Corgard

Atrial Fibrillation, Migraine, Thyrotoxicosis + 4 more
Treatment
2 FDA approvals
20 Active Studies for Corgard

What is Corgard

NadololThe Generic name of this drug
Treatment SummaryNadolol is a medication used to lower blood pressure. It is a type of drug known as a nonselective beta blocker, which works by blocking certain receptors in the body. Nadolol was approved by the FDA in 1979, but newer beta blockers with fewer side effects have since been developed and are used more often today.
Corgardis the brand name
image of different drug pills on a surface
Corgard Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Corgard
Nadolol
1979
120

Approved as Treatment by the FDA

Nadolol, commonly known as Corgard, is approved by the FDA for 2 uses which include Chest Pain and Hypertensive disease .
Chest Pain
Helps manage Angina Pectoris
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)

Effectiveness

How Corgard Affects PatientsNadolol is a type of medicine that helps to reduce blood pressure. It's usually taken once a day and can be taken in doses ranging from 40mg to 240mg. If you stop taking nadolol suddenly, it can make existing heart problems worse, so it is important not to stop taking it without discussing it with your doctor first.
How Corgard works in the bodyNadolol is a beta blocker, which means it blocks the effects of hormones that cause your heart to beat faster and your blood vessels to narrow. This reduces the risk of low blood pressure and improves insulin sensitivity. It also stops the release of hormones that make your heart beat faster, your muscles store sugar, and your lungs open up. Finally, it stops hormones from causing your body to retain water and make your blood vessels narrow.

When to interrupt dosage

The recommended dosage of Corgard is contingent upon the diagnosed condition, including Chest Pain, Atrial Fibrillation and Thyrotoxicosis. The dosage amount is contingent upon the method of delivery indicated in the following table.
Condition
Dosage
Administration
Atrial Fibrillation
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Oral, Tablet - Oral
Migraine
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Oral, Tablet - Oral
Gastroesophageal variceal hemorrhage prophylaxis
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Oral, Tablet - Oral
Hypertensive disease
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Oral, Tablet - Oral
Thyrotoxicosis
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Oral, Tablet - Oral
Migraine Disorders
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Oral, Tablet - Oral
Chest Pain
20.0 mg, , 40.0 mg, 80.0 mg, 160.0 mg, 120.0 mg
, Tablet, Oral, Tablet - Oral

Warnings

Corgard has five contraindications and should not be merged with the circumstances listed in the following table.Corgard Contraindications
Condition
Risk Level
Notes
Heart Failure
Do Not Combine
Heart Block
Do Not Combine
Sinus Bradycardia
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Asthma
Do Not Combine
There are 20 known major drug interactions with Corgard.
Common Corgard Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Nadolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Nadolol.
Abediterol
Major
Nadolol may decrease the bronchodilatory activities of Abediterol.
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Nadolol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Nadolol.
Corgard Toxicity & Overdose RiskThe lowest toxic dose of a drug in mice is 4500mg/kg. Signs of an overdose may include a slow heart rate, heart failure, low blood pressure, and difficulty breathing. Treatments for overdose include atropine to stabilize the heart rate, digitalis and diuretics to treat heart failure, medications to raise blood pressure, and drugs to open the airways. In addition, doctors may use stomach pumping and dialysis to clear out the drug from the body.
image of a doctor in a lab doing drug, clinical research

Corgard Novel Uses: Which Conditions Have a Clinical Trial Featuring Corgard?

245 active clinical trials are currently investigating the potential of Corgard to reduce the risk of Gastroesophageal variceal hemorrhage, mitigate Thyrotoxicosis and manage Hypertensive disease.
Condition
Clinical Trials
Trial Phases
Migraine
54 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Thyrotoxicosis
0 Actively Recruiting
Chest Pain
2 Actively Recruiting
Not Applicable, Phase 2, Phase 3
Gastroesophageal variceal hemorrhage prophylaxis
0 Actively Recruiting
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Atrial Fibrillation
96 Actively Recruiting
Not Applicable, Phase 2, Phase 4, Phase 1, Phase 3, Early Phase 1
Migraine Disorders
1 Actively Recruiting
Phase 3

Corgard Reviews: What are patients saying about Corgard?

5Patient Review
4/5/2009
Corgard for Abnormal Heart Rhythm
I've been on the generic for this treatment for about two decades, and only recently have I experienced some more skipped beats and a fast heart rate. I had a successful stress test and try to exercise three times a week, but my heart was still racing. So, I started taking Inderal LA 80mg once per day yesterday and hope this works. If not, than I'll go back on Corgard. This has been a very good drug up until now, so hopefully this change will be effective.
5Patient Review
11/14/2010
Corgard for Migraine Prevention
Corgard has been a true lifesaver for me. It's prevented migraines for 37 years now, and if I do have one it's not as bad as it otherwise would be.
5Patient Review
11/17/2010
Corgard for Mitral Valve Prolapse Syndrome
This medication has been a godsend for my mitral valve prolapse syndrome. It's greatly reduced the palpitations I was experiencing and allowed me to sleep better at night.
5Patient Review
4/1/2012
Corgard for Abnormal Heart Rhythm
I've been on this treatment for over 20 years and it's done alright. Recently, I started getting headaches. I read that beta blockers can help with headaches, so I may try the name brand instead of the generic. Has anybody else experienced these headaches?
5Patient Review
9/30/2011
Corgard for Mitral Valve Prolapse Syndrome
I've been on this medication for a long time, and under my doctor's supervision, I'm slowly reducing the dosage. Recently, every fifth day when I don't take the drug, I've felt jittery and shaky. Is this to be expected?
View All Reviews
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Patient Q&A Section about corgard

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Corgard the same as nadolol?

"In some cases, they may not be available in every strength or form as the brand-name drug.

Nadolol is a drug that is available as the brand-name drug Corgard. It is also available in a generic version. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug."

Answered by AI

What is the medication Corgard used for?

"Nadolol is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and with less force. Nadolol is also used to treat or prevent heart attack, and to reduce the severity and frequency of migraine headaches.

Nadolol is used to either treat high blood pressure on its own or with other medications, as well as to prevent chest pain. By lowering high blood pressure, it helps to prevent strokes, heart attacks, and kidney problems. As a beta-blocker, nadolol works by affecting the response to nerve impulses in certain parts of the body, such as the heart. This then causes the heart to beat slower and with less force. Nadolol is also used to either treat or prevent heart attacks, and to reduce the severity and frequency of migraine headaches."

Answered by AI

What is the drug nadolol used for?

"Nadolol is used to treat high blood pressure by reducing the workload of the heart and arteries. If left untreated, high blood pressure can damaging the heart and arteries over time."

Answered by AI

Why was Corgard discontinued?

"The manufacturer of nadolol (Corgard®) has confirmed that this product has been discontinued. The product has been discontinued for commercial reasons. Nadolol, a beta blocker, was licensed for use in hypertension, angina, arrhythmias, migraine prophylaxis and adjunctive treatment of thyrotoxicosis. Apr 13, 2016"

Answered by AI

Clinical Trials for Corgard

Have you considered Corgard clinical trials? We made a collection of clinical trials featuring Corgard, we think they might fit your search criteria.
Have you considered Corgard clinical trials? We made a collection of clinical trials featuring Corgard, we think they might fit your search criteria.
Have you considered Corgard clinical trials? We made a collection of clinical trials featuring Corgard, we think they might fit your search criteria.
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