Clomipramine Hydrochloride

Panic Disorder, Depression, Obsessive-Compulsive Disorder
Treatment
2 FDA approvals
20 Active Studies for Clomipramine Hydrochloride

What is Clomipramine Hydrochloride

ClomipramineThe Generic name of this drug
Treatment SummaryClomipramine is a tricyclic antidepressant (TCA) used to treat depression and other mental health conditions. It works by increasing the activity of neurotransmitters serotonin and norepinephrine in the brain to improve mood. Common side effects include sedation, blurred vision, dry mouth, constipation, and urinary retention. Clomipramine is also used to treat obsessive-compulsive disorder, panic disorder, chronic pain, cataplexy, trichotillomania, stuttering, premature ejaculation, and premenstrual syndrome. It is absorbed quickly from the gut and metabolized in
Anafranilis the brand name
image of different drug pills on a surface
Clomipramine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Anafranil
Clomipramine
1989
104

Approved as Treatment by the FDA

Clomipramine, also called Anafranil, is approved by the FDA for 2 uses like Obsessive Compulsive Disorder (OCD) and Obsessive-Compulsive Disorder .
Obsessive Compulsive Disorder (OCD)
Helps manage Obsessive Compulsive Disorder (OCD)
Obsessive-Compulsive Disorder
Helps manage Obsessive Compulsive Disorder (OCD)

Effectiveness

How Clomipramine Hydrochloride Affects PatientsClomipramine is an antidepressant medication which works by blocking certain chemicals in the brain that control mood. It usually takes around two weeks for people's mood to improve after taking this drug. It is thought that clomipramine changes how receptors in the brain respond to other chemicals, which leads to increased production of a certain chemical that affects mood. Clomipramine is also used to treat certain types of pain, especially those caused by nerve damage.
How Clomipramine Hydrochloride works in the bodyClomipramine is a drug that affects the reuptake of serotonin in the brain. It also blocks certain receptors and sodium channels, which may help to reduce chronic pain, especially neuropathic pain.

When to interrupt dosage

The proposed dose of Clomipramine Hydrochloride is based on the diagnosed disorder, such as Obsessive-Compulsive Disorder, Depression and Panic Disorder. The measure of dosage is contingent on the method of administration listed in the table below.
Condition
Dosage
Administration
Obsessive-Compulsive Disorder
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg, 100.0 mg
Capsule, , Oral, Capsule - Oral, Tablet, Tablet - Oral
Panic Disorder
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg, 100.0 mg
Capsule, , Oral, Capsule - Oral, Tablet, Tablet - Oral
Depression
25.0 mg, , 50.0 mg, 75.0 mg, 10.0 mg, 100.0 mg
Capsule, , Oral, Capsule - Oral, Tablet, Tablet - Oral

Warnings

Clomipramine Hydrochloride Contraindications
Condition
Risk Level
Notes
Myocardial Infarction
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Clomipramine Hydrochloride.
Common Clomipramine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Anagrelide.
Apixaban
Major
The metabolism of Apixaban can be decreased when combined with Clomipramine.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Clomipramine is combined with Asenapine.
Clomipramine Hydrochloride Toxicity & Overdose RiskAnafranil overdose can cause a range of symptoms, from mild to severe, which depend on the amount taken, age of the person, and how long ago the drug was taken. Severe reactions include changes in heart rhythm, very low blood pressure, seizures, and loss of consciousness. In some cases, death has occurred due to an Anafranil overdose. Other side effects include drowsiness, blurry vision, dry mouth, constipation, difficulty urinating, dizziness when standing up, rapid heartbeat, high blood pressure, heart failure, memory problems and confusion, and mood swings in those with bipolar disorder. Withdraw
image of a doctor in a lab doing drug, clinical research

Clomipramine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Clomipramine Hydrochloride?

634 active clinical trials are currently assessing the potential of Clomipramine Hydrochloride to alleviate Panic Disorder, Obsessive-Compulsive Disorder and Depression.
Condition
Clinical Trials
Trial Phases
Obsessive-Compulsive Disorder
66 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1
Panic Disorder
13 Actively Recruiting
Not Applicable
Depression
305 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4, Phase 3

Clomipramine Hydrochloride Reviews: What are patients saying about Clomipramine Hydrochloride?

