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What is Accupril
QuinaprilThe Generic name of this drug
Treatment SummaryQuinapril is a medication used to treat high blood pressure and heart failure. It works by blocking an enzyme in the body that increases blood pressure. It was approved by the FDA in 1991 and a combination tablet with hydrochlorothiazide was approved in 1999. ACE inhibitors, of which quinapril is one, are often prescribed as the first line of treatment for high blood pressure.
Quinapril Hydrochlorideis the brand name
Accupril Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Quinapril Hydrochloride
Quinapril
1991
190
Approved as Treatment by the FDA
Quinapril, also known as Quinapril Hydrochloride, is approved by the FDA for 2 uses including Hypertensive disease and Congestive Heart Failure .Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Congestive Heart Failure
Used in combination with other therapies
Effectiveness
How Accupril Affects PatientsQuinapril is a drug used to treat high blood pressure or to help with heart failure. It is considered to be relatively safe and produces long lasting effects when a proper dose is taken daily.
How Accupril works in the bodyAngiotensin II tightens coronary blood vessels and increases oxygen consumption. Over time this can cause cell enlargement and more cell growth in the vessels. Angiotensin II also triggers the production of a substance which increases the risk of blood clots. Quinaprilat stops the conversion of angiotensin I to angiotensin II, reducing the amount of this substance in the body. This lowers the risk of blood clots, especially after a heart attack.
When to interrupt dosage
The prescribed quantity of Accupril is contingent upon the determined affliction, including Diabetic Nephropathy, Heart Attack and Left Ventricular Dysfunction. The amount of dosage will differ in relation to the delivery approach (e.g. Tablet, film coated or Tablet, film coated - Oral) detailed in the table below.Condition
Dosage
Administration
Diabetic Nephropathy
, 5.0 mg, 10.0 mg, 20.0 mg, 40.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Heart Attack
, 5.0 mg, 10.0 mg, 20.0 mg, 40.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Hypertensive disease
, 5.0 mg, 10.0 mg, 20.0 mg, 40.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Congestive Heart Failure
, 5.0 mg, 10.0 mg, 20.0 mg, 40.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Left Ventricular Dysfunction
, 5.0 mg, 10.0 mg, 20.0 mg, 40.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Warnings
Accupril ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Angioedema
Do Not Combine
Common Accupril Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Quinapril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Quinapril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Quinapril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Quinapril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Quinapril.
Accupril Toxicity & Overdose RiskThe lowest toxic dose of quinapril in rats has been found to be 3541mg/kg and in mice is 1739mg/kg. Those who overdose on quinapril may experience dangerously low blood pressure. Since quinapril binds strongly to proteins, it cannot be removed from the bloodstream by dialysis. Patients should be treated with fluids to restore their normal blood pressure.
Accupril Novel Uses: Which Conditions Have a Clinical Trial Featuring Accupril?
111 trials are presently investigating the potential of Accupril to provide relief for Left Ventricular Dysfunction, Heart Attack and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Heart Attack
53 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Congestive Heart Failure
22 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Left Ventricular Dysfunction
6 Actively Recruiting
Not Applicable, Phase 4
Accupril Reviews: What are patients saying about Accupril?
5Patient Review
8/10/2012 I've had type 1 diabetes for 37 years, and my kidneys were leaking protein. So my doctor put me on Accupril. I didn't have high blood pressure, so I started with 2.5mg, and now I'm up to 5mg without any major issues. I have developed a cough that sometimes interferes with my eating and makes me a bit breathless, but I'm not too worried about it. Considering I was only expected to live 10 more years when I was first diagnosed, I'm doing pretty well!
5Patient Review
7/9/2013 For the first four hours or so, this drug effectively lowers my blood pressure. However, after that time frame it becomes ineffective and my blood pressure returns to normal.
5Patient Review
7/21/2013 I took this medication for a decade without any issues. However, about a year ago I developed a dry cough that wouldn't go away. Once I changed medications, the cough disappeared.
5Patient Review
8/1/2014 After taking this medication for a decade or more, many people in the midsouth region began having serious side effects. Some even needed to go to the emergency room.
4.7Patient Review
12/26/20094.7Patient Review
2/10/20114.3Patient Review
11/13/2013 I was on this medication for a decade and saw great results. Recently, my readings have started going up again, though I'm not sure if that's because I switched to a different medication (my insurance refused to cover the cost of Accupril) or not. I'm currently on three different medications and experiencing some side effects, but I'm going to tell my doctor that I want to go back on Accupril.
4Patient Review
9/12/2012 I took 20 mg of this medication for one year. My blood pressure was only slightly lowered to around 155/84. I always felt tired and needed to take it at bedtime. Additionally, there was slight swelling of my hands and the area around my eyes. I stopped taking it and tried other blood pressure medications but their side effects were worse so now I'm back on Accupril.
4Patient Review
10/25/20114Patient Review
4/25/2014 I was feeling really bad and I thought I was going to die. My heart was racing and then slowing down and I felt like harming people. This treatment helped me a lot.
4Patient Review
1/30/2014 This medication has helped me a lot with my dry cough.
4Patient Review
12/17/2013 This treatment is effective and helped me.
4Patient Review
11/11/2014 I had been on Accupril or quinapril 10 for a long time without any issues. It kept my blood pressure under control. However, last month I experienced swelling of my tongue and was rushed to the hospital. I now know that this is a side effect of the drug. It can happen at any time and can stay in your system for up to six weeks. I have since changed my BP medication.
2.7Patient Review
12/20/20092.7Patient Review
1/25/20102.7Patient Review
3/20/2012 I take 80mg of accupril 2 times a day when I wake up on Mondays. My blood pressure is 160 over 80.
2Patient Review
5/18/20112Patient Review
7/2/2014 I had a cough and low sodium levels.
1.7Patient Review
2/4/2014 This medication has effectively kept my blood pressure in check.
Patient Q&A Section about accupril
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the generic name for Accupril?
"Quinapril is used for the treatment of high blood pressure and congestive heart failure.
Quinapril is an ACE inhibitor used for treating high blood pressure and congestive heart failure."
Answered by AI
What type of drug is Accupril?
"Quinapril is a medication used to treat heart failure and hypertension. It is classified as an ACE inhibitor, meaning that it works by relaxing blood vessels and allowing blood to flow more easily."
Answered by AI
What is the difference between Accupril and lisinopril?
"Zestril lowers blood pressure effectively and protects kidney function. Accupril lowers blood pressure, reduces the risk of heart attack and stroke, and protects kidneys, making it a good choice for people with diabetes or mild-to-moderate kidney disease."
Answered by AI
What is the medication Accupril used for?
"It is also used to treat heart failure and to improve survival after a heart attack."
Answered by AI