This trial is evaluating whether Nitric Oxide will improve 1 primary outcome and 4 secondary outcomes in patients with Stroke. Measurement will happen over the course of Conclusion of the 35 minute protocol.
This trial requires 40 total participants across 2 different treatment groups
This trial involves 2 different treatments. Nitric Oxide is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"There is a wide diversity of environmental and genetic factors that contribute to the occurrence of stroke. This is important because the use of specific medications and risk factors can reduce both fatal and non-fatal stroke occurrences. Current treatments, especially for the prevention of second and third strokes, are not well supported by scientific evidence. In general, the aim of preventive medicine is to reduce the risk of stroke through strategies that lower blood pressure or use of medications to prevent blood sugar from rising too high. However, further research is needed to study the exact risks and effective preventive strategies of all stroke types." - Anonymous Online Contributor
"There are many important points in the body of evidence that show that there are several clinical signs that are strongly associated with stroke. There is strong evidence that the initial clinical signs of stroke can be seen almost simultaneously with the onset of a ischemic stroke. The time of onset of a stroke appears to be important for identification of the underlying mechanism. There is also evidence that in patients that have had a stroke before they show any symptoms it is also important to look at what is happening to the brain of those not having had a stroke. It is also evident that specific clinical signs of stroke appear before specific areas of the body are affected. For example, loss of vision and speech may be found before loss of limbs." - Anonymous Online Contributor
"Most stroke events are treated by a combination of treatments, although most treatments are often not used, with their individual efficacy, side effects or cost/cost considerations. There is a need for a review of standard treatment algorithms." - Anonymous Online Contributor
"Stroke is a disorder characterized by a sudden loss of brain function, usually due to a blood clot occluding the blood vessels of the brain. About 62.4% of strokes are due to a blood clot blocking one of the blood vessels leading to the brain while 42.6% are a complication of a previous stroke. Most strokes are the result of a blood clot occluding an artery that supplies the brain-stem and/or the brain with oxygen. Most strokes are related to problems occurring in the heart or blood vessels." - Anonymous Online Contributor
"About 80,000 people develop a first stroke, and approximately 46,000 of these will be recurrence and major strokes in the year following the index stroke. The vast majority of strokes are ischemic but there is an emerging proportion of strokes caused by vascular lesions or, more rarely, arterial embolism. Stroke due to arterial embolism is a relatively uncommon cause of recurrent ischaemic stroke." - Anonymous Online Contributor
"Even very early stroke rehabilitation might have a beneficial effect on the neurological outcome. Stroke is a devastating disease. It is an irreversible condition because stroke is usually triggered by long-term, and very high risk factors. Early intervention is very important because it allows to halt or reverse the deterioration into a permanent neurological deficit in most patients." - Anonymous Online Contributor
"The average age of stroke patients is 58.3 years. Stroke patients are more likely to be female, black or African American, and have hypertension. After adjusting for demographic factors, stroke severity increases per decade in patients." - Anonymous Online Contributor
"The latest studies have a promising outlook of treatments in progress. At least two therapies have some positive results. This is an area where future research needs to be directed and more emphasis more seriously be given." - Anonymous Online Contributor
"Nitric oxide has promising therapeutic implications for acute strokes and for acute/subacute myocardial infarction when administered in appropriate doses and for long-term cardiovascular disease when used in conjunction with traditional cardiovascular risk factors." - Anonymous Online Contributor
"Despite NO being important in the formation of NO in the lungs, the results suggest that nitric oxide is not harmful for healthy people. Results from a recent clinical trial were also the case when nitric oxide was added to a sterile blood-containing solution. The NO concentration in such solutions was in the range of that observed in blood plasma. This leads us to believe that the NO concentrations in both the human airways and lungs are probably too high to be toxic to the airway or lung function." - Anonymous Online Contributor
"Stroke related familial pattern in the three generations of our family in the Indian population can be due to a complex interaction of genetic and environmental factors." - Anonymous Online Contributor
"This preliminary study confirms the potential value of NO in acute stroke as well as the positive effects of NO on neurological outcome. However, further study is needed with a larger number of patients to ensure that positive results are statistically significant." - Anonymous Online Contributor