5Patient Review
2/3/2017
Clomipramine Hydrochloride for Obsessive Compulsive Disorder
This drug has done wonders for my OCD. It's helped me more than any other SRIs I've tried, to the point where I only have mild symptoms that I can manage. The side effects are a bit of a nuisance (dry mouth and constipation), but they're worth it in light of the benefits I've experienced.
5Patient Review
6/24/2022
Clomipramine Hydrochloride for Depression
This treatment is much more effective than an SSRI.
5Patient Review
2/6/2014
Clomipramine Hydrochloride for Obsessive Compulsive Disorder
I've been taking 100mg per day for about a month now with no negative side effects. This medication helped me almost immediately with my OCD by curbing my excessive counting behavior.
4.7Patient Review
4/4/2017
Clomipramine Hydrochloride for Anxious
I've found this to be the best medication for intrusive thoughts, anxiety, and panic. That being said, it can have some nasty side effects that one should be aware of before taking it. Please speak with a professional to see if this is the right drug for you.
4.7Patient Review
9/18/2015
Clomipramine Hydrochloride for Panic Disorder
It took a little while for this to start working, but it was very effective in treating my OCD. I also saw a massive improvement in my insomnia and panic attacks.
4.3Patient Review
10/9/2017
Clomipramine Hydrochloride for Anxious
I've been taking 100mg of clomipramine every day, and it has really helped me sleep better. The only downside is that I developed ringing in my ears, which may be a side effect of the drug.
4.3Patient Review
11/1/2022
Clomipramine Hydrochloride for Obsessive Compulsive Disorder
This medication saved me. I had been struggling with chronic IBS and OCD for years, trying all sorts of different treatments to no avail. But as soon as I started taking Clomiprine, everything changed. Within a week my diarrhea and unwanted thoughts were gone. If you're struggling with anything similar, I urge you to give this medication a try.
4.3Patient Review
4/3/2014
Clomipramine Hydrochloride for Obsessive Compulsive Disorder
I was struggling with some serious mental health issues, and this medication really turned things around for me. I felt a difference from the very first day, and now my intrusive thoughts are gone.
4.3Patient Review
10/6/2018
Clomipramine Hydrochloride for Obsessive Compulsive Disorder
Despite the dry mouth and constipation, this medication is worth it because it helps me stay balanced and employed.
3.3Patient Review
2/16/2020
Clomipramine Hydrochloride for Depression
I've been using this medication for a couple years now. It's helped me feel better, but I have noticed some negative side effects like memory problems and an irregular heartbeat.
3Patient Review
3/21/2013
Clomipramine Hydrochloride for Anxious
I found that clomipramine was more effective than alprazolam for me, but everyone is different.
1.7Patient Review
5/4/2017
Clomipramine Hydrochloride for Obsessive Compulsive Disorder
I have severe OCD and this medication, which my doctor just raised the dosage of last week, did not help alleviate my symptoms at all. In addition to that, it caused some very unpleasant side effects like a fast heartbeat, muscle pain, and anorexia.
1.7Patient Review
3/23/2020
Clomipramine Hydrochloride for Obsessive Compulsive Disorder
Made me feel very unstable and my thoughts were racing while I was on it.
1.7Patient Review
10/8/2012
Clomipramine Hydrochloride for Obsessive Compulsive Disorder
I think this medication led to me overeating and gaining weight.
1Patient Review
7/3/2014
Clomipramine Hydrochloride for Obsessive Compulsive Disorder
Unfortunately, this drug did not work well for me. I had heart palpitations on a small dosage of 10mg and it only got worse when the doctor increased my dosage to 20mg. I felt incredibly tired and had no appetite while taking this medication, and now that I'm off of it I feel like I have the flu.
1Patient Review
5/17/2017
Clomipramine Hydrochloride for Obsessive Compulsive Disorder
Unfortunately, this medicine exacerbated my bipolar and OCD symptoms. I would go for a couple days without sleep, then sleep for a couple days in a row. It was constant twitching in my legs and feet that i didn't have before i started this medicine
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about clomipramine hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is clomipramine a strong antidepressant?

