Amcinonide

Inflammation, Skin Diseases, Itching
Treatment
20 Active Studies for Amcinonide

What is Amcinonide

AmcinonideThe Generic name of this drug
Treatment SummaryAmcinonide is a steroid medication used to reduce inflammation and treat certain skin conditions.
Cyclocortis the brand name
Amcinonide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cyclocort
Amcinonide
1999
6

Effectiveness

How Amcinonide Affects PatientsAmcinonide is a type of steroid medicine used to reduce inflammation and reduce itching. The exact way it works is unknown, but scientists believe it helps control certain chemicals in the body that cause swelling and irritation. It usually comes as an ointment, and can also help the skin stay hydrated.
How Amcinonide works in the bodyTopical steroids, like amcinonide, reduce inflammation. It is believed that this is achieved by blocking the release of arachidonic acid, which is a precursor for inflammatory molecules like prostaglandins and leukotrienes. Amcinonide has a strong affinity for the glucocorticoid receptor but only weak affinity for progesterone, mineralocorticoid, estrogen, and androgen receptors.

When to interrupt dosage

The advised dosage of Amcinonide is predicated upon the diagnosed affliction, including Inflammation, corticosteroid-responsive dermatoses and Itch. The quantity of dosage is contingent upon the technique of administration (e.g. Cream - Topical or Lotion) featured in the table below.
Condition
Dosage
Administration
Inflammation
, 0.001 mg/mg, 0.1 %
, Topical, Cream, Cream - Topical, Ointment, Ointment - Topical, Lotion - Topical, Lotion
Skin Diseases
, 0.001 mg/mg, 0.1 %
, Topical, Cream, Cream - Topical, Ointment, Ointment - Topical, Lotion - Topical, Lotion
Itching
, 0.001 mg/mg, 0.1 %
, Topical, Cream, Cream - Topical, Ointment, Ointment - Topical, Lotion - Topical, Lotion

Warnings

There are 20 known major drug interactions with Amcinonide.
Common Amcinonide Drug Interactions
Drug Name
Risk Level
Description
Allogeneic processed thymus tissue
Minor
The therapeutic efficacy of Allogeneic processed thymus tissue can be decreased when used in combination with Amcinonide.
Inebilizumab
Minor
The risk or severity of infection can be increased when Amcinonide is combined with Inebilizumab.
Vibrio cholerae CVD 103-HgR strain live antigen
Minor
The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Amcinonide.
2,4-thiazolidinedione
Moderate
The risk or severity of hyperglycemia can be increased when Amcinonide is combined with 2,4-thiazolidinedione.
AICA ribonucleotide
Moderate
The risk or severity of hyperglycemia can be increased when Amcinonide is combined with AICA ribonucleotide.
Amcinonide Toxicity & Overdose RiskA person is unlikely to experience any health risks from applying an excessive amount of the drug to their skin or accidentally swallowing it.
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Amcinonide Novel Uses: Which Conditions Have a Clinical Trial Featuring Amcinonide?

200 active trials are being conducted to ascertain the effectiveness of Amcinonide in providing relief for Corticosteroid-responsive Dermatoses, Itch and Inflammation.
Condition
Clinical Trials
Trial Phases
Skin Diseases
0 Actively Recruiting
Itching
2 Actively Recruiting
Phase 3, Not Applicable
Inflammation
61 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1, Phase 2, Phase 3, Phase 4

Amcinonide Reviews: What are patients saying about Amcinonide?

5Patient Review
11/29/2009
Amcinonide for Genital Itching
3Patient Review
2/10/2010
Amcinonide for Plaque Psoriasis
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Patient Q&A Section about amcinonide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Cyclocort used for?

"This medication is a strong corticosteroid that is used to treat various skin conditions, such as eczema, dermatitis, allergies, and rash. Amcinonide works by reducing the swelling, itching, and redness that can be associated with these conditions."

Answered by AI

What is Amcinonide cream used for?

"This medicine is a corticosteroid. It is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions."

Answered by AI

Is Cyclocort over the counter?

"Cyclocort is a prescription medicine used to treat the symptoms that are responsive to corticosteroids. Cyclocort may be used alone or with other medications."

