Niacin and Aspirin for Prostaglandin D2 Metabolism Pathways
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial uses niacin and aspirin to study their effects on a body chemical in healthy volunteers. Researchers measure chemicals in urine and blood to understand how this chemical is broken down.
Will I have to stop taking my current medications?
Yes, you will need to stop taking your current medications, as the trial is for healthy volunteers not currently taking any medication. Additionally, you must not have used anti-inflammatory or over-the-counter pain medications for at least 2 weeks before the study.
Is the combination of niacin and aspirin generally safe for humans?
Aspirin, also known as acetylsalicylic acid, is widely used to relieve pain and reduce inflammation, but it can cause side effects like stomach upset and increased risk of bleeding. Niacin, or Vitamin B3, is generally safe but can cause flushing (a warm, red feeling in the skin) and, at high doses, liver damage. Combining these drugs may have additional effects, so it's important to consult with a healthcare provider before use.12345
How does the drug niacin differ from other treatments for prostaglandin D2 metabolism pathways?
Niacin is unique because it increases the production of prostaglandin D2 (PGD2), which can cause flushing, a common side effect. This drug works by activating specific receptors and pathways that are not typically targeted by other treatments, and its effects can be modulated by combining it with aspirin or omega-3 fatty acids to reduce side effects.678910
What data supports the effectiveness of this drug?
Research shows that niacin (Vitamin B3) can increase the production of prostaglandin D2 (PGD2), which is involved in various body functions, including blood flow and inflammation. Additionally, aspirin is known to inhibit certain enzymes that produce prostaglandins, potentially balancing the effects of niacin-induced PGD2 production.78111213
Who Is on the Research Team?
Claus M Schneider, PhD
Principal Investigator
Vanderbilt University
Are You a Good Fit for This Trial?
This trial is for healthy volunteers who aren't on any medications. It's not open to those who've taken anti-inflammatory or over-the-counter pain meds like NSAIDs in the two weeks before the study starts.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive niacin and aspirin treatments, with urine and blood samples collected at specified intervals
Monitoring
Participants are monitored for prostaglandin metabolites in urine and blood over a 10-hour period post-treatment
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Aspirin
- Niacin
- PGD2
Find a Clinic Near You
Who Is Running the Clinical Trial?
Vanderbilt University
Lead Sponsor
Vanderbilt University Medical Center
Collaborator