"Although Clomipramine is most commonly used as a treatment for obsessive-compulsive disorder, it is also an effective antidepressant. It works by affecting certain receptors in the brain, as shown in the table below."

Answered by AI

What are the most common side effects of clomipramine?

"The following side effects may occur when taking clomipramine: feeling dizzy or tired, dry mouth, trouble Line, upset stomach, nausea or vomiting, changes in appetite or weight, flushed skin, sweating, tiredness, or blurred vision. Symptoms of anxiety may get worse when you first start taking clomipramine."

Answered by AI

How does clomipramine make you feel?

"Clomipramine may make you feel sleepy, so your doctor may start you on a small dose. They may then gradually increase your dose as your body gets used to it. Clomipramine is usually taken once a day at bedtime, but it can also be taken in smaller doses two to three times a day."

Answered by AI

What is clomipramine prescribed for?

"It affects chemicals in the brain that may become unbalanced and cause OCD.

Clomipramine is used to treat obsessive compulsive disorder (OCD). OCD is a nervous condition wherein a person has recurring thoughts or ideas or does repetitive things because they are anxious. Clomipramine is a tricyclic antidepressant (TCA). It affects chemicals in the brain that may become unbalanced, which can lead to OCD."

Answered by AI

Clinical Trials for Clomipramine Hydrochloride

Image of Lincoln Middle School in Cottage Grove, United States.

Behavioral Interventions for Depression in Students

Any Age
All Sexes
Cottage Grove, OR
The goal of this clinical trial is to learn if two behavioral interventions work to reduce office disciplinary referrals, improve attendance, and reduce depression and anxiety in 7th grade students. This project combines two evidence-based programs-the Inclusive Skill-building Learning Approach (ISLA) for school-wide discipline reform and the Family Check-Up Online (FCU-O) for family-centered support-in an adaptive design to examine the unique and additive effects of these interventions on these child behavior outcomes. The main questions it will answer are: 1. What is the relative efficacy of ISLA vs. School-as-Usual? 2. What is the optimal sequencing of these interventions? 3. Which overall sequence of intervention strategies was most effective? Researchers will compare 6 combinations of these interventions to see which combination and sequencing provides the best student outcomes. School personnel participating in the project will be trained to implement the two interventions at their school. They will answer surveys in the fall, winter, and spring of their year of participation. Parent and Youth participants will complete surveys at baseline and then again 6 months and 12 months later.
Waitlist Available
Has No Placebo
Lincoln Middle School (+12 Sites)Beth Stormshak, PhD
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Living Well Program for Anxiety in Breast Cancer

18+
Female
Los Angeles, CA
The goal of this study is to evaluate the efficacy and cost-effectiveness of the Living Well Program, a digital therapeutic application with telecoaching support, in breast cancer patients with moderate-to-severe anxiety. The main question the study aims to answer is: does digital cognitive-behavioral therapy-based interventions decrease the overall healthcare costs of patients with stage II to IV breast cancer? The study has one group of participants who will use the Living Well app and telecoaching support. This group will be compared to retroactively matched controls. Over 3 months, patients will complete 21 mental health modules and 5 telecoaching sessions. In the following 3 months, they will complete any outstanding telecoaching sessions and modules while still being monitored, even if they finished all modules and sessions in the first 3 months. The 6 months after that will be the follow-up phase. They will still have access to the Living Well app and may continue to use it, and they will complete the same assessment questionnaires as baseline to identify any changes in their overall mental health.
Waitlist Available
Has No Placebo
Cedars-Sinai Medical CenterScott Irwin, MD
Image of Baylor College of Medicine in Houston, United States.