Answered by AI

Clinical Trials for Amcinonide

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Cognitive Remediation for Memory and Thinking Difficulties

18+
All Sexes
Farmington, CT
The goal of this clinical trial is to determine if a neuroscience-based computerized cognitive remediation ("brain training") program can treat neurocognitive dysfunction (i.e., memory or thinking difficulties) that emerges in some older adults following a viral infection. The main questions it aims to answer are: * Does computerized cognitive remediation improve cognitive performance and day-to-day functioning in older adults with postviral neurocognitive dysfunction? * Will treatment effects be maintained over time, leading to better long term cognitive outcomes? * Does the treatment lead to reductions in blood-based markers of inflammation as a potential mechanism of cognitive symptom improvement? * Can the treatment be optimized and refined based on feedback from participants to improve user (patient) experience? Researchers will compare the computerized cognitive remediation program to an active computer-based control condition (alternative computer activities) to see if the computerized cognitive remediation program works to treat postviral neurocognitive dysfunction. Participation takes approximately 43-48 hours over 7 months, with most activities (40-46 hours) completed within the first 7-8 weeks, including: * Initial intake visit: Eligibility confirmation (\~2-3 hours) * Computer activities: About 5 hours per week for \~6 weeks (total \~30 hours) completed on a computer tablet provided by the study and loaned to participants for use during the treatment phase * Weekly remote check-in meetings: \~30 minutes each during treatment * Blood draws: Two sessions (before and after treatment), \~20-30 minutes each * Three research visits: Pre-treatment, post-treatment, and 6-month follow-up (\~2-3 hours each, including assessments of cognitive, emotional, and daily functioning)
Waitlist Available
Has No Placebo
UConn HealthCutter Lindbergh, Ph.D.
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Freeze-dried Grape Powder for Healthy Aging

50 - 75
All Sexes
Storrs, CT
The purpose of this study is to investigate the effects of consuming grape powder on immune profiles in healthy middle- and older-aged individuals. Specifically, the investigators are interested in evaluating the potential effects of grapes in influencing markers of immune function, inflammation, and metabolism that are known to change with aging. Grapes contain several nutrients and antioxidant polyphenols such as resveratrol, quercetin, vitamin K and fiber, which are known to promote heart and immune health. However, the effects of grapes on altering immune profiles within the context of aging is not well understood. Therefore, this study will explore how daily grape consumption impacts certain markers of immunity in healthy middle- and older-aged adults. The main study procedures include consumption of a freeze-dried grape powder and control powder (which tastes the same but has none of the grape compounds that are being studied) mixed with water as a beverage on a daily basis for 4 weeks each. The investigators will additionally ask that participants avoid eating grapes and certain other antioxidant/grape-related foods and beverages throughout the 13-week study. Participants will additionally be asked to complete surveys about their diet, physical activity, and medical history, as well as provide blood samples and body weight measures throughout the course of the study. Participation in the study is expected to last about 6.25 hours over the course of 13 weeks and will include 7 visits.
Recruiting
Paid Trial
Department of Nutritional Sciences
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High Salt Intake for High Blood Pressure

60 - 85
All Sexes
Bloomington, IN
Most Americans consume excess dietary salt based on the recommendations set by the American Heart Association and Dietary Guidelines for Americans. High dietary salt impairs blood pressure control by affecting systemic blood vessels and the kidneys. These changes contribute to excess salt consumption being associated with increased risk for chronic kidney disease and cardiovascular disease, the leading cause of death in America. Salt is particularly deleterious in older adults who are more likely to exhibit salt-sensitive hypertension. However, salt consumption remains high in the United States. Thus, there is a critical need for strategies to counteract the effects of high dietary salt as consumption is likely not going to decrease. One promising option is ketones, metabolites that are produced in the liver during prolonged exercise and very low-calorie diets. While exercise and low-calorie diets are beneficial, not many people engage in these activities. Limited evidence indicates that ketone supplements improve cardiovascular health in humans. Additionally, published rodent data indicates that ketone supplements prevent high salt-induced increases in blood pressure, blood vessel dysfunction, and kidney injury. Our human pilot data also indicates that high dietary salt reduces intrinsic ketone production, but it is unclear whether ketone supplementation confers humans' protection against high salt similar to rodents. Therefore, the investigators seek to conduct a short-term high-dietary salt study to determine whether ketone supplementation prevents high dietary salt from eliciting increased blood pressure, blood vessel dysfunction, and kidney injury/impaired blood flow. The investigators will also measure inflammatory markers in blood samples and isolate immune cells that control inflammation. Lastly, the investigators will also measure blood ketone concentration and other circulating metabolites that may be altered by high salt, which could facilitate novel therapeutic targets to combat high salt.
Recruiting
Has No Placebo
School of Public Health
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Biophoton Therapy for Stem Cell Proliferation

