What is Corgard
NadololThe Generic name of this drug
Treatment SummaryNadolol is a medication used to lower blood pressure. It is a type of drug known as a nonselective beta blocker, which works by blocking certain receptors in the body. Nadolol was approved by the FDA in 1979, but newer beta blockers with fewer side effects have since been developed and are used more often today.
Corgardis the brand name
Corgard Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Corgard
Nadolol
1979
120
Approved as Treatment by the FDA
Nadolol, commonly known as Corgard, is approved by the FDA for 2 uses which include Chest Pain and Hypertensive disease .Chest Pain
Helps manage Angina Pectoris
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Effectiveness
How Corgard Affects PatientsNadolol is a type of medicine that helps to reduce blood pressure. It's usually taken once a day and can be taken in doses ranging from 40mg to 240mg. If you stop taking nadolol suddenly, it can make existing heart problems worse, so it is important not to stop taking it without discussing it with your doctor first.
How Corgard works in the bodyNadolol is a beta blocker, which means it blocks the effects of hormones that cause your heart to beat faster and your blood vessels to narrow. This reduces the risk of low blood pressure and improves insulin sensitivity. It also stops the release of hormones that make your heart beat faster, your muscles store sugar, and your lungs open up. Finally, it stops hormones from causing your body to retain water and make your blood vessels narrow.
When to interrupt dosage
The recommended dosage of Corgard is contingent upon the diagnosed condition, including Chest Pain, Atrial Fibrillation and Thyrotoxicosis. The dosage amount is contingent upon the method of delivery indicated in the following table.Condition
Dosage
Administration
prophylaxis of migraine headaches
80.0 mg, 40.0 mg, , 120.0 mg, 20.0 mg, 160.0 mg
Oral, , Tablet, Tablet - Oral
Chest Pain
80.0 mg, 40.0 mg, , 120.0 mg, 20.0 mg, 160.0 mg
Oral, , Tablet, Tablet - Oral
Atrial Fibrillation
80.0 mg, 40.0 mg, , 120.0 mg, 20.0 mg, 160.0 mg
Oral, , Tablet, Tablet - Oral
Thyrotoxicosis
80.0 mg, 40.0 mg, , 120.0 mg, 20.0 mg, 160.0 mg
Oral, , Tablet, Tablet - Oral
Migraine
80.0 mg, 40.0 mg, , 120.0 mg, 20.0 mg, 160.0 mg
Oral, , Tablet, Tablet - Oral
Gastroesophageal variceal hemorrhage prophylaxis
80.0 mg, 40.0 mg, , 120.0 mg, 20.0 mg, 160.0 mg
Oral, , Tablet, Tablet - Oral
Hypertensive disease
80.0 mg, 40.0 mg, , 120.0 mg, 20.0 mg, 160.0 mg
Oral, , Tablet, Tablet - Oral
Warnings
Corgard has five contraindications and should not be merged with the circumstances listed in the following table.Corgard ContraindicationsCondition
Risk Level
Notes
Shock, Cardiogenic
Do Not Combine
Bronchial Asthma
Do Not Combine
Sinus Bradycardia
Do Not Combine
overt cardiac failure
Do Not Combine
Heart Block
Do Not Combine
Common Corgard Drug Interactions
Drug Name
Risk Level
Description
4-Bromo-2,5-dimethoxyphenethylamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyphenethylamine can be decreased when used in combination with Nadolol.
4-Methoxyamphetamine
Major
The therapeutic efficacy of 4-Methoxyamphetamine can be decreased when used in combination with Nadolol.
Abediterol
Major
Nadolol may decrease the bronchodilatory activities of Abediterol.
Abemaciclib
Major
The excretion of Abemaciclib can be decreased when combined with Nadolol.
Adrafinil
Major
The therapeutic efficacy of Adrafinil can be decreased when used in combination with Nadolol.
Corgard Toxicity & Overdose RiskThe lowest toxic dose of a drug in mice is 4500mg/kg. Signs of an overdose may include a slow heart rate, heart failure, low blood pressure, and difficulty breathing. Treatments for overdose include atropine to stabilize the heart rate, digitalis and diuretics to treat heart failure, medications to raise blood pressure, and drugs to open the airways. In addition, doctors may use stomach pumping and dialysis to clear out the drug from the body.
Corgard Novel Uses: Which Conditions Have a Clinical Trial Featuring Corgard?
245 active clinical trials are currently investigating the potential of Corgard to reduce the risk of Gastroesophageal variceal hemorrhage, mitigate Thyrotoxicosis and manage Hypertensive disease.Condition
Clinical Trials
Trial Phases
Migraine
61 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Phase 3
Atrial Fibrillation
168 Actively Recruiting
N/A, Phase 2, Not Applicable, Phase 4, Phase 3, Phase 1, Early Phase 1
Chest Pain
10 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4
prophylaxis of migraine headaches
0 Actively Recruiting
Gastroesophageal variceal hemorrhage prophylaxis
0 Actively Recruiting
Thyrotoxicosis
0 Actively Recruiting
Corgard Reviews: What are patients saying about Corgard?