Stepped Care Treatment for Anxiety

7 - 17
All Sexes
Houston, TX
Childhood anxiety disorders (CAD) are common and impairing. Family based cognitive behavioral therapy (CBT) is efficacious in treating CAD. Yet, many children do not receive care due to barriers such as limited provider availably, high treatment costs, and constrained family resources (e.g., time). To combat these barriers, other treatment methods have been developed. The stepped care treatment models maximize resources by providing low-intensity, low-cost interventions as a first time treatment, while stepping up care for those needing more intensive treatment. Specifically, a stepped care model for CAD that begins with a parent-focus intervention has great promise to deliver efficacious and cost-effective treatment without having to engage the child. While stepped care approaches show promise in treating CAD with comparable efficacy to standard CBT, there remains a large research-to-practice gap. The stepped care model for CAD that begins with a parent-focused intervention has yet been explored, and very little is known about intervention mediators that explain mechanisms of change. This research is being done to improve the reach and quality of services using a stepped care model, offering an affordable and practical solution to the widespread gap in youth mental health care.
Waitlist Available
Has No Placebo
Baylor College of Medicine
Have you considered Clomipramine Hydrochloride clinical trials? We made a collection of clinical trials featuring Clomipramine Hydrochloride, we think they might fit your search criteria.Go to Trials
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Virtual Reality for Cancer

18 - 90
All Sexes
Jacksonville, FL
This clinical trial tests the safety, tolerability, and effectiveness of a virtual reality intervention to improve psychological symptom burden for cancer patients undergoing treatment. Virtual reality (VR) is a technology that allows users to experience and interact with three-dimensional, computer-generated environments that simulate the real world or imagined settings. The VR intervention consists of a preloaded with immersive environments designed to engage the senses through simulated sights and sounds. This may include a walk through of a serene forest, exploring vibrant coral reefs, swimming with dolphins, or standing at the base of a majestic waterfall. These environments are created to provide a relaxing and engaging experience. Completing the VR intervention may be a safe and effective way to improve quality of life, reduce anxiety, enhance focus, and promote healthy living for cancer patients undergoing treatment.
Recruiting
Has No Placebo
Mayo Clinic in FloridaJuan C. Cardenas Rosales, MD
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Akashic Records Sessions for Mental Health

18+
All Sexes
Palm City, FL
The goal of this clinical study is to learn the impact of two Akashic Records sessions on mental health symptoms in adults. We want to see how sessions are linked to stress, anxiety, and depression, and to resilience (ability to bounce back) and feelings of connectedness (to self, community, and humanity). Main questions this study will answer are: After two sessions, what is the impact on stress, anxiety, and depression? After two sessions, what is the impact on resilience and connectedness? How do participants describe their experience of the sessions? After two sessions, what are participants' views of their problems (insight), emotional experiences (impact) and observable behaviors in their daily life? What participants will do: Complete online surveys about their mood at four points: before the first session, before the second session, after the second session, and again 2 months later. Surveys include: DASS-21 (Depression, Anxiety, and Stress Scale) CD-RISC-10 (Connor-Davidson Resilience Scale) WATTS (Connectedness Scale) A short demographic form and satisfaction survey Attend two individual Akashic Records sessions (50-90 minutes each) over private video platform with a licensed clinical social worker (principal investigator) The first 50 participants will also join a one-hour interview with open ended questions with a licensed clinical social worker (co-investigator) about one week after the second session to share their experience in their own words. Who can take part: Adults ages 18 and older who can read and consent in English and who have experienced stress, anxiety, or low mood in the past year. How the research will happen: Sessions are held by secure video call. Participants will also complete private online surveys before, during, and after the sessions. Some participants may be invited to share their experiences in a one-on-one interview. All information is kept private and names are removed before analysis. Risks and benefits: Talking about personal topics may bring up strong emotions. Licensed clinicians conduct sessions, offer support, and provide referrals if needed. Possible benefits include new insights, greater peace or meaning, and improved coping; benefits are not guaranteed. Why this matters: Many people seek spiritual or transpersonal support for emotional concerns. This pilot study will provide early evidence on whether Akashic Records sessions may be a helpful, low-risk option and will guide future research.
Waitlist Available
Has No Placebo
Virtual/ No Physical FacilityCandice S Rasa, LCSW
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Virtual Reality Reward Training for Depression

