Aredia

osteolytic Bone metastases, Osteolytic lesion, Malignant Neoplasms + 3 more
Treatment
6 FDA approvals
20 Active Studies for Aredia

What is Aredia

Pamidronic acidThe Generic name of this drug
Treatment SummaryPamidronic acid is a type of drug used to treat conditions related to bone loss and mineral metabolism. It is a second-generation bisphosphonate, similar to drugs like neridronic acid and alendronic acid. Pamidronic acid was first described in 1977 and was approved by the FDA in 1991. It is less commonly used than newer third-generation bisphosphonates such as ibandronic acid, zoledronic acid, minodronic acid, and risedronic acid.
Arediais the brand name
image of different drug pills on a surface
Aredia Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Aredia
Pamidronic acid
1991
39

Approved as Treatment by the FDA

Pamidronic acid, also known as Aredia, is approved by the FDA for 6 uses like Paget’s Disease and Multiple Myeloma .
Paget’s Disease
Multiple Myeloma
osteolytic Bone metastases
Breast Cancer
Osteolytic lesion
Malignant Neoplasms

Effectiveness

How Aredia Affects PatientsPamidronic acid is a medication used to prevent bone loss. It is usually taken once every three to four weeks, and is considered to be a safe drug. However, there is a risk of elevated blood urea nitrogen, kidney damage, and renal tubular necrosis. Patients should be warned about these possible side effects.
How Aredia works in the bodyBisphosphonates are taken into the bones, where they attach to hydroxyapatite. This causes the osteoclasts, which break down bone, to detach from the bone and prevents further resorption. When the osteoclasts become acidic, the bisphosphonates are released and taken into the cell, where they interfere with the mevalonate pathway. This pathway is responsible for attaching GTP-binding proteins, like Rap1, to molecules. When it doesn't happen, apoptosis is triggered, leading to cell death. In addition, caspases 3 and 9 are activated, further contributing to

When to interrupt dosage

The prescribed measure of Aredia is contingent on the determined condition, including Paget’s Disease, Osteolytic lesion and Multiple Myeloma. The dosage relies on the delivery technique featured in the table below.
Condition
Dosage
Administration
Malignant Neoplasms
, 3.0 mg/mL, 9.0 mg/mL, 30.0 mg, 90.0 mg, 60.0 mg, 15.0 mg, 6.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution, concentrate, Solution, concentrate - Intravenous
Breast Cancer
, 3.0 mg/mL, 9.0 mg/mL, 30.0 mg, 90.0 mg, 60.0 mg, 15.0 mg, 6.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution, concentrate, Solution, concentrate - Intravenous
Multiple Myeloma
, 3.0 mg/mL, 9.0 mg/mL, 30.0 mg, 90.0 mg, 60.0 mg, 15.0 mg, 6.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution, concentrate, Solution, concentrate - Intravenous
osteolytic Bone metastases
, 3.0 mg/mL, 9.0 mg/mL, 30.0 mg, 90.0 mg, 60.0 mg, 15.0 mg, 6.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution, concentrate, Solution, concentrate - Intravenous
Osteolytic lesion
, 3.0 mg/mL, 9.0 mg/mL, 30.0 mg, 90.0 mg, 60.0 mg, 15.0 mg, 6.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution, concentrate, Solution, concentrate - Intravenous
Paget’s Disease
, 3.0 mg/mL, 9.0 mg/mL, 30.0 mg, 90.0 mg, 60.0 mg, 15.0 mg, 6.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Injection, Injection - Intravenous, Powder, for solution, Powder, for solution - Intravenous, Solution, Solution - Intravenous, Liquid, Liquid - Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Solution, concentrate, Solution, concentrate - Intravenous

Warnings

Aredia Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Pamidronic Acid may interact with Pulse Frequency
There are 20 known major drug interactions with Aredia.
Common Aredia Drug Interactions
Drug Name
Risk Level
Description
Neomycin
Major
The risk or severity of nephrotoxicity can be increased when Pamidronic acid is combined with Neomycin.
Tenofovir
Major
Pamidronic acid may increase the nephrotoxic activities of Tenofovir.
Tenofovir alafenamide
Major
Pamidronic acid may increase the nephrotoxic activities of Tenofovir alafenamide.
Tenofovir disoproxil
Major
Pamidronic acid may increase the nephrotoxic activities of Tenofovir disoproxil.
Abacavir
Minor
Pamidronic acid may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aredia Toxicity & Overdose RiskOverdosing on gentamicin may cause low calcium levels, fever, low blood pressure, and abnormal taste. Treatment may involve giving steroids and calcium intravenously to manage the symptoms.
image of a doctor in a lab doing drug, clinical research

Aredia Novel Uses: Which Conditions Have a Clinical Trial Featuring Aredia?

