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What is Zonalon
DoxepinThe Generic name of this drug
Treatment SummaryDoxepin is a medication used to treat depression and anxiety. It works by blocking certain receptors in the brain that are linked to these conditions. Doxepin is a type of antidepressant known as a tricyclic, which means it shares properties with other drugs in its class like amitriptyline and desipramine. It was first developed by Pfizer and approved by the FDA in 1969 as an antidepressant. In 2010, it was also approved to treat insomnia.
Sinequanis the brand name
Zonalon Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sinequan
Doxepin
1969
307
Effectiveness
How Zonalon Affects PatientsDoxepin is a type of antidepressant that works by decreasing the electrical activity of the brain. It can have effects such as making someone feel calmer and easing depression, but it can also make them feel sleepy. These effects usually take a few weeks to be fully felt, but the sedative effect is felt right away. High doses produce more noticeable side effects, like dizziness, confusion, and dry mouth.
How Zonalon works in the bodyDoxepin works by blocking histamine receptors, which helps relieve skin conditions. It also works on the central nervous system to increase levels of norepinephrine and serotonin at synapse nerve terminals. This helps increase activity at post-synaptic neuron receptor sites and desensitizes serotonin 1A receptors and beta-adrenergic receptors. Finally, it increases dopamine levels in the frontal cortex, which helps improve its transmission in this area.
When to interrupt dosage
The prescribed measure of Zonalon depends on the recognized condition, including Depression, Involutional, Mental Disorder, Organic and Insomnia. The magnitude of dosage is contingent upon the method of delivery (e.g. Oral or Tablet - Oral) featured in the below table.Condition
Dosage
Administration
Behcet Syndrome
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
psychotic depressive disorder
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Neurotic depression
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Insomnia
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Neuropathic Pain
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Itching
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Generalized Anxiety Disorder
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Lichen simplex chronicus
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Depression
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Depression, Involutional
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Alcoholism
, 10.0 mg/mL, 10.0 mg, 25.0 mg, 50.0 mg, 75.0 mg, 100.0 mg, 0.05 mg/mg, 150.0 mg, 3.0 mg, 6.0 mg, 5.0 %
, Oral, Solution, concentrate, Solution, concentrate - Oral, Capsule, Capsule - Oral, Topical, Cream, Cream - Topical, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, film coated - Oral, Tablet, film coated
Warnings
Zonalon has four potential contraindications and should not be utilized when any of the conditions specified in the following table are present.Zonalon ContraindicationsCondition
Risk Level
Notes
untreated narrow angle glaucoma
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Doxepin may interact with Pulse Frequency
Pulse Frequency
Do Not Combine
Urinary Retention
Do Not Combine
Common Zonalon Drug Interactions
Drug Name
Risk Level
Description
4-Methoxyamphetamine
Major
Doxepin may increase the vasopressor activities of 4-Methoxyamphetamine.
Acepromazine
Major
Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Doxepin is combined with Aclidinium.
Alfuzosin
Major
Doxepin may increase the hypotensive activities of Alfuzosin.
Aripiprazole
Major
Doxepin may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.
Zonalon Toxicity & Overdose RiskTaking too much doxepin can cause seizures, abnormal heart rhythms, coma, low blood pressure, or even death. It has also been linked to reduced fertility in both males and females, including reduced number of viable embryos and lower sperm motility. There is no evidence to suggest that doxepin is carcinogenic or mutagenic.
Zonalon Novel Uses: Which Conditions Have a Clinical Trial Featuring Zonalon?
A vast 1020 active trials are being conducted to explore the potential of Zonalon in providing relief from Generalized Anxiety Disorder, Atopic Dermatitis and Bipolar Disorder.Condition
Clinical Trials
Trial Phases
Insomnia
93 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 3, Phase 1, Early Phase 1
Generalized Anxiety Disorder
243 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1, Phase 4
Itching
10 Actively Recruiting
Phase 4, Phase 3, Phase 2, Phase 1
Neurotic depression
0 Actively Recruiting
Depression, Involutional
0 Actively Recruiting
Behcet Syndrome
2 Actively Recruiting
Not Applicable
Alcoholism
7 Actively Recruiting
Phase 3, Not Applicable, Phase 2
Lichen simplex chronicus
0 Actively Recruiting
Depression
698 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1, Early Phase 1, Phase 4
psychotic depressive disorder
0 Actively Recruiting
Neuropathic Pain
27 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Phase 4
Zonalon Reviews: What are patients saying about Zonalon?
5Patient Review
11/30/2013 Over-the-counter itch creams and cold compresses failed to provide me with any relief from my neurodermatitis. This prescription, however, was very effective. I got instant relief but it made me drowsy.
5Patient Review
9/7/2009 Shoulder and hip pain has been a problem for me for a while, but after using this treatment, I get quick and long-lasting relief. I highly recommend it to anyone with similar issues.
4.7Patient Review
2/1/2014 Worked great for my severe pain from shingles, but I unfortunately developed an allergy to it. Now I'm on the lookout for a new treatment that can help me with the pain in my left armpit.
3Patient Review
6/6/2010 The itching on my forearms has decreased with use, but now the skin is more red. I'll keep using it for now, but I'm also going to look for other options.
1Patient Review
12/19/2008 I've tried this medication for three weeks now and I haven't seen any results. In fact, I think I'm having an allergic reaction to it. My eyes are itching, my genitals are rashy, and I feel itchy all over.
1Patient Review
9/17/2009 I don't think this would be effective for shingles.
Patient Q&A Section about zonalon
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is doxepin and what are the side effects?
"Doxepin is a medication used to treat depression and anxiety by increasing the levels of certain natural substances in the brain. It is also available in tablet form to treat insomnia."
Answered by AI
Who makes Zonalon?
"Doxepin hydrochloride (equivalent to 4.4% doxepin) in a vehicle of sorbitol, cetyl alcohol, isopropyl myristate, glyceryl stearate, PEG-100 stearate, petrolatum, benzyl alcohol, titanium dioxide and purified water."
Answered by AI
What is the drug doxepin used for?
"Doxepin is a medication used to treat symptoms of anxiety or depression, as well as insomnia. It is classified as a tricyclic antidepressant (TCA), meaning it works by affecting the levels of certain chemicals in the brain."
Answered by AI
What is Zonalon cream used for?
"This medication is used to relieve itchiness from certain skin conditions such as eczema, neurodermatitis, and atopic dermatitis. However, it should only be used for a short amount of time not exceeding 8 days."
Answered by AI