18+
All Sexes
Los Angeles, CA
The purpose of this study is to compare the effects of enhanced Virtual Reality-Reward Training (eVR-RT) with an active control condition, Virtual Reality-Memory Training (VR-MT), on positive affect and other clinical symptoms. Enhanced VR-Reward Training is a novel intervention aimed at enhancing savoring of positive experiences among individuals with depression and low positive affect through guided imaginal recounting following immersion in positive VR experiences. The current study tests an enhanced version of this training using improved virtual reality technology. Target enrollment is 80 participants with low positive affect, depression, and impaired functioning, who are at least 18 years old, who will be randomly assigned to 7 weeks of either enhanced Virtual Reality-Reward Training (VR-RT) or Virtual Reality-Memory Training (VR-MT). Participants will complete in-person VR sessions, laboratory assessments, self-report questionnaires as part of the study. A subset of 8 participants randomly assigned to VR-RT will complete fMRI scans and EMA surveys. The total length of participation is around 3 months.
Phase 2
Recruiting
University of California, Los Angeles
Have you considered Clomipramine Hydrochloride clinical trials? We made a collection of clinical trials featuring Clomipramine Hydrochloride, we think they might fit your search criteria.Go to Trials
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Advertising Claims for Anxiety and Depression

18+
All Sexes
Lebanon, NH
In the U.S., legal cannabis is frequently advertised as an effective treatment for mental health problems such as anxiety and depression-particularly online. States that have legalized cannabis have not implemented regulations to address this type of advertising. This project aims to investigate the influence of psychotherapeutic advertising claims (PAC) and mental health warning labels (WL) on online cannabis purchasing behaviors among light-to-moderate cannabis users with symptoms of depression and/or anxiety. The specific aims are to determine whether PAC increases cannabis purchasing intentions and whether a mental health WL can mitigate this effect. A realistic online cannabis shopping experience will be simulated using the digital Platform for Online Evaluation of Marijuana Marketing and Sales (POEMMS). The study will employ a between-subjects experimental design by randomizing 2,000 participants to one of four online stores that vary in PAC and WL content: (1) a control claims (CC)-only store, (2) a PAC store, (3) a WL store, and (4) a PAC + WL store. Participants will browse and select items as if making real purchases. Analyses will examine three primary outcomes to determine the influence of PAC and WL on purchasing behaviors: (1) total milligrams of THC purchased, (2) average potency (%THC) of products, and (3) overall number of products purchased. The long-term objective is to inform evidence-based cannabis policy and regulatory strategies by understanding the impact of cannabis marketing on vulnerable populations. This research is relevant to public health by addressing the potential risks associated with misleading cannabis marketing, which may lead to increased use and exacerbation of mental health symptoms among individuals with depression and anxiety. The project leverages a multidisciplinary team with expertise in addiction, mental health, epidemiology, and digital health technology. The findings have the potential to inform the development of targeted interventions and policies to reduce harms associated with cannabis advertising-ultimately contributing to better health outcomes and more effective regulation.
Waitlist Available
Has No Placebo
Center for Technology and Behavioral Health (CTBH), Geisel School of Medicine at Dartmouth CollegeJennifer Emond, PHD
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Self-Help Intervention for Depression and PTSD

18+
All Sexes
Syracuse, NY
It is important to provide support and resources for the many post-9/11 Veterans with mental health symptoms and poor psychosocial functioning who do not engage in psychotherapy. One of the biggest reasons post-9/11 Veterans do not seek treatment is a preference to handle problems on their own. This study examines a self-help intervention that teaches Veterans healthy coping strategies they can use on their own and how to seek out recovery support services such as mental health treatment or whole-person care if they decide to do so in the future. This study will compare the impact of self-help and standard resources at improving mental health and resource utilization. Two hundred Veterans will complete 6 brief assessments across 40 weeks.
Waitlist Available
Has No Placebo
Syracuse VA Medical Center, Syracuse, NY (+1 Sites)Robyn L. Shepardson, PhD
Have you considered Clomipramine Hydrochloride clinical trials? We made a collection of clinical trials featuring Clomipramine Hydrochloride, we think they might fit your search criteria.Go to Trials
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