Eligibility
18+
All Sexes
What conditions do you have?
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Study Summary
This trial is measuring the cerebral blood flow response to inhaled nitric oxide in acute ischemic stroke patients and healthy subjects.
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 4 Secondary · Reporting Duration: Conclusion of the 35 minute protocol
Conclusion of the 35 minute protocol
Change in blood flow velocity as measured by TCD during iNO administration
Change in cerebral blood flow during the administration of iNO
Change in mean arterial blood pressure (MAP) during iNO administration
Duration of residual effect after cessation of iNO (time to return to baseline)
Time to maximum CBF effect after the introduction of iNO
Trial Safety
Safety Progress
This is further along than 68% of similar trials
Trial Design
2 Treatment Groups
Acute Ischemic Stroke
1 of 2
Healthy Controls
1 of 2
Experimental Treatment
40 Total Participants · 2 Treatment Groups
Primary Treatment: Nitric Oxide · No Placebo Group · Phase 2
Acute Ischemic Stroke
Drug
Experimental Group · 1 Intervention: Nitric Oxide · Intervention Types: DrugHealthy Controls
Drug
Experimental Group · 1 Intervention: Nitric Oxide · Intervention Types: DrugTreatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Nitric Oxide
FDA approved
Trial Logistics
Trial Timeline
Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: conclusion of the 35 minute protocol
Who is running the clinical trial?
Steven MesseLead Sponsor
MallinckrodtIndustry Sponsor
199 Previous Clinical Trials
16,558 Total Patients Enrolled
Steven R Messe, M.D.Principal InvestigatorUniversity of Pennsylvania
Eligibility Criteria
Age 18+ · All Participants · 5 Total Inclusion Criteria
Mark “yes” if the following statements are true for you:About The Reviewer
Michael Gill holds a Bachelors of Science in Integrated Science and Mathematics from McMaster University. During his degree he devoted considerable time modeling the pharmacodynamics of promising drug candidates. Since then, he has leveraged this knowledge of the investigational new drug ecosystem to help his father navigate clinical trials for multiple myeloma, an experience which prompted him to co-found Power Life Sciences: a company that helps patients access randomized controlled trials.
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Conditions
Cancer Related
Treatments