive Heart Failure, inducing Diuresis and managing Hepatitis.Condition
Clinical Trials
Trial Phases
Chronic Kidney Disease (CKD)
244 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Oral administration complication
0 Actively Recruiting
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Congestive Heart Failure
312 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Diuresis
0 Actively Recruiting
induction of Diuresis
0 Actively Recruiting
Demadex Reviews: What are patients saying about Demadex?
5Patient Review
6/25/2009 The medication was easy to take and it did help lower my blood pressure and fluid retention. However, I experienced extreme joint and muscle pain as a side effect that forced me to discontinue use. Unfortunately, the side effects lasted longer than the benefits of the medication.
5Patient Review
9/29/2011 I've been using Demadex since 2003 to combat sudden water retention (which my maternal grandmother also experienced at the same age). The generic torsemide didn't work for me, but Demadex has given me excellent results. Just be warned that you'll need to be near a restroom because it takes effect within half an hour! I haven't experienced any side effects, but I do eat a banana every day to replenish potassium and have regular blood tests. I would highly recommend this medication.
5Patient Review
4/10/2011 I've been on Demidex for a few months and, while I did have some muscle cramping the first time I took it, I haven't experienced any negative side effects this time around.
5Patient Review
11/5/20074.7Patient Review
12/27/2010 I was struggling with a lot of edema and within a week of taking this medication, I saw incredible results. Here's hoping the next week brings even more improvement!
4.7Patient Review
3/26/2010 I've used this medication for a number of years with great results. However, in December of 2009 I started becoming dehydrated and vomiting (dry heaves) and had diarrhea for several hours. I was admitted to the ER and then to the hospital. They didn't give me Demadex while I was there, and I haven't used it since coming home. It did reduce the edema in my legs though - less swelling.
3.7Patient Review
5/13/2010 I found this drug to be very effective in reducing fluid retention.
3.7Patient Review
6/26/2010 Worked great the first day! I experienced some pretty severe side effects, though.
3.3Patient Review
1/10/2010 No improvement after several days. In fact, potassium levels became so depleted that I had to take breaks from the treatment to urinate and recover some energy.
3Patient Review
5/18/2019 I started taking this medication while I was in the hospital. A few months later, I developed blisters on my tongue whenever I took the pill. It wasn't worth the pain to continue taking this medicine.
3Patient Review
5/19/2009 I was still experiencing fairly regular muscle and joint pain, even with potassium. Additionally, I generally felt run down and exhausted.
2.7Patient Review
9/11/2008 I'm really thirsty since starting this medication, and I've also developed some pain in both of my nipples. Are those side effects that I should be aware of?
2Patient Review
2/1/2012 After just three days of taking this medication, I started vomiting uncontrollably and had to be hospitalized. Once I was released, I thought maybe it wasn't the drug that caused the problem so I tried taking it again. Unfortunately, the same thing happened. While the medication is effective, my body can't tolerate it.
1Patient Review
7/5/2009 I started taking this for fluid retention and it's already helping! I can see my ankles again, which is a huge relief.
Patient Q&A Section about demadex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Demadex stronger than Lasix?
"Furosemide (Lasix) is the most widely used diuretic in heart failure patients, however torsemide (Demadex) has a better pharmacokinetic and pharmacodynamic profile. Torsemide is more potent with a longer half-life and greater bioavailability."
Answered by AI
How quickly does Demadex work?
"In patients with essential hypertension, DEMADEX has been shown in controlled studies to lower blood pressure when administered once a day at doses of 5 mg to 10 mg. The antihypertensive effect is most pronounced after 4 to 6 weeks of treatment, but it may continue to increase for up to 12 weeks."
Answered by AI
What are the side effects of Demadex?
"or menstrual irregularities
Some side effects of the medication include increased urination, dizziness, nausea, headache, diarrhea, constipation, and joint pain. In some cases, women may also experience irregularities in their menstrual cycle."
Answered by AI
What is the medication Demadex used for?
"Torsemide is used to reduce extra fluid in the body. This can lessen symptoms such as shortness of breath and swelling in your arms, legs, and abdomen."
Answered by AI