5Patient Review
4/5/2009 I've been on the generic for this treatment for about two decades, and only recently have I experienced some more skipped beats and a fast heart rate. I had a successful stress test and try to exercise three times a week, but my heart was still racing. So, I started taking Inderal LA 80mg once per day yesterday and hope this works. If not, than I'll go back on Corgard. This has been a very good drug up until now, so hopefully this change will be effective.
5Patient Review
11/14/2010 Corgard has been a true lifesaver for me. It's prevented migraines for 37 years now, and if I do have one it's not as bad as it otherwise would be.
5Patient Review
11/17/2010 This medication has been a godsend for my mitral valve prolapse syndrome. It's greatly reduced the palpitations I was experiencing and allowed me to sleep better at night.
5Patient Review
4/1/2012 I've been on this treatment for over 20 years and it's done alright. Recently, I started getting headaches. I read that beta blockers can help with headaches, so I may try the name brand instead of the generic. Has anybody else experienced these headaches?
5Patient Review
9/30/2011 I've been on this medication for a long time, and under my doctor's supervision, I'm slowly reducing the dosage. Recently, every fifth day when I don't take the drug, I've felt jittery and shaky. Is this to be expected?
5Patient Review
1/24/2014 I've been taking this medication for my heart palpitations and it has worked great. I've been taking it 3 times a day since 1983 with no adverse reactions.
5Patient Review
6/9/2018 I had a quadruple bypass 21 years ago and have been on this medication since. It's really effective!
5Patient Review
3/31/2010 I've had great success in controlling my essential tremor by taking this drug regularly for many years.
5Patient Review
9/29/2010 Being that I've been taking this for such a long time, it's really become a part of my life. It effectively helps with my racing heart and I haven't found anything else that does the job as well as this medication.
4.3Patient Review
6/14/2008 It takes a little while to see results from this medication if you're used to consuming a lot of caffeine. However, it's been very effective in preventing migraines for me. The only downside is that I sometimes get a headache in the morning when I first wake up; but drinking some water or having orange juice usually takes care of that within 10-15 minutes.
4.3Patient Review
10/23/2011 Corgard has been working just as well as Inderal LA for me, but at a much lower cost. I was taking Inderal LA 120 mg 5x a day, and Corgard 1x a day is doing the trick. Definitely worth trying if you're on the fence!
4Patient Review
9/11/2009 The drug has effectively kept my arrythmia in check. However, it does make me drowsy to the point of sleepiness within thirty minutes of taking it. This can be a bit inconvenient, but it's better than the alternative.
4Patient Review
7/2/2013 I've been on this medication for a while now, and I recently developed a cough that won't go away. I'm wondering if the two could be related.
3.7Patient Review
1/21/2012 CORGARD has helped to reduce the severity of my hand tremors over the past three weeks.
3.3Patient Review
4/12/2011 I gained nearly 30 pounds, despite a healthy diet and plenty of exercise, while taking Corgard. Additionally, I experienced hair loss (as a woman, this was very upsetting), joint pain, nightmares, and insomnia. As soon as I switched medications, all of my symptoms went away and my weight started decreasing.
3.3Patient Review
7/29/2008 I've used this treatment for 18 years and the only problem I've had is with thinning hair and hair loss. So, I asked to be put on something else.
1.3Patient Review
1/4/2013 After recently being diagnosed with pre-hypertension, I consistently had high blood pressure (close to 140/90). The generic medication I was prescribed gave me headaches every day for the first three weeks. It also never completely lowered my blood pressure, so my doctor increased the dosage. As a result, I experienced an increased heart rate and extreme nausea, as well as swelling in my feet/ankles/hands.
Patient Q&A Section about corgard
Is Corgard the same as nadolol?
"In some cases, they may not be available in every strength or form as the brand-name drug.
Nadolol is a drug that is available as the brand-name drug Corgard. It is also available in a generic version. Generic drugs usually cost less than the brand-name version. In some cases, they may not be available in every strength or form as the brand-name drug." - Anonymous Online Contributor
Unverified Answer
What is the medication Corgard used for?
"Nadolol is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and with less force. Nadolol is also used to treat or prevent heart attack, and to reduce the severity and frequency of migraine headaches.
Nadolol is used to either treat high blood pressure on its own or with other medications, as well as to prevent chest pain. By lowering high blood pressure, it helps to prevent strokes, heart attacks, and kidney problems. As a beta-blocker, nadolol works by affecting the response to nerve impulses in certain parts of the body, such as the heart. This then causes the heart to beat slower and with less force. Nadolol is also used to either treat or prevent heart attacks, and to reduce the severity and frequency of migraine headaches." - Anonymous Online Contributor
Unverified Answer
What is the drug nadolol used for?
"Nadolol is used to treat high blood pressure by reducing the workload of the heart and arteries. If left untreated, high blood pressure can damaging the heart and arteries over time." - Anonymous Online Contributor
Unverified Answer
Why was Corgard discontinued?
"The manufacturer of nadolol (Corgard®) has confirmed that this product has been discontinued. The product has been discontinued for commercial reasons. Nadolol, a beta blocker, was licensed for use in hypertension, angina, arrhythmias, migraine prophylaxis and adjunctive treatment of thyrotoxicosis. Apr 13, 2016" - Anonymous Online Contributor
Unverified Answer