688 current investigations are analyzing the efficacy of Aredia in managing Multiple Myeloma, osteolytic Bone metastases and Breast Cancer.
Condition
Clinical Trials
Trial Phases
Breast Cancer
713 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Malignant Neoplasms
0 Actively Recruiting
Paget’s Disease
0 Actively Recruiting
osteolytic Bone metastases
0 Actively Recruiting
Osteolytic lesion
0 Actively Recruiting
Multiple Myeloma
12 Actively Recruiting
Phase 2, Phase 1

Aredia Reviews: What are patients saying about Aredia?

5Patient Review
4/18/2011
Aredia for Osteoporosis caused by Anti-Androgen Drugs
Despite the severe flu-like symptoms I experience for a few days after each infusion, this treatment has been very effective in reducing my bone pain.
4.7Patient Review
7/30/2009
Aredia for Breast Cancer that has Spread to the Bones
I had some mild side effects, including a fever for two days, nausea and vomiting, rigors (shivering), chills, and tingling sensations. These resolved within a few days and I felt much better afterwards.
4Patient Review
2/20/2014
Aredia for Cancer Metastasis to Bone
After receiving this monthly injection for about a year, my bone mass has remained the same---and even shown some improvement in degeneration. My leg pain has decreased and I no longer experience back pain. Additionally, I have not experienced any negative side effects that are worth mentioning. It is also very important to eat nutritiously; I've started going to Chinese buffets and loading up on healthy options like fish, chicken, vegetables, fruit, and hot tea. This treatment has really helped revive my appetite.
4Patient Review
12/22/2010
Aredia for Breast Cancer that has Spread to the Bones
I've been taking this drug approximately every four weeks since being diagnosed with bone cancer four years ago. I usually experience mild, flu-like symptoms for a few days afterwards; however, it is definitely worth taking if it protects my bones!
4Patient Review
7/26/2010
Aredia for Breast Cancer that has Spread to the Bones
I had some dental work done and then was diagnosed with ONJ.
2.3Patient Review
6/29/2010
Aredia for Breast Cancer that has Spread to the Bones
I've only tried this treatment a couple times, but both times I had most of the listed side effects in addition to an infection/inflammation at the IV site. My doctor put me on Cipro for that and it did the job. They'll be giving me Benadryl before my next treatment to see if we can avoid the infection altogether. All things considered, it's manageable.
2.3Patient Review
6/26/2009
Aredia for Breast Cancer that has Spread to the Bones
While there have been no observed side effects, this treatment has helped to improve my bone density.
1Patient Review
3/28/2013
Aredia for Lesions in the Bone of the Disease Multiple Myeloma
I haven't seen any benefits from taking this drug.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about aredia

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How often is Aredia given?

"The suggested amount of Aredia for patients with bone metastases that are causing bones to break down is 90 mg given as an infusion over a 2-hour period every 3-4 weeks."

Answered by AI

What is Aredia used to treat?

"Pamidronate is a member of the bisphosphonate class of drugs and is indicated for the management of high levels of serum calcium due to malignancy or bone pain and weakness associated with myeloma or metastatic breast carcinoma."

Answered by AI

Is Aredia a chemo drug?

"Aredia can be used to help reduce bone complications and pain in patients with advanced-stage breast cancer that has spread to the bone. It is typically given intravenously, along with chemotherapy medications."

Answered by AI

What type of drug is Aredia?

"Aredia is a bisphosphonate drug which inhibits osteoclast activity and prevents bone complications such as pain, fractures, or high calcium levels."

Answered by AI

Clinical Trials for Aredia

Have you considered Aredia clinical trials? We made a collection of clinical trials featuring Aredia, we think they might fit your search criteria.
Have you considered Aredia clinical trials? We made a collection of clinical trials featuring Aredia, we think they might fit your search criteria.
Have you considered Aredia clinical trials? We made a collection of clinical trials featuring Aredia, we think they might fit your search criteria.
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