18 - 70
All Sexes
Tampa, FL
Study Objective The purpose of this clinical study is to evaluate if biophoton therapy, delivered by Tesla BioHealing® Biophoton Generators (Biophotonizer), can increase self-grown stem cells naturally. Study Design This is a randomized, double-blinded, placebo-controlled intervention clinical study to assess the effectiveness of biophoton therapy in impacting stem cells. Approximately 46 volunteers who want to increase self-grown stem cells will participate in the study. Study Randomization The biostatistician will prepare a randomization schedule including a serial of subject numbers. A subject number will be randomly assigned to each study participant, which will assign them to either the control group or the treatment group. Other than the Informed Consent Form (ICF), all study information will be recorded by using the subject number. The Principal Investigator, study physicians, study nurse, data-entry specialists, and biostatisticians, as well as the participants, will be blinded about who received which product during the first two weeks of study participation.
Recruiting
Online Trial
Tesla MedBed at Tampa-FL (+1 Sites)James Z Liu, MD, PhD
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Physical Activity for Delayed Onset Muscle Soreness

18 - 35
All Sexes
Toronto, Canada
After completing novel activity or exercise we may experience exercise-induced muscle damage (EIMD), resulting in a period of reduced muscle function and delayed onset muscle soreness (DOMS). DOMS is characterized by muscle pain and tenderness that typically resolves within a week. While the precise cause of DOMS is unknown, there is growing evidence implicating damage to the connective tissue that surrounds our muscle fibers and is related to a small amount of inflammation. This inflammation is a normal part of our body's ability to recovery from injuries and may be visualized through the use of ultrasound technology. A variety of recovery techniques have been proposed that may help with the recovery of DOMS such as massage and electrical muscle stimulation, but these are not always accessible. Therefore, we are interested in investigating whether the number of daily steps can affect how you experience DOMS.
Waitlist Available
Has No Placebo
Goldring Center for High Performance Sport
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Moisturizers for Aging

65+
All Sexes
San Francisco, CA
This is a randomized, investigator-blinded, self-controlled pilot study of the physiologic response to topical moisturizers among older adults with dry skin. The overarching hypothesis is that skin barrier decline is an important source of chronic inflammation, and that skin barrier restoration with moisturizers can reduce serum biomarkers of inflammation. The primary objective is to determine the feasibility for a larger trial, and the secondary objectives are to determine the extent to which measures of serum inflammation, skin barrier function, and the skin microbiome change in response to moisturizers. Participants will be asked to apply one of two topical moisturizers that are widely available over the counter in the US (Vaseline® 100% pure petroleum jelly or CeraVe® moisturizing cream) once daily for 4 weeks to the front of the torso, buttocks, arms, and legs. Subjects will act as their own control (i.e. they will be asked to apply the study moisturizer they are randomized to for one intervention period (4 weeks) and not to apply topical moisturizers for the other 4- week intervention period). Participants will be randomized in a 1:1:1:1 ratio to one of 4 treatment groups: i. no intervention then CeraVe; ii. CeraVe then no intervention; iii. no intervention then Vaseline; iv. Vaseline then no intervention. At each visit (baseline, week 4, and week 8), participants will undergo skin barrier testing, skin microbiome sampling, and phlebotomy to measure serum inflammatory markers.
Phase 4
Recruiting
UCSFKatrina Abuabara, MD
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